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| 1 | Oxidative stress and extracellular matrices after hepatectomy and liver transplantation in rats显示文摘AIM:To investigate oxidative stress(OS)-mediated damage and the behavior of extracellular matrices in various rat models because shear stress with portal hypertension and cold ischemia/warm reperfusion injury trigger the liver regeneration cascade after surgery. These injuries also cause fatal liver damage.METHODS: Rats were divided into four groups according to the surgery performed: control; hepatectomy with 40% liver remnant(60% hepatectomy); orthotopic liver transplantation(OLT) with whole liver graft(100% OLT); and split OLT(SOLT) with 40% graft(40% SOLT). Survival was evaluated. Blood and liver samples were collected at 6 h after surgery. Biochemical and histopathological examinations were performed. OSinduced damage, 4-hydroxynonenal, ataxia-telangiectasia mutated kinase, histone H2AX, phosphatidylinositol 3-kinase(PI3K) and Akt were evaluated by western blotting. Behavior of extracellular matrices, matrix metalloproteinase(MMP)-9, MMP-2, tissue inhibitor of metalloproteinase(TIMP)-1 and TIMP-2 were also evaluated by western blotting and zymography. RESULTS: Although 100% OLT survived, 60% hepatectomy and 40% SOLT showed poor survival. Histopathological, immunohistological, biochemical and protein assays revealed that 60% hepatectomy, 100% OLT and 40% SOLT showed liver damage. PI3K and Akt were decreased in 60% hepatectomy and 40% SOLT. For protein expression, 40% SOLT showed differences in MMP-9, MMP-2 and TIMP-2. TIMP-1 showed differences in 60% hepatectomy and 40% SOLT. For protein activity, MMP-9 demonstrated significant differences in 60% hepatectomy, 100% OLT and 40% SOLT. CONCLUSION: Under conditions with an insufficient liver remnant, prevention of OS-induced damage via the Akt/PI3K pathway may be key to improve the postoperative course. MMP-9 may be also a therapeutic target after surgery. | Tomohide Hori Shinji Uemoto Feng Chen Lindsay B Gardner Ann-Marie T Baine Toshiyuki Hata Takayuki Kogure Justin H Nguyen | 2014 | World Journal of Hepatology2014，6，2： | 7 |
| 2 | Simple and reproducible hepatectomy in the mouse using the clip technique显示文摘AIM: To investigate the reliability of massive hepatectomy models by using clip techniques. METHODS: We analyzed anatomical findings in 100 mice following massive hepatectomy induced by liver reduction > 70%. The impact of various factors in the different models was also analyzed, including learning curves, operative time, survival curves, and histopathological findings.RESULTS: According to anatomical results, models with 75%, 80%, and 90% hepatectomy produced massive hepatectomy. Learning curves and operative times were most optimal with the clip technique. Each hepatectomy performed using the clip technique produced a reasonable survival curve, and there were no differences in histopathological findings between the suture and clip techniques. CONCLUSION: Massive hepatectomy by the clip technique is simple and can provide reliable and relevant data. | Tomohide Hori Norifumi Ohashi Feng Chen Ann-Marie T Baine Lindsay B Gardner Toshiyuki Hata Shinji Uemoto Justin H Nguyen | 2012 | World Journal of Gastroenterology2012，18，22： | 4 |
| 3 | A prospective randomized trial of blastocyst culture and transfer in in-vitro fertilization显示文摘 | Gardner D K Schoolcraft W B Wagley L | 1998 | Hum Reprod1998，13，12： | 3 |
| 4 | Blastocyst score affects implantation and pregnancy outcome: towards a single blastocyst transfer显示文摘 | David K Gardner Michelle Lane John Stevens Terry Schlenker William B Schoolcraft | 2000 | Fertility and Sterility2000，，6： | 2 |
| 5 | Neutral models for the analysis of broad-scale landscape pattern显示文摘 | Gardner R H Mime B T Turner M G | 1987 | Landscape Ecology1987，1，1： | 2 |
| 6 | IL-IO mediates signal receptor dependent suppression of antitumor immunity 显示文摘 | Zhu LX Sharma S Gardner B | 2003 | J Immunol2003，170，7： | 1 |
| 7 | Variable pore size, variable chemical functionality, and an example of reactivity within porous phenylaeetylene silver salts 显示文摘 | Kiang Y H Gardner G B Lobkovsky E B | 1999 | J Am Chem Soc1999，121，： | 1 |
| 8 | Strength Enhancements Induced During Cold Forming of Stainless Steel Sections显示文摘 | Rachel B Cruise Gardner L | 2008 | Journal of Constructional Research2008，64，1： | 1 |
| 9 | One- class novelty detection for seizure analysis from intracranial EEG 显示文摘 | GARDNER A B KRIEGER A VACHTSEVANOS G | 2006 | Journal of Machine Learning Research2006，7，： | 1 |
| 10 | Atmospheric refractivity corrections in satellite laser ranging显示文摘 | ABSHIRE J B GARDNER C S | 1985 | IEEE Trans Geos & Remote Sensing1985，23，： | 1 |
| 11 | The Product and Brand显示文摘 | Burleigh B Gardner Sidney J Levy | 1955 | Harvard Business Review 3 - 41955，3339，： | 1 |
| 12 | Modelling Motivation and Habit in Stable Travel Mode Contexts显示文摘 | GARDNER B | 2009 | Transportation Re- search Part F2009，12，1： | 1 |
| 13 | Using clinical data for nursing research and management in health services显示文摘 | Heslop L Gardner B Diers D | | 0，，1： | 1 |
| 14 | Authentic Leadership:Development and Validation of a Theo- ry-Based Measure显示文摘 | Walumbwa F Avolio B Gardner W L Wernsing T | 2008 | Journal of Management2008，34，1： | 1 |
| 15 | Modeling of residual stresses instructural stainless steel sections显示文摘 | Gardner L Cruise R B | 2009 | Journal of Struc-tural Engineering2009，135，1： | 1 |
| 16 | Crystal morphological investigation in thin films of poly(aryl ether ketone ketone) having a meta-linka_ge显示文摘 | Gardner K H Hsiao B S Ho R M | 1997 | Polymer1997，20，： | 1 |
| 17 | Embryo transfer: techniques and variables affecting success显示文摘 | Sehoolcraft W B Surrey E S Gardner D K | 2001 | Fertil Sleri12001，76，5： | 1 |
| 18 | Principles of Endoneurosurgery显示文摘 | KASSAM A B GARDNER P A PREVEDELLO D M | 2012 | Prog Neurol Surg2012，26，： | 1 |
| 19 | Calcium-free vitrification reduces eryoprotectant-induced zona pellucida hardening and increases fertilization rates in mouse oocytes显示文摘 | Larmnan M G Sheehan C B Gardner D K | 2006 | Reproduction2006，131，： | 1 |
| 20 | Localizedtransient expression of GUS in leaf disc following cocultivation with Agrobacterium显示文摘 | JANSSON B J GARDNER R C | 1989 | Plant Mol Biol1989，14，： | 1 |
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