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| 1 | 难治性类风湿关节炎的临床特点:一项国际问卷调查研究显示文摘目的尽管按照目前欧洲抗风湿联盟(EULAR)的推荐对类风湿关节炎(rheumatoid arthritis,RA)患者进行治疗,难治性RA患者的临床症状却仍然没有得到完全控制,目前EULAR指南主要关注的是RA的早期治疗和药物治疗。本研究的目的在于分析难治性RA患者的临床特点,以及在患者管理中需要探索然而现有EULAR指南并未涉及的问题。方法对多个国家的风湿科医生进行问卷调查,分析难治性RA的临床特点。问卷包括多选题以及开放性问题,从开放性问题的回答中发现需要进一步阐明的问题以及现有EULAR指南需要增加的内容。结果410名受访者完成了调查问卷,关于难治性RA的特点:50%受访者认为基于28个关节评估的疾病活动评分(disease activity score assessing 28 joints,DAS28)>3.2或存在疾病活动的征象;42%受访者认为疲劳是其特点;48%认为至少两种传统合成改变病情抗风湿药(DMARDs)以及使用至少两种生物制剂或靶向合成DMARDs治疗失败;89%认为糖皮质激素不能减量到5 mg/天或泼尼松不能减量到10 mg/天或同等剂量的其他激素。另外,现有EULAR指南中应增加合并症和关节外表现的干预以及多种药物联合治疗等重要内容。结论目前风湿科医生对难治性RA的定义有很大争议。难治性RA患者的很多重要问题目前EULAR指南中均没有涉及。 | Nadia MT Roodenrijs Maria J H de Hair Marlies C van der Goes Johannes WG Jacobs Paco MJ Welsing Désirée van der Heijde Daniel Aletaha Maxime Dougados Kimme L Hyrich Iain B McInnes Ulf Mueller-Ladner Ladislav Senolt Zoltan Szekanecz Jacob Mvan Laar Nagy Gyorgy 黄艳荣(译) 张卓莉(审校) | 2019 | 英国医学杂志中文版2019，22，2： | 1 |
| 2 | Prevalence andpredictors of pulmonary embolism in patients with acutely decompensated heart failure显示文摘 | Correia LC Goes C Ribeiro H | 2012 | Arq Bras Cardiol2012，98，2： | 1 |
| 3 | High-volmne peritoneal dialysis in acute kidney injury: indications and limitations 显示文摘 | Ponce D Berbel MN Regina de goes C | 2012 | Clin J Am Soc Nephrol2012，7，6： | 1 |
| 4 | Biofertilizer for control ofGuignardia citricarpa,the causal agent of citrus black spot显示文摘 | Kuppera K C Bettiol W Goes De A | 2006 | CropProtection2006，，26： | 1 |
| 5 | High-volume peritoneal dialysis in acute kidney injury:indications and limitations显示文摘 | Ponce D Berbel MN Regina de Goes C | 2012 | Clin J Am Soc Nephrol2012，7，6： | 1 |
| 6 | Dynamic analysis of staggered truss framing system 显示文摘 | GUPTA R P GOES C | 1972 | Journal of Structural Division1972，98，7： | 1 |
| 7 | High-volume peritoneal dialysis in acute kidney injury:indications and limitations显示文摘 | Ponce D Berbel MN Regina de Goes C | | 0，，： | 1 |
| 8 | Breast implant stability in the subfaacial plane and the new shaped silicone gel breast implants显示文摘 | SAMPAIO GOES J C | 2009 | Aesthetic Plast Surg2009，21，： | 1 |
| 9 | The application of mesh support in periareolar breast surgery:clinical and mammographic evaluation显示文摘 | GOES J C LANDECKER A LYRA E C | 2004 | Aesthetic Plast Surg2004，28，5： | 1 |
| 10 | Population and mutation analysis of 17Y-STR loci from Rio de Janeiro(Brazil)显示文摘 | Goes A C Carvalho E Gomes I | 2005 | Int J Legal Med2005，119，2： | 1 |
| 11 | Dielectric properties of BaTiO3 (BTO)-CaCu3Ti4O12 (CCTO) composite screen-printed thick films for high dielectric constant devices in the medium frequency (MF) range显示文摘 | Goes P B A Valente J C | 2004 | Materials Science and Engineering2004，111，： | 1 |
| 12 | Are changes in bone mineral density different between groups of early rheumatoid arthritis patients treated according to a tight control strategy with or without prednisone if osteoporosis prophylaxis is applied 显示文摘 | van der Goes M C Jacobs J W Jurgens M S | 2013 | Osteoporosis Int2013，24，4： | 1 |
| 13 | Popularity Effect in User-Gener- ated Content:Evidence from Online Product Reviews 显示文摘 | Goes P B Lin M Au Y C | 2014 | In- formation Systems Research2014，25，2： | 1 |
| 14 | Analysis of expressed sequence tags from multiple Vitis species and development of a compendium of gene expression during berry development显示文摘 | GOES DA SIL V A F IANDOLINO A AL-KAYAL F BOHLMANN M C CUSHMAN M A LIM H ERGULA FIGUEROA R KABULOGLU E K OSBORNE C ROWE J Characterizing the grape transcriptome | 2005 | Plant Physiology2005，139，2： | 1 |
| 15 | Systematic design for optimization of high-speed self-calibrated pipelined A/D converters显示文摘 | GOES J VITAL J C FRANCA J E | 1998 | IEEE Transactions on Circuits and Systems Part Ⅱ:Analog and Digital Signal Processing1998，，12： | 1 |
| 16 | Ol显示文摘 | Van der Goes van Naters W M Den Otter C J Maes F W | 1998 | Chemical Senses1998，23，3： | 1 |
| 17 | Comparative modeling and QM/MM studies of cysteine protease mutant of Theobroma cacao显示文摘 | ANDRADE D V G D GOES NETO A JUNIOR M C et al | 2012 | Int J Quantum Chem2012，112，19： | 1 |
| 18 | Pesticide residues in cashew apple, guava, kaki and peach: GC-tLECD, GC-FPD and LC-MS/MS multiresidue method validation, analysis and cumulative acute risk assessment 显示文摘 | Jardim A N O Mello D C Goes F C S | 2014 | Food Chemistry2014，164，： | 1 |
| 19 | Discrimination of hydrothermally altered and unahered rocks in visible and near- infi'ared multispectral images显示文摘 | Rowan L C Goe~A F H Ashley R P | 1977 | Geophysics1977，42，3： | 1 |
| 20 | Monitoring adverse events of low-dose glucocorticoid therapy: EULAR recommendations for clinical trials and daily practice 显示文摘 | van der Goes M C Jacobs J W Boers M | 2010 | Ann Rheum Dis2010，69，11： | 1 |
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