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| 1 | Bacterial Phosphoproteomic Analysis Reveals the Correlation Between Protein Phosphorylation and Bacterial Pathogenicity显示文摘Increasing evidence shows that protein phosphorylation on serine, threonine and tyrosine residues is a major regulatory post-translational modification in the bacteria. This review focuses on the implications of bacterial phosphoproteome in bacterial pathogenicity and highlights recent development of methods in phosphoproteomics and the connectivity of the phosphorylation networks. Recent technical developments in the high accuracy mass spectrometry have dramatically transformed proteomics and made it possible the characterization of a few exhaus- tive site-specific bacterial phosphoproteomes. The high abundance of tyrosine phosphorylations in a few bacterial phosphoproteomes suggests their roles in the pathogenicity, especially in the case of pathogen-host interactions; the high abundance of multi-phosphorylation sites in bacterial phosphoprotein is a compensation of the relatively small phosphorylation size and an indicator of the delicate regulation of protein functions. | Ruiguang Ge Weiran Shan | 2011 | Genomics, Proteomics & Bioinformatics2011，9，4： | 2 |
| 2 | The in vivo functions of a histidine-rich protein Hpn in Helicobacter pylori : Linking gastric and Alzheimer’s diseases together?显示文摘 | Ruiguang Ge Xuesong Sun | 2011 | Medical Hypotheses2011，，5： | 1 |
| 3 | Histidine-rich protein Hpn from Helicobacter pylori forms amyloid-like fibrils in vitro and inhibits the proliferation of gastric epithelial AGS cells显示文摘 | Ruiguang Ge Xuesong Sun Dongxian Wang Qinglu Zhou Hongzhe Sun | 2011 | BBA - Molecular Cell Research2011，，8： | 1 |
| 4 | Iron trafficking system in Helicobacter pylori显示文摘 | Ruiguang Ge Xuesong Sun | 2012 | BioMetals2012，，2： | 1 |
| 5 | MicroRNA-15b regulates cell cycle progression by targeting cyclins in glioma cells显示文摘 | Hongping Xia Yanting Qi Samuel S. Ng Xiaona Chen Shen Chen Marong Fang Dan Li Yu Zhao Ruiguang Ge Guo Li Yangchao Chen Ming-Liang He Hsiang-fu Kung Lihui Lai Marie C. Lin | 2009 | Biochemical and Biophysical Research Communications2009，，2： | 1 |
| 6 | microRNA-146b inhibits glioma cell migration and invasion by targeting MMPs显示文摘 | Hongping Xia Yanting Qi Samuel S. Ng Xiaona Chen Dan Li Shen Chen Ruiguang Ge Songshan Jiang Guo Li Yangchao Chen Ming-Liang He Hsiang-fu Kung Lihui Lai Marie C. Lin | 2008 | Brain Research2008，，： | 1 |
| 7 | A proteomic approach for the identification of bismuth-binding proteins in Helicobacter pylori显示文摘 | Ruiguang Ge Xuesong Sun Qing Gu Rory M. Watt Julian A. Tanner Benjamin Chun Yu Wong Harry Huaxiang Xia Jian-Dong Huang Qing-Yu He Hongzhe Sun | 2007 | JBIC Journal of Biological Inorganic Chemistry2007，，6： | 1 |
| 8 | Iron acquisition by Streptococcus species: An updated review显示文摘Streptococcus is a genus of spherical Gram-positive bacteria responsible for many cases of meningitis,bacterial pneumonia, endocarditis, erysipelas, and necro-tizing fasciitis. To survive in the host environment withlimited free iron available, Streptococcus species havedeveloped various mechanisms to uptake iron as anessential nutrient. They can directly extract the metalions from host iron-containing proteins such as ferritin,transferrin, lactoferrin, and hemoproteins. Other iron-uptake strategies, which are broadly distributed in thestrains, include the employment of specialized secretedhemophores to acquire heme and the usage of smallmolecules called siderophores as high-affinity ferricchelators. This review intends to discuss the most recentdiscoveries of these iron acquisition systems and theirrelevant regulators in Streptococcus species. | Ruiguang GE Xuesong SUN Qingyu HE | 2009 | Frontiers in Biology2009，4，4： | 0 |
| 9 | Responses of Carbonic Anhydrase to Cadmium in the Zinc/Cadmium Hyperaccumulator Picris divaricata Vant.显示文摘A number of higher plants are able to hyperaccumulate cadmium(Cd). However, it is unknown whether cadmium(Cd) plays a biological functional role in the carbonic anhydrase(CA) of hyperaccumulators. A hydroponic experiment was conducted to explore the potentially physiological function of Cd in CA and the accumulation and tolerance of Cd in the Zn/Cd hyperaccumulator Picris divaricata Vant. P. divaricata was exposed to nutrient solutions with six Cd concentrations(0, 5, 10, 25, 50 and 75 μmol L^(-1)). After 12 d, plants were harvested for the analysis of plant biomass, Cd concentration and CA activity. The Cd concentrations in plant increased with the increasing Cd in nutrient solution, reaching 640 and 3 100 mg kg^(-1) in shoot and root, respectively, at the 75 μmol L^(-1) Cd treatment. Meanwhile, plant growth was enhanced by the Cd treatments at 5–25 μmol L^(-1), but it was significantly inhibited when the plants were exposed to solutions with higher Cd concerntrations(50 and 75 μmol L^(-1)). Exposure to Cd significantly increased the CA activity in P. divaricata, which reached a maximum value of 21.27 U mg^(-1) proteins at the 25 μmol L^(-1)Cd treatment, and the CA activity and shoot Cd concentration were positively correlated at solutions Cd of ≤ 25 μmol L^(-1). Moreover, two protein bands appeared on the denatured gel electrophoresis of purified CA, indicating that P. divaricata may have CA isomers with their respective molecular weights at around 60 and 55 k Da, at least one of which is Cd-bound. In addition, trace amounts of Cd in purified CA significantly increased with the supplied Cd concentration in nutrient solution(5–25 μmol L^(-1)). The results suggested that Cd may play a biological role by enhancing the activities and forming the active Cd-specific CA in the hyperaccumulator P. divaricata. | LIU Saihua TANG Yetao QIU Rongliang YING Rongrong GE Ruiguang JI Xionghui | 2016 | Pedosphere2016，26，5： | 0 |
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