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| 1 | Denileukin diftitox for the treatment of steroid-resistant acute graft-versus-host disease 显示文摘 | Shaughnessy P J Bachier C Grimley M | 2005 | Biol Blood Marrow Transplant2005，11，3： | 1 |
| 2 | Thalidomide and low-dose dexamethasone in myeloma treatment 显示文摘 | MYERS B GRIMLEY C DOLAN G | 2001 | Br J Haematol2001，114，： | 1 |
| 3 | Tranexamic acid for intracerebral haemorrhage within 2 hours of onset: protocol of a phase Ⅱ randomised placebo-controlled double-blind multicentre trial显示文摘Rationale Haematoma growth is common early after intracerebral haemorrhage(ICH),and is a key determinant of outcome.Tranexamic acid,a widely available antifibrinolytic agent with an excellent safety profile,may reduce haematoma growth.Methods and design Stopping intracerebral haemorrhage with tranexamic acid for hyperacute onset presentation including mobile stroke units(STOP-MSU)is a phase Ⅱ double-blind,randomised,placebo-controlled,multicentre,international investigator-led clinical trial,conducted within the estimand statistical framework.Hypothesis In patients with spontaneous ICH,treatment with tranexamic acid within 2 hours of onset will reduce haematoma expansion compared with placebo.Sample size estimates A sample size of 180 patients(90 in each arm)would be required to detect an absolute difference in the primary outcome of 20%(placebo 39%vs treatment 19%)under a two-tailed significance level of 0.05.An adaptive sample size re-estimation based on the outcomes of 144 patients will allow a possible increase to a prespecified maximum of 326 patients.Intervention Participants will receive 1 g intravenous tranexamic acid over 10 min,followed by 1 g intravenous tranexamic acid over 8 hours;or matching placebo.Primary efficacy measure The primary efficacy measure is the proportion of patients with haematoma growth by 24±6 hours,defined as either≥33%relative increase or≥6 mL absolute increase in haematoma volume between baseline and follow-up CT scan.Discussion We describe the rationale and protocol of STOP-MSU,a phase Ⅱ trial of tranexamic acid in patients with ICH within 2 hours from onset,based in participating mobile stroke units and emergency departments. | Nawaf Yassi Henry Zhao Leonid Churilov Bruce C V Campbell Teddy Wu Henry Ma Andrew Cheung Timothy Kleinig Helen Brown Philip Choi Jiann-Shing Jeng Annemarei Ranta Hao-Kuang Wang Geoffrey C Cloud Rohan Grimley Darshan Shah Neil Spratt Der-Yang Cho Karim Mahawish Lauren Sanders John Worthington Ben Clissold Atte Meretoja Vignan Yogendrakumar Mai Duy Ton Duc Phuc Dang Nguyen Thai My Phuong Huy-Thang Nguyen Chung Y Hsu Gagan Sharma Peter J Mitchell Bernard Yan Mark W Parsons Christopher Levi Geoffrey A Donnan Stephen M Davis | 2022 | Stroke & Vascular Neurology2022，7，2： | 1 |
| 4 | Sensitivity analysis of parameters controlling oscillatory signaling in the NF-KB pathway: the roles of IKK and IKBet 显示文摘 | Ihekwaba A E C Broomhead D S Grimley R L | 2004 | IET Systems Biology2004，1，1： | 1 |
| 5 | Thalidomide and low-dose dexamethasone in myeloma treatment显示文摘 | Myers B Grimley C Doian G | 2001 | Br J Haematol2001，114，： | 1 |
| 6 | Thalidomide and low-dose dexamethasone in myeloma treatment显示文摘 | Myers B Grimley C Dolan G | 2001 | Br J Haematol2001，114，： | 1 |
| 7 | Denileukin diftitox for the treatment of steroid-resistant acute graft-versus-host disease显示文摘 | Shaughnessy PJ Bachier C Grimley M | 2005 | Biol Blood Marrow Transplant2005，11，3： | 1 |
| 8 | Sensitivity analysis of parameters controlling oscillatory signaling in the NF-κB pathway:the roles of IKK and IκBα 显示文摘 | IHEKWABA A E C BROOMHEAD D S GRIMLEY R L | 2004 | IEE Proe Systems Biology2004，1，1： | 1 |
| 9 | Sensitivity analysis of parameters controlling oscillatory signaling in the NF-kB pathway: the roles of IKK and IkBα 显示文摘 | Ihekwaba A E C Broomhead D S Grimley R L | 2004 | IEE Systems Biology2004，1，1： | 1 |
| 10 | A Mid-Late Quaternary loess-paleosol record in Simmons Farm in southern Illinois, USA显示文摘 | Wang H Lunstrom C C Zhang Z Grimley D Balsam W | 2009 | Quaternary Science Reviews2009，，： | 1 |
| 11 | Secondary Hemophagocytic Lymphohistiocytosis(HLH) From a Brown Recluse Spider Bite 显示文摘 | Dandoy C Grimley M | 2013 | Biol Blood MarrowTransplant2013，19，： | 1 |
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