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| 1 | Severe infection with multidrug-resistant Salmonella choleraesuis in a young patient with primary sclerosing cholangitis显示文摘Massive global spread of multidrug-resistant(MDR) Salmonella spp. expressing extended-spectrum beta-lactamase(ESBL) and additional resistance to fluoroquinolones has often been attributed to high international mobility as well as excessive use of oral antibiotics in livestock farming. However, MDR Salmonella spp. have not been mentioned as a widespread pathogen in clinical settings so far. We demonstrate the case of a 25-year-old male with primary sclerosing cholangitis who tested positive for MDR Salmonella enterica serotype Choleraesuis expressing ESBL and fluoroquinolone resistance. The pathogen was supposedly acquired during a trip to Thailand, causing severe fever, cholangitis andpancreatitis. To our knowledge, this is the first report of Salmonella enterica serotype Choleraesuis in Europe expressing such a multidrug resistance pattern. ESBL resistance of Salmonella enterica spp. should be considered in patients with obstructive biliary tract pathology and travel history in endemic countries. | Philip G Ferstl Claudia Reinheimer Katalin Jozsa Stefan Zeuzem Volkhard AJ Kempf Oliver Waidmann Georgios Grammatikos | 2017 | World Journal of Gastroenterology2017，23，11： | 2 |
| 2 | n-3 and n-6 fatty acid Processing and growth effects in neoplastic and non-cancerous humanmammary epithelial cell lines显示文摘 | Grammatikos SI Subbaiah PV Victor TA | 1994 | Br J Cancer1994，70，： | 1 |
| 3 | Damping gimballess inertial navigation system显示文摘 | Grammatikos A Schuler A R Fegley K A | 1967 | IEEE Transactions on Aerospace and Electronic Systems1967，3，3： | 1 |
| 4 | Potential of old- generation antibiotics to address current need for new antibiotics 显示文摘 | Falagas ME Grammatikos AP Michalopeulos A | 2008 | Anti Infect Ther2008，6，5： | 1 |
| 5 | Respiratory fluoroquinolones for the treatment of community-acquired pneumoma: a metaanalysis of randomized controlled trials 显示文摘 | Vardakas KZ Siempos II Grammatikos A | 2008 | CMAJ2008，179，： | 1 |
| 6 | Futures price variability: A test of maturity and volume effects显示文摘 | Grammatikos T Saunders A | 1986 | Journal of Business1986，59，： | 1 |
| 7 | Damping gimballess inertial navigation systems显示文摘 | GRAMMATIKOS A SCHULER A R FEGLEY K A | 1967 | IEEE Transactions on Aerospace and Electronic Systems1967，3，3： | 1 |
| 8 | Do we still need the aminoglycosiges显示文摘 | Duvente ME Grammatikos A Utili R | 2009 | Intern J Antimicrob Agents2009，33，3： | 1 |
| 9 | Do we still need the aminoglycosides显示文摘 | Durante-Mangoni E Grammatikos A Utili R | 2009 | Int J Antimicrob Agents2009，33，3： | 1 |
| 10 | Futures Price Variability:A Test of Maturity and Volume Effects显示文摘 | GRAMMATIKOS T SAUNDERS A | 1986 | Journal of Business1986，59，2： | 1 |
| 11 | Continuous debonding monitoring of a patch repaired helicopter stabilizer:damage assessment and analysis显示文摘 | Pavlopoulou S Grammatikos S A Kordatos E Z | 2015 | Composite Structures2015，127，： | 1 |
| 12 | Spleen tyrosine kinase (Syk) regulates systemic lupus erythematosus (SLE) T cell signaling 显示文摘 | Grammatikos AP Ghosh D Devlin A | 2013 | PLoS One2013，8，74： | 1 |
| 13 | 血清鞘脂类的变化与肝纤维化进展及治疗效果的关系显示文摘【据《Hepatology》2015年3月报道】题:血清鞘脂类的变化与HCV感染而非HBV感染的肝纤维化进展及治疗效果不佳有关(作者Grammatikos G等) | 孔文丽 李婉玉 Grammatikos G | 2015 | 临床肝胆病杂志2015，31，4： | 1 |
| 14 | Pegylated IFN-α2b added to ongoing lamivudine therapy in patients with lamivudine-resistant chronic hepatitis B显示文摘AIM: To investigate the role of pegylated-interferon (IFN)α-2b in the management of patients with lamivudine-resistant chronic hepatitis B. METHODS: Twenty consecutive anti-HBe positive patients were treated with pegylated IFNα-2b (100μg sc once weekly) for 12 mo. There was no interruption in lamivudine therapy. Hematology, liver biochemistry, serum HBV DNA levels were detected by PCR, and vital signs were also assessed. Liver histology was assessed in some patients at entry and at wk 52 for comparison. RESULTS: Nine patients (45%) had a partial viro-logical end-treatment response; seven patients (35%) showed complete virological end-treatment response. Eight patients (40%) showed biochemical end-treatment response. There was a trend for higher virological response rates in patients who had previously responded to IFN and relapsed compared to IFN non-responders (four out of seven patients vs none out of six patients, respectively; P=0.1). Patients without virological end-treatment response showed significant worsening of fibrosis [median score 2 (range, 1 to 3) vs median score 3 (range, 1 to 4)], in the first and second biopsy respectively (P=0.014), whereas necroinflammatory activity was not significantly affected. Patients with complete or partial virological end-treatment response did not show any significant changes in histological findings, possibly due to the small number of patients with paired biopsies (n = 5). Nevertheless, after 12 mo of follow-up, only one patient (5%) showed sustained virological response and only 2 patients (10%) showed sustained biochemical response. Two patients (10%) discontinued pegylated IFN both after 6 mo of treatment due to flu-like symptoms. CONCLUSION: Pegylated IFNα-2b, when added to ongoing lamivudine therapy in patients with lamivudine-resistant chronic hepatitis B, induces sustained responses only in a small minority of cases. | Themistoklis Vassiliadis Kalliopi Patsiaoura Konstantinos Tziomalos Theodoros Gkiourtzis Olga Giouleme Nikolaos Grammatikos Despoina Rizopoulou Nikolaos Nikolaidis Panagiotis Katsinelos Eleni Orfanou-Koumerkeridou Nikolaos Eugenidis | 2006 | World Journal of Gastroenterology2006，12，15： | 1 |
| 15 | Evaluating playfulness:Construct validity of the children's playfulness scale显示文摘 | EFTHIMIOS TREVLAS VASILIOS GRAMMATIKO POULOU NIKOLAOS TSIGILIS | | 0，，01： | 1 |
| 16 | Diverse effects of essential (n?6 andn?3) fatty acids on cultured cells显示文摘 | Stephanos I. Grammatikos Papasani V. Subbaiah Thomas A. Victor William M. Miller | 1994 | Cytotechnology (-)1994，，1： | 1 |
| 17 | Options Trading and the Bidask Spread of the Underlying Stocks显示文摘 | FEDENIA M T GRAMMATIKOS | 1992 | Journal of Business1992，65，： | 1 |
| 18 | Do we still need the aminoglycosides显示文摘 | Duvente-Mangoni E Grammatikos A Utili R | 2009 | Intern J Antimi- crob Agents2009，33，3： | 1 |
| 19 | Do we still need the aminoglycosides? 显示文摘 | DURANTE-MANQONI E GRAMMATIKOS A UTILI R | 2009 | Int J Antimi crob Agents2009，33，3： | 1 |
| 20 | The genetic and environmental basis of atopic diseases显示文摘 | GRAMMATIKOS A P | 2008 | Ann Med2008，40，7： | 1 |
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