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| 1 | Meteorin-β/Meteorin like/IL-41 attenuates airway inflammation in house dust mite-induced allergic asthma显示文摘We sought to examine the regulatory effect of Meteorin-β(Metrnβ)/Meteorin like(Metrnl)/IL-41 on lung inflammation in allergic asthma.We found that Metrnβwas elevated significantly in asthmatic patients and in mice with allergic asthma induced by house dust mite(HDM)extract.Upon exposure to HDM,Metrnβwas secreted predominantly by airway epithelial cells and inflammatory cells,including macrophages and eosinophils.The increased Metrnβeffectively blocked the development of airway hyperreactivity(AHR)and decreased inflammatory cell airway infiltration and type 2 cytokine production,which was associated with downregulated DC-mediated adaptive immune responses.Moreover,Metrnβimpaired the maturation and function of bone marrow-derived dendritic cells in vitro.Asthmatic mice adoptively transferred with dendritic cells isolated from Metrnβ-treated allergic mice displayed decreased AHR,airway inflammation,and lung injury.Metrnβalso displayed anti-inflammatory properties in immunodeficient SCID mice with allergic asthma and in in vitro 3D ALI airway models.Moreover,blockade of Metrnβby anti-Metrnβantibody treatment promoted the development of allergic asthma.These results revealed the unappreciated protective roles of Metrnβin alleviating DC-mediated Th2 inflammation in allergic asthma,providing the novel treatment strategy of therapeutic targeting of Metrnβin allergic asthma. | Xun Gao Ting-Fan Leung Gary Wing-Kin Wong Wing-Hung Ko Mengyun Cai Ellie Jiayi He Ida Miu-Ting Chu Miranda Sin-Man Tsang Ben Chung-Lap Chan Jiawei Ling Xiao Fan Liwei Lu Christopher Wai-Kei Lam Chun-Kwok Wong | 2022 | Cellular & Molecular Immunology2022，19，2： | 5 |
| 2 | Combinatorial control of smooth muscle specific gene expression显示文摘 | Meena SK Gary KO | 2003 | Arterioscler Thromb Vasc Biol2003，23，3： | 1 |
| 3 | Molecular regulation of vascular smoothmuscle cell differentiation in development and disease显示文摘 | Gary KO Meena K Brian W | 2004 | Physiol Rev2004，84，： | 1 |
| 4 | Combinatorial control of smooth muscle specific gene expression显示文摘 | MEENA SK GARY KO | 2003 | Arterioscier Thromb Vasc Biol2003，23，3： | 1 |
| 5 | Use of sulphonylurea and cancer in type 2 diabetes—The Hong Kong Diabetes Registry显示文摘 | Xilin Yang Wing Yee So Ronald C.W. Ma Linda W.Y. Yu Gary T.C. Ko Alice P.S. Kong Vanessa W.S. Ng Andrea O.Y. Luk Risa Ozaki Peter C.Y. Tong Chun-Chung Chow Juliana C.N. Chan | 2010 | Diabetes Research and Clinical Practice2010，，3： | 1 |
| 6 | Outcomes of Screening for Diabetes in High-Risk Hong Kong Chinese Subjects 显示文摘 | Gary TC Ko Vincent TF Yeung Juliana CA Chan | 2000 | Diabetes Care 23: 1293-12942000，，： | 1 |
| 7 | Combined use of a fasting plasma glucose concentration and HbAle or fruetosamine predicts the likelihood of having diabetes in high - risk subjects 显示文摘 | Gary TC Ko Juliana CN Chart Vincent TF Yeung | 1998 | Diabetes Care1998，21，： | 1 |
| 8 | A 10- week Tai-Chi program improved the blood pressure, lipid pro file and SF-36 scores in Hong Kong Chinese women显示文摘 | Gary T C Ko Patrick C C Tsang Hamlsh C K Chan | 2006 | Med Sci Monil2006，12，5： | 1 |
| 9 | Combinatorial control of smooth muscle specific gene expression 显示文摘 | Meena SK Gary KO | 2003 | Arteriosclerosis Thrombosis Vascular Biology2003，23，： | 1 |
| 10 | Expression of smooth muscle-specific a-isoaction in culture vascular smooth muscle cells: relationship between growth and cytodifferentiation显示文摘 | Gary KO Alex L David G | 1986 | J Cell Biol1986，102，2： | 1 |
| 11 | Doubling over ten years of central obesity in Hong Kong Chinese working men显示文摘背景肥胖现在是在世界的大多数部分的流行病。在这生气部分研究,我们在香港在肥胖上报导最近的数据中国工作人口并且在在2000年7月和2002年3月之间的 10 years.Methods 上比较变化,从在香港的工作的班的 5882 个成年对象被招募( 2716 个男人(46.2%)和 3166 个女人(53.8%))。他们随机用计算机被选择根据职业组的分发产生了代码。这研究的结果与在中国工作人口在 1990 进行了的一个香港( 1513 个题目, 910 个男人(60.1%)和 603 个女人(39.9%))为心血管的风险因素从流行调查收集的数据相比 .Results 标准化了过重,肥胖,和中央肥胖的百分比,用香港汉语,工作人口是59.7%,35.0%,26.7%在男人并且32.0%,21.7%,26.7%在女人。比作在 1990 收集的数据,肥胖的百分比在男人增加了 5% 并且在女人在 6% 减少了。在男人加倍的中央肥胖的百分比(从 12.2% ~ 26.7%) 但是在在那里的 women.Conclusions 的仍然是的马厩是一在香港加倍中央肥胖的百分比在以前的十年的中国工作男人。教育和合适的生活方式修正编程序处理这个社会健康问题着急地被显示。 | KO Gary Tin-choi CHAN Juliana CHAN Amy WONG Patrick HUI Stanley CHOW Ferrie TONG Spencer CHAN Cecilia | 2007 | Chinese Medical Journal2007，，13： | 0 |
| 12 | Association between smoking,pancreatic insulin secretion and insulin resistance in Chinese subjects with or without glucose intolerance显示文摘在那里的背景是研究建议吸烟可以增加在胰岛素分泌物上吸烟的类型 2 diabetes.Effects 的风险,然而,胰岛素抵抗(红外)是这是的 controversial.Methods 在那里的代表性的 study.Since 是在香港中国女人之中的很少的吸烟者,仅仅男人( n=1068 )在这 report.Fasting 和2小时的血浆葡萄糖被分析,胰岛素由计算机模型基于 homeostatic 模型评价( HOMA )是 measured.Insulinogenic 索引以及贝它房间功能和红外(惊讶1.59 椠 ? 慦桳潩? | KO Gary Tin-Choi TONG Peter Chun-Yip SO Wing-Yee COCKRAM Clive S. CHAN Juliana Chung-Ngor | 2007 | Chinese Medical Journal2007，，24： | 0 |
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