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| 1 | Secretion of melatonin and 6-sulfatoxymelatonin urinary excretion in functional dyspepsia显示文摘AIM:To evaluate blood concentration of melatonin and urinary excretion of its metabolite,6-sulfatoxymelatonin(6-OHMS),in functional dyspepsia(FD).METHODS:Ninety individuals were enrolled in the study:30 in each study group:patients with postprandial distress syndrome(PDS),epigastric pain syndrome(EPS),and controls.Blood samples were drawn at 02:00 and 09:00 h and 24-h urine collection was performed.Serum melatonin and urinary 6-OHMS concentrations were measured by enzyme-linked immunosorbent assay.RESULTS:Serum melatonin concentration at night and in the morning was significantly(P < 0.001) higher in PDS patients [at 02:00 h-93.3 pg/mL,quartile range(QR):79.8-116.2;at 09.00 h-14.3 pg/mL,QR:7.06-19.0] than in EPS(57.2 pg/mL,QR:42.6-73.1;8.1 pg/mL,QR:4.1-9.3) and control patients(57.7 pg/mL,QR:51.2-62.5;8.1 pg/mL,QR:5.4-10.3).A similar relationship was observed for urinary 6-OHMS excretion.Patients with severe PDS symptoms had a higher melatonin concentration than these with moderate syndromes,whereas patients with severe EPS had a lower urinary 6-OHMS excretion than patients with moderate symptoms.CONCLUSION:Evaluation of melatonin serum concentrations and 24-h urinary 6-OHMS excretion are useful methods for differential diagnosis of various clinical forms of FD. | Cezary Chojnacki Tomasz Poplawski Grazyna Klupinska Janusz Blasiak Jan Chojnacki Russel J Reiter | 2011 | World Journal of Gastroenterology2011，17，21： | 8 |
| 2 | Evaluation of enterochromaffin cells and melatonin secretion exponents in ulcerative colitis显示文摘AIM: To study an assessment of the number of enterochromaffin cells and expression of hydroxyindole-Omethyltransferase in colonic mucosa and urine excretion of 6-sulfatoxymelatonin in patients with ulcerative colitis. METHODS: The study included 30 healthy subjects (groupⅠ-C), 30 patients with ulcerative proctitis [group Ⅱ-ulcerative proctitis (UP)] and 30 patients with ulcerative colitis [group Ⅲ-ulcerative colitis (UC)] in acute phases of these diseases. The number of enterochromaffin cells (EC) was estimated in rectal and colonic mucosa. Bioptates were assembled from many different parts of the large intestine. Immunorective cells collected from various parts of the colon were counted according to the Eurovision DAKO (Dako A/S, Copenhagen, Denmark) System in the range of 10 fields in each bioptate at × 200 magnification. The level of mRNA expression of hydroxyindole-O-methyltransferase (HIOMT) in colonic mucosa was estimated with RT-PCR. Urine 6-sulfatoxymelatonin (6-HMS) excretion was determined immunoenzymatically using an IBL (IBL International GmbH, Hamburg, Germany) kit (RE 54031). RESULTS: The number of EC cells in healthy subjects (C) was 132.40 ± 31.26. In patients of group Ⅱ (UP) and group Ⅲ (UC) the number of these cells was higher 225.40 ± 37.35 (P < 0.001) and 225.24 ± 40.50 (P < 0.001) respectively. Similar differences were related to HIOMT expression, which was 1.04 ± 0.36 in group C, 1.56 ± 0.56 (P < 0.01) in group UP and 2.00 ± 0.35 (P < 0.001) in group UC. Twenty-four hour 6-HMS urinary excretion was as follows: C 16.32 ± 4.95 μg/24 h, UP 26.30 ± 7.29 μg/24 h (P < 0.01), UC 42.30 ± 12.56 μg/24h (P < 0.001). A correlation between number of EC cells and 6-HMS excretion was noted in all groups: r = 0.766 in patients with UP, r = 0.703 with UC and r = 0.8551 in the control group; the correlation between the results is statistically significant. CONCLUSION: In the acute phases of both UP and UC, proliferation of EC cells and high expression of HIOMT and urine excretion of 6-HMS is noted. These changes may represent a beneficial response in the anti-inflammatory and defense mechanism. | Cezary Chojnacki Maria Wisniewska-Jarosińska Grazyna Kulig Ireneusz Majsterek Russel J Reiter Jan Chojnacki | 2013 | World Journal of Gastroenterology2013，19，23： | 5 |
| 3 | Cloning,sequencing,and regulation of the glutathione reductase gene from the Cyanobacterium anabaena PCC 7120显示文摘 | Fanyi J Ulf H Grazyna E S | 1995 | J Biol Chem1995，270，22： | 1 |
| 4 | Impact of Age on the Importance of Systolic and Diastolic Blood Pressures for Stroke Risk: The MOnica, Risk, Genetics, Archiving, and Monograph (MORGAM) Project显示文摘 | Julie K.K. Vishram Anders Borglykke Anne H. Andreasen J?rgen Jeppesen Hans Ibsen Torben J?rgensen Grazyna Broda Luigi Palmieri Simona Giampaoli Chiara Donfrancesco Frank Kee Giuseppe Mancia Giancarlo Cesana Kari Kuulasmaa Susana Sans Michael H. Olsen | 2012 | Hypertension2012，，5： | 1 |
| 5 | Effect of Dose Rate and Mixtures of Fungicides on Selection for QoI Resistance in Populations of Plasmopara viticola显示文摘 | JEAN-LUC G GRAZYNA J FRANCINE D | 2006 | Pest Manag Sci2006，62，： | 1 |
| 6 | Use of onion extract to prevent enzymatic browning of frozen Agaricus bisporus mushrooms显示文摘 | EMILIA B GRAZYNA J | 2015 | International Journal of Refrigeration2015，57，： | 1 |
| 7 | Temperament, relationships and young children's receptive cooperation with their parents显示文摘 | GRAZYNA KOCHANSKA NAZAN AKSAN JENNIFER J CARLSON | 2005 | Devdopmental Psychology2005，，41： | 1 |
| 8 | Thermal stability and flammability of styrene-butadiene rubber(SBR)composites显示文摘 | PRZEMYSLAW R GRAZYNA J MALGORZATA J | 2013 | Journal of Thermal Analysis and Calorimetry2013，113，： | 1 |
| 9 | Modification of plasma membrane and vacuolar H+-ATPases in response to NaCl and ABA显示文摘 | Malgorzata J R Grazyna K | 2007 | Journal of Plant Physiology2007，，164： | 1 |
| 10 | Biological mode of action of famoxadone on plasm opera viticola and phytophthora infestans显示文摘 | Nathalie A Grazyna J Jean-Luc G | 2001 | Crop Protection2001，20，： | 1 |
| 11 | Biological mode of action of famoxadone on plasmopara viticola and phytophthora infestans显示文摘 | A Nathalie J Grazyna G Jean-Luc | 2001 | Crop Protection2001，20，： | 1 |
| 12 | Effect of pore size distribution of coal-based activated carbons on double layer capacitance显示文摘 | GRAZYNA G MACHNIKOWSKI J LORENC-GRABOWSKA E | 2005 | Electrochimica Acta2005，50，： | 1 |
| 13 | Modification of plasma membrane and vacuolar H^+-ATPases in response to NaC1 and ABA显示文摘 | Malgorzata J R Grazyna K | 2007 | Journal of Plant Physiology2007，164，： | 1 |
| 14 | Role of uhrasonography in diagnosis and differentiation of pleomorphic Adenomas 显示文摘 | Ewa J Bialek Wieslaw Jakubowski Grazyna karpinska | 2003 | Arch Otolaryngol Head Neck Surg2003，129，： | 1 |
| 15 | Removal of cobalt ions from aqueous solutions by polymer assisted ultrafihration using experimental design approach, part 1:Optimization of complexation conditions 显示文摘 | Corneliu C Grazyna Z T Agnieszka J | 2009 | Journal of Hazardous Materials2009，169，123： | 1 |
| 16 | The effect of oral health education on dental plaque development and the level of caries-related Streptococcus mutans and Lactobacillus spp显示文摘 | GRAZYNA S S JOANNA J Z | 2007 | Eur J Orthedont2007，29，2： | 1 |
| 17 | Computational simulations of the hydrodynamic parameters of a trickle-bed reactor operating at periodically changing feeding the bed with liquid 显示文摘 | DANIEL J ANDRZEJ B GRAZYNA B | 2008 | Chemical and Process Engineering2008，，29： | 1 |
| 18 | 显示文摘 | Józef F Aleksander W | 2000 | Industrial Crops and Products2000，11，3： | 1 |
| 19 | Modification of plasma membrane and vacuolar H^+-ATPases in response to NaCl and ABA显示文摘 | Malgorzata J R Grazyna K | 2007 | Journal of Plant Physiology2007，164，： | 1 |
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