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| 1 | Clinical significance of NOD2/CARD15 and Toll-like receptor 4 gene single nucleotide polymorphisms in inflammatory bowel disease显示文摘AIM: To evaluate the role of genetic factors in the pathogenesis of Crohn's disease (CD) and ulcerative colitis (UC), we investigated the single nucleotide poly- morphisms (SNPs) of NOD2/CARD15 (R702W, G908R and L1007fi nsC), and Toll-like receptor 4 (TLR4) genes (D299G and T399I) in a selected inflammatory bowel disease (IBD) population coming from Southern Italy. METHODS: Allele and genotype frequencies of NOD2/ CARD15 (R702W, G908R and L1007finsC) and TLR4 (D299G and T399I) SNPs were examined in 133 CD pa-tients, in 45 UC patients, and in 103 healthy controls. A genotype-phenotype correlation was performed. RESULTS: NOD2/CARD15 R702W mutation was sig-nificantly more frequent in CD (9.8%) than in controls (2.4%, P = 0.001) and in UC (2.3%, P = 0.03). No sig-nificant difference was found between UC patients and control group (P > 0.05). In CD and UC patients, no signifi cant association with G908R variant was found. L1007f insC SNP showed an association with CD (9.8%) compared with controls (2.9%, P = 0.002) and UC patients (2.3%, P = 0.01). Moreover, in CD patients, G908R and L1007finsC mutations were significantly associated with different phenotypes compared to CD wild-type patients. No association of IBD with the TLR4 SNPs was found in either cohort (allele frequencies: D299G-controls 3.9%, CD 3.7%, UC 3.4%, P > 0.05; T399I-controls 2.9%, CD 3.0%, UC 3.4%, P > 0.05). CONCLUSION: These findings confirm that, in our IBD patients selected from Southern Italy, the NOD2/ CARD15, but not TLR4 SNPs, are associated with in-creased risk of CD. | Luciana Rigoli Claudio Romano Rosario Alberto Caruso Maria A Lo Presti Chiara Di Bella Vincenzo Procopio Giuseppina Lo Giudice Maria Amorini Giuseppe Costantino Maria D Sergi Caterina Cuppari Giovanna Elisa Calabrò Romina Gallizzi Carmelo Damiano Salpietro Walter Fries | 2008 | World Journal of Gastroenterology2008，14，28： | 8 |
| 2 | Transarterial chemoembolization using 40 μm drug eluting beads for hepatocellular carcinoma显示文摘AIM To assess the safety and efficacy of transarterial chemoembolization(TACE) of hepatocellular carcinoma(HCC) using a new generation of 40 μm drug eluting beads in patients not eligible for curative treatment.METHODS Drug eluting bead TACE(DEB-TACE) using a new generation of microspheres(embozene tandem,40 μm) preloaded with 100 mg of doxorubicin was performed on 48 early or intermediate HCC patients with compensatedcirrhosis.Response to therapy was assessed with Response Evaluation Criteria in Solid Tumors(RECIST) and modified RECIST(m RECIST) guidelines applied to computed tomography or magnetic resonance imaging.Eleven out of the 48 treated patients treated progressed on to receive liver orthotopic transplantation(OLT).This allowed for histological analysis on the treated explanted nodules.RESULTS DEB-TACE with 40 μm showed a good safety profile without major complications or 30-d mortality.The objective response rate of treated tumors was 72.6% and 26.7% according to m RECIST and RECIST respectively.Histological examination in 11 patients assigned to OLT showed a necrosis degree > 90% in 78.6% of cases.The overall time to progression was 13 mo(11-21).CONCLUSION DEB-TACE with 40 μm particles is an effective treatment for the treatment of HCC in early-intermediate patients(Barcelona Clinic Liver Cancer stage A/B) with a good safety profile and good results in term of objective response rate and necrosis. | Giorgio Greco Tommaso Cascella Antonio Facciorusso Roberto Nani Rodolfo Lanocita Carlo Morosi Marta Vaiani Giuseppina Calareso Francesca G Greco Antonio Ragnanese Marco A Bongini Alfonso V Marchianò Vincenzo Mazzaferro Carlo Spreafico | 2017 | World Journal of Radiology2017，9，5： | 3 |
| 3 | Assessing the zearalenone binding activity of adsorbent materials during passage through a dynamic in vitro gastrointestinal model 显示文摘 | Giuseppina A Robert H | 2003 | Toxicity2003，41，： | 1 |
| 4 | Geographic variation and environmental conditions as cofactors in Chlamydia psittaci association with ocular adnexal lymphomas:a comparison between Italian and African samples显示文摘 | Alessandro C Anna O Giuseppina A | 2010 | Hernatol Oncol2010，28，： | 1 |
| 5 | Assessing the ZEN ralenone-bindingactivity of adsorbent materials during passage through a dy-namic in vitro gastro intestinal model显示文摘 | Giuseppina A Robert H | 2003 | Toxicity2003，41，10： | 1 |
| 6 | Riboflavin-overproducing strains of Lactobacillus fermentum for riboflavin-enriched bread显示文摘 | Pasquale Russo Vittorio Capozzi Mattia Pia Arena Giuseppina Spadaccino María Teresa Due?as Paloma López Daniela Fiocco Giuseppe Spano | 2014 | Applied Microbiology and Biotechnology2014，，8： | 1 |
| 7 | Assessing the zearalenone binding activity of adsorbent materialsduring passage through a dynamic in vitro gastrointestinal model显示文摘 | Giuseppina A Robert H | 2003 | Toxicity2003，41，： | 1 |
| 8 | Asymptotic stability for nonlinear kirchhoff systems 显示文摘 | GIUSEPPINA A PATRIZIA P MARIA C S | 2009 | Nonlinear Analysis (Real World Appl)2009，10，： | 1 |
| 9 | Discrimination of apricot cultivars by gas multisensor array using an artificial neural network显示文摘 | Giuseppina P P Fabbri A Domenichelli S | 2007 | Biosystems Engineering2007，97，3： | 1 |
| 10 | Acquisition and analysis of EMG signals to recognize multiple hand movements for prosthetic applications显示文摘 | Giuseppina G Matteo A Lan S | 2012 | Applied Bionics and Biomechanics2012，9，2： | 1 |
| 11 | Silicon Photomultipliers (SiPM) as novel photodetectors for PET显示文摘 | Del GA Belcari N Giuseppina BM et a/ | 2011 | Nucl Instrum and Methods Physics Res A2011，648，： | 1 |
| 12 | Assessing the zearalenone - binding activity of adsorbent materialsduring passage through a dy- namic in vitro gastrointestinal model 显示文摘 | Giuseppina A Robert H | 2003 | Toxicity2003，41，： | 1 |
| 13 | Evaluation of the intestinal absorption of deoxynivalenol and nivalenol by an in vitro gastrointestinal model,and the binding efficacy of activated carbon and other adsorbent materials显示文摘 | Giuseppina A Robert H Angelo V | 2004 | Food and Chemical Toxicology2004，42，： | 1 |
| 14 | Poten- tial 18F-labeled biomarkers for epidermal growth factor receptor tyro- sine kinase 显示文摘 | Bonasem Thomas A Ortua Giuseppina Rozen Yulia | 2001 | Nuclear Medicine and Biology2001，28，： | 1 |
| 15 | Latest de- velopments in micro total analysis systems 显示文摘 | ARUN A GIUSEPPINA S GEORGETTE B S | 2010 | Anal Chem2010，82，12： | 1 |
| 16 | Antiproliferative triterpene saponins from Trevesia palmata显示文摘 | Nunziatina D T Giuseppina A Aurora B | 2000 | J Nat Prod2000，63，： | 1 |
| 17 | The nACHR4 594C/T polymorphism in Alzheimer disease显示文摘 | Sonya V Giuseppina C Alessandra A | 2006 | Rejuvenation Res2006，9，1： | 1 |
| 18 | Characterization of Buffalo Milk by Pnuclear Magnetic Resonance Spectroscopy 显示文摘 | GIUSEPPINA A ENRICO T ANDREA M | 2006 | Journal of Food Composition and Analysis2006，19，： | 1 |
| 19 | Effect of fi'eezing/thawing process indifferent sizes of blue fish in the Mediterranean through lysosomal enzymatic tests 显示文摘 | Giuseppina R A Alberio Riccardo N Barbagallo Aldo Todaro | 2014 | Food Chemistry2014，1480，： | 1 |
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