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| 1 | Assessing the relationship between the rumen microbiota and feed efficiency in Nellore steers显示文摘Background:Ruminants rely upon a complex community of microbes in their rumen to convert host-indigestible feed into nutrients.However,little is known about the association between the rumen microbiota and feed efficiency traits in Nellore(Bos indicus)cattle,a breed of major economic importance to the global beef market.Here,we compare the composition of the bacterial,archaeal and fungal communities in the rumen of Nellore steers with high and low feed efficiency(FE)phenotypes,as measured by residual feed intake(RFI).Results:The Firmicutes to Bacteroidetes ratio was significantly higher(P<0.05)in positive-RFI steers(p-RFI,low feed efficiency)than in negative-RFI(n-RFI,high feed efficiency)steers.The differences in bacterial composition from steers with high and low FE were mainly associated with members of the families Lachnospiraceae,Ruminococcaceae and Christensenellaceae,as well as the genus Prevotella.Archaeal community richness was lower(P<0.05)in p-RFI than in n-RFI steers and the genus Methanobrevibacter was either increased or exclusive of p-RFI steers.The fungal genus Buwchfawromyces was more abundant in the rumen solid fraction of n-RFI steers(P<0.05)and a highly abundant OTU belonging to the genus Piromyces was also increased in the rumen microbiota of highefficiency steers.However,analysis of rumen fermentation variables and functional predictions indicated similar metabolic outputs for the microbiota of distinct FE groups.Conclusions:Our results demonstrate that differences in the ruminal microbiota of high and low FE Nellore steers comprise specific taxa from the bacterial,archaeal and fungal communities.Biomarker OTUs belonging to the genus Piromyces were identified in animals showing high feed efficiency,whereas among archaea,Methanobrevibacter was associated with steers classified as p-RFI.The identification of specific RFI-associated microorganisms in Nellore steers could guide further studies targeting the isolation and functional characterization of rumen microbes potentially important for the energy-harvesting efficiency of ruminants. | Déborah Romaskevis Gomes Lopes Márcio de Souza Duarte Alex J.La Reau Ibrahim Zuniga Chaves Tiago Antônio de Oliveira Mendes Edenio Detmann Cláudia Braga Pereira Bento Maria Eugênia Zerlotti Mercadante Sarah Figueiredo Martins Bonilha Garret Suen Hilário Cuquetto Mantovani | 2021 | Journal of Animal Science and Biotechnology2021，12，4： | 3 |
| 2 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 3 | Alternative tissue engineering scaffolds based on starch: processing methodologies, morphology, degradation and mechanical properties显示文摘 | Gomes M E Godinho J S Tchalamov D | 2002 | Materials Science and Engineering2002，，19： | 2 |
| 4 | Chitosan microparticles as injectable scaffolds for tissue engineering 显示文摘 | CRUZ D M IVIRICO J L GOMES M M | 2008 | J Tissue Eng Regen Med2008，2，6： | 1 |
| 5 | Comprehensive two-dimensional gas chromatography/mass spectrometric analysis of pepper voatiles显示文摘 | Cardeal Z L Gomes da Silva M D Marriott P J | 2006 | Rapid Commun Mass Spectrom2006，20，： | 1 |
| 6 | Supercritical fluid extraction of lipids from spent coffee grounds显示文摘 | Ricardo M C Joao F Gomes da Silva M D R | 2009 | Journal of Supercritical Fluids2009，51，： | 1 |
| 7 | Effect of high-pressure treatment on the activity of some polyphenoloxidases显示文摘 | Gomes M R A Ledward D A | 1996 | Food Chemistry1996，56，1： | 1 |
| 8 | Steroid-estrogen determination in sediment and sewage sludge: a critique of sample preparation and chromatographic/mass,spectrometry considerations, incorporating a case study in method development显示文摘 | GOMES R L AVCIOGLU E SCRIMSHAW M D | 2004 | TrAC Trends Anal Chem2004，23，1011： | 1 |
| 9 | A critical review of interventions to improve compliance with prescribed medications显示文摘 | Haynes R B Wang E Gomes D M | 1987 | Patient Education and Counseling1987，10，2： | 1 |
| 10 | Steroid estrogen determination in sediment and sewage sludge:A critique of sample preparation and chromatographic/mass spectrometry considerations,incorporating a case study in method development显示文摘 | Gomes R L Avcioglu E Scrimshaw M D | 2004 | Trac-Trends in Analytical Chemistry2004，23，1011： | 1 |
| 11 | Effect of high-pressure treatment on the activity of some polyphenoloxidases显示文摘 | GOMES M R A LEDWARD D A | 1996 | Food Chemistry1996，56，1： | 1 |
| 12 | Auto- nomic activity and glycemic homeostasis are maintained by pre- cocious and low intensity training exercises in MSG-pro- grammed obese mice显示文摘 | SCOMPARIN D X GOMES R M GRASSIOLLI S | 2009 | Endocrine2009，36，3： | 1 |
| 13 | Laser Ablation Inductively Coupled Plasma Optical Emission Spectrometry for Analysis of Pellets of Plant Materials 显示文摘 | Gomes M S Schenk E R Santos Jr D | 2014 | Spectrochimica Acta Part B:Atomic Spectroscopy2014，9495，： | 1 |
| 14 | The use of headspace solid phase microextraction for the characterization of volatile compounds in olive oil matrices显示文摘 | Ribeiro L H Freitas A M C Gomes da Silva M D R | 2008 | Talanta2008，77，1： | 1 |
| 15 | Retrostemal goiters:safety of surgical treatment显示文摘 | PAR RA-MEMB R IVE S P SANCHE Z-BLANC 0 J M GOME Z-RUBlO D et a1 | 2003 | Int Surg2003，88，20： | 1 |
| 16 | Effect of high-pressure treatment on the activity of some polyphenoloxidases 显示文摘 | Gomes M R A Ledward D A | 1996 | Food Chemistry1996，56，1： | 1 |
| 17 | Use of sugarcane bagacse and grass hydrolysates as carbon sources for xylanase production by Bacillus cira()in submerged fermentation显示文摘 | Bocchini D A Oliveira O M M F Gomes E | 2005 | Process Biochemistry2005，40，： | 1 |
| 18 | Plant defensins and defensin-like peptides-biological activities and biotechnological applications显示文摘 | Carvalho A D Gomes V M | 2011 | Curr Pharm Design2011，17，38： | 1 |
| 19 | Positive solutions of a second-order singular ordinary differential equation 显示文摘 | Bonheure D Gomes J M Sanehez L | 2005 | Nonlinear Anal2005，61，： | 1 |
| 20 | Capsule expression by bovine isolates of Staphylococcus aureus from Argentina:genetic and epidemiologic analyses显示文摘 | Sordelli D O F R Buzzola M I Gomes | 2000 | Clin Microbiol2000，38，： | 1 |
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