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| 1 | Lake eutrophication and its ecosystem response显示文摘China is a country with many lakes,about one-third of which are freshwater mainly distributed in the middle and lower reaches of the Yangtze River.Currently most of the lakes are mesotrophic or eutrophic.Lake eutrophication has become one of the major ecological and environmental problems faced by lakes in China and can lead to a series of abnormal ecosystem responses,including extinction of submerged plants,frequent occurrence of cyanobacterial blooms,increased microbial biomass and productivity,decreased biodiversity,accelerated cycles,and a change in the efficient use of nutrients.With development of eutrophication,the whole lake ecosystem suffers decreased biodiversity,simplification of biotic community structure,instability of the ecosystem,and ultimately the clear-water,macrophyte-dominated ecosystem gradually shifts to a turbid-water,algae-dominated ecosystem.This ecosystem succession mechanism is speculated to be caused by different nutrient utilization efficiencies of macrophytes and phytoplankton.The ultimate ecosystem succession trend of seriously eutrophic lakes is that a phytoplankton-dominated autotrophic lake shifts to a heterotrophic lake dominated by micro-organisms,protozoans. | QIN BoQiang GAO Guang ZHU GuangWei ZHANG YunLin SONG YuZhi TANG XiangMing XU Hai DENG JianMing | 2013 | Chinese Science Bulletin2013，58，9： | 63 |
| 2 | T-PBFT: An EigenTrust-Based Practical Byzantine Fault Tolerance Consensus Algorithm显示文摘Blockchain with these characteristics of decentralized structure, transparent and credible, time-series and immutability, has been considering as a promising technology. Consensus algorithm as one of the core techniques of blockchain directly affects the scalability of blockchain systems. Existing probabilistic finality blockchain consensus algorithms such as PoW, PoS, suffer from power consumptions and low efficiency;while absolute finality blockchain consensus algorithms such as PBFT, HoneyBadgerBFT, could not meet the scalability requirement in a largescale network. In this paper, we propose a novel optimized practical Byzantine fault tolerance consensus algorithm based on EigenTrust model, namely T-PBFT, which is a multi-stage consensus algorithm. It evaluates node trust by the transactions between nodes so that the high quality of nodes in the network will be selected to construct a consensus group. To reduce the probability of view change, we propose to replace a single primary node with a primary group. By group signature and mutual supervision, we can enhance the robustness of the primary group further. Finally, we analyze T-PBFT and compare it with the other Byzantine fault tolerant consensus algorithms. Theoretical analysis shows that our T-PBFT can optimize the Byzantine fault-tolerant rate,reduce the probability of view change and communication complexity. | Sheng Gao Tianyu Yu Jianming Zhu Wei Cai | 2019 | China Communications2019，16，12： | 40 |
| 3 | Efficacy and safety of a novel anti-HER2 therapeutic antibody RC48 in patients with HER2-overexpressing,locally advanced or metastatic gastric or gastroesophageal junction cancer:a single-arm phase II study显示文摘Background:Current treatment options for human epidermal growth factor receptor 2(HER2)-overexpressing gastric cancer at third-line have shown limited clinical benefit.Further,there is no specific treatment for HER2 immunohistochemistry(IHC)2+and fluorescence in-situ hybridization-negative patients.Here,we report the efficacy and safety of a novel anti-HER2 antibody RC48 for patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer.Methods:Patients with HER2-overexpressing(IHC 2+or 3+),locally advanced or metastatic gastric or gastroesophageal junction cancer who were under at least second-line therapy were eligible and received RC482.5 mg/kg alone every 2 weeks.The primary endpoint was the objective response rate(ORR)assessed by an independent review committee.Secondary endpoints included progressionfree survival(PFS),overall survival(OS),duration of response,time to progression,disease control rate,and safety.Results:Of 179 patients screened,125 were eligible and received RC48 treatment.The ORR was 24.8%(95%confidence interval[CI]:17.5%-33.3%).The median PFS and OS were 4.1 months(95%CI:3.7-4.9 months)and 7.9 months(95%CI:6.7-9.9 months),respectively.The most frequently reported adverse events were decreased white blood cell count(53.6%),asthenia(53.6%),hair loss(53.6%),decreased neutrophil count(52.0%),anemia(49.6%),and increased aspartate aminotransferase level(43.2%).Serious adverse events(SAEs)occurred in 45(36.0%)patients,and RC48-related SAEs were mainly decreased neutrophil count(3.2%).Seven patients had adverse events that led to death were not RC48-related.Conclusions:RC48 showed promising activity with manageable safety,suggesting potential application in patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer who have previously received at least two lines of chemotherapy. | Zhi Peng Tianshu Liu Jia Wei Airong Wang Yifu He Liuzhong Yang Xizhi Zhang Nanfeng Fan Suxia Luo Zhen Li Kangsheng Gu Jianwei Lu Jianming Xu Qingxia Fan Ruihua Xu Liangming Zhang Enxiao Li Yuping Sun Guohua Yu Chunmei Bai Yong Liu Jiangzheng Zeng Jieer Ying Xinjun Liang Nong Xu Chao Gao Yongqian Shu Dong Ma Guanghai Dai Shengmian Li Ting Deng Yuehong Cui Jianmin Fang Yi Ba Lin Shen | 2021 | Cancer Communications2021，41，11： | 29 |
| 4 | 2018: The Hottest Summer in China and Possible Causes显示文摘In 2018,China experienced the hottest summer since 1961.The maximum,mean,and minimum temperatures all reached the highest.Air temperatures in most regions were much higher than normal;in northern China especially,the temperature anomalies were above double of the standard deviations.Consistent variations of temperature anomalies appeared in the national mean and in northern China on different timescales from intraseasonal to annual,indicating that the above normal temperature in northern China contributed significantly to the record-breaking hot summer of entire China.Relationships among the high temperature in summer 2018,the tropospheric circulation,and the global sea surface temperatures(SSTs)are further analyzed.It is found that the intensified and more northward western Pacific subtropical high(WPSH),weakened Northeast China cold vortex(NECV),and positive geopotential height anomaly from northern China to the Sea of Japan resulted in the abnormally high temperature in summer 2018.From late July to mid August,the WPSH was stronger than normal,with its ridge line jumping to north of 40°N;meanwhile,the NECV was much weaker and more northward than normal;both of the two systems led to the persistent high temperature in northern China during this period.In addition,the SSTs in Kuroshio and its extension area(K–KE)in summer 2018 were also the highest since 1961 and the greatest positive SST anomaly in K–KE was favorable for the above normal geopotential height over North China–Northeast China–Japan at 500 hPa,giving rise to the exceptionally high temperature in northern China. | Ting DING Yuan YUAN Jianming ZHANG Hui GAO | 2019 | Journal of Meteorological Research2019，33，4： | 13 |
| 5 | Synthesis,characterization,and adsorption performance of Pb(Ⅱ)-imprinted polymer in nano-TiO_2 matrix显示文摘Surface ion-imprinted in combination with sol-gel process was applied to synthesis a new Pb(Ⅱ)-imprinted polymer for selective separation and enrichment of trace Pb(II) from aqueous solution. The prepared material was characterized by using the infrared spectra, X-ray diffractometer, and scanning electron microscopy. The batch experiments were conducted to study the optimal adsorption condition of adsorption trace Pb(Ⅱ) from aqueous solutions on Pb(Ⅱ)-imprinted polymer. The equilibrium was achieved in approximately 4.0 h, and the experimental kinetic data were fitted the pseudo second-order model better. The maximum adsorption capacity was 22.7 mg/g, and the Langmuir equation fitted the adsorption isotherm data. The results of selectivity experiment showed that selectively adsorbed rate of Pb(Ⅱ) on Pb(Ⅱ)-imprinted polymer was higher than all other studied ions. Desorption conditions of the adsorbed Pb(Ⅱ) from the Pb(Ⅱ)-imprinted polymer were also studied in batch experiments. The prepared Pb(Ⅱ)-imprinted polymer was shown to be promising for the separation and enrichment of trace Pb(Ⅱ) from water samples. The adsorption and desorption mechanisms were proposed. | LI Chunxiang GAO Jie PAN Jianming ZHANG Zulei YAN Yongsheng | 2009 | Journal of Environmental Sciences2009，21，12： | 12 |
| 6 | Menthol-modified casein nanoparticles loading 10-hydroxycamptothecin for glioma targeting therapy显示文摘Chemotherapy outcomes for the treatment of glioma remains unsatisfactory due to the inefficient drug transport across the blood–brain barrier(BBB) and insufficient drug accumulation in the tumor region. Although many approaches, including various nanosystems, have been developed to promote the distribution of chemotherapeutics in the brain tumor, the delivery efficiency and the possible damage to the normal brain function still greatly restrict the clinical application of the nanocarriers.Therefore, it is urgent and necessary to discover more safe and effective BBB penetration and gliomatargeting strategies. In the present study, menthol, one of the strongest BBB penetration enhancers screened from traditional Chinese medicine, was conjugated to casein, a natural food protein with brain targeting capability. Then the conjugate self-assembled into the nanoparticles to load anti-cancer drugs.The nanoparticles were characterized to have appropriate size, spheroid shape and high loading drug capacity. Tumor spheroid penetration experiments demonstrated that penetration ability of mentholmodified casein nanoparticles(M-CA-NP) into the tumor were much deeper than that of unmodified nanoparticles. In vivo imaging further verified that M-CA-NPs exhibited higher brain tumor distribution than unmodified nanoparticles. The median survival time of glioma-bearing mice treated with HCPT-MCA-NPs was significantly prolonged than those treated with free HCPT or HCPT-CA-NPs. HE staining ofthe organs indicated the safety of the nanoparticles. Therefore, the study combined the advantages of traditional Chinese medicine strategy with modern delivery technology for brain targeting, and provide a safe and effective approach for glioma therapy. | Caifang Gao Jianming Liang Ying Zhu Chengli Ling Zhekang Cheng Ruixiang Li Jing Qin Weigen Lu Jianxin Wang | 2019 | Acta Pharmaceutica Sinica B2019，9，4： | 12 |
| 7 | Abrasive Waterjet Machining Simulation by Coupling Smoothed Particle Hydrodynamics /Finite Element Method显示文摘In dealing with abrasive waterjet machining(AWJM) simulation,most literatures apply finite element method(FEM) to build pure waterjet models or single abrasive particle erosion models.To overcome the mesh distortion caused by large deformation using FEM and to consider the effects of both water and abrasive,the smoothed particle hydrodynamics(SPH) coupled FEM modeling for AWJM simulation is presented,in which the abrasive waterjet is modeled by SPH particles and the target material is modeled by FEM.The two parts interact through contact algorithm.Utilizing this model,abrasive waterjet with high velocity penetrating the target materials is simulated and the mechanism of erosion is depicted.The relationships between the depth of penetration and jet parameters,including water pressure and traverse speed,etc,are analyzed based on the simulation.The simulation results agree well with the existed experimental data.The mixing multi-materials SPH particles,which contain abrasive and water,are adopted by means of the randomized algorithm and material model for the abrasive is presented.The study will not only provide a new powerful tool for the simulation of abrasive waterjet machining,but also be beneficial to understand its cutting mechanism and optimize the operating parameters. | WANG Jianming GAO Na GONG Wenjun | 2010 | Chinese Journal of Mechanical Engineering2010，23，5： | 10 |
| 8 | Effects of dissolved organic matter from sewage sludge on the atrazine sorption by soils显示文摘The effects of dissolved organic matter (DOM), water soluble organic matter derived from sewage sludge, on the sorption of atrazine (2-chloro-4-ethylamino-6-isopropylamino-1,3,5-trazine) by soils were studied using a batch equilibrium technique. Six paddy soils, chosen so as to have different organic carbon contents, were experimented in this investigation. Atrazine sorption isotherms on soils were described by the linear equation, and the distribution coefficients without DOM (Kd) or with DOM (Kd*) were obtained. Generally, the values of Kd*/Kd initially insoil-solution system form. Critical concentrations of DOM (DOMnp) were obtained where the value of Kd* was equal to Kd. The presence of DOM with concentrations lower than DOMnp promoted atrazine sorption on soils (Kd* > Kd), whereas the presence of DOM with concentrations higher than DOMnp tended to inhibit atrazine sorption (Kd* < Kd). Interestingly, DOMnp for tested soils was negatively correlated to the soil organic carbon content, and the maximum of Kd*/Kd (i.e.Kmax) correlated positively with the maximum of DOM sorption on soil (Xmax). Further investigations showed that the presence of hydrophobic fraction of DOM evidently promoted the atrazine sorption on soils, whereas the presence of hydrophilic DOM fraction obviously tended to inhibit the atrazine sorption. Interactions of soil surfaces with DOM and its fractions were suggested to be the major processes determining atrazine sorption on soils. The results of this work provide a reference to the agricultural use of organic amendment such as sewage sludge for improving the availability of atrazine in soils. | LING Wanting, XU Jianming & GAO Yanzheng College of Environmental and Natural Resource Sciences, Zhejiang University, Hangzhou 310029, China College of Natural Resource and Environmental Sciences, Nanjing Agricultural University, Najing 210095, China | 2005 | Science China(Life Sciences)2005，48，z1： | 9 |
| 9 | Time Dependent Chloride Diffusion Coefficient in Concrete显示文摘In order to study how to correctly apply the two different time dependencies to service life prediction models, the definition of parameters in the time dependent equation using the long-term test method and the short-term test method, and its relationship were discussed. The experimental results show that, as the two time dependencies have different meanings, they have different manners when handled in service life prediction models. Time dependency of chloride diffusion coefficients in concrete was obtained by fitting experimental data. A large number of accurate experimental data were required to fit the formula of time dependency to ensure the accuracy of service life prediction model. | 宋鲁光 孙伟 GAO Jianming | 2013 | Journal of Wuhan University of Technology(Materials Science)2013，28，2： | 4 |
| 10 | Surface modification of PGP for a neutrophil–nanoparticle co-vehicle to enhance the anti-depressant effect of baicalein显示文摘Exploiting cells as vehicles combined with nanoparticles combined with therapy has attracted increasing attention in the world recently. Red blood cells, leukocytes and stem cells have been used for tumor immunotherapy, tissue regeneration and inflammatory disorders, and it is known that neutrophils can accumulate in brain lesions in many brain diseases including depression. N-Acetyl Pro–Gly–Pro(PGP) peptide shows high specific binding affinity to neutrophils through the CXCR2 receptor. In this study, PGP was used to modify baicalein-loaded solid lipid nanoparticles(PGP-SLNs) to facilitate binding to neutrophils in vivo. Brain-targeted delivery to the basolateral amygdala(BLA) was demonstrated by enhanced concentration of baicalein in the BLA. An enhanced anti-depressant effect was observed in vitro and in vivo. The mechanism involved inhibition of apoptosis and a decrease in lactate dehydrogenase release. Behavioral evaluation carried out with rats demonstrated that anti-depression outcomes were achieved. The results indicate that PGP-SLNs decrease immobility time, increase swimming time and climbing time and attenuate locomotion in olfactory-bulbectomized(OB) rats. In conclusion, PGP modification is a strategy for targeting the brain with a cell–nanoparticle delivery system for depression therapy. | Baoyu Chen Man Luo Jianming Liang Chun Zhang Caifang Gao Jue Wang Jianxin Wang Yongji Li Desheng Xu Lina Liu Ning Zhang Huijun Chen Jing Qin | 2018 | Acta Pharmaceutica Sinica B2018，8，1： | 4 |
| 11 | Effects of methylphenidate on resting-state brain activity in normal adults: an fMRI study显示文摘Methylphenidate (MPH) is one of the most commonly used stimulants for the treatment of attention deficit hyperactivity disorder (ADHD). Although several studies have evaluated the effects of MPH on human brain activation during specific cognitive tasks using functional magnetic resonance imaging (fMRI), few studies have focused on spontaneous brain activity. In the current study, we investigated the effect of MPH on the intra-regional synchronization of spontaneous brain activity during the resting state in 18 normal adult males. A handedness questionnaire and the Wechsler Adult Intelligence Scale were applied before medication, and a resting-state fMRI scan was obtained 1 h after medication (20 mg MPH or placebo, order counterbalanced between participants). We demonstrated that: (1) there were no significant differences in the performance of behavioral tasks between the MPH and placebo groups; (2) the left middle and superior temporal gyri had stronger MPH-related regional homogeneity (ReHo); and (3) the left lingual gyrus had weaker MPH-related ReHo. Our findings showed that the ReHo in some brain areas changes with MPH compared to placebo in normal adults, even though there are no behavioral differences. This method can be applied to patients with mental illness who may be treated with MPH, and be used to compare the difference between patients taking MPH and normal participants, to help reveal the mechanism of how MPH works. | Yihong Zhu Bin Gao Jianming Hua Weibo Liu Yichao Deng Lijie Zhang Biao Jiang Yufeng Zang | 2013 | Neuroscience Bulletin2013，29，1： | 4 |
| 12 | Casein kinase Ⅱ interacts with prion protein in vitro and forms complex with native prion protein in vivo显示文摘最必要、关键的步在能递送的海绵状的 encephalopathy 的致病期间是到病理学的 isoform 的细胞的 prion 蛋白质的 conformational 变化。酷蛋白 kinase II (CK2 ) 是一无所不在地表示了并且 evolutionarily 保存了为生存能力是必要的多种的蛋白质 kinase。探索在 CK2 和 prion 蛋白质(PrP ) 之间的可能的分子的相互作用,人的 CK2α 和 CK2β 的全身的序列互补 DNA 作为模板从房间线 SH-SY5Y 用彻底的送信人 RNA 与反向的抄写聚合酶链反应被放大;然后,熔化蛋白质 histidine-CK2α 和谷胱甘肽 S-transferase-histidine-CK2β 在 Escherichia 关口 i 被表示。在 CK2 和 PrP 之间的相互作用与 co-immunoprecipitation 和下拉试金被评估。结果证明 recombinant PrP 与 CK2α ,然而并非与 CK2β 明确地跳了。在仓鼠大脑的本国的 CK2 和 PrP 与对方一起交往了,形成蛋白质建筑群。从正常大脑的 PrP (diglycosylated, monoglycosylated 和 unglycosylated PrP ) 的三种不同 glycosylated 形式与 CK2α 子单元交往了,尽管 unglycosylated PrP 似乎与 CK2α 子单元有一个更强壮的有约束力的能力。负责与 CK2α 交往的领域在 PrP 的 C 终端片断被定位(残余 91 231 ) 。这研究为在 PrP 和 CK2α 之间的分子的相互作用建议了可靠试验性的数据(两个在 recombinant 和本国的范畴) ,为进一步估计 PrP-CK2 相互作用的潜在的生物意义的科学线索,和在 prion 疾病的致病的 CK2 的可能的角色。 | Jianming Chen Chen Gao Qi Shi Guirong Wang Yanjun Lei Bing Shan Baoyun Zhang Chenfang Dong SongShi Xin Wang Chan Tian Jun Han Xiaoping Dong | 2008 | Acta Biochimica et Biophysica Sinica2008，40，12： | 3 |
| 13 | mRNA profiles of cytokine receptors in unstimulated peripheral blood mononuclear cells from patients with chronic idiopathic urticaria显示文摘This present study was aimed to investigate the roles of the receptors of Th1/Th2 cytokines and chemokines in the pathogenesis of chronic idiopathic urticaria (CIU).Thirty patients with CIU,30 patients with dermographism and 30 healthy controls were randomly enrolled.Reverse transcription-PCR (RT-PCR) was used to analyze the mRNA of cytokine receptors in peripheral blood mononuclear cells (PBMCs).The mRNA levels of tumor necrosis factor receptor (TNFR),interferon-γ receptor (IFN-γR),and interleukin-10 receptor (IL-10R) were statistically increased in the CIU group (P < 0.05),while IL-2R,IL-4R,IL-6R,and IL-13R showed no significant differences between the CIU and other groups.The mRNA levels of CCR3 and CCR6 were statistically increased in the CIU group (P < 0.05).The toll-like receptor 2 (TLR2) mRNA level was significantly lower in the CIU group than the healthy control group (P < 0.05).These findings indicate that the regulation of mRNA of TNFR,IFN-γR,IL-10R,CCR3,CCR6 and TLR2 may be involved in the pathogenesis of CIU. | Jianming Gao Aizhen Yang Min Chen Ansheng Li Xu Yao Yumei Li Shihai Xie Xueyuan Yang Liansheng Zhong Zhiqiang Chen | 2011 | The Journal of Biomedical Research2011，25，2： | 3 |
| 14 | PrP mutants with different numbers of octarepeat sequences are more susceptible to the oxidative stress显示文摘One of the physiological functions of cellular prion protein(PrP C )is believed to work as a cellular resistance to oxidative stress,in which the octarepeats region within PrP plays an important role.However,the detailed mechanism is less clear.In this study,the expressing plasmids of wild-type PrP (PrP-PG5)and various PrP mutants containing 0(PrP-PG0),9(PrP-PG9)and 12(PrP-PG12)octarepeats were generated and PrP proteins were expressed both in E.coli and in mammalian cells.Protein aggregation and formation of carbonyl groups were clearly seen in the recombinant PrPs expressed from E.coli after treatment of H2O2.MTT and trypan blue staining assays revealed that the cells expressing the mutated PrPs within octarepeats are less viable than the cells expressing wild-type PrP.Statistically significant high levels of intracellular free radicals and low levels of glutathione peroxidase were observed in the cells transfected with plasmids containing deleted or inserted octarepeats.Remarkably more productions of carbonyl groups were detected in the cells expressing PrPs with deleted and inserted octarepeats after exposing to H2O2.Furthermore,cells expressing wild-type PrP showed stronger resistant activity to the challenge of H2O2 at certain extent than the mutated PrPs and mock. These data provided the evidences that the octarepeats number within PrP is critical for maintaining its activity of antioxidation.Loss of its protective function against oxidative stress may be one of the possible pathways for the mutated PrPs to involve in the pathogenesis of familial Creutzfeldt-Jacob diseases. | AN Run1 ,2,DONG ChenFang 2,LEI YanJun 1,2,HAN Lu 2,LI Ping 2,CHEN JianMing 2,WANG GuiRong 2, SHI Qi 2 ,GAO Chen 2 ,JIANG HuiYing 2 ,ZHOU Wei 2 ,HAN Jun 2 ,CHU YongLie 1 ,DONG XiaoPing 2 1School of Medicine,Xi’an JiaoTong University,Xi’an 710061,China 2State Key Laboratory for Infectious Disease Prevention and Control,National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention,YingXin Rd 100,Beijing 100052,China | 2008 | Science China(Life Sciences)2008，51，7： | 3 |
| 15 | Biosynthesis of clinically used antibiotic fusidic acid and identification of two short-chain dehydrogenase/reductases with converse stereoselectivity显示文摘Fusidic acid is the only fusidane-type antibiotic that has been clinically used. However,biosynthesis of this important molecule in fungi is poorly understood. We have recently elucidated the biosynthesis of fusidane-type antibiotic helvolic acid, which provides us with clues to identify a possible gene cluster for fusidic acid(fus cluster). This gene cluster consists of eight genes, among which six are conserved in the helvolic acid gene cluster except fusC1 and fusB1. Introduction of the two genes into the Aspergillus oryzae NSAR1 expressing the conserved six genes led to the production of fusidic acid. A stepwise introduction of fusC1 and fusB1 revealed that the two genes worked independently without a strict reaction order. Notably, we identified two short-chain dehydrogenase/reductase genes fusC1 and fusC2 in the fus cluster, which showed converse stereoselectivity in 3-ketoreduction. This is the first report on the biosynthesis and heterologous expression of fusidic acid. | Zhiqin Cao Shaoyang Li Jianming Lv Hao Gao Guodong Chen Takayoshi Awakawa Ikuro Abe Xinsheng Yao Dan Hu | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 3 |
| 16 | Synthesis and Performance Characterization of a Low Adsorption Clay-resistant Polycarboxylate Superplasticizer显示文摘A low adsorption clay-resistant polycarboxylate superplasticizer(KN-PC)was synthesized using acrylic acid and isopentenol polyoxyethylene ether as the main reaction materials.The structural characterization and clay-resistant mechanism of the KN-PC were explored using Fourier transform infrared spectroscopy and X-ray diffraction,and the effect of the KN-PC on the performance of composite paste with various montmorillonite(MMT)contents was analyzed.Compared with ordinary polycarboxylate superplasticizer(PC),the KN-PC has a low sensitivity to the MMT.By the action of the MMT,the adsorption dosage of the KN-PC on the MMT is much smaller than that of the PC. | 张营 WANG Pengshuo 孙国文 YANG Jianming GAO Rui | 2021 | Journal of Wuhan University of Technology(Materials Science)2021，36，3： | 2 |
| 17 | 2021 Chinese consensus on the diagnosis and management of primary immune thrombocytopenia in pregnancy显示文摘Immune thrombocytopenia(ITP)is an acquired disease characterized by isolated thrombocytopenia,which is one of the most common causes of thrombocytopenia during pregnancy.Women with ITP who have severe thrombocytopenia are at an increased risk for life-threatening obstetric complications.Therefore,we established this consensus statement on the diagnosis and management of ITP during pregnancy(detailed information is available in the Supplementary File,http://gffzz16e312a87a7141a5hvwwnqv6pwuu56fxn.ffgz.tsg.suse.edu.cn/A978). | Zhang Xiaohui Chen Fangping Chen Xiequn Cheng Yunfeng Fang Meiyun Feng Jianming Fu Haixia Gao Hong Han Yue He Aili Hou Ming Hu Yu Huang Ruibin Huang Wenrong Jing Zhicheng Kong Peiyan Liang Aibin Liang Meiying Liu Daihong Liu Junling Liu Lin Liu Xiaowei Ma Liangming Mei Heng Ni Heyu Niu Ting Peng Jun Qiao Jianlin Ren Jinhai Song Yongping Tang Liang V Tong Tong Wang Shaoyuan Wang Xin Wang Zhao Wei Hui Wu Depei Wu Guangsheng Xu Caigang Xu Xue Xu Yajing Yang Linhua Yang Renchi Yang Tonghua Yin Chenghong Yu Li Zhang Guangsen Zhang Lei Zhang Liansheng Zhang Xi Zhao Weili Zhao Yongqiang Zhou Daobin Zhou Hu Zhou Zeping Zhu Tienan Wang Jianliu Huang Xiaojun | 2022 | Chinese Medical Journal2022，，8： | 2 |
| 18 | Classification of partial discharge severities of ceramic insulators based on texture analysis of UV pulses显示文摘Inspection of partial discharge before contamination flashover is of great importance for preventing exterior insulation accidents.In this study,a new method for identification of discharge severities is proposed.Specifically,a low‐cost ultraviolet(UV)sensor detection system was combined with time-frequency method,texture analysis and support vector machine(SVM)classifier to classify partial discharge severities for ceramic insulators.The visible images and the root‐mean‐square value of leakage currents detected simulta-neously are used to classify the UV signals into different discharge faults.The frequency and amplitude integration of UV pulses are minimum in corona discharge and larger in arc discharge.The images of UV signal spectrograms differ significantly at different discharge stages.The density and brightness of image textures are minimal in corona discharge and larger in arc discharge.Valid and reliable features selected by two texture feature extraction methods with SVM classifier have a reliable classification accuracy of 90.6%for ceramic insulators,and outperform a single time feature or other texture features.SVM outperforms k‐Nearest Neighbour,Naive Bayes and Decision Tree.Our new method with computational effectiveness and high practicality can solve the problem of high randomness and low accuracy of UV sensor detection.It can be further applied to the deterioration diagnosis of power facilities. | Danrui Ma Lijun Jin Jianming He Kai Gao | 2021 | High Voltage2021，6，6： | 2 |
| 19 | Implementation of Dynamic System Control Circuit Board Test System of Pure Electric Vehicles显示文摘The dynamic system control circuit board(DSCCB)is one of the most important components for dynamic system of pure electric vehicles. The current detection of the DSCCB is done manually, which is not only inefficient in the detection but also difficult to guarantee the data accuracy. In order to improve the detection efficiency and accuracy, a new testing system is designed by Labview. The total test time can be further reduced by about 75% compared with the results of the manual detection. In this paper, the three-parameter sine wave curve-fit algorithm theory is applied to the phase delay detection of the current sensor sampling circuit on the DSCCB. This method solves the problem of big error in the phase delay detection. | BI Wei, WANG Jianming, DOU Ruzhen, GAO Hua (Department of Information and Communication, Tianjin Polytechnic University, Tianjin 300160, CHN) | 2010 | Semiconductor Photonics and Technology2010，16，4： | 2 |
| 20 | The abnormal behavior of polymers glass transition temperature increase and its mechanism显示文摘In terms of the classical theory in textbooks, the two components with phase separation in a binary polymer blend will, depending on their compatibility, have their respective Tg get closer or remain in their original values. According to the classical theory, the Tg of plastic component shall remain unchanged or move toward the lower Tg of rubber component in a rubber/plastic blend. However, ultra-fine full-vulcanized powdered rubber (UFPR) with a diameter of ca. 100 nm can simultaneously increase the toughness and the Tg of plastics, which is abnormal and is difficult to explain by classical theory. In this feature article, the abnormal behavior and its mechanism are discussed in detail. | WANG Xiang QI GuiCun ZHANG XiaoHong GAO JianMing LI BingHai SONG ZhiHai QIAO JinLiang | 2012 | Science China Chemistry2012，55，5： | 2 |
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