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| 1 | Bone biomaterials and interactions with stem cells显示文摘Bone biomaterials play a vital role in bone repair by providing the necessary substrate for cell adhesion,proliferation, and differentiation and by modulating cell activity and function. In past decades, extensive efforts have been devoted to developing bone biomaterials with a focus on the following issues:(1)developing ideal biomaterials with a combination of suitable biological and mechanical properties;(2)constructing a cell microenvironment with pores ranging in size from nanoscale to submicro-and microscale;and(3) inducing the oriented differentiation of stem cells for artificial-to-biological transformation. Here we present a comprehensive review of the state of the art of bone biomaterials and their interactions with stem cells. Typical bone biomaterials that have been developed, including bioactive ceramics, biodegradable polymers, and biodegradable metals, are reviewed, with an emphasis on their characteristics and applications. The necessary porous structure of bone biomaterials for the cell microenvironment is discussed,along with the corresponding fabrication methods. Additionally, the promising seed stem cells for bone repair are summarized, and their interaction mechanisms with bone biomaterials are discussed in detail.Special attention has been paid to the signaling pathways involved in the focal adhesion and osteogenic differentiation of stem cells on bone biomaterials. Finally, achievements regarding bone biomaterials are summarized, and future research directions are proposed. | Chengde Gao Shuping Peng Pei Feng Cijun Shuai | 2017 | Bone Research2017，5，4： | 17 |
| 2 | Microstructure, biodegradation, antibacterial and mechanical properties of ZK60-Cu alloys prepared by selective laser melting technique显示文摘Magnesium(Mg) alloys are receiving increasing attention for body implants owing to their good biocompatibility and biodegradability. However, they often suffer from bacterial infections on account of their insufficient antibacterial ability. In this study, ZK60-x Cu(x = 0, 0.2, 0.4, 0.6 and 0.8 wt%) alloys were prepared by selective laser melting(SLM) with alloying copper(Cu) to enhance their antibacterial ability.Results showed that ZK60-Cu alloys exhibited strong antibacterial ability due to combination of release of Cu ions and alkaline environment which could kill bacteria by destroying cellular membrane structure,denaturing enzymes and inhibiting deoxyribonucleic acid(DNA) replication. In addition, their compressive strength increased due to grain refinement and uniformly dispersing of short-bar shaped MgZnCu phases. Moreover, ZK60-Cu alloys also exhibited good cytocompatibility. In summary, ZK60-Cu alloys with antibacterial ability may be promising implants for biomedical applications. | Cijun Shuai Long Liu Mingchun Zhao Pei Feng Youwen Yang Wang Guo Chengde Gao Fulai Yuan | 2018 | Journal of Materials Science & Technology2018，34，10： | 12 |
| 3 | ^(14)C measurement of forest soils in Dinghushan Biosphere Reserve显示文摘Organic carbon in forest soils of Qingyunsi and Wukesong profiles can be divided into fast and slow components. Δ14C values of these profiles decrease with increasing of depth. The Δ14C values in 30—40 cm depth interval of Wukesong profile are decreasing sharply until a very low value,showing that a strong geological environment change occurred about 1 560 years ago. The 14C apparent ages of Wukesong profile show that the coniferous and broad-leaf mixed forests around Wukesong profile have been developing since 425 a BP, which is consistent with historical documents. The penetrating depths of 'bomb 14C' in Qingyunsi and Wukesong profiles are 10 and 20 cm, respectively. | SHEN Chengde , LIU Dongsheng (LIU Tungsheng) , PENG Shaolin, SUN Yanmin , JIANG Mantao , Yl Weixi , XING Changping , GAO Quanzhou , LI Zhi’an and ZHOU Guoyi Guangzhou Institute of Geochemisry, Chinese Academy of Sciences, Guangzhou 510640, China Institute of Geology, Chinese Academy of Sciences , Beijing 100029, China South China Institute of Botany, Chinese Academy of Sciences, Guangzhou 510650, China | 1999 | Chinese Science Bulletin1999，44，3： | 7 |
| 4 | Influence of graphene oxide(GO)on microstructure and biodegradation of ZK30-xGO composites prepared by selective laser melting显示文摘Different graphene oxide(GO)contents were chosen as the addition to prepare ZK30-xGO composites by selective laser melting(SLM).The microstructure and biodegradation of the SLMed ZK30-xGO composites were investigated.The results indicated that(i)SLM effectively produced a small grain size,(ii)the incorporation of GO into ZK30 caused a further decrease in grain size,and(iii)GO has a strong effect on the formation of the MgZn2 precipitates.The SLMed ZK30-0.6GO had the lowest biodegradation rate,which is attributed to the fact that the effect of the increased grain refinement and decreased amount of the MgZn?precipitates counteracted the effect of the increased GO content on the biodegradation rate.Furthermore,the SLMed ZK30-xGO composites had good cytocompatibility.This work provided a novel approach to the composition design and fabrication of novel biodegradable GO reinforced Mg-based biomedical implants. | Jun-Xi Tao Ming-Chun Zhao Ying-Chao Zhao Deng-Feng Yin Long Liu Chengde Gao Cijun Shuai Andrej Atrens | 2020 | Journal of Magnesium and Alloys2020，8，3： | 4 |
| 5 | Nano-SiC reinforced Zn biocomposites prepared via laser melting:Microstructure,mechanical properties and biodegradability显示文摘Zn has been regarded as new kind of potential implant biomaterials due to the desirable biodegradability and good biocompatibility,but the low strength and ductility limit its application in bone repairs.In the present study,nano-SiC was incorporated into Zn matrix via laser melting,aiming to improve the mechanical performance.The microstructure analysis showed that nano-SiC distributed along Zn grain boundaries.During the laser rapid solidification,nano-SiC particles acted as the sites for heterogeneous nucleation,which resulted in the reduction of Zn grain size from 250μm to 15μm with 2 wt%SiC(Zn-2 SiC).Meanwhile,nano-SiC acted as a reinforcer by virtue of Orowan strengthening and dispersion strengthening.As a consequence,the nanocomposites showed maximal compressive yield strength(121.8±5.3 MPa)and high microhardness(72.24±3.01 HV),which were increased by 441%and 78%,respectively,compared with pure Zn.Moreover,fracture analysis indicated a more ductile fracture of the nanocomposites after the incorporation of nano-SiC In addition,the nanocomposites presented favorable biocompatibility and accelerated degradation caused by intergranular corrosion.These findings suggested that the nano-SiC reinforced Zn biocomposites may be the potential candidates for orthopedic implants. | Chengde Gao Meng Yao Cijun Shuai Shuping Peng Youwen Deng | 2019 | Journal of Materials Science & Technology2019，35，11： | 4 |
| 6 | Physical stimulations and their osteogenesis-inducing mechanisms显示文摘Physical stimulations such as magnetic,electric and mechanical stimulation could enhance cell activity and promote bone formation in bone repair process via activating signal pathways,modulating ion channels,regulating bonerelated gene expressions,etc.In this paper,bioeffects of physical stimulations on cell activity,tissue growth and bone healing were systematically summarized,which especially focused on their osteogenesis-inducing mechanisms.Detailedly,magnetic stimulation could produce Hall effect which improved the permeability of cell membrane and promoted the migration of ions,especially accelerating the extracellular calcium ions to pass through cell membrane.Electric stimulation could induce inverse piezoelectric effect which generated electric signals,accordingly up-regulating intracellular calcium levels and growth factor synthesis.And mechanical stimulation could produce mechanical signals which were converted into corresponding biochemical signals,thus activating various signaling pathways on cell membrane and inducing a series of gene expressions.Besides,bioeffects of physical stimulations combined with bone scaffolds which fabricated using 3D printing technology on bone cells were discussed.The equipments of physical stimulation system were described.The opportunities and challenges of physical stimulations were also presented from the perspective of bone repair. | Cijun Shuai Wenjing Yang Shuping Peng Chengde Gao Wang Guo Yuxiao Lai Pei Feng | 2018 | International Journal of Bioprinting2018，4，2： | 3 |
| 7 | Dual alloying improves the corrosion resistance of biodegradable Mg alloys prepared by selective laser melting显示文摘Mg alloys have been regarded as revolutionary metallic biomaterials for biodegradable bone implants,but their applications are mainly blocked by the too rapid degradation in physiological environment.This study explores the dual alloying effects of Mn and/or Sn on the performance of Mg alloys prepared by selective laser melting.The observed microstructure indicated remarkable refinement of both the grains and intermetallic phases in the Mn-and/or Sn-containing alloys during the rapid solidification process.Moreover,approximately a half decrease in corrosion rate was observed for AZ61-0.4Mn-0.8Sn alloy with respect to AZ61 alloy.The improved corrosion behavior was primarily due to the enhanced protective effects of surface layers,in which Mn-and/or Sn-rich phases acted as a helpful barrier against medium penetration and thereby alleviated the current exchange with the matrix.In addition,the solute Mn and/or Sn positively shifted the corrosion potential,which also brought about a better corrosion resistance.Furthermore,the strength and hardness of the alloys were also effectively improved and comparable to those of cortical bone.This could be ascribed to the dissolved Mn and/or Sn atoms and the finely dispersed intermetallic phases,which might cause lattice distortion and precipitation hardening.Besides,the Mn-and/or Sn-containing alloys showed good cytocompatibility as indicated by the normal morphology and increased viability of MG-63 cells.These findings suggest that the developed AZ61-Mn-Sn alloy is a promising candidate for biodegradable bone implants. | Chengde Gao Sheng Li Long Liu Shizhen Bin Youwen Yang Shuping Peng Cijun Shuai | 2021 | Journal of Magnesium and Alloys2021，9，1： | 3 |
| 8 | Mechanism for corrosion protection of β-TCP reinforced ZK60 via laser rapid solidification显示文摘It remains the primary issue to enhance the corrosion resistance of Mg alloys for their clinical applications.In this study,β-tricalcium phosphate(β-TCP)was composited with Mg-6Zn-1Zr(ZK60)using laser rapid solidification to improve the degradation behavior.Results revealed rapid solidification effectively restrained the aggregation ofβ-TCP,which thus homogenously distributed along grain boundaries ofα-Mg.Significantly,the uniformly distributedβ-TCP in the matrix promoted the formation of apatite layer on the surface,which contributed to the formation of a compact corrosion product layer,hence retarding the further degradation.Furthermore,ZK60/8β-TCP(wt.%)composite showed improved mechanical strength,as well as improved cytocompatibility.It was suggested that laser rapidly solidified ZK60/8β-TCP composite might be a potential materials for tissue engineering. | Youwen Deng Youwen Yang Chengde Gao Pei Feng Wang Guo Chongxian He Jian Chen Cijun Shuai | 2018 | International Journal of Bioprinting2018，4，1： | 2 |
| 9 | Riverine organic carbon in the Xijiang River ( South China) : seasonal variation in content and flux budget 显示文摘 | GAO Quanzhou TAO Zhen SHEN Chengde | 2002 | Environmental Geology2002，41，7： | 1 |
| 10 | An nMgO containing scaffold:Antibacterial activity,degradation properties and cell responses显示文摘Bone repair failure caused by implant-related infections is a common and troublesome problem.In this study,an antibacterial scaffold was developed via selective laser sintering with incorporating nano magnesium oxide(nMgO)to poly(3-hydroxybutyrate-co-3-hydroxyvalerate)(PHBV).The results indicated the scaffold exerted high antibacterial activity.The antibacterial mechanism was that nMgO could cause oxidative damage and mechanical damage to bacteria through the production of reactive oxygen species(ROS)and direct contact action,respectively,which resulted in the damage of their structures and functions.Besides,nMgO significantly increased the compressive properties of the scaffold including strength and modulus,due to its excellent mechanical properties and uniform dispersion in the PHBV matrix.Moreover,the degradation tests indicated nMgO neutralized the acid degradation products of PHBV and benefited the degradation of the scaffold.The cell culture demonstrated that nMgO promoted the cellular adhesion and proliferation,as well as osteogenic differentiation.The present work may open the door to exploring nMgO as a promising antibacterial material for tissue engineering. | Cijun Shuai Wang Guo Chengde Gao Youwen Yang Ping Wu Pei Feng | 2018 | International Journal of Bioprinting2018，4，1： | 1 |
| 11 | Additive manufacturing of bone scaffolds显示文摘Additive manufacturing(AM)can obtain not only customized external shape but also porous internal structure for scaffolds,both of which are of great importance for repairing large segmental bone defects.The scaffold fabrication process generally involves scaffold design,AM,and post-treatments.Thus,this article firstly reviews the state-of-the-art of scaffold design,including computer-aided design,reverse modeling,topology optimization,and mathematical modeling.In addition,the current characteristics of several typical AM techniques,including selective laser sintering,fused deposition modeling(FDM),and electron beam melting(EBM),especially their advantages and limitations are presented.In particular,selective laser sintering is able to obtain scaffolds with nanoscale grains,due to its high heating rate and a short holding time.However,this character usually results in insufficient densification.FDM can fabricate scaffolds with a relative high accuracy of pore structure but with a relative low mechanical strength.EBM with a high beam-material coupling efficiency can process high melting point metals,but it exhibits a low-resolution and poor surface quality.Furthermore,the common post-treatments,with main focus on heat and surface treatments,which are applied to improve the comprehensive performance are also discussed.Finally,this review also discusses the future directions for AM scaffolds for bone tissue engineering. | Youwen Yang Guoyong Wang Huixin Liang Chengde Gao Shuping Peng Lida Shen Cijun Shuai | 2019 | International Journal of Bioprinting2019，5，1： | 1 |
| 12 | En-hancement mechanisms of graphene in nano-58S bioactive glass scaffold: mechanical and biological performance 显示文摘 | GAO Chengde LIU Tingting SHUAI Cijun | 2014 | Sci Rep2014，4，： | 1 |
| 13 | Graphene- reinforced mechanical properties of calcium silicate scaffolds by laser sintering 显示文摘 | SHUAI Cijun GAO Chengde FENG Pei | 2014 | RSC Adv2014，4，12： | 1 |
| 14 | A multi-scale porous scaffold fabricated by a combined additive manufacturing and chemical etching process for bone tissue engineering显示文摘It is critical to develop a fabrication technology for precisely controlling an interconnected porous structure of scaffolds to mimic the native bone microenvironment.In this work,a novel combined process of additive manufacturing(AM)and chemical etching was developed to fabricate graphene oxide/poly(L-lactic acid)(GO/PLLA)scaffolds with multiscale porous structure.Specially,AM was used to fabricate an interconnected porous network with pore sizes of hundreds of microns.And the chemical etching in sodium hydroxide solution constructed pores with several microns or even smaller on scaffolds surface.The degradation period of the scaffolds was adjustable via controlling the size and quantity of pores.Moreover,the scaffolds exhibited surprising bioactivity after chemical etching,which was ascribed to the formed polar groups on scaffolds surfaces.Furthermore,GO improved the mechanical strength of the scaffolds. | Cijun Shuai Youwen Yang Pei Feng Shuping Peng Wang Guo Anjie Min Chengde Gao | 2018 | International Journal of Bioprinting2018，4，2： | 1 |
| 15 | Selenium Enriched Trionyx sinensis : A New Choice for the Sustainable Development Model of Modern Agriculture显示文摘Based on the analysis of the current situation and existing problems of traditional Chinese soft shelled turtle(Trionyx sinensis)breeding industry,combined with the fact that selenium enriched functional agriculture is the future demand of mankind,this paper put forward the necessity of developing selenium enriched Chinese soft shelled turtles and promoting the sustainable development of modern agriculture:the development of selenium-enriched Chinese soft-shelled turtle is the need of the consumer market for food safety,the need to reduce the production cost of soft-shelled turtles and improve the production efficiency of soft-shelled turtles,the need to enrich the Chinese soft-shelled turtle market,and the need to promote the sustainable development of modern agriculture(fishery). | Bo YANG Wei HUANG Xianghui QIN Jun YAN Chengde LIN Xiaofeng GAO Yinglan HUANG | 2021 | Agricultural Biotechnology2021，10，6： | 0 |
| 16 | Spiral-eutectic-reinforced Biodegradable Zn-Mg-Ag Alloy Prepared via Selective Laser Melting显示文摘Zn is a promising biodegradable metal owing to its moderate degradation rate and acceptable biocompatibility.However,the insufficient mechanical strength and plasticity of pure Zn limits its application in bone implants.In this study,a spiral eutectic structure is constructed in Zn-Mg-Ag alloys prepared via selective laser melting to improve their mechanical properties.Results show that the prepared Zn-Mg-Ag alloys are composed of a primary Zn matrix and a eutectic phase,which is composed of alternating��-Zn and an intermetallic compound,MgZn 2.Moreover,the eutectic phase resembles a spiral and increases with Ag content in the alloys.The eutectic pinning effect hinders dislocation and hence results in dislocation accumulation.Meanwhile,the spiral structure alters the propagation direction and dissipates the propagation energy of cracks layer by layer.Consequently,a compressive strength of up to 309±15 MPa and an improved strain of 27%are exhibited in Zn-3Mg-1Ag alloy.Moreover,the Zn-Mg-Ag alloys show high biocompatibility with MG-63 cells and antibacterial activity against Escherichia coli.These findings indicate the potential of spiral eutectic structures for enhancing both the mechanical strength and plasticity of biodegradable Zn alloys. | Chengde Gao Chuanzhi Li Shuping Peng Cijun Shuai | 2022 | Chinese Journal of Mechanical Engineering(Additive Manufacturing Frontiers)2022，1，2： | 0 |
| 17 | Science and Technology on China Onshore Petroleum Industry Towards 21st Century显示文摘ScienceandTechnologyonChinaOnshorePetroleumIndustryTowards21stCentury￥FuChengde;LiuBingyiandGaoChao(ScienceandTechnololgyDeve... | Fu Chengde Liu Bingyi and Gao Chao(Science and Technololgy Development Bureau ,CNPC) | 1995 | China Oil & Gas1995，2，2： | 0 |
| 18 | Additive manufacturing of promising heterostructure for biomedical applications显示文摘As a new generation of materials/structures,heterostructure is characterized by heterogeneous zones with dramatically different mechanical,physical or chemical properties.This endows heterostructure with unique interfaces,robust architectures,and synergistic effects,making it a promising option as advanced biomaterials for the highly variable anatomy and complex functionalities of individual patients.However,the main challenges of developing heterostructure lie in the control of crystal/phase evolution and the distribution/fraction of components and structures.In recent years,additive manufacturing techniques have attracted increasing attention in developing heterostructure due to the unique flexibility in tailored structures and synthetic multimaterials.This review focuses on the additive manufacturing of heterostructure for biomedical applications.The structural features and functional mechanisms of heterostructure are summarized.The typical material systems of heterostructure,mainly including metals,polymers,ceramics,and their composites,are presented.And the resulting synergistic effects on multiple properties are also systematically discussed in terms of mechanical,biocompatible,biodegradable,antibacterial,biosensitive and magnetostrictive properties.Next,this work outlines the research progress of additive manufacturing employed in developing heterostructure from the aspects of advantages,processes,properties,and applications.This review also highlights the prospective utilization of heterostructure in biomedical fields,with particular attention to bioscaffolds,vasculatures,biosensors and biodetections.Finally,future research directions and breakthroughs of heterostructure are prospected with focus on their more prospective applications in infection prevention and drug delivery. | Cijun Shuai Desheng Li Xiong Yao Xia Li Chengde Gao | 2023 | International Journal of Extreme Manufacturing2023，5，3： | 0 |
| 19 | Science and Technology of China Onshore Petroleum Industry Towards 21st Century(part 2)显示文摘ScienceandTechnologyofChinaOnshorePetroleumIndustryTowards21stCentury(part2)￥FuChengde,LiuBingyiandGaoChao(ScienceandTechnolo... | Fu Chengde,Liu Bingyi and Gao Chao(Science and Technology Development Bureau,CNPC) | 1995 | China Oil & Gas1995，2，3： | 0 |
| 20 | Science and Technology of China Onshore Petroleum Industry Towards 21st Century(part 3)显示文摘ScienceandTechnologyofChinaOnshorePetroleumIndustryTowards21stCentury(part3)￥FuChengde;LiuBingyiandGaoChao(ScienceandTechnolo... | Fu Chengde Liu Bingyi and Gao Chao(Science and Technology Development Bureau, CNPC) | 1995 | China Oil & Gas1995，2，4： | 0 |
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