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您的检索式：作者名="Funan Huang"
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| 1 | Emerging systemic delivery strategies of oncolytic viruses:A key step toward cancer immunotherapy显示文摘Oncolytic virotherapy(OVT)is a novel type of immunotherapy that induces anti-tumor responses through selective self-replication within cancer cells and oncolytic virus(OV)-mediated immunostimulation.Notably,talimogene laherparepvec(T-Vec)developed by the Amgen company in 2015,is the first FDA-approved OV product to be administered via intratumoral injection and has been the most successful OVT treatment.However,the systemic administration of OVs still faces huge challenges,including in vivo pre-existing neutralizing antibodies and poor targeting delivery efficacy.Recently,state-of-the-art progress has been made in the development of systemic delivery of OVs,which demonstrates a promising step toward broadening the scope of cancer immunotherapy and improving the clinical efficacy of OV delivery.Herein,this review describes the general characteristics of OVs,focusing on the action mechanisms of OVs as well as the advantages and disadvantages of OVT.The emerging multiple systemic administration approaches of OVs are summarized in the past five years.In addition,the combination treatments between OVT and traditional therapies(chemotherapy,thermotherapy,immunotherapy,and radiotherapy,etc.)are highlighted.Last but not least,the future prospects and challenges of OVT are also discussed,with the aim of facilitating medical researchers to extensively apply the OVT in the cancer therapy. | Weiyue Ban Jianhuan Guan Hanwei Huang Zhonggui He Mengchi Sun Funan Liu Jin Sun | 2022 | Nano Research2022，15，5： | 2 |
| 2 | Modulation of ATP levels alters the of hydrogen peroxide induced cell death in primary cortical cultures:effects of putative neurprective agents显示文摘 | Funan Huang Mohan C Vemuri J S Schneider | 2004 | Brain Research2004，997，： | 1 |
| 3 | Modulation of ATP levels alters the hydrogen peroxide - induced cell death in primary- cortical cultures:effects of putative neurprotective agents 显示文摘 | Funan Huang Mohan C Vemuri J SSchneider | 2004 | Brain Res2004，997，： | 1 |
| 4 | Modulation of ATP levels alters the of hydrogen peroxide-induced cell death in primary cortical cultures:effects of putative neurprotective agents显示文摘 | Funan Huang Mohan C Vemuri J S Schneider | 2004 | Brain Research2004，997，： | 1 |
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