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| 1 | Cartilage oligomeric matrix protein: A novel non-invasive marker for assessing cirrhosis and risk of hepatocellular carcinoma显示文摘AIM: To assess serum cartilage oligomeric matrix protein(COMP) as a marker of cirrhosis and risk of progression to hepatocellular carcinoma(HCC). METHODS: A COMP enzyme-linked immunosorbentassay was used to test 187 patients with chronic liver diseases at the time point of first evaluation. The selected patients included 72 with chronic hepatitis B infection, 75 with chronic hepatitis C infection, 22 with primary biliary cirrhosis, 7 with autoimmune hepatitis type 1, and 11 with alcoholic liver disease. Demographic, biochemical, histological and clinical characteristics of the patients were recorded at the first evaluation. One hundred and forty-seven patients were followed for a median [interquartile range(IQR)] duration of 96.5(102) mo. The clinical, biochemical and histological data, as well as the development of cirrhosis, HCC according to internationally accepted criteria and in case of death, a liver-related cause during the follow-up period, were recorded at the electronic database of our clinic. COMP determination was also performed in 43 healthy individuals who served as the control study group.RESULTS: COMP positivity(> 15 U/L) was detected in 22%-36% among chronic liver disease groups. Strikingly, almost 83% of COMP-positive patients were cirrhotic at baseline, independently of cause of liver disease. Among the patients who developed HCC during follow-up, 73.7%(14/19) were COMP positive at baseline. COMP positivity was significantly associated with older age(P < 0.001), advanced fibrosis(P = 0.001) and necroinflammatory activity(P = 0.001), higher aspartate aminotransferase(P < 0.001), alanine aminotransferase(P < 0.02), γ-glutamyl transpeptidase(P = 0.003), alkaline phosphatase(P = 0.001), bilirubin(P < 0.05), international normalized ratio(P = 0.002) and alpha-fetoprotein levels(P < 0.02), and lower albumin(P < 0.001), and platelet count(P = 0.008). COMP levels [median(IQR)] were significantly higher in cirrhotics compared to non-cirrhotics [13.8(7.9) U/L vs 9.8(4.6) U/L, respectively; P < 0.001]. On multivariate logistic regression analysis, COMP-positivity was independently associated only with cirrhosis(OR = 4.40, 95%CI: 1.33-14.69, P = 0.015). Kaplan-Meier analysis showed that COMP positivity was significantly associated with HCC development(P = 0.007) and higher incidence of liver-related death(P < 0.001). CONCLUSION: Elevated COMP levels are strongly associated with cirrhosis and HCC progression. Serum COMP is a new promising non-invasive biomarker for HCC risk assessment in surveillance programs. | Gary L Norman Nikolaos K Gatselis Zakera Shums Christos Liaskos Dimitrios P Bogdanos George K Koukoulis George N Dalekos | 2015 | World Journal of Hepatology2015，7，14： | 7 |
| 2 | 针对患者利益的机器学习和人工智能研究:在透明性、可重复性、伦理和有效性等方面的20个关键问题显示文摘机器学习(ML)、人工智能(AI)和其他现代统计方法正为利用先前尚未开发且极速增长的数据资源提供新的机会,以期让患者获益。尽管目前正在进行许多有前景的研究,特别是在图像方面,但就文献整体而言还缺乏透明度、对可重复性清晰的阐述、对潜在伦理问题的探究,以及对有效性的明确验证。这些问题的存在有许多原因,其中最重要的一点(为此我们提供了初步解决方案)就是当前缺乏针对ML和AI的最佳实践指南。我们认为从事研究的跨学科团队和应用ML/AI影响健康的项目,将因解决有关透明度、可重复性、伦理和有效性(TREE)的一系列问题而受益。这里提出的20个关键问题为研究团队提供了一个研究设计、实施和报告框架;帮助编辑和同行评审专家评估文献的贡献;让患者、临床医生和政策制定者评估新发现可能会给患者带来的获益。 | Sebastian Vollmer Bilal A Mateen Gergo Bohner Franz J Kirdly Rayid Ghani Pall Jonsson Sarah Cumbers Adrian Jonas Katherine S L McAllister Puja Myles David Granger Mark Birse Richard Branson Karel G M Moons Gary S Collins John P A Chris Holmes Harry Hemingwayp 李峰(译) 徐磊(校) 赵邑(校) | 2020 | 英国医学杂志中文版2020，23，9： | 5 |
| 3 | Crisis management, Booz & Company CEO succession survey 显示文摘 | Karlsson P O Gary L N | 2009 | Strategy Business2009，35，11： | 1 |
| 4 | Looking forward to performance improvement:A field test of the feedforward interview for Performance management显示文摘 | Marie-Hélène B Gary P L Laxmikant M | 2015 | Human Resource Management2015，，54： | 1 |
| 5 | Benefits associated with supplier integration into new product development under conditions of technology uncertainty 显示文摘 | GARY L R ROBERT B H KENNETH J P | 2002 | Business Research2002，，55： | 1 |
| 6 | Classification of Coronary Atherosclerotic Plaques Ex Vivo With T1, T2, and Ultrashort Echo Time CMR显示文摘 | Mihály Károlyi Harald Seifarth Gary Liew Christopher L. Schlett Pál Maurovich-Horvat Paul Stolzmann Guangping Dai Shuning Huang Craig J. Goergen Masataka Nakano Fumiyuki Otsuka Renu Virmani Udo Hoffmann David E. Sosnovik | 2013 | JACC: Cardiovascular Imaging2013，，4： | 1 |
| 7 | Characterization of polyploid wheat genomic diversity using a high-density 90 000 single nucleotide polymorphism array 显示文摘 | Wang SC Debbie W Kerrie F Alexandra A Shiaoman C Bevan EH Marco M Silvio S Sara GM Luigi C Anna MM Alex W Stuart S Gary B Ralf W Joerg P International Wheat Genome Sequencing Consortium Morten L Diane M Rudi A Rudy D Gina BG Abraham K Alina RA Catherine F Jerome S Michele M Curtis P Luo MC Jan DMM Jorge D Martin G Roberto T Cindy L Ivan M Colin C Keith JE Matthew H Eduard A | 2014 | Plant Biotechnol J2014，12，： | 1 |
| 8 | Non- destructive Estimation of Wood Chemical Compo- sition of Radial Strips by Diffuse Reflectance Near Infrared Spectroscopy显示文摘 | Jones P D Schimleck L R Gary F P | 2005 | Wood Science and Technol- ogy2005，39，7： | 1 |
| 9 | Supplier integration into new product development:coordinating product,process and supply chain design显示文摘 | KENNERH J P ROBERT B H GARY L R | 2005 | Journal of Operations Management2005，23，： | 1 |
| 10 | High surface area polymer coatings for SAW-based chemical sensor applications 显示文摘 | Natalia L Dmitry P Gary T | 2002 | Sensors and Actuators B: Chemical2002，82，23： | 1 |
| 11 | Determinants of Portfolio Performance显示文摘 | BRINSON GARY P L RANDOLPH HOOD GILBERT L BEEBOWER | 1986 | Financial Analysts Journal1986，，： | 1 |
| 12 | Applying DBP models to full-scale plants显示文摘 | Westerhoff P Debroux J Gary L A | 2000 | AWWA2000，92，3： | 1 |
| 13 | The effects of multiple impacts on the cushioning properties of closed-cell foams 显示文摘 | Burgess J Singh S P | 1990 | Packaging Tech Sci1990，3，： | 1 |
| 14 | Non-HDL Cholesterol Shows Improved Accuracy for Cardiovascular Risk Score Classification Compared to Direct or Calculated LDL Cholesterol in a Dyslipidemic Population显示文摘 | van Deventer Hendrick E Miller W Greg Myers Gary L Sakurabayashi Ikunosuke Bachmann Lorin M Caudill Samuel P Dziekonski Andrzej Edwards Selvin Kimberly Mary M Korzun William J Leary Elizabeth T Nakajima Katsuyuki Nakamura Masakazu Shamburek | 2011 | EN2011，，3： | 1 |
| 15 | Determinants of Portfolio Performance显示文摘 | BRINSON GARY P L RANDOLPH HOOD GILBERT L BEEBOWER | 1986 | Financial Analysts Journal1986，，78： | 1 |
| 16 | A model of supplier integration into new product development显示文摘 | KENNETH J P ROBERT B H GARY L R | 2003 | Jour- nal of Product Innovation Management2003，20，4： | 1 |
| 17 | Structuralism, post- structuralism, and the library : de Saussure and Foucault显示文摘 | Gary P Radford Marie L Radford | 2005 | Journal of Documentation2005，61，1： | 1 |
| 18 | The Reliability and Validity of the Critical Incident Technique: A Closer Look 显示文摘 | Ronan W W Gary P L | 1974 | Studies in Personnel Psychology1974，6，1： | 1 |
| 19 | Library outreach:overcoming health literacy challenges 显示文摘 | Ruth P Gary L | 2005 | J Med Library Assoc2005，93，4： | 1 |
| 20 | An efficient combinatorial optimization algorithm for optimal scheduling of aircraft arrivals at congested airports显示文摘 | ADITYA P S GARY L S | 2006 | IEEE2006，23，3： | 1 |
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