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| 1 | MiR-9 reduces human acyl-coenzyme A:cholesterol acyltransferase-1 to decrease THP-1 macrophage-derived foam cell formation显示文摘MicroRNAs (miRNAs ) post-transcriptionally 由指向 mRNAs 调整基因表示并且控制大量生物函数。最近的研究显示了 miRNAs 能在哺乳动物调整类脂化合物和胆固醇新陈代谢。酰辅酶 A:cholesterol acyltransferase (ACAT ) 是在细胞的胆固醇新陈代谢的关键酶。积累的 cholesteryl 酉旨被 ACAT1 主要在泡沫房间的形成期间综合,早动脉粥样硬化患者损害的一个特点。这里,我们表明 miR-9 能指向人的 ACAT1 mRNA 的 3-untranslated 区域,明确地在不同人的房间线减少人的 ACAT1 或记者萤火虫酶(Fluc ) 蛋白质然而并非他们的 mRNAs,并且机能上地减少从 THP-1-derived 巨噬细胞的泡沫房间的形成。我们的调查结果建议 miR-9 可能是在细胞的胆固醇动态平衡和减少的一个重要管理者在由减少 ACAT1 蛋白质的 vivo 的泡沫房间的形成。 | Jiajia Xu Guangjing Hu Ming Lu Ying Xiong Qin Li Catherine C.Y. Chang Baoliang Song Tayuan Chang Boliang Li | 2013 | Acta Biochimica et Biophysica Sinica2013，45，11： | 17 |
| 2 | ACAT1 regulates the dynamics of free cholesterols in plasma membrane which leads to the APP-a-processing alteration显示文摘 | Ming Zhu Xiaonan Zhao Jia Chen Jiajia Xu Guangjing Hu Dongqing Guo Qin Li Xiaowei Zhang Catherine C.Y. Chang Baoliang Song Ying Xiong Tayuan Chang Boliang Li | 2015 | Acta Biochimica et Biophysica Sinica2015，47，12： | 7 |
| 3 | Effect of Quercetin on Formation of Choroidal Neovascularization (CNV) in Age-related Macular Degeneration (AMD)显示文摘Purpose:Age-related macular degeneration(AMD)as a disease entity is 'dry' at early stage and made up of two main components at late stage:atrophic AMD and exudative AMD.Quercetin acts as an anti-oxidant to protect retinal pigment epithelial cells(RPE)from damaged by oxidative stress,but its effect on formation of choroidal neovascularization(CNV)in AMD is unclear.The aim of this study is to investigate the effect of quercetin on the formation of CNV in AMD.Methods:The development of CNV induced by laser was detected.by fluorescein angiography(FA).Colored microsphere technique was used to determine the choroidal blood flow in ocular hypertensive rabbit eyes.In in vitro studies,HUVECs were treated with NaIO3,H2O2 and NaN3 to induce oxidative cell damages.The effect of quercetin on various oxidations-induced injuries in HUVECs was measured by MTT assay.HUVECs migration was assessed using a wound healing assay.Results:Quercetin significantly inhibited the formation of laser-induced CNV.The choroidal blood flow in rabbit eyes was significantly increased after quercetin instillation.In vitro results showed quercetin enhanced various oxidations-induced injuries in HUVECs and inhibited migration of HUVECs during wound healing.Conclusion:Quercetin inhibited the formation of CNV both in vivo and in vitro and increased choroidal blood flow.It could become a promising candidate for the treatment of AMD. | George C.Y. Chiou | 2011 | Eye Science2011，26，1： | 7 |
| 4 | The optional long 5'-untranslated region of human ACAT1 mRNAs impairs the production of ACAT1 protein by promoting its mRNA decay显示文摘我们以前报导了人的 ACAT1 mRNAs 用 AUG13971399 开始 codon 生产 50 kDa 蛋白质,并且另外一个未成年者用在上游的在里面框架 GGC12741276 开始 codon 的 56 kDa isoform。GGC12741276 codon 在可选的长 5-untranslated 区域被定位(5-UTR, nt 11396 ) mRNAs。相应于这 5-UTR 的 DNA 序列位于二个不同染色体, 7 和 1。在当前的工作,我们报导可选的长 5-UTR 显著地损害从 AUG13971399 codon 开始的人的 ACAT1 蛋白质的生产,主要由支持它的 mRNA 腐烂。西方的污点分析显示可选的长 5-UTR potently 损害了从 AUG13971399 codon 开始的不同蛋白质的生产,意味着这损害效果没被 3-UTR 或 ACAT1 mRNA 的编码顺序影响。反向的抄写量的聚合酶链反应的结果证明这 5-UTR 戏剧性地减少了它的连接 mRNAs 的内容。到 mRNA 比率的蛋白质的分析证明这 5-UTR 主要减少了它的 mRNA 稳定性而非改变它的翻译效率。我们下次执行了 plasmid transfection 实验并且使用了放线菌素 D 禁止抄写。结果证明这 5-UTR 支持了它的 mRNA 腐烂。用在 vitro 准备的 RNA 的另外的 transfection 和 nucleofection 实验说明了那,在细胞质和房间的原子核,没有连接,可选的长 5-UTR-linked mRNAs 比那些快腐烂了。总的来说,我们的学习在抄写以后的水平把新卓见带到人的 ACAT1 基因表示的规定。 | Xiaonan Zhao Jia Chen Lei Lei Guangjing Hu Ying Xiong Jiajia Xu Qin Li Xinying Yang Catherine C.Y. Chang Baoliang Song Tayuan Chang Boliang Li | 2009 | Acta Biochimica et Biophysica Sinica2009，41，1： | 6 |
| 5 | AUTHENTICATED SYMMETRIC-KEY ESTABLISHMENT FOR MEDICAL BODY SENSOR NETWORKS显示文摘This study concerns security issues of the emerging Wireless Body Sensor Network (WBSN) formed by biomedical sensors worn on or implanted in the human body for mobile healthcare appli-cations. A novel authenticated symmetric-key establishment scheme is proposed for WBSN,which fully exploits the physiological features obtained by network entities via the body channel available in WBSN but not other wireless networks. The self-defined Intrinsic Shared Secret (ISS) is used to replace the pre-deployment of secrets among network entities,which thus eliminates centralized services or au-thorities essential in existing protocols,and resolves the key transport problem in the pure symmet-ric-key cryptosystem for WBSN as well. The security properties of the proposed scheme are demon-strated in terms of its attack complexity and the types of attacks it can resist. Besides,the scheme can be implemented under a light-weight way in WBSN systems. Due to the importance of the ISS concept,the analysis on using false acceptance/false rejection method to evaluate the performance of ISS for its usage in the scheme is also demonstrated. | Bao Shudi Poon Carmen C.Y. Shen Lianfeng Zha.ng Yuanting | 2007 | Journal of Electronics(China)2007，24，3： | 6 |
| 6 | Elastic deformation behaviour of Ti–24Nb–4Zr–7.9Sn for biomedical applications显示文摘 | Y.L. Hao S.J. Li S.Y. Sun C.Y. Zheng R. Yang | 2006 | Acta Biomaterialia2006，，2： | 5 |
| 7 | Mayo临床中心肺癌CT筛查的长期效果评价显示文摘目的分析Mayo临床中心肺癌CT筛查研究受试者的单组个体数据,评价筛查的长期效果,同时对比评价已知肺癌模拟模型和应用相同数据建立的不同模型之间的差别。方法本研究经伦理审查委员会批准,并且符合HIPPA。在Mayo临床中心,由1520例肺癌筛查受试者(年龄50~85岁,吸烟或有吸烟史)的匿名资料组成肺癌政策模型.包括微观的肺癌发展模拟模型、CT筛查所见、治疗结果和长期结果。模型用于预测单位研究小组内(包括连续5a肺癌年筛查和不进行肺癌筛查)肺癌的诊断和死亡。 | P.M. McMahon C.Y. Kong B.E. Johnson M.C. Weinstein J.C. Weeks K.M.Kuntz 高莉(译) 唐光健(校) | 2008 | 国际医学放射学杂志2008，31，5： | 5 |
| 8 | A Subpopulation of CD26 + Cancer Stem Cells with Metastatic Capacity in Human Colorectal Cancer显示文摘 | Roberta Pang Wai Lun Law Andrew C.Y. Chu Jensen T. Poon Colin S.C. Lam Ariel K.M. Chow Lui Ng Leonard W.H. Cheung Xiao R. Lan Hui Y. Lan Victoria P.Y. Tan Thomas C. Yau Ronnie T. Poon Benjamin C.Y. Wong | 2010 | Cell Stem Cell2010，，6： | 4 |
| 9 | Condensate Polishing System for PWR Nuclear Power Plant显示文摘 | A.L. Wang C.Y. Zhang Y.Q. Yang L.L. Yin | 2011 | Journal of Energy and Power Engineering2011，5，10： | 4 |
| 10 | EFFECT OF CHEMICAL COMPOSITION AND PROCESSES ON THE TEXTURE OF HOT-ROLLED DEEP DRAWING STEEL SHEET显示文摘A hot-rolled deep drawing (HDD) steel with high r-value and uniform distribution of {111} texture in thickness was developed by hot rolling in ferrite region with lubricating between the roller and the steel. The experimental results show that the carbon content and finish rolling temperature have significant effects on beneficial texture {111}, and lubricating during hot rolling at low temperature in α-region makes the distribution of the texture uniform. Three basic requirements needed to meet for HDD steel were concluded by comparing different carbon contents and hot rolling processes. | Y. Chen, X. Chen, C.Y. Li, X.Y. Li and Y.L. KangTechnical Center of Wuhan Iron and Steel Group Co., Wuhan 430080, ChinaWuhan University of Science and Technology, Wuhan 430080, ChinaCentral General Iron and Steel Research Institute, Beijing 100081, ChinaU | 2002 | Acta Metallurgica Sinica(English Letters)2002，15，3： | 3 |
| 11 | Entecavir Monotherapy Is Effective in Suppressing Hepatitis B Virus After Liver Transplantation显示文摘 | James Fung Cindy Cheung See–Ching Chan Man–Fung Yuen Kenneth S.H. Chok William Sharr Wing–Chiu Dai Albert C.Y. Chan Tan–To Cheung Simon Tsang Banny Lam Ching–Lung Lai Chung–Mau Lo | 2011 | Gastroenterology2011，，4： | 3 |
| 12 | Fast-track surgery improves postoperative recovery in patients undergoing partial hepatectomy for primary liver cancer: A prospective randomized controlled trial显示文摘 | C.Y. Ni Y. Yang Y.Q. Chang H. Cai B. Xu F. Yang W.Y. Lau Z.H. Wang W.P. Zhou | 2013 | European Journal of Surgical Oncology2013，，： | 3 |
| 13 | Grain refinement mechanism of multiple laser shock processing impacts on ANSI 304 stainless steel显示文摘 | J.Z. Lu K.Y. Luo Y.K. Zhang G.F. Sun Y.Y. Gu J.Z. Zhou X.D. Ren X.C. Zhang L.F. Zhang K.M. Chen C.Y. Cui Y.F. Jiang A.X. Feng L. Zhang | 2010 | Acta Materialia2010，，16： | 3 |
| 14 | World Gastroenterology Organisation Global Guideline: Constipation—A Global Perspective显示文摘 | Greger Lindberg Saeed S. Hamid Peter Malfertheiner Ole Ostergaard Thomsen Luis Bustos Fernandez James Garisch Alan Thomson Khean-Lee Goh Rakesh Tandon Suliman Fedail Benjamin C.Y. Wong Aamir Ghafoor Khan Justus H. Krabshuis Anton LeMair | 2011 | Journal of Clinical Gastroenterology2011，，6： | 3 |
| 15 | Kaolin-based geopolymers with various NaOH concentrations显示文摘Kaolin geopolymers were produced by the alkali-activation of kaolin with an activator solution (a mixture of NaOH and sodium silicate solutions). The NaOH solution was prepared at a concentration of 6-14 mol/L and was mixed with the sodium silicate solution at a Na2SiO3 /NaOH mass ratio of 0.24 to prepare an activator solution. The kaolin-to-activator solution mass ratio used was 0.80. This paper aimed to analyze the effect of NaOH concentration on the compressive strength of kaolin geopolymers at 80℃for 1, 2, and 3 d. Kaolin geopolymers were stable in water, and strength results showed that the kaolin binder had adequate compressive strength with 12 mol/L of NaOH concentration. When the NaOH concentration increased, the SiO2/Na2O decreased. The increased Na2O content enhanced the dissolution of kaolin as shown in X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR) analyses. However, excess in this content was not beneficial for the strength development of kaolin geopolymers. In addition, there was the formation of more geopolymeric gel in 12 mol/L samples. The XRD pattern of the samples showed a higher amorphous content and a more geopolymer bonding existed as proved by FTIR analysis. | C.Y. Heah H. Kamarudin A.M. Mustafa Al Bakri M. Bnhussain M. Luqman I. Khairul Nizar C.M. Ruzaidi Y.M. Liew | 2013 | International Journal of Minerals,Metallurgy and Materials2013，20，3： | 3 |
| 16 | Effects of conservation tillage on corn and soybean yield in the humid continental climate region of Northeast China显示文摘 | Y. Chen S. Liu H. Li X.F. Li C.Y. Song R.M. Cruse X.Y. Zhang | 2011 | Soil & Tillage Research2011，，： | 3 |
| 17 | Grain refinement of LY2 aluminum alloy induced by ultra-high plastic strain during multiple laser shock processing impacts显示文摘 | J.Z. Lu K.Y. Luo Y.K. Zhang C.Y. Cui G.F. Sun J.Z. Zhou L. Zhang J. You K.M. Chen J.W. Zhong | 2010 | Acta Materialia2010，，11： | 2 |
| 18 | Review on microencapsulated phase change materials (MEPCMs): Fabrication, characterization and applications显示文摘 | C.Y. Zhao G.H. Zhang | 2011 | Renewable and Sustainable Energy Reviews2011，，8： | 2 |
| 19 | Randomized Controlled Trial of Danoprevir Plus Peginterferon Alfa-2a and Ribavirin in Treatment-Naive Patients with HCV Genotype 1 Infection显示文摘 | P. Marcellin C. Cooper L. Balart D. Larrey T. Box E. Yoshida E. Lawitz P. Buggisch P. Ferenci M. Weltman E. Labriola-Tompkins S. Le Pogam I. Nájera D. Thomas G. Hooper N.S. Shulman Y. Zhang M.T. Navarro C.Y. Lim M. Brunda N.A. Terrault E.S. Yetzer | 2013 | Gastroenterology2013，，： | 2 |
| 20 | Does corporate social responsibility affect the cost of capital?显示文摘 | Sadok El Ghoul Omrane Guedhami Chuck C.Y. Kwok Dev R. Mishra | 2011 | Journal of Banking and Finance2011，，9： | 2 |
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