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| 1 | 欧洲呼吸学会和欧洲胸外科医师学会恶性胸膜间皮瘤诊疗指南显示文摘恶性胸膜间皮瘤(malignant pleural mesothelioma,MPM)是一种罕见肿瘤,但发病率正逐渐上升,且预后较差。2008年,欧洲呼吸学会(European Respiratory Society,ERS)和欧洲胸外科医师学会(European Society of Tho-racic Surgeons,ESTS)特别工作组召集各方专家计划制定MPM诊治经验及更新指南。为了使MPM得到及时准确的诊断,专家推荐对患者实施胸腔镜检查,有手术禁忌和胸腔粘连的病例除外。约10%的病例采用标准染色方法无法获得满意的结果。因此我们推荐在胸膜活检的基础上,采用特异性免疫组化标志物。由于目前缺乏一个统一的、切实有效的分期系统,我们推荐应用最新的TNM分期,并且提出三个阶段的治疗前评估。在MPM的治疗中,患者的体力状态评分和组织亚型是目前唯一的、具有重要临床价值的预后因素。在临床试验中,应对其它潜在因素进行初步探讨并予以报道。MPM对化疗高度耐受,仅有少数患者可接受根治性手术。本文对新的治疗方法和策略进行了综述。目前由于最佳综合治疗的资料有限,适合采用多种方案联合治疗策略的患者应被纳入专业机构的前瞻性试验中。 | A. Scherpereel P. Astoul P. Baas T. Berghmans H. Clayson P. de Vuyst H. Dienemann F. Galateau-Salle C. Hennequin G. Hillerdal C. Le Pe'choux L. Mutti J-C. Pairon R. Stahel P. van Houtte J. van Meerbeeck D. Waller W. Weder 宋作庆 徐萧洪 | 2010 | 中国肺癌杂志2010，，10： | 56 |
| 2 | Mesenchymal stem cells over-expressing hepatocyte growth factor improve small-for-size liver grafts regeneration显示文摘 | Yu, Y. Yao, A. H. Chen, N. Pu, L. Y. Fan, Y. Lv, L. Sun, B. C. Li, G. Q. Wang, X. H. | 2007 | 南京医科大学学报(自然科学版)2007，27，10： | 45 |
| 3 | 美国临床肿瘤学会IV期非小细胞肺癌化疗的临床实践指南更新显示文摘本文旨在为IV期非小细胞肺癌患者的治疗提供更新版推荐。本文资料检索源自2002年以来公布的相关随机试验文献。此指南范围限于化疗与生物治疗。更新委员会对这些文献进行了总结并提供了推荐更新。162篇文献符合标准被纳入参考。本推荐基于可改善总生存期的治疗方法。仅改善无进展生存期的治疗方法推动了对毒性及生存质量的监测。对于体力状态评分为0分或1分患者的一线治疗,可推荐以铂类为基础的细胞毒性药物的两药联用。对铂类治疗有禁忌的患者,可采用非铂类细胞毒性两药联合。对于体力状态评分为2分的患者,单一细胞毒性药物即可。对于疾病进展或经过4个周期的治疗仍对治疗无反应的患者,应停止一线细胞毒性化疗。即使在6个周期后患者对治疗仍有反应,亦应停止两药细胞毒性化疗。对于伴有明确的表皮生长因子受体(epidermal growth factor receptor,EGFR)突变的患者,可推荐一线采用吉非替尼治疗;对于EGFR突变为阴性或不明确的患者,细胞毒性化疗更佳。除具有特定临床特征的患者外,可推荐贝伐单抗与卡铂-紫杉醇联用。对于通过免疫组化证实EGFR阳性的肿瘤患者,可推荐西妥昔单抗与顺铂-长春瑞滨联用。多西紫杉醇、厄洛替尼、吉非替尼或培美曲塞被推荐作为二线治疗。对于未曾接受过厄洛替尼或吉非替尼治疗的患者,可推荐厄洛替尼作为三线治疗。现有数据不足以推荐常规三线采用细胞毒性药物。已有的证据也不足以推荐常规应用分子标记物选择化疗。 | Christopher G. AZZOLI Sherman Baker JR Sarah TEMIN William PAO Timothy ALIFF Julie BRAHMER David H. JOHNSON Janessa L. LASKIN Gregory MASTERS Daniel MILTON Luke NORDQUIST David G. PFISTER Steven PIANTADOSI Joan H. SCHILLER Reily SMITH Thomas J. SMITH John R. STRAWN David TRENT Giuseppe GIACCONE 丁燕(翻译) 南娟(翻译) 刘谦(翻译) 周清华(校对) 陈军(校对) | 2010 | 中国肺癌杂志2010，13，3： | 43 |
| 4 | A community-derived classification for extant lycophytes and ferns显示文摘发展史长通知了蕨类植物分类。当我们推断进化的树的能力改善了,针对认出生来的组的分类变得逐渐地预兆、稳定。这里,我们为 lycophytes 和蕨纲植物提供一个现代、全面分类,在下面,利用一条基于社区的途径类水平。我们 monophyly 用作主要标准让 taxa,而且目的识别保存两个广泛地被接受的存在 taxa 和界限并且与我们蕨类植物发展史的理解一致。总共,这个分类对待一在 337 个类, 51 个家庭, 14 目,和二个班估计了 11 916 种类。这个分类没在 lycophyte 和蕨纲植物上作为最后的词被打算分类,而是当前的假设的概括陈述,源于最好的可得到的数据并且在问题由熟悉植物的那些大多数塑造了。我们希望它将在蕨类植物上为最近的文学的那些想要的参考用作一个资源发展史和分类,为指导未来调查的一个框架,和推进讲话的刺激。 | Eric Schuettpelz Harald Schneider Alan R. Smith Peter Hovenkamp Jefferson Prado Germinal Rouhan Alexandre Salino Michael Sundue Thafs Elias Almeida Barbara Parris Emily B. Sessa Ashley R. Field Andre Luis de Gasper Carl J. Rothfels Michael D. Windham Marcus Lehnert Benjamin Dauphin Atsushi Ebihara Samuli Lehtonen Pedro Bond Schwartsburd Jordan Metzgar Li-Bing Zhang Li-Yaung Kuo Patrick J. Brownsey Masahiro Kato Marcelo Daniel Arana Francine C. Assis Michael S. Barker David S. Barrington Ho-Ming Chang Yi-Han Chang Yi-Shan Chao Cheng-Wei Chen De-Kui Chen Wen-Liang Chiou Vinicius Antonio de Oliveira Dittrich Yi-Fan Duan Jean-Yves Dubuisson Donald R. Farrar Susan Fawcett Jose Maria Gabriel y Galan Luiz Armando de Araujo Goes-Neto Jason R. Grant Amanda L. Grusz Christopher Haufler Warren Hauk Hai He Sabine Hennequin Regina Yoshie Hirai Layne Huiet Michael Kessler Petra Korall Paulo H. Labiak Anders Larsson Blanca Leen Chun-Xiang Li Fay-Wei Li Melanie Link-Perez Hong-Mei Liu Ngan Thi Lu Esteban I. Meza-Torres Xin-Yuan Miao Robbin Moran Claudine Massi Mynssens Nathalie Nagalingum Benjamin Ollgaard Alison M. Paul Jovani B. de S. Pereira Leon R. Perrie Monica Ponce Tom A. Ranker Christian Schulz Wataru Shinohara Alexander Shmakov Erin M. Sigel Filipe Soares de Souza Lana da Silva Sylvestre Weston Testo Luz Amparo Triana-Moreno Chie Tsutsumi Hanna Tuomisto IvAn A. Valdespino Alejandra Vasco Raquel Stauffer Viveros Alan Weakley Ran Wei Stina Weststrand Paul G. Wolf George Yatskievych Xiao-Gang Xu Yue-Hong Yan Liang Zhang Xian-Chun Zhang Xin-Mao Zhou | 2016 | Journal of Systematics and Evolution2016，54，6： | 44 |
| 5 | Development of distributed time-variant gain model for nonlinear hydrological systems显示文摘In this paper, a rainfall-runoff modeling system is developed based on a nonlinear Volterra functional series and a hydrological conceptual modeling approach. Two models, i.e. the time-variant gain model (TVGM) and the distributed time-variant gain model (DTVGM) that are built on the platform of Digital Elevation Model (DEM), Remote Sensing (RS) and Unit Hydro-logical Process were proposed. The developed DTVGM model was applied to two cases in the Heihe River Basin that is located in the arid and semiarid region of northwestern China and the Chaobai River basin located in the semihumid region of northern China. The results indicate that, in addition to the classic dynamic differential approach to describe nonlinear processes in hy-drological systems, it is possible to study such complex processes through the proposed sys-tematic approach to identify prominent hydrological relations. The DTVGM, coupling the advan-tages of both nonlinear and distributed hydrological models, can simulate variant hydrological processes under different environment conditions. Satisfactory results were obtained in fore-casting the time-space variations of hydrological processes and the relationships between land use/cover change and surface runoff variation. | XIA Jun1, 2, WANG Gangsheng1, TAN Ge1, YE Aizhong2 & G. H. Huang3 1. Key Laboratory of Water Cycle & Related Land Surface Processes, Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101, China 2. State Key Laboratory of Water Resources & Hydropower Engineering Sciences, Wuhan University, Wuhan 430072, China 3. Faculty of Engineering, University of Regina, 3737 Wascana Parkway, Regina, Sask., S4S 0A2, Canada Correspondence should be addressed to Xia Jun | 2005 | Science China Earth Sciences2005，48，6： | 32 |
| 6 | Intracellular tat of human immunodeficiency virus type 1 activates lytic cycle replication of Kaposi's sarcoma-associated herpesvirus. Role of JAK/STAT signaling显示文摘 | Zeng, Y. Zhang, X. H. Huang, Z. Cheng, L. Yao, S. H. Qin, D. Chen, X. Y. Tang, Q. Lv, Z. G. Zhang, L. Lu, C. | 2007 | 南京医科大学学报(自然科学版)2007，27，5： | 31 |
| 7 | EGF promoter SNPs, plasma EGF levels and risk of breast cancer in Chinese women显示文摘 | Wang, Y. | 2008 | 南京医科大学学报(自然科学版)2008，28，12： | 32 |
| 8 | Responses of Soil Microbial Community Structure and Diversity to Agricultural Deintensification显示文摘Using a scheme of agricultural fields with progressively less intensive management (deintensification), different manage- ment practices in six agroecosystems located near Goldsboro, NC, USA were tested in a large-scale experiment, including two cash-grain cropping systems employing either tillage (CT) or no-tillage (NT), an organic farming system (OR), an integrated cropping system with animals (IN), a successional field (SU), and a plantation woodlot (WO). Microbial phos- pholipid fatty acid (PLFA) profiles and substrate utilization patterns (BIOLOG ECO plates) were measured to examine the effects of deintensification on the structure and diversity of soil microbial communities. Principle component analyses of PLFA and BIOLOG data showed that the microbial community structure diverged among the soils of the six systems. Lower microbial diversity was found in lowly managed ecosystem than that in intensive and moderately managed agro- ecosystems, and both fungal contribution to the total identified PLFAs and the ratio of microbial biomass C/N increased along with agricultural deintensification. Significantly higher ratios of C/N (P < 0.05) were found in the WO and SU systems, and for fungal/bacterial PLFAs in the WO system (P < 0.05). There were also significant decreases (P < 0.05) along with agricultural deintensification for contributions of total bacterial and gram positive (G+) bacterial PLFAs. Agricultural deintensification could facilitate the development of microbial communities that favor soil fungi over bacteria. | ZHANG Wei- Jian RUI Wen-Yi C. TU H. G. DIAB F. J. LOUWS J. P. MUELLER N. CREAMER M. BELL M.G. WAGGER S. HU | 2005 | Pedosphere2005，15，4： | 29 |
| 9 | Blockade of cholecystokinin-2 receptor and cyclooxygenase-2 synergistically induces cell apoptosis, and inhibits the proliferation of human gastric cancer cells in vitro显示文摘Gastrin and cyclooxygenase-2(COX-2) playimportant roles in the carcinogenesis and progression ofgastric cancer.However,it remains unknown whether the combination of cholecystokinin-2(CCK-2) receptor antagonist plus COX-2 inhibitor exerts synergistic anti-tumor effects on human gastric cancer.Here,we demonstrated that the combination of AG-041R(a CCK-2 receptor antagonist) plus NS-398(a selective COX-2 inhibitor) treatment had synergistic effects on proliferation inhibition,apoptosis induction,down-regulation of Bcl-2 and up-regulation of Bax expression in MKN-45 cells.These results indicate that simultaneous targeting of CCK-2 receptor and COX-2 may inhibit gastric cancer development more effectively than targeting either molecule alone.(C)2008 Elsevier Ireland Ltd.All rights reserved. | Sun, W. H. | 2008 | 南京医科大学学报(自然科学版)2008，28，9： | 30 |
| 10 | NUMERICAL SIMULATION OF ROUND TO OVAL ROLLING PROCESS显示文摘Three dimensional thermal-mechanical coupled elasto-plastic FEM has been used for simulation of round to oval single pass rolling. The analysis was conducted using MARC/AUTOFORCE1. 2 code. The material is assumed to be elasto-plastic and it obey the Von Mises yield criterion and Prandtl- Reuss rule. Deformation of the workpiece is simulated in a step-by-step manner,updating the coordinates of material points and the property after each step, so that both nonsteady-state and stendy-state deformation can be simulated. The heat transfter between the workpiece, the rolls, and enviroment and the heat generation due to plastic work and friction force, are considered in the analys- is.Predicted the deformation shape of the workpiece, distributions of strains, stresses, strain rates and temperatures, roll-separating force and roll torque are presented. | Y. W. Wang, Y. L. King, D. H. Yuan, S. G. Liu and Z. Y. Yu 1 ) University of Science and Technology Beijing, Beijing 100083, China 2) Daye Special Steel Co., Huangshi 435001, China | 2000 | Acta Metallurgica Sinica(English Letters)2000，13，2： | 27 |
| 11 | Water and Heavy Metal Transport in Roadside Soils显示文摘Roads with very high traffic loads in regions where soils are low in both pH and sorption capacity might be a source of percolation water loaded with heavy metals. Looking at some 'worst case' scenarios, this study focused on the input of traffic related pollutants and on Pb, Cd, Cu, Zn, Ni and Cr concentrations in the soil matrix and soil solution, respectively. The analysis also included pH and electrical conductivity and at some sites DOC. The investigations were carried out on sandy soils with more or less low pH values at four motorway sites in Germany. The average of daily traffic was about 50 000 up to 90 000 vehicles. Soil pore water was collected in two soil depths and at four distances from the road. The pH in general decreased with increasing distance from the roadside. The elevated pH near the roadside was presumably caused by deposition of dust and weathering residues of the road asphalt, as well as by infiltration of salt that was used during winter time. At these road sites, increased heavy metal concentrations in the soil matrix as well as in the soil solution were found. However, the concentrations seldom exceeded reference values of the German Soil Protection Act. The soil solution concentrations tended to increase from the road edge to 10 m distance, whereas the concentration in the soil matrix decreased. Elevated DOC concentrations corresponded with elevated Cu concentrations but did not substantially change this tendency. High soil water percolation rates were found near the roads. Thus, even low metal concentrations of percolation water could yield high metal loads in a narrow area beside the road. | B. KOCHER G. WESSOLEK H. STOFFREGEN | 2005 | Pedosphere2005，15，6： | 25 |
| 12 | 动脉瘤性蛛网膜下腔出血处理指南 美国心脏协会卒中委员会特别写作组给医疗专业人员的声明显示文摘蛛网膜下腔出血(subarachnoid hemorrhage,SAH)是一种常见病,常常导致严重后果,约占全部卒中病例的5%,在美国每年有多达3万人罹患该病。美国心脏协会(American Heart Association,AHA)曾发表过“动脉瘤性SAH处理指南”。此后,在血管内技术、诊断方法以及手术和围手术期管理方面已取得了显著进展。尽管如此,SAH患者的预后依然较差,基于人群研究报告的病死率高达45%,并且存活者会遗留严重残疾。一些多中心前瞻性随机试验和前瞻性队列分析已对SAH的治疗方案产生影响。然而, | Joshua B. Bederson E. Sander Connolly H. Hunt Batjer Ralph G. Dacey Jacques E. Dion Michael N. Diringer John E. Duldner Robert E. Harbaugh Aman B. Patel Robert H. Rosenwasser 高翔(译) 李洛(译) 李海峰(译) | 2009 | 国际脑血管病杂志2009，17，4： | 24 |
| 13 | Aquaporin-4 deficiency down-regulates glutamate uptake and GLT-1 expression in astrocytes显示文摘 | Zeng, X. N. Sun, X. L. Gao, L. Fan, Y. Ding, J. H. Hu, G. | 2007 | 南京医科大学学报(自然科学版)2007，27，5： | 20 |
| 14 | STUDY ON THE HOT DEFORMATION BEHAVIORS OF Al-Zn-Mg-Cu-Cr ALUMINUM ALLOY显示文摘Al-Zn-Mg-Cu-Cr 铝合金的热变丑行为和 mierostructures 用热模拟测试,光显微镜学和传播电子显微镜学被学习了。作为结果,在各种各样的变丑条件下面的真压力对真紧张曲线和微观结构被获得。微观结构逐渐地倾向与升起的变丑温度和与变丑温度的减少或与提起紧张率精制的再结晶谷物动态再结晶。在在随后的热处理的 Zener-HoUomon 参数(Z) 和平均再结晶谷物尺寸之间的量的关系被建立。 | G. Y. Lin Z.F. Zhang H. Zhang D.S. Peng J. Zhou | 2008 | Acta Metallurgica Sinica(English Letters)2008，21，2： | 19 |
| 15 | 生物质气化特性研究及分析显示文摘为了提高生物质能的利用效率以及生物质气化合成气的品质,基于AspenPlus模拟平台,以松木、玉米秸秆和木屑为气化原料,对生物质气化特性进行了研究并对气化过程进行了分析。计算了空燃比为0.7~2.3、生物质含水率为30%条件下的气化炉运行温度、合成气低位热值和效率等主要气化过程性能指标,并通过提高气化剂温度、干燥生物质原料等方法对生物质气化过程进行了优化分析。结果表明,生物质种类及其含水率对气化过程性能有较大的影响;降低生物质含水率、提高气化剂温度有利于提高气化过程的效率和合成气低位热值。 | 张小桃 黄明华 王爱军 张燕 H. Arellano-Garcia G. Wozny | 2011 | 农业工程学报2011，27，2： | 18 |
| 16 | Estimations of primary production and export production in the South China Sea based on sediment trap experiments显示文摘The results of time series sediment trap experiments in the South China Sea show that particulate organic carbon (POC) fluxes are influenced by the monsoons. The increase of productivity in the northern South China Sea is mainly due to northeast monsoon while in the central South China Sea the influence of southwest monsoon becomes more prominent. The annual primary production and export production calculated based on POC fluxes are 53 0-63 4 and 10 32-12 93 gC·m -2·a -1, respectively. The enhancement of POC flux during monsoon period suggest that higher palaeoproductivity or organic carbon accumulation rate in glacial age in the South China Sea might be the result of strengthening of the monsoons. | Jianfang Chen Lianfu Zheng M. G. Wiesner Ronghua Chen Yulong Zheng H. K. Wong | 1998 | Chinese Science Bulletin1998，43，7： | 18 |
| 17 | The b2/b3 subdeletion shows higher risk of spermatogenic failure and higher frequency of complete AZFc deletion than the gr/gr subdeletion in a Chinese population显示文摘 | Lu, C. C. Zhang, J. Li, Y. C. Xia, Y. K. Zhang, F. Wu, B. Wu, W. Ji, G. X. Gu, A. H. Wang, S. L. Jin, L. Wang, X. R. | 2009 | 南京医科大学学报(自然科学版)2009，29，4： | 16 |
| 18 | 颅内血管神经介入治疗的适应证美国心脏协会心血管放射学和介入委员会、卒中委员会、心血管外科和麻醉委员会、外周血管病跨学科委员会以及护理质量和转归研究跨学科委员会的联合学术声明显示文摘颅内血管内介入是一种使用微侵袭血管内技术治疗脑血管病的方法。该专业领域在过去10年里取得了巨大进展,而且随着该学科得到越来越多的临床认可,这种进步的速度还在加快。 | Philip M. Meyers H. Christian Schumacher Randall T. Higashida Stanley L. Barnwell Mark A. Creager Rishi Gupta Cameron G. McDougall Dilip K. Pandey David Sacks Lawrence R. Wechsler 乔梵(译) 刘建民(译) 洪波(译) | 2009 | 国际脑血管病杂志2009，17，10： | 16 |
| 19 | 利用混合实时仿真器测试HVDC控制与保护显示文摘介绍使用实时数字仿真器 RTDS对 HVDC控制和保护系统进行测试。为获得高精度的阀触发脉冲和高频下的仿真性能 ,采用了先进的混合 HVDC实时仿真器。其中 ,HVDC换流器采用传统的物理模拟装置 ,直流系统和并联的复杂交流系统均采用实时纯数字仿真 ,由 RTDS仿真器实现。该混合实时仿真器被选择用于中国天—广 HVDC工程。基于 HVDC控制和保护系统的测试 ,文中给出了新的混合实时仿真器的结构实现方法和性能校验结果。与 EMTDC计算机仿真结果比较 ,HVDC控制和保护系统的性能得到了校验。 | 李函 韩英铎 王仲鸿 M. Claus H. Messner D. Retzmann G. Wild | 2000 | 电力系统自动化2000，24，17： | 15 |
| 20 | 胚胎分泌的人白细胞抗原G与体外受精中的高妊娠率相关 | Yie S.-M. Balakier H. Motamedi G. Librach C.L. 李跃萍 | 2005 | 世界核心医学期刊文摘(妇产科学分册)2005，0，6： | 14 |
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