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| 1 | 血糖控制良好的2型糖尿病患者血清VEGF-A及其受体VEGFR1和VEGFR2含量检测(英文)显示文摘研究目的:探讨血糖控制良好的2型糖尿病患者血管内皮生长因子-A(VEGF-A)及其受体VEGFR1和VEGFR2含量及其临床意义。研究方法:本文以31例血糖得到良好控制且没有明显大血管或微血管病变的2型糖尿病患者作为研究对象(实验组),30位健康志愿者为对照组,同期检测患者及健康志愿者的空腹血糖、血脂、糖化血红蛋白水平,及血清VEGF-A、VEGFR1和VEGFR2含量,并加以比较和统计学分析。重要结论:研究结果表明,血糖控制良好的2型糖尿病患者血清中的VEGF-A及其受体VEGFR1和VEGFR2的含量和健康志愿者基本一致,两者无统计学意义,这可能显示血糖水平的合理控制能延缓血管并发症的产生。同时,2型糖尿病患者的血清VEGFR2含量和高密度脂蛋白胆固醇水平之间存在负相关,而血清VEGF-A、VEGFR2含量和甘油三脂水平之间存在正相关,这也表明糖尿病患者的血脂紊乱可能参与了血管生成的调节。 | Barbara RUSZKOWSKA-CIASTEK Alina SOKUP Maciej W. SOCHA Zofia RUPRECHT Lidia HALAS Barbara GóRALCZYK Krzysztof GóRALCZYK Grazyna GADOMSKA Danuta ROSC | 2014 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2014，15，6： | 2 |
| 2 | Lack of a functional p21WAF1/CIP1 gene accelerates caspase-indepentdent apoptosis induced by cisplatin in renal cells 显示文摘 | Grazyna N Peter M P Rick G S | 2003 | Am J Physiol Renal Physiol2003，285，3： | 1 |
| 3 | Human leptin administered intraperitoneally stimulates natriuresis and decrease renal medullary Na+-K+-ATPase activity in the rat-impaired effect in dietary-induced obesity 显示文摘 | Jerzy B Grazyna W Dionizy G | 2002 | Med Sci Monit2002，8，6： | 1 |
| 4 | Effect of Dose Rate and Mixtures of Fungicides on Selection for QoI Resistance in Populations of Plasmopara viticola显示文摘 | JEAN-LUC G GRAZYNA J FRANCINE D | 2006 | Pest Manag Sci2006，62，： | 1 |
| 5 | Novel cardiac troponin T mutation as a cause of familial dilated cardiomyopathy 显示文摘 | Duanxiang L Grazyna ZC Oscar G | 2001 | Circulation2001，104，： | 1 |
| 6 | An indirect double-antibody sandwich enzyme-linked immunosorbent assay(ELISA)using baculovirus-expressed antigen for the detection of antibodies to glycoprotein E of Pseudorabies virus and comparison of the method with blocking ELISAs显示文摘 | Tjeerd G Kimman Olav De Leeuw Grazyna Kochan etal | 1996 | Clin Diagn Lab Immunol1996，3，2： | 1 |
| 7 | Novel cardiac troponin T mutation as a cause of familial dilated cardiomyopathy显示文摘 | Duanxiang L Grazyna ZC Oscar G | 2001 | Circulation2001，104，： | 1 |
| 8 | Sulfur transformations during pyrolysis of a high sulfur Polish coking coal显示文摘 | GRAZYNA G | 1995 | Fuel1995，74，3： | 1 |
| 9 | Novel cardiac troponin T mutation as a cause of familial dilated cardiomyopathy显示文摘 | Duanxiang L Grazyna ZC Oscar G | 2001 | Circulation2001，104，： | 1 |
| 10 | Biological mode of action of famoxadone on plasm opera viticola and phytophthora infestans显示文摘 | Nathalie A Grazyna J Jean-Luc G | 2001 | Crop Protection2001，20，： | 1 |
| 11 | Biological mode of action of famoxadone on plasmopara viticola and phytophthora infestans显示文摘 | A Nathalie J Grazyna G Jean-Luc | 2001 | Crop Protection2001，20，： | 1 |
| 12 | Effect of pore size distribution of coal-based activated carbons on double layer capacitance显示文摘 | GRAZYNA G MACHNIKOWSKI J LORENC-GRABOWSKA E | 2005 | Electrochimica Acta2005，50，： | 1 |
| 13 | 显示文摘 | Ewa L G Grazyna G | 2005 | Journal of Colloid and Interface Sci ence2005，284，2： | 1 |
| 14 | An indirect double-antibody sandwich enzyme-linked immunosorbent assay(ELISA) using baculovirus-expressed antigen for the detection of antibodies to glycoprotein E of Pseudorabies virus and comparison of the method with blocking ELISAs显示文摘 | TJEERD G K OLAV DE L GRAZYNA K | 1996 | Clin Diagn Lab Immunol1996，3，2： | 1 |
| 15 | Adsorption characteristics of Congo Red on coal-based mesoporousactivated carbon显示文摘 | Ewa L G Grazyna G | 2007 | Dyes and Pigments2007，，74： | 1 |
| 16 | Plasminogen activators(tPA and u- PA )and plasminogen activators inhibitors (PAI- 1 and PAI-2) in some myeloproliferative syndromes 显示文摘 | Danuta R Elzbieta K N Grazyna G | 2000 | Med Sci Monit2000，6，4： | 1 |
| 17 | Membrane Processes in Nuclear Technology-Application for Liquid Radioactive Waste Treatment显示文摘 | Grazyna Zakrazeska-Trznadel Harasimowicz M Chmielewski A G | 2001 | Sep Purif Technol2001，2223，： | 1 |
| 18 | Mcmbrauce processes in nuclear technology-application for liquid waste treatment显示文摘 | Grazyna Zakrzewska-Trznadel Marian Harasimowicz Andrzej G Chmielewski | 2001 | Separation and Purification Technology2001，621，： | 1 |
| 19 | 未受控制的高血糖对2型糖尿病患者粘附分子的影响(英文)显示文摘目的:评估可溶性血管细胞间黏附分子(s VCAM-1)、可溶性细胞间黏附分子(s ICAM-1)、可溶性选择素E和可溶性血栓调节蛋白在血糖控制良好和不受控制的2型糖尿病患者中的水平。创新点:对2型糖尿病患者的血管内皮炎症标记物进行评估。方法:62例糖尿病患者分成两组:第一组包括35个血糖控制良好的糖尿病患者,第二组包括27个未控制血糖并伴有微蛋白尿的糖尿病患者。对照组由25名健康志愿者组成。测定血浆中s VCAM-1、s ICAM-1、可溶性选择素E和可溶性血栓调节蛋白的浓度,同时测定血清肌酐及血浆中空腹血糖和糖化血红蛋白(Hb A1c)的浓度。结论:与血糖控制良好的糖尿病组相比,未控制血糖组具有相对低的ICAM-1水平和更高的VCAM-1水平。未控制血糖组中患者的糖化血红蛋白和ICAM-1之间呈正相关,肾小球滤过率和可溶性选择素E之间呈正相关,而肌酐和ICAM-1之间呈负相关。研究证实2型糖尿病的发病机理中炎症过程的出现与血管内皮功能受损有关。未受控制的高血糖对粘附分子的反向作用表明,在糖尿病的并发症中VCAM-1和ICAM-1具有不同功能。 | Barbara RUSZKOWSKA-CIASTEK Alina SOKUP Tomasz WERNIK Zofia RUPRECHT Barbara GóRALCZYK Krzysztof GóRALCZYK Grazyna GADOMSKA Danuta RO | 2015 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2015，16，5： | 0 |
| 20 | Risk of venous thromboembolic disease in postmenopausal women taking oral or transdermal hormone replacement therapy显示文摘Objective: The influence of hormone replacement therapy (HRT) on hemostasis processes depends on the type of hormone,the combination of doses,the time of taking HRT,and the route of administration (oral,transdermal,implanted).The aim of the current study was to assess some parameters of coagulation,especially tissue factor pathway inhibitor (TFPI) and tissue factor (TF) in postmenopausal women using oral or transdermal HRT.Methods: The study was conducted on 76 healthy women,including 46 women aged 44–58 years who were taking oral (26) or transdermal (20) HRT,and 30 women aged 44–54 years who did not take HRT as the control group.Plasma concentrations of TF,TFPI,thrombin-antithrombin complex (TAT),and D-dimer were performed by enzyme-linked immunosorbent assay (ELISA).Moreover,the concentration of fibrinogen and activity of protein C were measured by chromogenic and chronometric methods.Results: We observed a significantly higher concentration of TF and a significantly lower concentration of TFPI in women taking oral and transdermal HRT in comparison with the control group.We also found a significantly lower concentration of fibrinogen in women taking oral HRT vs.the control group.Moreover,no statistically significant changes in concentrations of TAT and D-dimer,or activity of protein C were noted.Conclusions: In this study,the occurrence of an increased TF concentration simultaneously with a decreased concentration of TFPI in women taking HRT indicates hypercoagulability.No significant modification of TAT or D-dimer occurred,and thus there may not be increased risk of thrombosis. | Barbara RUSZKOWSKA GraZyna GADOMSKA Liliana BIELIS Marzena GRUSZKA Barbara GóRALCZYK Danuta RO GraZyna ODROWAZ-SYPNIEWSKA | 2011 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2011，12，1： | 0 |
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