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| 1 | Ascorbate antagonizes nickel ion to regulate JMJD1A expression in kidney cancer cells显示文摘histone demethylase Jumonji 包含域的蛋白质 1A (JMJD1A ) 的反常表示与许多种癌症被联系。JMJD1A 也是 hypoxic 反应基因,它的表示被组织缺氧可诱导的 factor-1 (HIF-1 ) 调整。在这研究,我们在开发和组织缺氧小径决定了 JMJD1A 的角色。我们也测量了 JMJD1A 和二组织缺氧因素葡萄糖 transporter 的表示 1 ( GLUT1 )并且在 786-0 和 HEK293 细胞的脉管的 endothelial 生长因素( VEGF )为 24 h 与 NiCl2 ( 2.5100 M )的不同集中对待,并且发现 JMJD1A mRNA 和蛋白质与 NiCl2 的增加的集中是起来调整的。我们然后观察到 ascorbate 能延迟以通过减少的一种剂量依赖者方式的导致 NiCl2 的 JMJD1A 表示的起来调整的效果 HIF-1 的稳定性蛋白质。Immunohistochemical 分析进一步证明 ascorbate 在 786-0, HEK293,和 OS-RC-2 房间反对了 JMJD1A 表示的导致 Ni2+ 的起来规定。这些调查结果建议 Ni2+ 和 ascorbate 能调整 histone demethylase JMJD1A 的表示,它为癌症开发或抑制是重要的。 | Xiaoqiang Guo Jingxiao Lu Yuejia Wang Yaoting Gui Xianglin Duan Zhiming Cai | 2012 | Acta Biochimica et Biophysica Sinica2012，44，4： | 5 |
| 2 | Regulation of histone demethylase KDM6B by hypoxia-inducible factor-2α显示文摘离氨酸(K) 特定的 demethylase 6B (KDM6B ) 是 histone H3K27 demethylase,它明确地催化 H3 lysine-27 tri/dimethylation (H3K27me3/2 ) 的 demethylation。KDM6B 能由支持与 RNA 聚合酶 II 和相关延伸因素被联系的 transcriptional 延伸激活基因抄写。KDM6B 因此为基因表示的规定是重要的。以前的研究显示了象 KDM3A, KDM4B,和 KDM4C 那样的几 histone demethylases 被组织缺氧可诱导的因素(HIF ) 调整。但是, KDM6B 上的组织缺氧的效果充分没被理解。在这研究,我们发现 KDM6B mRNA 和蛋白质的表示层次在组织缺氧下面是平常地起来调整的(1% O 2) 或模仿组织缺氧(desferrioxamine mesylate 或 CoCl 2 处理)(P < 0.05 ) 。RNAi 的结果证明 KDM6B 的起来规定依赖于 HIF-2,然而并非在 HIF-1 上。染色质 immunoprecipitation 试金的结果显示在 KDM6B 倡导者(4041 ~ 4037 ) 有一个组织缺氧反应元素。Co-IP 试金的结果显示 KDM6B 能与 HIF-2 或 HIF-1 形成建筑群。击倒的实验暗示 KDM6B 是为 HIF-2 目标基因的一个潜在的管理者。这些数据证明 KDM6B 是 HIF-2 调整的新组织缺氧反应基因。我们的结果也证明 KDM6B 是 HIF- 的潜在的激活剂,它为组织缺氧反应基因的激活是重要的。 | Xiaoqiang Guo Zha ntao Tian Xuliang Wang Shuhong Pan Weiren Huang Yongqing Shen Yaoting Gui Xianglin Duan Zhiming Cai | 2015 | Acta Biochimica et Biophysica Sinica2015，47，2： | 5 |
| 3 | Long intergenic non‐coding RNA TUG1 is overexpressed in urothelial carcinoma of the bladder显示文摘 | Yonghua Han Yuchen Liu Yaoting Gui Zhiming Cai | 2012 | J. Surg. Oncol2012，，： | 2 |
| 4 | Single-Cell Exome Sequencing Reveals Single-Nucleotide Mutation Characteristics of a Kidney Tumor显示文摘 | Xun Xu Yong Hou Xuyang Yin Li Bao Aifa Tang Luting Song Fuqiang Li Shirley Tsang Kui Wu Hanjie Wu Weiming He Liang Zeng Manjie Xing Renhua Wu Hui Jiang Xiao Liu Dandan Cao Guangwu Guo Xueda Hu Yaoting Gui Zesong Li Wenyue Xie Xiaojuan Sun Min Shi Zhiming | 2012 | Cell2012，，5： | 1 |
| 5 | Telomerase Reverse Transcriptase Gene Promoter Mutations Help Discern the Origin of Urogenital Tumors: A Genomic and Molecular Study显示文摘 | Song Wu Peide Huang Chong Li Yi Huang Xianxin Li Yongqiang Wang Chao Chen Zhaojie Lv Aifa Tang Xiaojuan Sun Jingxiao Lu Weiping Li Jie Zhou Yaoting Gui Fangjian Zhou Daping Wang Zhiming Cai | 2013 | European Urology2013，，： | 1 |
| 6 | Investigating urachal carcinoma for more than 15 years显示文摘 | Duqun Chen Yifan Li Zuhu Yu Zhengming Su Liangchao Ni Yaoting Gui Shangqi Yang Bentao Shi Yongqing Lai | 2014 | Oncology Letters2014，，5： | 1 |
| 7 | Local injury to the endometrium improves the pregnancy rate in patients undergoing in vitro fertilization显示文摘 | Rong Li Yaoting Gui Lihua Lu | 2004 | International Congress Series2004，，1271： | 1 |
| 8 | Local injury to the endometrium improves the pregnancy rate in patients undergoing in vitro fertilization显示文摘 | Rong Li Yaoting Gui Lihua Lu | 2004 | International Congress Series2004，，1271： | 1 |
| 9 | Long intergenic non‐coding RNA TUG1 is overexpressed in urothelial carcinoma of the bladder显示文摘 | Yonghua Han Yuchen Liu Yaoting Gui Zhiming Cai | 2012 | J Surg Oncol2012，，5： | 1 |
| 10 | Mutations of MSH5 in nonobstructive azoospermia(NOA)and rescued via in vivo gene editing显示文摘Dear Editor,Male infertility is a multifactorial heterogeneous pathological condition affecting∼7%of men.Nonobstructive azoospermia(NOA)is one of the most severe male reproductive diseases and occurs in∼1%of men of reproductive age.1 However,its etiology remains elusive. | Min Chen Chencheng Yao Yingying Qin Xiuhong Cui Peng Li Zhiyong Ji Limei Lin Haowei Wu Zhi Zhou Yaoting Gui Zheng Li Fei Gao | 2022 | Signal Transduction and Targeted Therapy2022，7，2： | 0 |
| 11 | Subelliptic Harmonic Maps with Values in Metric Spaces of Nonpositive Curvature显示文摘We prove the Holder continuity of a harmonic map from a domain of a sub-Riemannian manifold into a locally compact manifold with nonpositive curvature,and more generally into a non-positively curved metric space in the Alexandrov sense. | Yaoting Gui Jürgen Jost Xianqing Li-Jost | 2022 | Communications in Mathematical Research2022，38，4： | 0 |
| 12 | Evidence for GAL3ST4 mutation as the potential cause of Dectus excavatum显示文摘 | Song Wu Xiaojuan Sun Weimin Zhu Yi Huang Lisha Mou Mingming Liu Xia Li Feiyang Li Xianxin Li Yong Zhang Zheng Wang Wencui Li Zesong Li Aifa Tang Yaoting Gui Rongfu Wang Weiping Li Zhiming Cai Daping Wang | 2012 | Cell Research2012，22，12： | 0 |
| 13 | A Singular Moser-Trudinger Inequality on Metric Measure Space显示文摘Let(X,d,μ)be a metric space with a Borel-measureμ,supposeμsatisfies the Ahlfors-regular condition,i.e.birs≤μu(Br(x))≤b2rs,VBr(x)CX,r>0,where bi,b2 are two positive constants and s is the volume growth exponent.In this paper,we mainly study two things,one is to consider the best constant of the Moser-Trudinger inequality on such metric space under the condition that s is not less than 2.The other is to study the generalized Moser-Trudinger inequality with a singular Weight. | GUI Yaoting | 2022 | Journal of Partial Differential Equations2022，35，4： | 0 |
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