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| 1 | Combined genomic, transcriptomic, and metabolomic an alyses provide in sights into chayote (Sechium edule) evolution and fruit development显示文摘Chayote(Sechium edule)is an agricultural crop in the Cucurbitaceae family that is rich in bioactive components.To enhance genetic research on chayote,we used Nanopore third-generation sequencing combined with Hi-C data to assemble a draft chayote genome.A chromosome-level assembly anchored on 14 chromosomes(N50 contig and scaffold sizes of 8.40 and 46.56 Mb,respectively)estimated the genome size as 606.42 Mb,which is large for the Cucurbitaceae,with 65.94%(401.08 Mb)ofthe genome comprising repetitive sequences;28,237 protein-coding genes were predicted.Comparative genome analysis indicated that chayote and snake gourd diverged from sponge gourd and that a whole-genome duplication(WGD)event occurred in chayote at 25±4 Mya.Transcriptional and metabolic analysis revealed genes involved in fruit texture,pigment,fl avor,fl avonoids,antioxidants,and plant hormones during chayote fruit development.The analysis of the genome,transcriptome,and metabolome provides insights into chayote evolution and lays the groundwork for future research on fruit and tuber development and genetic improvements in chayote. | Anzhen Fu Qing Wang Jianlou Mu Lili Ma Changlong Wen Xiaoyan Zhao Lipu Gao Jian Li Kai Shi Yunxiang Wang Xuechuan Zhang Xuewen Zhang Fengling Wang Donald Grierson Jinhua Zuo | 2021 | Horticulture Research2021，8，1： | 6 |
| 2 | Qiguiyishen decoction reduced the accumulation of extracellular matrix in the kidneys of rats with adriamycin-induced nephropathy显示文摘OBJECTIVE: To investigate the effect of Qiguiyishen decoction(QGYS) on the severity of nephropathy.METHODS: Twenty-four rats were randomly divided into four groups(Ⅰ, Ⅱ, Ⅲ, Ⅳ) according to the random number table. Group Ⅰ as control group did not establish nephropathy model. Groups Ⅱ,Ⅲ, and Ⅳ were intravenously administered Adriamycin(7.5 mg/kg) through the tail vein to establish nephropathy model. QGYS was prepared with the extracts of Huangqi(Radix Astragali Mongolici),Danggui(Radix Angelicae Sinensis),Niuxi(RadixAchyran-this Bidentatae), and Chuanxiong(Rhizoma Chuanxiong).Group Ⅳ was administered QGYS (2mL·kg-1·d-1), group Ⅲ was administered benazepril(10 mL·kg-1·d-1), and group Ⅰ, Ⅱ was administered water(2mL·kg-1·d-1)once daily for eight weeks.RESULTS: QGYS reduced the excretion of urinary protein and N-acetyl-β-D-glucosaminidase and alleviated the accumulation of extracellular matrix(ECM) in renal tissue. Additionally, QGYS effectively regulated the levels of transforming growth factor,tissue inhibitor of matrix metalloproteinase, and matrixmetalloprote in asesin the kidney of the rats.CONCLUSION:QGYS may reduce the accumulation of ECM in the kidneys of rats with Adriamycin-induced nephropathy. | Minggang Wei Wei Sun Weiming He Li Ni Xiaofeng Cai Zongqi Cheng Kun Gao Fengling Li Lin Chen Xinping Zhang | 2014 | Journal of Traditional Chinese Medicine2014，34，3： | 4 |
| 3 | Experimental study of the spray characteristics of biodiesel based on inedible oil显示文摘 | Yuan Gao Jun Deng Chunwang Li Fengling Dang Zhuo Liao Zhijun Wu Liguang Li | 2009 | Biotechnology Advances2009，，5： | 2 |
| 4 | Metamodel-Based Multi-Objective Reliable Optimization for Front Structure of Electric Vehicle显示文摘In this paper,a multi-objective reliable optimization(MORO)procedure for the front body of an electric vehicle is proposed and compared with determinate multi-objective optimization(DMOO).The energy absorption and peak crash force of the simplified vehicle model under the full-lap frontal impact condition are used as the design objectives,with the weighted sum of the basic frequency,the first-order torsional and bending frequencies of the full-size vehicle model,and the weight of the front body taken as the constraints.The thicknesses of nine components on the front body are defined as design variables,and their geometric tolerances determine the uncertainty factor.The most accurate metamodel using the polynomial response surface,kriging,and a radial basis function is selected to model four design criteria during optimization,allowing the efficiency improvement to be computed.Monte Carlo simulations are adopted to handle the probability constraints,and multi-objective particle swarm optimization is employed as the solver.The MORO results indicate reliability levels of R=100%,demonstrating the significant enhancement in reliability of the front body over that given by DMOO,and reliable design schemes and proposals are provided for further study. | Fengling Gao Shan Ren Cheng Lin Yingchun Bai Wenwei Wang | 2018 | Automotive Innovation2018，1，2： | 2 |
| 5 | Two cases of chronic myelomonocytic leukemia combined with monoclonal gammopathy of undetermined significance and a literature review显示文摘To describe myelodysplastic syndrome(MDS)/myeloproliferative neoplasm(MPN) combined with monoclonal gammopathy of undetermined significance(MGUS) in order to investigate the potential association between these 2 diseases. Two cases of confirmed chronic myelomonocytic leukemia(CMML) combined with MGUS were reported. In addition, prior publications of cases with combined MDS or MPN with MGUS were reviewed. The first case was of a 77-year-old man whose routine blood tests showed abnormal hemogram results. The diagnosis was CMML combined with Ig M monoclonal gammopathy, and the disease course was 4 years. The CMML gradually progressed and the patient presented with anemia, thrombocytopenia, autoimmune hemolysis, and an increase in the number of immature cells in the bone marrow. Although the MGUS caused fluctuations in the concentrations of Ig M, no Ig M-associated organ damage was observed. Eventually, this patient died from a lung infection. The second case was of a 78-year-old man who sought treatment because of fever and a cough. An increase in the number of monocytes was discovered in the peripheral blood. Bone marrow smear results suggested obvious active granulocytes and an increase in the percentages of promyelocytes, myelocytes, and metamyelocytes. Unhealthy granulocytes and immature monocytes could also be observed, and the percentage of monocytes was increased. In addition, serum Ig G levels were increased, and immunofixation electrophoresis results showed Ig G-κ type M proteins. The diagnosis was CMML combined with Ig G monoclonal gammopathy. These diseases were stable and follow-up was conducted for 1 year after diagnosis. The cases in this study combined with those that were reviewed in the relevant literature indicate that the presence of these 2 diseases in the same patient might not be a coincidence. The development of the 2 diseases in case 1 was different, and we speculate that they might have had different clonal origins. Whether CMML is a risk factor for MGUS and the role of clonal plasma cells in the occurrence and development of MDS and MDS/MPN requires further studies on a larger number of cases. | Fengling Min Lijia Zhai Wei Zhou Xiaohui Gao Lina Zhang | 2017 | Oncology and Translational Medicine2017，3，1： | 2 |
| 6 | A new recoverable Au(III) catalyst supported on magnetic polymer nanocomposite for aromatic bromination显示文摘 | Bai Li Linfeng Gao Fengling Bian Wei Yu | 2012 | Tetrahedron Letters2012，，： | 1 |
| 7 | Simulated soil erosion from a semiarid typical steppe watershed using an integrated aeolian and fluvial prediction model显示文摘 | Xixi Wang Tingxi Liu Fengling Li Ruizhong Gao Xiaomin Yang Limin Duan Yanyun Luo Rui Li | 2014 | Hydrol Process2014，，2： | 1 |
| 8 | Experimental study of the spray characteristics of biodiesel based on inedible oil显示文摘 | Yuan Gao Jun Deng Chunwang Li Fengling Dang Zhuo Liao Zhijun Wu Liguang Li | 2009 | Biotechnology Advances2009，，5： | 1 |
| 9 | Investigation on step overcharge to self-heating behavior and mechanism analysis of lithium ion batteries显示文摘To obtain intrinsic overcharge boundary and investigate overcharge mechanism,here we propose an innovative method,the step overcharge test,to reduce the thermal crossover and distinguish the overcharge thermal behavior,including 5%state of charge(SOC)with small current overcharge and resting until the temperature equilibrium under adiabatic conditions.The intrinsic thermal response and the self-excitation behaviour are analysed through temperature and voltage changes during the step overcharge period.Experimental results show that the deintercalated state of the cathode is highly correlated to self-heating parasitic reactions.Before reaching the upper limit of Negative/Positive(N/P)ratio,the temperature changes little,the heat generation is significantly induced by the reversible heat(endothermic)and ohmic heat,which could balance each other.Following that the lithium metal is gradually deposited on the surface of the anode and reacts with electrolyte upon overcharge,inducing selfheating side reaction.However,this spontaneous thermal reaction could be“self-extinguished”.When the lithium in cathode is completely deintercalated,the boundary point of overcharge is about 4.7 V(~148%SOC,>40℃),and from this point,the self-heating behaviour could be continuously triggered until thermal runaway(TR)without additional overcharge.The whole static and spontaneous process lasts for 115 h and the side reaction heat is beyond 320,000 J.The continuous self-excitation behavior inside the battery is attributed to the interaction between the highly oxidized cathode and the solvent,which leads to the dissolution of metal ions.The dissolved metal ions destroy the SEI(solid electrolyte interphase)film on the surface of the deposited Li of anode,which induces the thermal reaction between lithium metal and the solvent.The interaction between cathode,the deposited Li of anode,and solvent promotes the temperature of the battery to rise slowly.When the temperature of the battery reaches more than 60℃,the reaction between lithium metal and solvent is accelerated.After the temperature rises rapidly to the melting point of the separator,it triggers the thermal runaway of the battery due to the short circuit of the battery. | Fengling Yun Shiyang Liu Min Gao Xuanxuan Bi Weijia Zhao Zenghua Chang Minjuan Yuan Jingjing Li Xueling Shen Xiaopeng Qi Ling Tang Yi Cui Yanyan Fang Lihao Guo Shangqian Zhao Xiangjun Zhang Shigang Lu | 2023 | Journal of Energy Chemistry2023，，4： | 0 |
| 10 | Thermodynamic Evaluation of Transcritical CO_(2) Heat Pump Considering Temperature Matching under the Constraint of Heat Transfer Pinch Point显示文摘The non-linear temperature glide in the supercritical CO_(2) cooling process makes the heat transfer pinch point of heat exchanger show multiplicity,like size,location distribution and quantity,which makes the thermodynamic performance of the CO_(2) transcritical cycle more complex and eventually affects the evaluation of the optimal operating state of the system.Based on the second law of thermodynamics and the constraints of heat transfer pinch,a thermodynamic evaluation method of CO_(2) transcritical heat pump system was proposed according to the degree of temperature matching.The influence mechanism of multi-characteristic change of heat transfer pinch point on temperature matching degree and the effect of temperature matching degree on thermodynamic performance of CO_(2) transcritical heat pump system were discussed.The relationship between temperature matching degree,COP and exergy efficiency of the system was analyzed.It is considered that the change of temperature matching index value can clearly characterize the change trends of COP and exergy efficiency.That is,the smaller the temperature matching degree is,the closer the temperature distribution of heat transfer fluids on both sides of the heat exchanger is to Lorenz cycle,and the greater the COP and exergy efficiency are.Furthermore,by monitoring the outlet temperature of the CO_(2) cooler,which has an essential relationship with the temperature matching degree during the heat exchange process,the deviation between actual and optimal working condition can be judged online,which is beneficial to real-time evaluation of the working state of the system. | LIU Ruijian GAO Fengling LIANG Kunfeng WANG Lin WANG Moran MI Guoqiang LI Yachao | 2021 | Journal of Thermal Science2021，30，3： | 0 |
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