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| 1 | 显示文摘 | Gao Hongze Su Zhongmin | 2005 | Theochem J Mol Struct2005，722，： | 1 |
| 2 | Ultrasound responsive organogels based on cholesterol-appended quinacridone derivatives with mechanochromic behaviors显示文摘A series of cholesterol-appended quinacridone (QA) derivatives 1a-1d have been synthesized,in which 1b and 1c could form stable organogels in a wide range of organic solvents upon ultrasound irradiation.Field emission scanning electronic microscope (FESEM) and transmission electron microscopy (TEM) of xerogels or precipitates indicated that 1b and 1c formed 1D fibrous nanostructure,while 1a assembled into 3D flower-like microstructures.The ultrasound-induced organogel process was characterized by kinetic UV-vis and photoluminescence spectroscopic methods suggesting the formation of ?-? aggregates in the gel state.Experimental results demonstrated that the ultrasound could promote molecules to contact frequently in the solution and induce semistable initial aggregates,which propagate to form nano/micro superstructures.The aggregation model was optimized by semiempirical AM1 calculation suggesting the hierarchical self-assembly process.In addition,the formed xerogel film exhibited mechanochromic property,and the phase transition process was accompanied by the fluorescence changes between yellowish green and orange. | DOU ChuanDong LI Di ZHANG HongYu GAO HongZe ZHANG JingYing WANG Yue | 2011 | Science China Chemistry2011，54，4： | 1 |
| 3 | Optimization of Well Position and Sampling Frequency for Groundwater Monitoring and Inverse Identification of Contamination Source Conditions Using Bayes’Theorem显示文摘Coupling Bayes’Theorem with a two-dimensional(2D)groundwater solute advection-diffusion transport equation allows an inverse model to be established to identify a set of contamination source parameters including source intensity(M),release location(0 X,0 Y)and release time(0 T),based on monitoring well data.To address the issues of insufficient monitoring wells or weak correlation between monitoring data and model parameters,a monitoring well design optimization approach was developed based on the Bayesian formula and information entropy.To demonstrate how the model works,an exemplar problem with an instantaneous release of a contaminant in a confined groundwater aquifer was employed.The information entropy of the model parameters posterior distribution was used as a criterion to evaluate the monitoring data quantity index.The optimal monitoring well position and monitoring frequency were solved by the two-step Monte Carlo method and differential evolution algorithm given a known well monitoring locations and monitoring events.Based on the optimized monitoring well position and sampling frequency,the contamination source was identified by an improved Metropolis algorithm using the Latin hypercube sampling approach.The case study results show that the following parameters were obtained:1)the optimal monitoring well position(D)is at(445,200);and 2)the optimal monitoring frequency(Δt)is 7,providing that the monitoring events is set as 5 times.Employing the optimized monitoring well position and frequency,the mean errors of inverse modeling results in source parameters(M,X0,Y0,T0)were 9.20%,0.25%,0.0061%,and 0.33%,respectively.The optimized monitoring well position and sampling frequency canIt was also learnt that the improved Metropolis-Hastings algorithm(a Markov chain Monte Carlo method)can make the inverse modeling result independent of the initial sampling points and achieves an overall optimization,which significantly improved the accuracy and numerical stability of the inverse modeling results. | Shuangsheng Zhang Hanhu Liu Jing Qiang Hongze Gao Diego Galar Jing Lin | 2019 | Computer Modeling in Engineering & Sciences2019，，5： | 1 |
| 4 | A novel TNKS/USP25 inhibitor blocks the Wnt pathway to overcome multi-drug resistance in TNKS-overexpressing colorectal cancer显示文摘Modulating Tankyrases(TNKS),interactions with USP25 to promote TNKS degradation,rather than inhibiting their enzymatic activities,is emerging as an alternative/specific approach to inhibit the Wnt/β-catenin pathway.Here,we identified UAT-B,a novel neoantimycin analog isolated from Streptomyces conglobatus,as a small-molecule inhibitor of TNKS-USP25 protein-protein interaction(PPI)to overcome multi-drug resistance in colorectal cancer(CRC).The disruption of TNKS-USP25 complex formation by UAT-B led to a significant decrease in TNKS levels,triggering cell apoptosis through modulation of the Wnt/β-catenin pathway.Importantly,UAT-B successfully inhibited the CRC cells growth that harbored high TNKS levels,as demonstrated in various in vitro and in vivo studies utilizing cell line-based and patient-derived xenografts,as well as APC^(min/+)spontaneous CRC models.Collectively,these findings suggest that targeting the TNKS-USP25 PPI using a small-molecule inhibitor represents a compelling therapeutic strategy for CRC treatment,and UAT-B emerges as a promising candidate for further preclinical and clinical investigations. | Hongrui Zhu Yamin Gao Liyun Liu Mengyu Tao Xiao Lin Yijia Cheng Yaoyao Shen Haitao Xue Li Guan Huimin Zhao Li Liu Shuping Wang Fan Yang Yongjun Zhou Hongze Liao Fan Sun Houwen Lin | 2024 | Acta Pharmaceutica Sinica B2024，14，1： | 0 |
| 5 | Self-Assembly of Luminescent Twisted Fibers Based on Achiral Quinacridone Derivatives显示文摘It is a great challenge to spontaneously assemble achiral molecules into twisted nanostructures in the absence of chiral substances.Here we show that two achiral centrosymmetric quinacridone(QA)derivatives,N,N’-di(n-hexyl)-1,3,8,10-tetramethylquinacridone(C6TMQA)and N,N’-di(n-decyl)-1,3,8,10-tetramethylquinac ridone(C10TMQA),can be employed as building blocks to fabricate well-defi ned twisted nanostructures by controlling the solvent composition and concentration.Bowknot-like bundles with twisted fiber arms were prepared from C6TMQA,whilst uniform twisted fibers were generated from C10TMQA in ethanol/THF solution.Spectroscopic characterization and molecular simulation calculations revealed that the introduction of ethanol into the solution could induce a staggered aggregation of C6TMQA(or C10TMQA)molecules and the formation of twisted nanostructures.Such twisted materials generated from achiral organic functional molecules may be valuable in the design and fabrication of new materials for optoelectronic applications. | Yunfeng Zhao Yan Fan Xiaoyue Mu Hongze Gao Jia Wang Jingying Zhang Wensheng Yang Lifeng Chi Yue Wang | 2009 | Nano Research2009，2，6： | 0 |
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