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| 1 | Magnetic resonance imaging in breast cancer:A literature review and future perspectives显示文摘Early detection and diagnosis of breast cancer are essential for successful treatment. Currently mammography and ultrasound are the basic imaging techniques for the detection and localization of breast tumors. The low sensitivity and specificity of these imaging tools resulted in a demand for new imaging modalities and breast magnetic resonance imaging(MRI) has become increasingly important in the detection and delineation of breast cancer in daily practice. However, the clinical benefits of the use of pre-operative MRI in women with newly diagnosed breast cancer is still a matter of debate. The main additional diagnostic value of MRI relies on specific situations such as detecting multifocal, multicentric or contralateral disease unrecognized on conventional assessment(particularly in patients diagnosed with invasive lobular carcinoma), assessing the response to neoadjuvant chemotherapy, detection of cancer in dense breast tissue, recognition of an occult primary breast cancer in patients presenting with cancer metastasis in axillary lymph nodes, among others. Nevertheless, the development of new MRI technolo-gies such as diffusion-weighted imaging, proton spectroscopy and higher field strength 7.0 T imaging offer a new perspective in providing additional information in breast abnormalities. We conducted an expert literature review on the value of breast MRI in diagnosing and staging breast cancer, as well as the future potentials of new MRI technologies. | Gisela LG Menezes Floor M Knuttel Bertine L Stehouwer Ruud M Pijnappel Maurice AAJ van den Bosch | 2014 | World Journal of Clinical Oncology2014，5，2： | 25 |
| 2 | 成人期智力的年龄特征:中美比较研究显示文摘 | 申继亮 陈勃 王大华 Gisela Labouvie-Vief Manfred Diehl | 2001 | 心理科学2001，24，3： | 8 |
| 3 | Intervention to increase physical activity in irritable bowel syndrome shows long-term positive effects显示文摘AIM: To assess the long-term effects of physical activity on irritable bowel syndrome(IBS) symptoms and on quality of life, fatigue, depression and anxiety.METHODS: Seventy-six patients from a previous randomized controlled interventional study on increased physical activity in IBS were asked to participate in this long-term follow-up study. The included patients attended one visit in which they filled out questionnaires and they underwent a submaximal cycle ergometer test. The primary end point was the change in the IBS Severity Scoring System(IBS-SSS) at baseline, i.e., before the intervention and at follow-up. The secondary endpoints were changes in quality of life, fatigue, depression and anxiety.RESULTS: A total of 39 [32 women, median age 45(28-61) years] patients were included in this followup. Median follow-up time was 5.2(range: 3.8-6.2) years. The IBS symptoms were improved compared with baseline [IBS-SSS: 276(169-360) vs 218(82-328), P = 0.001]. This was also true for the majority of the dimensions of psychological symptoms such as disease specific quality of life, fatigue, depression and anxiety. The reported time of physical activity during the week before the visit had increased from 3.2(0.0-10.0) h at baseline to 5.2(0.0-15.0) h at follow-up, P = 0.019. The most common activities reported were walking, aerobics and cycling. There was no significant difference in the oxygen uptake 31.8(19.7-45.8) m L per min per kg at baseline vs 34.6(19.0-54.6) m L/min per kg at follow-up.CONCLUSION: An intervention to increase physical activity has positive long-term effects on IBS symptoms and psychological symptoms. | Elisabet Johannesson Gisela Ringstrom Hasse Abrahamsson Riadh Sadik | 2015 | World Journal of Gastroenterology2015，21，2： | 6 |
| 4 | Bone marrow-derived pancreatic stellate cells in rats显示文摘胰腺的星形的房间(PSC ) 在前,在期间并且在胰腺的损害以后的起源和命运是争论的一件事。在胰腺的纤维变性的致病的 PSC 的关键角色通常被接受。然而,房间的周转仍然保持阴暗。现在的学习处理了潜在的骨头髓(BM ) 的问题 PSC 的起源。我们由 grafting 使用了稳定的造血的 chimerism 的一个模型在领受人老鼠的照耀以后表示 BM 房间的提高的绿荧光蛋白质(eGFP ) 。Chimerism 被 eGFP 积极的房间的 FACS 分析在外部血检测。Dibutyltin 二氯化物(DBTC ) 被用来超过 4 个星期与随后的恢复导致尖锐胰腺的发炎。调查集中于孤立的房间检测休息 PSC 人口。从妄想的老鼠的胰获得的 eGFP 积极的 PSC 的发生在健康胰腺的织物是约 7% 并且 4 个星期在导致 DBTC 的尖锐发炎以后在恢复的胰显著地增加了到 18% 的一个平均数。我们的结果建议导出 BM 的祖先房间在胰代表可更新的星形的房间的来源。在新生以后放松 PSC 的增加的数字在导致发炎的激活以后向导出 BM 的房间的提高的招募指向一个静止状态的胰或重新获得。 | Gisela Sparmann Marie-Luise Kruse Nicole Hofmeister-Mielke Dirk Koczan Robert Jaster Stefan Liebe Daniel Wolff Joerg Emmrich | 2010 | Cell Research2010，20，3： | 4 |
| 5 | 放松功对老年高血压患者保健效果的研究显示文摘目的探讨放松功对老年高血压患者的保健效果。方法对自愿受试的老年高血压患者进行放松功锻炼,通过对照研究,观测其高血压的治疗效果。结果放松功治疗组患者血压下降水平明显优于对照组(P<0.05),症状改善效果尤佳。非药物治疗的5例高血压典型病例也取得较好的疗效。结论放松功作为老年高血压患者的辅助疗法,具有积极的保健效果。 | 曾尔亢 Gisela Hildenbrand Jin Liu 吴植恩 段凌 马如彪 赵要武 梁渊 李绍先 | 2013 | 中国社会医学杂志2013，30，5： | 4 |
| 6 | 选择冲洗法在碳纳米管内部填充金属粒子显示文摘报道一种直接合成纳米碳管衍生材料的方法。利用纳米碳管的表面张力和毛细管作用,经过注入和选择冲洗法的两步法,制备填充铁、钴和镍的纳米碳管。通过选择合适的注入和洗脱溶液,金属粒子只会填充在纳米管内部。使用扫描电镜和扫描透射电镜研究证实金属粒子仅存在于纳米碳管内部。 | 傅强 Gisela Weinberg 苏党生 | 2008 | 新型炭材料2008，23，1： | 4 |
| 7 | Cis-hydroxyproline-induced inhibition of pancreatic cancer cell growth is mediated by endoplasmic reticulum stress显示文摘瞄准:在老鼠上调查 cis-hydroxyproline (CHP ) 的生物效果,并且检验内在的分子的机制胰腺的癌房间线 DSL6A。方法:DSL6A 房间增长上的 CHP 的效果被使用 BrdU 加入估计。焦点的粘附激酶(FAK ) 的表示被西方的弄污和免疫荧光描绘。endoplasmic 感应(嗯) 应力被使用 RT-PCR 并且为葡萄糖相关的 protein-78 (GRP78 ) 和生长拘捕和 DNA 的西方的弄污调查可诱导的基因(GADD153 ) 。房间生存能力通过基于 DSL6A 房间的减小潜力测量新陈代谢的活动被决定。Apoptosis 被 caspase-3 激活的察觉和多形核白细胞(自动数据处理核糖) 的劈开分析象 DNA laddering 一样的聚合酶(PARP ) 。结果:除了增长的抑制,有 CHP 的孵化从焦点的粘附导致了 FAK 的解朊的劈开和酶的 delocalisation,由房间坚持的损失列在后面。同时,我们能显示出 GRP78 和 GADD153 的增加的表情,显示在 DSL6A 房间线的 ER 压力串联的调停 CHP 的激活。有 CHP 的 DSL6A 房间的延长孵化最后导致了 apoptotic 细胞死亡。在 L 脯氨酸旁边,由一个广谱朊酶禁止者的增加的细胞内部的解朊作用的抑制能在细胞的功能和分子的过程上废除 CHP 的效果。相反,阻碍执行 apoptosis caspases 的活动没在调停 CHP 的房间损坏上有影响。结论:我们的数据建议开始嗯由 CHP 的压力机械导致细胞内部的解朊的进程的激活包括 caspase 独立的 FAK 降级,导致损坏胰腺的癌房间。 | Christoph Mueller Joerg Emmrich Robert Jaster Dagmar Braun Stefan Liebe Gisela Sparmann | 2006 | World Journal of Gastroenterology2006，12，10： | 3 |
| 8 | Megacolon in adulthood after surgical treatment of Hirschsprung's disease in early childhood显示文摘Hirschsprung's disease (HD) is a disorder associated with congenital malformation of the enteric nervous system with segmental aganglionosis. Prevailing therapy includes a resection of the affected part of the bowel. However, patients often do not obtain complete functional improvement after surgical treatment. We present the case of a 25-year-old woman who had surgical treatment of HD in early childhood. After that procedure she had clinical features of constipation for years in the end,passing of stool once a week, requiring laxatives and enemas. We diagnosed an incomplete resection of the aganglionic bowel via rectal biopsy and resected the remaining aganglionic segment. Two months after surgery the patient's bowel function improved to a frequency of 1-4 stools per day. We conclude that regular follow-up is required to identify HD patients with persistent alterations of bowel function after surgery. In patients presenting with constipation, recognition of a remaining aganglionic segment or other alterations of the enteric nervous system should be aimed at in an early stage. | Christoph R.Werner Gisela Stoltenburg-Didinger Henning Weidemann Christoph Benckert Marco Schmidtmann Ivo R.van der Voort Viola Andresen Burghard F.Klapp Peter Neuhaus Bertram Wiedenmann Hubert Mnnikes | 2005 | World Journal of Gastroenterology2005，11，36： | 3 |
| 9 | Impact of gastroesophageal reflux control through tailored proton pump inhibition therapy or fundoplication in patients with Barrett's esophagus显示文摘AIM To determine the impact of upwards titration of proton pump inhibition(PPI) on acid reflux, symptom scores and histology, compared to clinically successful fundoplication.METHODS Two cohorts of long-segment Barrett's esophagus(BE) patients were studied. In group 1(n = 24), increasing doses of PPI were administered in 8-wk intervals until acid reflux normalization. At each assessment, ambulatory 24 h p H recording, endoscopy with biopsies and symptom scoring(by a gastroesophageal reflux disease health related quality of life questionnaire, GERD/HRLQ) were performed. Group 2(n = 30) consisted of patients with a previous fundoplication. RESULTS In group 1, acid reflux normalized in 23 of 24 patients, resulting in improved GERD/HRQL scores(P = 0.001), which were most pronounced after the starting dose of PPI(P < 0.001). PPI treatment reached the same level of GERD/HRQL scores as after a clinically successful fundoplication(P = 0.5). Normalization of acid reflux in both groups was associated with reduction in papillary length, basal cell layer thickness, intercellular space dilatation, and acute and chronic inflammation of squamous epithelium. CONCLUSION This study shows that acid reflux and symptom scores co-vary throughout PPI increments in long-segment BE patients, especially after the first dose of PPI, reaching the same level as after a successful fundoplication. Minor changes were found among GERD markers at the morphological level. | Francisco Baldaque-Silva Michael Vieth Mumen Debel Bengt Hakanson Anders Thorell Nuno Lunet Huan Song Miguel Mascarenhas-Saraiva Gisela Pereira Lars Lundell Hanns-Ulrich Marschall | 2017 | World Journal of Gastroenterology2017，23，17： | 3 |
| 10 | Incidence trends for childhood type 1 diabetes in Europe during 1989–2003 and predicted new cases 2005–20: a multicentre prospective registration study显示文摘 | Christopher C Patterson Gisela G Dahlquist Eva Gyürüs Anders Green Gyula Soltész | 2009 | The Lancet2009，，9680： | 2 |
| 11 | Treatment of Retinochorioiditis Caused by Toxoplasmosis with Traditional Symptom-related Acupuncture and Chronoacupuncture/Zi Wu Liu Zhu.A Case Study显示文摘目的:促进患病器官的气血流通和提高患处的气血含量对于针刺治疗是非常必要的.针灸治疗没有西医学的局限性.方法:以针刺交会穴开始,进行5步对症的时间针刺治疗,然后应用子午流注针法.结果:经过58次对症针刺治疗后,视力由10%上升到70%,并保持稳定.18个月后进行1次子午流注针法治疗后,1个小时内视力由70%升至90%.结论:眼科医师应为视网膜炎患者提供针刺治疗.应用子午流注针法和有效穴位能够强力补益气血和促进气血流通.子午流注针法对1例弓形体病引起的视网膜炎患者的有效性,显示针刺治疗可成功应用于西药无效的疾病. | Slopek,Axel FENGHai-tao Fanselow-Hinrichs,Gisela WANGRui-hua | 2005 | Journal of Acupuncture and Tuina Science2005，3，1： | 2 |
| 12 | Organ-specific changes in the activity and subunit composition of glutamine-synthetase isoforms of barley (Hordeum vulgare L.) after growth on different levels of NH+ 4显示文摘 | Gisela M?ck | 1995 | Planta1995，，2： | 1 |
| 13 | Effects of Ca- and Na-lignosulfonate on starchgelatinization and network formation显示文摘 | Gisela Richardson Yemin Sun Maud Langton etc | 2004 | Carbohydrate Polymers2004，57，： | 1 |
| 14 | Isolation and structural characterization of the milled - wood lignin from Paulownia fortunei wood显示文摘 | Jorge Rencoret Gisela Marques Ana Gutierrez | | 0，，01： | 1 |
| 15 | Cytokine mRNA Levels and Lymphocyte Infiltration in Pancreatic Tissue During Experimental Chronic Pancreatitis Induced by Dibutyltin Dichloride显示文摘 | Gisela Sparmann Stefan Behrend Jutta Merkord Hans-Dieter Kleine Elmara Graser Thomas Ritter Stefan Liebe J?rg Emmrich | 2001 | Digestive Diseases and Sciences2001，，8： | 1 |
| 16 | Plant metallothionein domains:functional insight into physiological metal binding and protein folding显示文摘 | Jordi Domènech Gisela Mir Sllvia Atrian | 2006 | Biochimie2006，88，： | 1 |
| 17 | Pharmacokinetic/Pharmacodynamic Modeling of Pegfilgrastim in Healthy Subjects显示文摘 | Lorin K. Roskos Peggy Lum Pamela Lockbaum Gisela Schwab Bing-Bing Yang | 2006 | The Journal of Clinical Pharmacology2006，，7： | 1 |
| 18 | Nitrogen uptake in relation to excess supply and its effects on the lichens Evernia prunastri (L.) Ach and Xanthoria parietina (L.) Th. Fr.显示文摘 | Gisela Gaio-Oliveira Lena Dahlman Kristin Palmqvist Maria Amélia Martins-Lou??o Cristina Máguas | 2005 | Planta2005，，5： | 1 |
| 19 | Preclinical and clinical evaluations of ABX-EGF, a fully human anti-epidermal growth factor receptor antibody显示文摘 | Kenneth A Foon Xiao-Dong Yang Louis M Weiner Arie S Belldegrun Robert A Figlin Jeffrey Crawford Eric K Rowinsky Janice P Dutcher Nicholas J Vogelzang Jared Gollub John A Thompson Garry Schwartz Ronald M Bukowski Lorin K Roskos Gisela M Schwab | 2004 | International Journal of Radiation Oncology Biology Physics2004，，3： | 1 |
| 20 | Incidence trends for childhood type 1 diabetes in Europe during 1989–2003 and predicted new cases 2005–20: a multicentre prospective registration study显示文摘 | Christopher C Patterson Gisela G Dahlquist Eva Gyürüs Anders Green Gyula Soltész | 2009 | The Lancet2009，，9680： | 1 |
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