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| 1 | Passive expansion of sub-maximally dilated transjugular intrahepatic portosystemic shunts and assessment of clinical outcomes显示文摘AIM To assess for passive expansion of sub-maximally dilated transjugular intrahepatic portosystemic shunts(TIPS) and compare outcomes with maximally dilated TIPS.METHODS Polytetrafluoroethylene covered TIPS(Viatorr) from July 2002 to December 2013 were retrospectively reviewed at two hospitals in a single institution. Two hundred and thirty patients had TIPS maximally dilated to 10 mm(m TIPS), while 43 patients who were at increased risk for hepatic encephalopathy(HE), based on clinical evaluation or low pre-TIPS portosystemic gradient(PSG), had 10 mm TIPS sub-maximally dilated to 8 mm(sm TIPS). Group characteristics(age, gender, Model for End-Stage Liver Disease score, post-TIPS PSG and clinical outcomes were compared between groups, including clinical success(ascites or varices), primary patency,primary assisted patency, and severe post-TIPS HE. A subset of fourteen patients with sm TIPS underwent follow-up computed tomography imaging after TIPS creation, and were grouped based on time of imaging(< 6 mo and > 6 mo). Change in diameter and crosssectional area were measured with 3D imaging software to evaluate for passive expansion.RESULTS Patient characteristics were similar between the sm TIPS and m TIPS groups, except for pre-TIPS portosystemic gradient, which was lower in the sm TIPS group(19.4 mm Hg ± 6.8 vs 22.4 mm Hg ± 7.1, P = 0.01). Primary patency and primary assisted patency between sm TIPS and m TIPS was not significantly different(P = 0.64 and 0.55, respectively). Four of the 55 patients(7%) with sm TIPS required TIPS reduction for severe refractory HE, while this occurred in 6 of the 218 patients(3%) with m TIPS(P = 0.12). For the 14 patients with follow-up computed tomography(CT) imaging, the median imaging follow-up was 373 d. There was an increase in median TIPS diameter, median percent diameter change, median area, and median percent area change in patients with CT follow-up greater than 6 mo after TIPS placement compared to follow-up within 6 mo(8.45 mm, 5.58%, 56.04 mm^2, and 11.48%, respectively, P = 0.01).CONCLUSION Passive expansion of sm TIPS does occur but clinical outcomes of sm TIPS and m TIPS were similar. Sub-maximal dilation can prevent complications related to overshunting in select patients. | Michael C Hsu Charles N Weber S William Stavropoulos Timothy W Clark Scott O Trerotola Richard D Shlansky Goldberg Michael C Soulen Gregory J Nadolski | 2017 | World Journal of Hepatology2017，9，12： | 11 |
| 2 | Inflammation-related gene expression profiles of salivary extracellular vesicles in patients with head trauma显示文摘At present,there is no reliable biomarker for the diagnosis of traumatic brain injury(TBI).Studies have shown that extracellular vesicles released by damaged cells into biological fluids can be used as potential biomarkers for diagnosis of TBI and evaluation of TBI severity.We hypothesize that the genetic profile of salivary extracellular vesicles in patients with head trauma differs from that in uninjured subjects.Findings from this hypothesis would help investigate the severity of TBI.This study included 19 subjects,consisting of seven healthy controls who denied history of head trauma,six patients diagnosed with concussion injury from an outpatient concussion clinic,and six patients with TBI who received treatment in the emergency department within 24 hours after injury.Real-time PCR analysis of salivary extracellular vesicles in participants was performed using TaqMan Human Inflammation array.Gene expression analysis revealed nine upregulated genes in emergency department patients(LOX5,ANXA3,CASP1,IL2RG,ITGAM,ITGB2,LTA4H,MAPK14,and TNFRSF1A)and 13 upregulated genes in concussion clinic patients compared with healthy participants(ADRB1,ADRB2,BDKRB1,HRH1,HRH2,LTB4R2,LTB4R,PTAFR,CYSLTR1,CES1,KLK1,MC2R,and PTGER3).Each patient group had a unique profile.Comparison between groups showed that 15 inflammation-related genes had significant expression change.Our results indicate that inflammation biomarkers can be used for diagnosis of TBI and evaluation of disease severity.This study was approved by the Institutional Review Board on December 18,2015(approval No.0078-12)and on June 9,2016(approval No.4093-16). | Yan Cheng Mandy Pereira Neha P.Raukar John L.Reagan Mathew Quesenberry Laura Goldberg Theodor Borgovan W Curt LaFrance Jr Mark Dooner Maria Deregibus Giovanni Camussi Bharat Ramratnam Peter Quesenberry | 2020 | Neural Regeneration Research2020，15，4： | 2 |
| 3 | Genome-wide fetal aneuploidy detection by maternal plasma DNA sequencing显示文摘 | Bianchi D W Platt L D Goldberg J D | 2012 | Obstet Gyneeol2012，119，5： | 1 |
| 4 | Cruise Ships, Pollution, and international law : The United States takes on royal Caribbean Cruise Lines 显示文摘 | Goldberg W A | 2000 | Wisconsin International Law Journal2000，，19： | 1 |
| 5 | COz mineral seques- tration studies in US显示文摘 | Goldberg P Chen Z Y O' eonnor W K | 2001 | Journal of Energy and Environmental Rs- search2001，1，1： | 1 |
| 6 | A computer model of the secondary arc in single phase operation of transmis- sion lines显示文摘 | Goldberg S Horton W F Tziouvaras D | 1989 | IEEE Trans on Power Delivery1989，4，1： | 1 |
| 7 | Synthesis of ethyl-(3R,5S)- dihydroxy-6-benzyloxyhexanoates via diastereo- and enantioseleetive microbial reduetion:eloning and expression of ketoreduetase III from Acinetobacter sp SC 13874 显示文摘 | Goldberg S Guo Z W Chen S | 2008 | Enzyme Mierob Teeh2008，43，7： | 1 |
| 8 | Management of colorectal carcinoma in children and young adults显示文摘 | Goldberg J Furman W L | | 0，，2： | 1 |
| 9 | A chimaeric ribonuclease-inhibitor gene restores fertility to male sterile plants显示文摘 | Mariani C Gosele V De Bluckeleer M De Block M Robert B Goldberg De Greef W Leemans J | 1992 | Nature1992，357，6： | 1 |
| 10 | Effects of losarton on blood: plasma rennin activity and angiotensin Ⅱin volunteers显示文摘 | Tanala W barchousky A | 1993 | Hypertension1993，21，： | 1 |
| 11 | Functional and physical interaction between the selenium-binding protein1(SBP1) and the glutathione peroxidase 1 selenoprotein显示文摘 | Fang W Goldberg ML Pohl NM | 2010 | Carcinogenesis2010，31，8： | 1 |
| 12 | A computer model of the secondary arc in single phase operation of transmission line显示文摘 | Goldberg S Horton W F | 1989 | IEEE Trans on Power Delivery1989，4，1： | 1 |
| 13 | Hemodialysis-related venous stenosis: treatment with ultrahigh pressure angioplastyballoons 显示文摘 | TREROTOLA S O STAVROPOULOS S W SHLANSKY- GOLDBERG R | 2004 | Radiology2004，231，1： | 1 |
| 14 | Effects of severe long-term food deprivation and refeeding on adipose tissue cells in the rat显示文摘 | Miller W H J Faust I M Goldberger A C | 1983 | Am J Physiol Endocrinol Metab1983，245，： | 1 |
| 15 | Into the loops: Practical issues in translation validation for optimizing compilers 显示文摘 | Goldberg B Zuck L D Barrett C W | 2005 | Electronic Notes Theory Computer Science2005，132，1： | 1 |
| 16 | Functional and physical interaction between the selenium-binding protein 1 (SBP1) and the glutathione peroxidase 1 sde- noprotein显示文摘 | Fang W Goldberg ML Pohl NM | 2010 | Carcinogenesis2010，31，8： | 1 |
| 17 | Subsynchronous resonance in series compensated transmission lines 显示文摘 | Balance J W Goldberg S | 1973 | IEEE Transactions on Power Apparatus and Systems1973，，： | 1 |
| 18 | Functional and physical interaction between the selenium-binding protein I (SBP1) and the glulathione peroxidase 1 selenoprotein显示文摘 | Fang W Goldberg ML Pohl NM | 2010 | Carcinogenesis2010，31，8： | 1 |
| 19 | Parallel recombinative simulated annealing: a genetic algorithm 显示文摘 | Mahfoud S W Goldberg D E | 1995 | Parallel Computing1995，21，1： | 1 |
| 20 | Objective and subjective outcomes in surgery for chronic sinusitis显示文摘 | KENNEDY Q W WRIGHT E D GOLDBERG A N | 2000 | Laryngoscope2000，110，： | 1 |
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