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| 1 | Immunopathogenesis of chronic hepatitis B显示文摘Chronic hepatitis B(CHB) is a widespread infectious disease with unfavorable outcomes and life-threatening consequences for patients, in spite of modern vaccination and antiviral treatment modalities. Cutting-edge experimental approaches have demonstrated key pathways that involve cross-talk between viral particles and host immune cells. All events, including penetration of hepatitis B virus(HBV) particles into host cells, establishing persistence, and chronization of CHB infection, and possibility of complete elimination of HBV particles are controlled by the immune system. Researchers have paid special attention to the replication capacity of HBV in host cells, which is associated with cellular changes that reflect presentation of viral antigens and variability of HBV antigen features. In addition, specific HBV proteins have an immune-modulating ability to initiate molecular mechanisms that 'avoid' control by the immune system. The relationship between immunological shifts and chronic infection stages has been intensively studied since it was recognized that the immune system is a direct participant in the recurrent(cyclic) nature of CHB. Understanding the wide diversity of molecular pathways and the crosstalk between innate and adaptive immune system components will provide fresh insight into CHB immune pathogenesis and the possibilities of developing new treatment strategies for this disease. | Irina P Balmasova Nikolay D Yushchuk Ospan A Mynbaev Nageswara R Alla Elena S Malova Zhongjie Shi Chang-Lu Gao | 2014 | World Journal of Gastroenterology2014，20，39： | 15 |
| 2 | 烟酰胺磷酸核糖基转移酶促进肺血管重塑,是肺动脉高压的治疗靶点显示文摘肺动脉高压(pulmonary arterial hypertension,PAH)是一种严重的进行性疾病,其标志之一是肺血管重塑。烟酰胺磷酸核糖基转移酶(nicotinamide phosphoribosyl transferase,NAMPT)是调节细胞内烟酰胺腺嘌呤二核苷酸水平、细胞氧化还原状态,调节组蛋白脱乙酰酶,促进细胞增殖和抑制凋亡的一种细胞酶。研究人员假设NAMPT可促进肺血管重塑, | Chen J Sysol JR Singla S Zhao S Yamamura A Valdez-Jasso D Abbasi T Shioura KM Sahni S Reddy V Sridhar A Gao H Torres J Camp SM Tang H Ye SQ Comhair S Dweik R Hassoun P Yuan JX Garcia JG Machado RF 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，2： | 10 |
| 3 | Global land cover mapping from MODIS: algorithms and early results显示文摘 | M.A Friedl D.K McIver J.C.F Hodges X.Y Zhang D Muchoney A.H Strahler C.E Woodcock S Gopal A Schneider A Cooper A Baccini F Gao C Schaaf | 2002 | Remote Sensing of Environment2002，，1： | 2 |
| 4 | 显示文摘 | Gao D S Chen W Xu Q | 2000 | J Wuhan Univ Techol Mater Sci Ed2000，15，： | 1 |
| 5 | Modeling of QW lasers for computer aided analysis of optoelectronic integrated circuit显示文摘 | Gao D S | 1990 | IEEE Journal of Quantum Electronics1990，26，7： | 1 |
| 6 | Densification and properties of barium zirconate ceramics by addition of P2O5显示文摘 | GAO D Y GUO R S | | 0，，05： | 1 |
| 7 | Microenvironmental regulation of epithelial-mesenchymal transitions in cancer显示文摘 | Gao D Vahdat LT Wong S | 2012 | Cancer Res2012，72，19： | 1 |
| 8 | An effective global harmony search algorithm for reliability problems显示文摘 | Zou D Gao L Li S | 2011 | Expert Systems with Applications2011，38，4： | 1 |
| 9 | Cyclovirobuxine D induces autophagy-associated cell death via the Akt/m TOR pathway in MCF-7 human breast cancer cells显示文摘 | Lu J Sun D Gao S | 2014 | J Pharmacol Sci2014，125，1： | 1 |
| 10 | Theoretical insight into the co-crystal explosive of 2,4,6,8,10,12-hexani-trohexaazaisowurtzitane ( CL-20 )/1,1-diamino-2,2-dini- troethylene( FOX-7 ) 显示文摘 | Gao H F Zhang S H Ren F D | 2015 | Comput Mater Sci2015，107，： | 1 |
| 11 | A novel global harmony search algorithm for task assignment problem显示文摘 | Zou D X Gao L Q Li S | 2010 | J of Systems and Software2010，83，10： | 1 |
| 12 | New chaotic algorithm for image encryption显示文摘 | Gao H Zhang Y Liang S Li D A | 2006 | Chaos Solutions and Fractals2006，29，： | 1 |
| 13 | L-selectin and ICAM-1 mediate reperfusion injury and neutrophil adhesion in the warm ischemia mouse liver显示文摘 | Yadav S Howell D Gao W | 1998 | Am J Phy1998，275，10： | 1 |
| 14 | Drag coefficients,roughness length and zero-plane displacement height as disturbed by artificial standing vegetation显示文摘 | Dong Z B Gao S Y Fryrear D W | 2001 | Journal of Arid Environments2001，45，： | 1 |
| 15 | Evolution of microstructural homogeneity in copper processed by high-pressure torsion 显示文摘 | An X H Wu S D Zhang Z F Figueiredo R B Gao N Langdon T G | 2010 | Scripta Materialia2010，63，： | 1 |
| 16 | Structural and electrochemical properties of yttrium-doped barium zirconate by addition of CuO显示文摘 | GAO D Y GUO R S | | 0，，1： | 1 |
| 17 | Contrast and resolution in imaging with a microfocus X-ray source显示文摘 | Pogany A Gao D Wilkins S W | 1997 | Reviezoof Scientific Instruments1997，68，： | 1 |
| 18 | Electrochemical capacitance of Co3O4nanowire arrays supported on nickel foam显示文摘 | Gao Y Y Chen S L Cao D X | 2010 | J Power Sources2010，195，： | 1 |
| 19 | Solving 0-1 knapsack problem by a novel global harmony search algorithm显示文摘 | Zou D X Gao L Q Li S | 2011 | Applied Soft Computing2011，11，2： | 1 |
| 20 | The cytostatic and cytotoxic effects of oridonin ( Rubescenin ), a diterpenoid from Rabdosia rubescens, on tumor cells of different lineage 显示文摘 | Chen S Gao J Halicka H D | 2005 | Int J Oncol2005，26，3： | 1 |
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