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| 1 | Ecological principle meets cancer treatment: treating children with acute myeloid leukemia with low-dose chemotherapy显示文摘Standard chemotherapy regimens for remission induction of pediatric acute myeloid leukemia(AML) are associated with significant morbidity and mortality. We performed a cohort study to determine the impact of reducing the intensity of remission induction chemotherapy on the outcomes of selected children with AML treated with a low-dose induction regimen plus granulocyte colony stimulating factor(G-CSF)(low-dose chemotherapy(LDC)/G-CSF). Complete response(CR) after two induction courses was attained in 87.0%(40/46) of patients receiving LDC/G-CSF. Post-remission therapy was offered to all patients, and included standard consolidation and/or stem cell transplantation. During the study period, an additional 94 consecutive children with AML treated with standard chemotherapy(SDC) for induction(80/94(85.1%) of the patients attained CR after induction Ⅱ, P = 0.953) and post-remission. In this non-randomized study, there were no significant differences in 4-year event-free(67.4 vs. 70.7%;P = 0.99)and overall(70.3 vs. 74.6%, P = 0.69) survival in the LDC/G-CSF and SDC cohorts, respectively. After the first course of induction, recovery of white blood cell(WBC) and platelet counts were significantly faster in patients receiving LDC/G-CSF than in those receiving SDC(11.5 vs. 18.5 d for WBCs(P < 0.001);15.5 vs. 22.0 d for platelets(P < 0.001)). To examine the quality of molecular response, targeted deep sequencing was performed. Of 137 mutations detected at diagnosis in 20 children who attained hematological CR after two courses of LDC/G-CSF(n = 9) or SDC(n = 11), all of the mutations were below the reference value(variant allelic frequency <2.5%) after two courses, irrespective of the treatment group. In conclusion, children with AML receiving LDC/G-CSF appear to have similar outcomes and mutation clearance levels, but significantly lower toxicity than those receiving SDC. Thus, LDC/G-CSF should be further evaluated as an effective alternative to remission induction in pediatric AML. | Yixin Hu Aili Chen Xinchang Zheng Jun Lu Hailong He Jin Yang Ya Zhang Pinpin Sui Jingyi Yang Fuhong He Yi Wang Peifang Xiao Xin Liu Yinmei Zhou Deqing Pei Cheng Cheng Raul C. Ribeiro Shaoyan Hu Qian-fei Wang | 2019 | National Science Review2019，6，3： | 3 |
| 2 | The characteristic of extrapolation in numerical inductive inference: An ERP study显示文摘 | Jialan Qin Feng Xiao Fuhong Li Wenju Sha Hong Li | 2009 | Brain Research2009，，： | 1 |
| 3 | Electrosynthesis of Azobenzenes Directly from Nitrobenzenes显示文摘The electrochemical reduction strategy of nitrobenzenes is developed.The chemistry occurs under ambient conditions.The protocol uses inert electrodes and the solvent,DMSO,plays a dual role as a reducing agent.Its synthetic value has been demonstrated by the highly efficient synthesis of symmetric,unsymmetric and cyclic azo compounds. | Yanfeng Ma Shanghui Wu Shuxin Jiang Fuhong Xiao Guo-Jun Deng | 2021 | Chinese Journal of Chemistry2021，39，12： | 1 |
| 4 | Rhodium(III)-catalyzed successive C(sp^(2))-H and C(sp^(2))-C(sp^(2))bond activation of aryl oximes:synthetic and mechanistic studies显示文摘Merging selective C-H cleavage with C-C cleavage in a tandem reaction has been a practical strategy that permits skeletal diversification from simple raw materials.Herein,we describe a rhodium(III)-catalyzed redox-neutral reaction of aryl oximes and internal alkynes to generate novel N-(2-cyanoaryl)indanone imines. | Cheng Li Huawen Huang Fuhong Xiao Bin Zhao Guo-Jun Deng | 2022 | Organic Chemistry Frontiers2022，9，3： | 0 |
| 5 | Three-Component Synthesis of 2-Heteroaryl-3-hydroxybenzo[b]- thiophenes under Transition-Metal-Free Conditions显示文摘A convenient synthetic route to 2-heteroaryl-3-hydroxybenzo[b]thiophene derivatives via K_(2)CO_(3)-promoted multicomponent cycliza-tion between o-halogenated benzaldehyde,2-methylquinolines and sulfur powder has been demonstrated.This reaction is performed smoothly under simple conditions to give the corresponding products in moderate to good yields.The resultant 3-hydroxybenzo[b]thiophenes have been proved to be versatile building blocks in a range of transition-metal-catalyzed cross-coupling reactions. | Dahan Wang Fuhong Xiao Feng Zhang Guo-Jun Deng | 2021 | Chinese Journal of Chemistry2021，39，9： | 0 |
| 6 | Copper-Catalyzed Aerobic Oxidative Ring Expansion of Isatins: A Facile Entry to Isoquinolino-Fused Quinazolinones显示文摘A copper-catalyzed aerobic oxidative ring expansion reaction of isatins with 1,2,3,4-tetrahydroisoquinoline for the synthesis of tetra-cyclic quinazolinones has been developed.This reaction is performed smoothly under simple conditions to give the corresponding products in moderate to good yields with good functional group tolerance. | Dahan Wang Fuhong Xiao Feng Zhang Huawen Huang Guo-Jun Deng | 2021 | Chinese Journal of Chemistry2021，39，1： | 0 |
| 7 | Synthesis of biheteroaryls via 2-methyl quinoline C(sp^(3))-H functionalization under metal-free conditions显示文摘An acetic acid-promoted C(sp^(3))-H functionalization of 2-methyl quinoline,enaminoesters and elemental sulfur for the synthesis of 3,4,5-trisubstituted isothiazoles under metal-free conditions has been developed.This approach provides viable access to various 5-(quinolin-2-yl)isothiazoles in moderate to good yields with good functional group tolerance.Moreover,the success of the gram-scale reaction gives this reaction a great potential application. | Dahan Wang Yuhan Yang Fuhong Xiao Jinbing Liu Guojiang Mao Guo-Jun Deng | 2024 | Green Synthesis and Catalysis2024，5，1： | 0 |
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