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您的检索式：作者名="Fushan Tang"
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| 1 | A designed amphiphilic peptide containing the silk fibroin motif as a potential carrier of hydrophobic drugs显示文摘amphiphilic 肽作为一个潜在的药搬运人正在变得吸引人在一个水的系统改进恐水病的药的 dissolvability;因此,由目标房间便于药举起。这里,我们报导新奇设计 amphiphilic 肽,能稳定分核的 Ac-RADAGAGARADAGAGA-NH 2, ,我们选择了在水的答案学习的恐水病的模型药。这设计的肽由在 peptide– 内包含分核形成了胶体的暂停;分核建筑群。鸡蛋 phosphatidylcholine (EPC ) 泡被用来模仿房间双性人层膜。我们发现那个分核被与 EPC 泡混合胶体的暂停免除肽涂层进 EPC 泡,它被稳定的荧光系列作为时间的功能跟随。为在一给定的时间释放进 EPC 泡的分核的数量的一条刻度曲线被用来决定免除进类脂化合物泡 peptide– 的分核的最后的集中;分核建筑群。peptide– 的版本率;分核建筑群是打算的确定进 EPC 泡的分核的转移。 | Qinghan Zhou Juan Lin Jing Wang Feng Li Fushan Tang Xiaojun Zhao | 2009 | Progress in Natural Science:Materials International2009，19，11： | 11 |
| 2 | Local bone metabolism balance regulation via double-adhesive hydrogel for fixing orthopedic implants显示文摘The effective osteointegration of orthopedic implants is a key factor for the success of orthopedic surgery.However,local metabolic imbalance around implants under osteoporosis condition could jeopardize the fixation effect.Inspired by the bone structure and the composition around implants under osteoporosis condition,alendronate(A)was grafted onto methacryloyl hyaluronic acid(H)by activating the carboxyl group of methacryloyl hyaluronic acid to be bonded to inorganic calcium phosphate on trabecular bone,which is then integrated with aminated bioactive glass(AB)modified by oxidized dextran(O)for further adhesion to organic collagen on the trabecular bone.The hybrid hydrogel could be solidified on cancellous bone in situ under UV irradiation and exhibits dual adhesion to organic collagen and inorganic apatite,promoting osteointegration of orthopedic implants,resulting in firm stabilization of the implants in cancellous bone areas.In vitro,the hydrogel was evidenced to promote osteogenic differentiation of embryonic mouse osteoblast precursor cells(MC3T3-E1)as well as inhibit the receptor activator of nuclear factor-κB ligand(RANKL)-induced osteoclast differentiation of macrophages,leading to the upregulation of osteogenic-related gene and protein expression.In a rat osteoporosis model,the bone-implant contact(BIC)of the hybrid hydrogel group increased by 2.77,which is directly linked to improved mechanical stability of the orthopedic implants.Overall,this organic-inorganic,dual-adhesive hydrogel could be a promising candidate for enhancing the stability of orthopedic implants under osteoporotic conditions. | Wei Jiang Fushan Hou Yong Gu Qimanguli Saiding Pingping Bao Jincheng Tang Liang Wu Chunmao Chen Cailiang Shen Catarina Leite Pereira Marco Sarmento Bruno Sarmento Wenguo Cui Liang Chen | 2022 | Bioactive Materials2022，7，6： | 0 |
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