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| 1 | Multidimensional clinical data denoising via Bayesian CP factorization显示文摘CANDECOMP/PARAFAC(CP) tensor factorization is an efficient technique for incomplete tensor-data processing through capturing the multilinear latent factors. Based on the incorporate a sparsity-inducing prior over multiple latent factors and appropriate hyper-priors over all hyper-parameters, a Bayesian-based hierarchical probabilistic CP factorization model could be formed. By this way, the rank of the incomplete tensor can be determined automatically. In this paper, we explored the tensor completion method in processing incomplete multidimensional electroencephalogram(EEG) and magnetic resonance imaging(MRI) clinical data. The empirical results indicated that the Bayesian CP tensor factorization of incomplete data method can effectively recover EEG signal with missing data and denoised the noisy MRI data. | CUI GaoChao ZHU Li GUI LiHua ZHAO QiBin ZHANG JianHai CAO JianTing | 2020 | Science China(Technological Sciences)2020，63，2： | 3 |
| 2 | Local injury to the endometrium improves the pregnancy rate in patients undergoing in vitro fertilization显示文摘 | Rong Li Yaoting Gui Lihua Lu | 2004 | International Congress Series2004，，1271： | 1 |
| 3 | Local injury to the endometrium improves the pregnancy rate in patients undergoing in vitro fertilization显示文摘 | Rong Li Yaoting Gui Lihua Lu | 2004 | International Congress Series2004，，1271： | 1 |
| 4 | Sulfation modification of dopamine in brain regulates aggregative behavior of animals显示文摘Behavioral plasticity and the underlying neuronal plasticity represent a fundamental capacity of animals to cope with environmental stimuli.Behavioral plasticity is controlled by complex molecular networks that act under different layers of regulation.While various molecules have been found to be involved in the regulation of plastic behaviors across species,less is known about how organisms orchestrate the activity of these molecules as part of a coherent behavioral response to varying environments.Here we discover a me chanism for the regulation of animal behavioral plasticity involving molecular sulfation in the brain,a modification of substrate molecules by sulfo transferase(ST)-catalyzed addition of a sulfonate group(SO_(3))from an obligate donor,3'-phosphoadenosine 5'-phosphosulfate(PAPS)to the substrates.We investigated aggregation behaviors of migratory locusts,which are well-known for extreme phase change plasticity triggered by population density.The processes of PAPS biosynthesis acted efficiently on induction of locust behavioral transition:Inhibition of PAPS synthesis solicited a behavioral shift from gregarious to solitarious states;external PAPS dosage,by contrast,promoted aggregation in solitarious locusts.Genetic or pharmacological intervention in the sulfation catalyzation resulted into pronounced solitarizing effects.Analysis of substrate-specific STs suggests a widespread involvement of sulfated neurotransmitters in the behavioral response.D opamine in the brain was finally identified to be actively sulfate conjugate d,and the sulfate conjugation enhanced the free DA-mediated behavioral aggregation.Similar results in Caenorhabditis elegans and mice indicate that sulfation may be involved more broadly in the modulation of animal aggregation.These findings reveal a general me chanism that effectively regulates animal social-like behavioral plasticity,possibly through sulfation-mediated modification of neural networks. | Bing Chen Xiwen Tong Xia Zhang Wanying Gui Guoming Ai Lihua Huang Ding Ding Jiangxu Zhang Le Kang | 2022 | National Science Review2022，9，4： | 0 |
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