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| 1 | Generalized megaviscera of lupus:Refractory intestinal pseudo-obstruction,ureterohydronephrosis and megacholedochus显示文摘Dilated dysfunction involving multiple visceral organs has been reported in patients with systemic lupus erythematosus(SLE).Chronic intestinal pseudo-obstruction(CIPO) resulting from intestinal smooth muscle damage has presented in conjunction with ureterohydronephrosis and, more rarely, biliary dilatation(megacholedochus).While the molecular pathogenesis is largely unknown, observed histo-pathologic features include widespread myositis, myocyte necrosis in the intestinal muscularis propria with subsequent atrophy and fibrosis, preserved myenteric innervations and little vasculitis.High dose immunosuppression usually results in resolution of symptoms with recovery of smooth muscle function, indicative of an autoimmune etiology.We report a patient with SLE who presented with intestinal pseudo-obstruction, ureterohydronephrosis and megacholedochus, and present images that illustrate megaviscera simultaneously involving all 3 visceral organs.Since the co-manifestation of all 3 is unusual and has been reported only once previously, wehave termed this rare clinical syndrome generalized megaviscera of lupus(GML).Although the SLE disease-activity parameters responded to aggressive immunomodulative therapy in our patient, clinical evidence of peristaltic dysfunction persisted in all involved viscera.This is a variation from the favorable outcomes reported previously in SLE patients with GML and we attribute this poor clinical outcome to disease severity and, most importantly, delayed clinical presentation.Since inflammation followed by atrophy and fibrosis are key aspects in the pathogenesis and natural history of GML, the poor response in our patient who presented late in the clinical course may be the result of ‘burnt out' inflammation with irreversible end-stage flbrosis.Thus, early recognition and timely initiation of treatment may be the key to recover visceral peristaltic function in patients with GML. | Frederick D Park Jeffrey K Lee Ganga D Madduri Pradipta Ghosh | 2009 | World Journal of Gastroenterology2009，15，28： | 20 |
| 2 | Anti-diabetic and anti-cholesterolemic activity of methanol extracts of three species of Amaranthus显示文摘Objective:To investigate the anti-diabetic and anti-cholesterolemic activity of methanol extracts of leaves of Amaranthus caudatus,Amaranthus spinosus and Amaranthus viridis in normal and streptozotocin(STZ) induced diabetic rats.Methods:In this study,the anti-diabetic and anti-cholesterolemic activity of methanol extracts of leaves of all three plants was evaluated by using normal and STZ induced diabetic rots at a dose of 200 mg/kg and 400 mg/kg p.o.daily for 21 days.Blood glucose levels and body weight were monitored at specific intervals,and different biochemical parameters,serum cholesterol,serum triglyceride,high density lipoprotein, low density lipoprotein and very low density lipoprotein were also assessed in the experimental animals.Histology of pancreas was performed.Results:It was found that all the three plants at 400 mg/kg dose showed significant anti-diabetic and anti-cholesterolemic activity(P<0.01),while at 200 mg/kg dose less significant anti-diabetic activity(P<0.05) was observed.Concluslons: Methanol extracts of Amaranthus caudatus,Amaranlhus spinosus and Amaranthus viridis showed significant anti-diabetic and anti-cholesterolemic activity,which provides the scientific proof for their traditional claims. | Girija K Lakshman K Udaya Chandrika Sabhya Sachi Ghosh Divya T | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，2： | 14 |
| 3 | Xanthogranulomatous cholecystitis:a premalignant condition?显示文摘BACKGROUND:Xanthogranulomatous cholecystitis(XGC)is an uncommon variant of chronic cholecystitis,characterized by marked thickening of the gallbladder wall and dense local adhesions.It often mimics a gallbladder carcinoma(GBC), and may coexist with GBC,leading to a diagnostic dilemma. Furthermore,the premalignant nature of this entity is not known.This study was undertaken to assess the p53,PCNA and beta-catenin expression in XGC in comparison to GBC and chronic inflammation. METHODS:Sections from paraffin-embedded blocks of surgically resected specimens of GBC(69 cases),XGC(65), chronic cholecystitis(18)and control gallbladder(10)were stained with the monoclonal antibodies to p53 and PCNA, and a polyclonal antibody to beta-catenin.p53 expression was scored as the percentage of nuclei stained.PCNA expression was scored as the product of the percentage of nuclei stained and the intensity of the staining(1-3).A cut-off value of 80 for this score was taken as a positive result. Beta-catenin expression was scored as type of expression-membranous,cytoplasmic or nuclear staining. RESULTS:p53 mutation was positive in 52%of GBC cases and 3%of XGC,but was not expressed in chronic cholecystitis and control gallbladders.p53 expression was lower in XGC than in GBC(P<0.0001).PCNA expression was seen in 65%of GBC cases and 11%of XGC,but not in chronic cholecystitis and control gallbladders.PCNA expression was higher in GBC than XGC(P=0.0001),but there was no significant difference between the XGC,chronic cholecystitis and control gallbladder groups.Beta-catenin expression was positive in the GBC,XGC, chronic cholecystitis and control gallbladder groups.But the expression pattern in XGC,chronic cholecystitis and control gallbladders was homogenously membranous,whereas in GBC the membranous expression pattern was altered to cytoplasmic and nuclear.CONCLUSION:The expression of p53,PCNA and beta-catenin in XGC was significantly different from GBC and similar to chronic cholecystitis,thus indicating the inflammatory nature of XGC and may not support a premalignant nature of the lesion. | Mila Ghosh Puja Sakhuja Anil K Agarwal | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，2： | 11 |
| 4 | Adsorption of methylene blue on kaolinite显示文摘 | GHOSH D BHATTACHARYYA K G | 2002 | Appl Clay Sci2002，20，： | 2 |
| 5 | Quercetin inhibits LPS-induced nitric oxide and tumor necrosis factor-α production in murine macrophages显示文摘 | Rao Manjeet K B Ghosh | 1999 | International Journal of Immunopharmacology1999，，7： | 2 |
| 6 | Evidence for colorectal sarcomatoid carcinoma arising from tubulovillous adenoma显示文摘Sarcomatoid carcinomas of the colorectum are rare tu- mors that display both malignant epithelial and stromal components. Clinically, they are aggressive tumors with early metastasis. Due to their infrequent occurrence, the pathogenesis is poorly understood. We report a case of a 52-year-old woman who presented with a rectal mass and intermittent hematochezia. Superficial biopsies during colonoscopy revealed a tubulovillous adenoma with high-grade dysplasia. Endoscopic ultra- sonography confirmed an invasive nature of the mass, and deeper biopsies revealed the presence of neoplasm with mixed histological components. The surgically- excised specimen demonstrated the presence of poorly differentiated spindle cells underneath the tubulovillous adenoma and an intermediate stage of invasive adeno- carcinoma. Based on the histological appearance and immunohistochemical studies, a diagnosis of sarcoma- toid carcinoma was made. Only nine cases of sarcoma- toid carcinomas of the colorectum have been reported to date. As a result, the terminology and pathogenesis of sarcomatoid carcinoma remain speculative. To the best of our knowledge, this is the first report of co- existence of sarcomatoid carcinoma and invasive ad- enocarcinoma with tubulovillous adenoma; all stages represented within the same tumor. This observation supports the 'monoclonal theory' of pathogenesis with an adenoma-sarcoma progression with or without an intermediate stage of carcinoma. | Jeffrey K Lee Pradipta Ghosh Valerie McWhorter Misty Payne Ryan Olson Mary L Krinsky Sonia Ramamoorthy John M Carethers | 2008 | World Journal of Gastroenterology2008，14，27： | 2 |
| 7 | Trinary flip-flops using Savart plate and spatial light modulator for optical computation in multivalued logic显示文摘The memory devices in multi-valued logic are of most significance in modern research. This paper deals with the imple-mentation of basic memory devices in multi-valued logic using Savart plate and spatial light modulator (SLM) based optoelectronic circuits. Photons are used here as the carrier to speed up the operations. Optical tree architecture (OTA) has been also utilized in the optical interconnection network. We have exploited the advantages of Savart plates,SLMs and OTA and proposed the SLM based high speed JK,D-type and T-type flip-flops in a trinary system. | Amal K Ghosh Amitabha Basuray | 2008 | Optoelectronics Letters2008，4，6： | 2 |
| 8 | Cathode shape prediction in electrochemical machining using a simulated cut-and-try procedure 显示文摘 | Bhattacharyya S Ghosh A Mallik A K | 1997 | Journal of Materials Processing Technology1997，66，： | 2 |
| 9 | Emerging insights into HAUSP (USP7) in physiology, cancerand other diseases显示文摘Herpesvirus-associated ubiquitin-specific protease(HAUSP)is a USP family deubiquitinase.HAUSP is a protein of immense biological importance as it is involved in several cellular processes,including host-virus interactions,oncogenesis and tumor suppression,DNA damage and repair processes,DNA dynamics and epigenetic modulations,regulation of gene expression and protein function,spatio-temporal distribution,and immune functions.Since its discovery in the late 1990s as a protein interacting with a herpes virus regulatory protein,extensive studies have assessed its complex roles in p53-MDM2-related networks,identified numerous additional interacting partners,and elucidated the different roles of HAUSP in the context of cancer,development,and metabolic and neurological pathologies.Recent analyses have provided new insights into its biochemical and functional dynamics.In this review,we provide a comprehensive account of our current knowledge about emerging insights into HAUSP in physiology and diseases,which shed light on fundamental biological questions and promise to provide a potential target for therapeutic intervention. | Seemana Bhattacharya Dipankar Chakraborty Malini Basu Mrinal K Ghosh | 2018 | Signal Transduction and Targeted Therapy2018，3，1： | 2 |
| 10 | Preface显示文摘This conference on Femtochemistry,Femtobiology,and Femtophysics(Femto IX)was organized in Beijing during the period of August8-13,2009.The event was timely not only because of the rise of science and technology in China and neighboring Asian countries but also because of the cultural and economic | Arne K DAHLE Amit K GHOSH | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，6： | 2 |
| 11 | Relationships of working conditions and individual characteristics to occupational injuries: a case-control study in coal miners显示文摘 | GHOSH A K BHATrACHERjEE A CHAU N | 2004 | J Occup Health2004，46，6： | 1 |
| 12 | Probing Zn^2+-binding effects on the zinc ribbon domain of human general transcription factor TFⅡB显示文摘 | Ghosh M Elsby L M Mal T K | 2004 | Biochem J2004，378，： | 1 |
| 13 | First-time development of FVIII inhibitor in haemophilia patients during the postoperative period 显示文摘 | Ghosh K Jijina F Shetty S | 2002 | Haemophilia2002，8，6： | 1 |
| 14 | TLR-TLR cross talk in human PBMC resulting in synergistic and antagonistic regulation of type-1 and 2 interferons, IL-12 and TNF-alpha 显示文摘 | Ghosh T K Mickelson D J Solberg J C | 2007 | Immunopharmacol2007，7，： | 1 |
| 15 | Analytical model for time to covet cracking in RC structures due to rebar corrosion显示文摘 | BHARGAVA K GHOSH A K MORI Y | 2006 | Nuclear Engineering and Design2006，，236： | 1 |
| 16 | Size-dependent optical and dielectric properties of nanocrystalline ZnS thin films synthesized via rf-magnetron sputtering technique显示文摘 | Ghosh P K Jana S Nandy S | 2007 | Materials Research Bulletin2007，42，3： | 1 |
| 17 | Interparticle coupling effect on the surface plasmon resonance of gold nanoparticles:from theory to applications 显示文摘 | Ghosh S K Pal T | 2007 | Chem Rev2007，107，： | 1 |
| 18 | Curvature catering-a new approach in manufacturing of sculptured surface, part 2: methodology 显示文摘 | WANG Xiaochun LI Yanbin GHOSH S K | 1993 | Journal of Materials Processing Technology1993，38，12： | 1 |
| 19 | Atrazine degradation in anaerobic environment by a mixed microbial consortium 显示文摘 | Ghosh P K Philip L | 2004 | Water Research2004，38，9： | 1 |
| 20 | Estimation Parameters in a Discrete Reliability Growth Model 显示文摘 | BHATTACHARYYA G K GHOSH J K | 1991 | Journal for Statistics Planning and Inference1991，29，： | 1 |
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