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| 1 | 广泛耐药革兰阴性菌感染的实验诊断、抗菌治疗及医院感染控制:中国专家共识显示文摘广泛耐药革兰阴性杆菌(XDR-GNB),是指除1~2类抗菌药物(主要指多黏菌素和替加环素)外,几乎对所有类别抗菌药物均不敏感的革兰阴性杆菌。XDR-GNB常见于肠杆菌科细菌、鲍曼不动杆菌、铜绿假单胞菌和嗜麦芽窄食单胞菌等。近年来,中国XDR-GNB的发生率呈不断上升趋势,由于缺乏有效的治疗药物,XDR-GNB感染成为公共卫生安全的一大威胁。我国有关感染的临床、微生物学及临床药理学专家们就XDR-GNB感染的实验室诊断、临床诊疗和医院感染控制等问题深入讨论,形成此共识。其中细菌药敏试验的抗菌药物品种及结果判定标准遵循美国临床和实验室标准化协会(CLSI)、欧洲抗菌药物敏感性试验委员会(EUCAST)或美国食品与药物监督管理局(FDA)的指南。研究提示长疗程使用广谱抗菌药物是引发XDR-GNB感染最重要的危险因素。根据现有的临床研究和实验室数据,共识提供治疗各种XDRGNB感染的联合用药推荐方案,其中常用的抗菌药物有替加环素、多黏菌素、碳青霉烯类、氨基糖苷类和磷霉素等。同时建议实行严格的感染控制措施,包括手卫生、接触隔离、主动筛查、环境消毒、去定植和抗菌药物应用管理等遏制XDRGNB感染的传播。 | 王明贵 X.Guan L.He B.Hu J.Hu X.Huang G.Lai Y.Li Y.Liu Y.Ni H.Qiu Z.Shao Y.Shi M.Wang R.Wang D.Wu C.Xie Y.Xu F.Yang K.Yu Y.Yu J.Zhang C.Zhuo | 2017 | 中国感染与化疗杂志2017，17，1： | 269 |
| 2 | Dual prognostic role of 2-oxoglutarate-dependent oxygenases in ten cancer types:implications for cell cycle regulation and cell adhesion maintenance显示文摘Background: Tumor hypoxia is associated with metastasis and resistance to chemotherapy and radiotherapy. Genes involved in oxygen-sensing are clinically relevant and have significant implications for prognosis. In this study, we examined the pan-cancer prognostic significance of oxygen-sensing genes from the 2-oxoglutarate-dependent oxygenase family. Methods: A multi-cohort, retrospective study of transcriptional profiles of 20,752 samples of 25 types of cancer was performed to identify pan-cancer prognostic signatures of 2-oxoglutarate-dependent oxygenase gene family (a family of oxygen-dependent enzymes consisting of 61 genes). We defined minimal prognostic gene sets using three independent pancreatic cancer cohorts (n = 681). We identified two signatures, each consisting of 5 genes. The ability of the signa-tures in predicting survival was tested using Cox regression and receiver operating characteristic (ROC) curve analyses. Results: Signature 1 (KDM8, KDM6B, P4HTM, ALKBH4, ALKBH7) and signature 2 (KDM3A, P4HA1, ASPH, PLOD1, PLOD2) were associated with good and poor prognosis. Signature 1 was prognostic in 8 cohorts representing 6 cancer types (n = 2627): bladder urothelial carcinoma (P = 0.039), renal papillary cell carcinoma (P = 0.013), liver cancer (P = 0.033 and P = 0.025), lung adenocarcinoma (P = 0.014), pancreatic adenocarcinoma (P < 0.001 and P = 0.040), and uterine corpus endometrial carcinoma (P < 0.001). Signature 2 was prognostic in 12 cohorts representing 9 cancer types (n = 4134): bladder urothelial carcinoma (P = 0.039), cervical squamous cell carcinoma and endocervical adenocar-cinoma (P = 0.035), head and neck squamous cell carcinoma (P = 0.038), renal clear cell carcinoma (P = 0.012), renal papillary cell carcinoma (P = 0.002), liver cancer (P < 0.001, P < 0.001), lung adenocarcinoma (P = 0.011), pancreatic adenocarcinoma (P = 0.002, P = 0.018, P < 0.001), and gastric adenocarcinoma (P = 0.004). Multivariate Cox regression confirmed independent clinical relevance of the signatures in these cancers. ROC curve analyses confirmed superior performance of the signatures to current tumor staging benchmarks. KDM8 was a potential tumor suppressor down- regulated in liver and pancreatic cancers and an independent prognostic factor. KDM8 expression was negatively correlated with that of cell cycle regulators. Low KDM8 expression in tumors was associated with loss of cell adhesion phenotype through HNF4A signaling. Conclusion: Two pan-cancer prognostic signatures of oxygen-sensing genes were identified. These genes can be used for risk stratification in ten diverse cancer types to reveal aggressive tumor subtypes. | Wai Hoong Chang Donall Forde Alvina G.Lai | 2019 | Cancer Communications2019，39，1： | 3 |
| 3 | Thee-Dimensional Numerical Study of Flows in Ope-n-Channel Junctions显示文摘 | Jianchun Huang Larry J.0Weber Yong G.Lai | | 0，，03： | 1 |
| 4 | 2-氧化戊二酸依赖性加氧酶在10种癌症中的双重预后作用:对细胞周期调节和细胞黏附维持的影响显示文摘背景与目的肿瘤缺氧与转移和放化疗耐药相关。氧敏感相关基因具有临床价值,对预后有重要意义。在本研究中,我们研究了2-氧化戊二酸依赖性加氧酶家族氧敏感基因的泛癌症预后意义。方法对25种癌症的20,752个样本的转录谱进行回顾性多队列研究,以鉴定2-氧化戊二酸依赖性加氧酶基因家族(由61个基因组成的氧依赖酶家族)的泛癌症预后特征。我们使用3个独立的胰腺癌队列(n=681)来确定最小的预后基因集。发现了2个特征,每个特征由5个基因组成。利用Cox回归和受试者工作特征(receiver operatingcharacteristic,ROC)曲线分析,测试了这些特征对生存的预测效能。结果特征1(KDM8、KDM6B、P4HTM、ALKBH4、ALKBH7)和特征2(KDM3A、P4HA1、ASPH、PLOD1、PLOD2)分别与预后良好、预后不佳相关。特征1在6种癌症的8个队列(n=2627)中具有预后意义:膀胱尿路上皮癌(P=0.039)、肾乳头细胞癌(P=0.013)、肝癌(P=0.033和P=0.025)、肺腺癌(P=0.014)、胰腺癌(P<0.001和P=0.040)和子宫内膜癌(P<0.001)。特征2在9种癌症的12个队列(n=4134)中具有预后意义:膀胱尿路上皮癌(P=0.039)、宫颈鳞状细胞癌和宫颈腺癌(P=0.035)、头颈鳞状细胞癌(P=0.038)、肾透明细胞癌(P=0.012)、乳头状细胞癌(P=0.002)、肝癌(P<0.001,P<0.001)、肺腺癌(P=0.011)、胰腺癌(P=0.002,P=0.018,P<0.001)和胃腺癌(P=0.004)。多变量Cox回归分析证实了这些癌症特征独立的临床相关性。ROC曲线分析证实了这些特征比目前的肿瘤分期标准更佳。在肝癌和胰腺癌中,KDM8可能是一种下调的肿瘤抑制因子,是一个独立的预后因子。KDM8表达与细胞周期调控因子表达负相关。肿瘤中KDM8低表达与HNF4A信号转导介导的细胞黏附力降低相关。结论明确了氧敏感基因的2个泛癌症预后特征。这些基因可用于10种不同癌症的风险分层,以揭示侵袭性肿瘤亚型。 | Wai Hoong Chang Donall Forde Alvina G.Lai | 2020 | 癌症2020，39，1： | 0 |
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