|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Cold-inducible RNA-binding protein activates splenic T cells during sepsis in a TLR4-dependent manner显示文摘Cold-inducible RNA-binding protein (CIRP) is a novel inflammatory mediator that stimulates the release of proinflammatory cytokines from macrophages in sepsis. Given the immune dysregulation that characterizes sepsis, the effect of CIRP on other immune cells is an area of increasing interest that has not yet been studied. In the present study, we hypothesized that extracellular CIRP promotes activation of T lymphocytes in the spleen during sepsis. We observed that mice subjected to sepsis by cecal ligation and puncture showed significantly higher expression of the early activation markers CD69 and CD25 at 20 h on CD4+ splenic T cells, and significantly higher CD69 expression on CD8+ splenic T cells compared with sham-operated controls. Furthermore, at 20 h after receiving intravenous injection of recombinant murine CIRP (rmCIRP, 5 mg/kg body weight (BW)) or PBS (vehicle), those mice receiving rmCIRP showed significantly increased expression of CD69 and CD25 on both CD4+ and CD8+ splenic T cells. This effect, however, was not seen in TLR4-deficient mice after rmCIRP injection. In addition, treatment with CIRP predisposed CD4+ T cells to a Th1 hyperinflammatory response profile, and influenced CD8+ T cells toward a cytotoxic profile. Taken together, our findings indicate that CIRP is a proinflammatory mediator that plays an important role in T-cell dysregulation during sepsis in a TLR4-dependent manner. | Alexandra C Bolognese Archna Sharma Weng-Lang Yang Jeffrey Nicastro Gene F Coppa Ping Wang | 2018 | Cellular & Molecular Immunology2018，15，1： | 4 |
| 2 | Marrow stromal cells migrate throughout forebrain and cerebellum, and they differentiat into astrocytes after injection into neonatal mouse brains 显示文摘 | Kopen Darwin J | 1999 | Proc Natl Acad Sci1999，96，10： | 1 |
| 3 | The Gene Ontology(GO)database and informatics resource显示文摘 | Gene O C | 2004 | Nucleic Acids Research2004，32，1： | 1 |
| 4 | in diabetic caucasians: Identification of a P12A PPARγ2 Missense Mutation 显示文摘 | Yen CJ Beamer BA Negri C Molecular scanning of the human peroxisome proliferator activated receptorγ gene 8 | 1997 | Biochem Biophys Res Commun1997，241，： | 1 |
| 5 | Identification and characterization of a melanin-concentrating hormone receptor显示文摘 | Songzhu A Gene C Jack JZ | 2001 | PNAS2001，98，13： | 1 |
| 6 | International Protection of Intellectual Property 显示文摘 | Grossman Gene M Edwin L - C Lai | 2004 | The American Economic Review2004，94，5： | 1 |
| 7 | Suitability of the YNZ22 (D17S5) VNTR polymorphismfor legal medicine investigations in the population of Catalonia(Spain)显示文摘 | Gene M Huguet E Sanchez Garcia C | 1995 | Int J Leagel Med1995，107，4： | 1 |
| 8 | elegans显示文摘 | Melendez A Talloczy Z Seaman M :Autophagy Genes Are Essential for Dauer Development and Life-Span Extension in C | 2003 | Science2003，301，： | 1 |
| 9 | Adjacent segment disease following lumbar thoracolumbar fusion with pedicle screw instru- mentation:aminimum 5-year follow-up显示文摘 | Gene C Keith H B Lawrence GL | 2007 | Spine2007，32，： | 1 |
| 10 | 显示文摘 | CARETTO S GIARDINA MC NI- COLODI C et aL Chlorsulfuron resis- tance in Daucus carotacell lines and plants: involvement of gene amplifica- tion | 1994 | Theor Appl Genet1994，88，： | 1 |
| 11 | PCC7002 显示文摘 | Sakmoto T Higashi S C Wada H J et aLLow-temperature- induced desaturation of fatty acid sandex pression of desaturase genes in the Cyanobacterium Synechocoeeus sp | 1997 | FEMS Microbiol Letters1997，152，2： | 1 |
| 12 | 显示文摘 | Eccleshall TR Malloy PJ The presence of a polymor -phism at the translation initiationsite of the vitamin D receptor gene is associated with low bone mineral density in postmenopausal Mexican- American women | 1996 | J Bone Miner Res1996，11，： | 1 |
| 13 | Everything you wanted to know about Copula Modeling but were afraid to ask 显示文摘 | GENES C FAVRE A C | 2007 | Journal of Hydrologic Engineering2007，12，4： | 1 |
| 14 | Guidelines for the prevention of falls in people over 65显示文摘 | Gene F Colin C Sheila D | 2000 | BMJ2000，321，7267： | 1 |
| 15 | 5 containing nerve fibers in human cervical facet joint capsules 显示文摘 | Kallakuriy H Singh A Chen C Demonstration of substance calcitonin generelated peptide and protein gene product 9 | 2004 | Spine2004，29，11： | 1 |
| 16 | Grossman,intellectual property rights and north-south trade显示文摘 | Chin Judith C Gene M | 1990 | Cambrige1990，1990，： | 1 |
| 17 | Mature cystis teratomas of the ovary:case series from one institution over 34 years显示文摘 | Ayhan A Bukulmez o Gene C | 2000 | Eur J Obstet Gynecol Reprod Biol2000，88，： | 1 |
| 18 | The Paradox of China's Growing Under -Urbanization显示文摘 | GENE HSIN CHANG JOSEF C BRADA | 2006 | Economic Systems2006，，30： | 1 |
| 19 | Electrical storm reversible by isoproterenol infusion in a striking case of early repolarization显示文摘 | BERNARD A GENEE O GRIMARD C et ol | 2009 | J Interv Card Electrophysiol2009，25，2： | 1 |
| 20 | The Gene Ontology project in 2008 显示文摘 | GENE O C | 2008 | Nucleic acids research2008，36，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员