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| 1 | The reversal of antineoplastic drug resistance in cancer cells by B-elemene显示文摘Multidrug resistance(MDR), deined as the resistance of cancer cells to compounds with diverse structures and mechanisms of actions, signiicantly limits the eicacy of antitumor drugs. A major mechanism that mediates MDR in cancer is the overexpression of adenosine triphosphate(ATP)?binding cassette transporters. These transporters bind to their respective substrates and catalyze their elux from cancer cells, thereby lowering the intracellular concentra?tions of the substrates and thus attenuating or even abolishing their eicacy. In addition, cancer cells can become resistant to drugs via mechanisms that attenuate apoptosis and cell cycle arrest such as alterations in the p53, check point kinase, nuclear factor kappa B, and the p38 mitogen?activated protein kinase pathway. In this review, we discuss the mechanisms by which β?elemene, a compound extracted from Rhizoma zedoariae that has clinical antitumor eicacy, overcomes drug resistance in cancer. | Guan-Nan Zhang Charles R.Ashby Jr. Yun-Kai Zhang Zhe-Sheng Chen Huiqin Guo | 2015 | Chinese Journal of Cancer2015，34，11： | 9 |
| 2 | Rice OsFLS2-Mediated Perception of Bacterial Flagellins Is Evaded by Xanthomonas oryzae pvs. oryzae and oryzicola显示文摘细菌的 flagellins 被受体 kinase FLAGELLIN SENSITIVE2 (FLS2 ) 经常认出并且在双子叶的植物激活被触发 MAMP 的免疫。然而,单子叶植物的米饭的能力理解糟糕认出关键米饭病原体和它的生物关联遗体的 flagellins。我们证明在 Arabidopsis 的宫外地表示的 OsFLS2 察觉到得到的 flg22 肽和 invitro 净化了 Acidovorax avenae (Aa ) 以一种表示水平依赖者方式的 flagellin,但是不认出净化的 flagellins 或衍生物 flg22 Xanthomonas oryzae pvs 的 Xo 肽。oryzae (Xoo ) 和 oryzicola (Xoc ) 。一致地, flg22 肽和净化的 Aa flagellin,然而并非 Xoo/Xoc flagellins,在米饭导致象防卫基因正式就职和 MAPK 激活那样的各种各样的有免疫力的回答。由米饭的 flagellin 的感觉确实导致强壮的抵抗到 Xoo 感染,在米饭的预告的处理与 Aa flagellin 离开以后,出现。OsFLS2 被发现在它的感觉特性或敏感不同于 AtFLS2 到不同 flg22 序列。另外, Xoc flagellin 的 translational 以后修正被编码 glycosyltransferase rbfC,而是这有的小效果的删除在 Xoc 活动性上改变, rpfC 变化 detectably 没在米饭上减少 Xoc 毒力。从 Xoo/Xoc 的编码 flagellin 警察的删除堵住了游泳活动性而且显著地没改变 Xoo/Xoc 毒力。当在米饭躲避古老的 flagellin 察觉系统时,这些结果建议 Xoo/Xoc 带允许活动性的 flg22 区域氨基酸变化,它为另外的细菌的病原体保留识别能力。 | Shanzhi Wang Zhe Sun Huiqin Wang Lijuan Liu Fen Lu Jun Yang Min Zhang Shiyong Zhang Zejian Guo Andrew F. Bent Wenxian Sun | 2015 | Molecular Plant2015，8，7： | 7 |
| 3 | Hypothesis review:The direct interaction of food nanoparticles with the lymphatic system显示文摘Besides digestion and assimilation,there are other modes of direct interaction between food and human body.As it is known,the mucosal layer of the digestive tract interfaces with food after the digestion process.It has been demonstrated to uptake the micro-and nanoparticles via mucosa-associated lymphatic tissues(MALT).On the other hand,food is a typical polydisperse system and contains micro-and nanoparticles with different sizes and properties.Accordingly,it is hypothesized that food nanoparticles can directly interact with MALT and more specifically with the support of the preliminary experimental data from our research,that antioxidant nanoparticles can interact with the lymphatic vessels.This kind of interaction would be of great physiological importance.The confirmation of the hypothesis will establish a significant and novel approach to understand food system and provide answers to currently incomprehensible phenomena such as the biological functions of phytochemicals with low bioavailability.©2012 Production and hosting by Elsevier B.V.on behalf of Beijing Academy of Food Sciences. | Wei Lu Jingke Guo Jianwu Zhou Lijing Ke Shutao Liu Guanzhen Gao Huiqin Wang Wei Ding Pingfan Rao | 2012 | Food Science and Human Wellness2012，1，1： | 5 |
| 4 | The ieasibility of enhanced soil washing ofp-nitrochlorobenzene(pNCB)with SDBS/Tween80 mixed surfactants显示文摘 | GUO Huiqin LIU Zhenyu YANG Shaogui | 2009 | Journal of Hazardous Materials2009，170，23： | 1 |
| 5 | Preliminary Investigation of the Clinical Significance of Detecting Circulating Tumor Cells Enriched from Lung Cancer Patients显示文摘 | Chi Wu Huaijie Hao Longyun Li Xiaoyun Zhou Zijian Guo Li Zhang Xiaotong Zhang Wei Zhong Huiqin Guo Ross Macrae Bremner Ping Lin | 2009 | Journal of Thoracic Oncology2009，，1： | 1 |
| 6 | A fluorimetric method for the determination of trace pentachlorophenol, based on its inhibitory effect on the redox reaction between the improved Fenton reagent and rhodamine B 显示文摘 | GUO HUIQIN FAN JING GUO YANHUI | 2007 | Luminescence2007，22，： | 1 |
| 7 | Screening for NDP Mutations in 44 Unrelated Patients with Familial Exudative Vitreoretinopathy or Norrie Disease显示文摘 | Huiqin Yang Shiqiang Li Xueshan Xiao Xiangming Guo Qingjiong Zhang | 2012 | Current Eye Research2012，，8： | 1 |
| 8 | Simple and sensitive fluorimetric method for determination of environmental hormone bisphenol A based on its inhibitory effect on the redox reaction between peroxyl radical and rhodamine 6G 显示文摘 | Fan Jing Guo Huiqin Liu Guoguang | 2007 | Analytiea Chimiea Aeta2007，585，1： | 1 |
| 9 | One-step fabrication of mesoporous sulfur-doped carbon nitride for highly selective photocatalytic transformation of native lignin to monophenolic compounds显示文摘Photocatalytic selective transform native lignin into valuable chemicals is an attractive but challenging task.Herein,we report a mesoporous sulfur-doped carbon nitride(MSCN-0.5)which is prepared by a facile one-step thermal condensation strategy.It is highly active and selective for the cleavage Cα-Cβbond inβ-O-4 lignin model compound under visible light radiation at room temperature,achieving 99%substrate conversion and 98%Cα-Cβbond cleavage selectivity.Mechanistic studies revealed that the Cβ-H bond of lignin model compounds activated by holes and generate key Cβradical intermediates,further induced the Cα-Cβbond cleavage by superoxide anion radicals(·O2-)to produce aromatic oxygenates.Waste Camellia oleifera shell(WCOS)was taken as a representative to further understand the reaction mechanisms on native lignin.33.2 mg of monophenolic compounds(Vanillin accounted for 22%and Syringaldehyde for 34%)can be obtained by each gram of WCOS lignin,which is 2.5 times as that of the pristine carbon nitride.The present work offers useful guidance for designing metal-free heterogeneous photocatalysts for Cα-Cβbond cleavage to harvest monophenolic compounds. | Conghao Ku Huiqin Guo Kexin Li Qiong Wu Liushui Yan | 2023 | Chinese Chemical Letters2023，34，1： | 1 |
| 10 | CONTROLLED HOT FORMING OF RETAINING RING OF GENERATOR显示文摘0INTRODUCTIONMostoftheretainingringsofgeneratorarecurentlymadeofthesteelof50Mn18Cr4orMn18Cr18N.Itbecomesadificultyinthemanufa... | Zhang Qiaoli Chen Huiqin Guo Huiguang Taiyuan Heavy Machinery Institute Guo Yajun Taiyuan Orient Three Stars New Technology Co. Ltd. | 1999 | Chinese Journal of Mechanical Engineering1999，12，2： | 1 |
| 11 | Akt1/protein Kinase Bα is Involved in Gastric Cancer Progression and Cell Proliferation显示文摘 | Zheyi Han Kaichun Wu Huiqin Shen Chunying Li Shuang Han Liu Hong Yongquan Shi Na Liu Changcun Guo Yan Xue Taidong Qiao Daiming Fan | 2008 | Digestive Diseases and Sciences2008，，7： | 1 |
| 12 | Effect of space flight factors on alfalfa seeds显示文摘 | Ren Weibo Zhang Yunwei Deng Bo Guo Huiqin Chen Li- bo Liu Yaxue | 2010 | African Journal of Biotechnology2010，9，43： | 1 |
| 13 | Preliminary Investigation of the Clinical Significance of Detecting Circulating Tumor Cells Enriched from Lung Cancer Patients显示文摘 | Chi Wu Huaijie Hao Longyun Li Xiaoyun Zhou Zijian Guo Li Zhang Xiaotong Zhang Wei Zhong Huiqin Guo Ross Macrae Bremner Ping Lin | 2009 | Journal of Thoracic Oncology2009，，1： | 1 |
| 14 | Simple and sensitive fluorimetric method for determination of environmental hormone bisphenol A based on its inhibitory effect on the redox reaction between peroxyl radical and rhodamine 6G显示文摘 | Jing Fan Huiqin Guo Guoguang Liu | 2007 | Analytica Chimica Acta2007，，585： | 1 |
| 15 | Sorption and cosorption of the nonionic herbicide mefenacet and heavy metals on soil and its components显示文摘Sorption and cosorption of the nonionic herbicide mefenacet and two typical metals (copper and silver) on black soil and its components (kaolinite and humic acid) were investigated. It was found that because of their different valences and properties, Cu2+and Ag+ presented different effects on the sorption of mefenacet. Due to the competition of Cu2+, along with the shells of dense water formed by its surface complexation, for sorption surface area with mefenacet, the addition of Cu2+ decreased the sorption amount of mefenacet on soil and its components, especially on humic acid. However, the addition of Ag+ significantly enhanced the sorption of mefenacet, which was attributed to the softness of the cation that weakened the hydrophilicity of the local region around Ag+-complexed functionalities, and thus mitigated the competitive sorption of water. In addition, the sorption of mefenacet on soil with or without the two metals was generally decreased with increasing pH, which was caused by the hydrolysis of carbonyl and carboxyl groups on the surface of the sorbents, π-π interaction between mefenacet and the soil organic matter, and so on. On the other hand, the presence of mefenacet seemed to have little effect on the sorption of Cu2+ and Ag+, indicating that Cu2+ and Ag+ might be sorbed strongly on the tested sorbents and the mefenacet added was too low in concentration to affect the sorption of the metals. | Zhenyu Liu Huiqin Guo Huan He Cheng Sun | 2012 | Journal of Environmental Sciences2012，24，3： | 1 |
| 16 | Identification of the sensitive area for targeted observation to improve vertical thermal structure prediction in summer in the Yellow Sea显示文摘The sensitive area of targeted observations for short-term(7 d)prediction of vertical thermal structure(VTS)in summer in the Yellow Sea was investigated.We applied the Conditional Nonlinear Optimal Perturbation(CNOP)method and an adjoint-free algorithm with the Regional Ocean Modeling System(ROMS).We used vertical integration of CNOP-type temperature errors to locate the sensitive areas,where reduction of initial errors is expected to yield the greatest improvement in VTS prediction for the selected verification area.The identified sensitive areas were northeast−southwest orientated northeast to the verification area,which were possibly related to the southwestward background currents.Then,we performed a series of sensitivity experiments to evaluate the effectiveness of the identified sensitive areas.Results show that initial errors in the identified sensitive areas had the greatest negative effect on VTS prediction in the verification area compared to errors in other areas(e.g.,the verification area and areas to its east and northeast).Moreover,removal of initial errors through deploying simulated observations in the identified sensitive areas led to more refined prediction than correction of initial conditions in the verification area itself.Our results suggest that implementation of targeted observation in the CNOP-based sensitive areas is an effective method to improve short-term prediction of VTS in summer in the Yellow Sea. | Huiqin Hu Jingyi Liu Lianglong Da Wuhong Guo Kun Liu Baolong Cui | 2021 | Acta Oceanologica Sinica2021，40，7： | 1 |
| 17 | Lung Cancer Survival Improvement through Surgical Intervention in PUMCH Hospital显示文摘客观:在最后 15 年期间在 PUMC 医院里在外科的干预以后调查并且评估肺癌症幸存的改进。方法:从 1989 年 1 月到 2003 年 12 月, 1574 个肺癌症案例经历了外科疗法并且列在后面起来。在这个系列的所有情况根据时间时期被划分成二个组:组织 A (1999-2003 ) 并且组织 B (1989-1998 ) 。在幸存的差别在组 A 之间评价, B 被比较。结果:在组 A 的 Themorbidity 和死亡与组 B 相比显著地被减少(11.2%vs.19.2% , 1.06% 对 1.93% ,分别地) 。然而, 3 年、 5 年的幸存率分别地从 42.35% ~ 56.07% ,并且从 28.46% ~ 38.99% 被增加。在幸存的重要改进也与阶段Ⅲ B 和Ⅳ与阶段Ⅰ,Ⅱ和Ⅲ A 在病人,然而并非在那些被观察,有叶切除术的病人比那些收到的 exploratorythoracotomy,有限切除术,肺切除术和袖口式切除术有更令人满意的结果。结论:叶切除术正系统的纵隔淋巴节点解剖为将切除成为了标准模式有能力的肺癌症。与淋巴一起的完全的切除术的联合节的解剖,和手术后的辅助化疗基于 platinum/3rd 产生化疗药, preliminarily 被认为正当,在长期的幸存为有效改进证明一条重要途径 ofnon 小的房间肺癌。 | GUO Feng ZHANG Zhiyong CUI Yushang LI Shanqing LI Li XU Xiaohui GE Feng GUO Huiqin LI Zejian | 2006 | The Chinese-German Journal of Clinical Oncology2006，5，4： | 1 |
| 18 | Synthesis of three types of amphiphilic poly(sebacic anhydride)-poly (ethylene glycol) block copolymers and studies on their micellar solutions 显示文摘 | ZHANG Na GUO Shengrong LI Huiqin | 2006 | Macromolecular chemistry and physics2006，207，： | 1 |
| 19 | Resonance Rayleigh scattering spectral method for determination of urinary 8-hydroxy- 2'-deoxyguanosine using gold nanoparticles as probe显示文摘 | GUO Huiqin XUE Kunpeng YAN Liushui | 2012 | Sensors and Actuators B: Chemical2012，171，： | 1 |
| 20 | Risk factors and clinical outcomes of incomplete endoscopic resection of small rectal neuroendocrine tumors in southern China:a 9-year data analysis显示文摘Background:The histologically complete resection(CR)rate of small rectal neuroendocrine tumors(RNETs)is unsatisfactory at the first endoscopy.Risk factors and clinical outcomes associated with incomplete resection(IR)have not been explicitly elucidated.This study aims to explore the relevant factors of IR.Methods:This retrospective study reviewed patients with small RNETs(10mm)in eight centers from January 2013 to December 2021.Clinicopathological characteristics and clinical outcomes were compared between the CR and IR groups,and the polypectomy and advanced treatment groups.Results:Of the 326 patients included,83(25.5%)were diagnosed with IR.Polypectomy(odds ratio[OR]=16.86),a central depression(OR=7.50),and treatment in the early period(OR=2.60)were closely associated with IR.Further analysis revealed that an atypical hyperemic appearance(OR=7.49)and treatment in the early period(OR=2.54)were significantly associated with the inappropriate use of polypectomy(both P<0.05).In addition,a total of 265(81.3%)were followed up with a median follow-up period of 30.9 months.No death,metastasis,or recurrence was found during the follow-up period.Conclusions:Polypectomy,a central depression,and treatment in the early period were risk factors for IR.Further,an atypical hyperemic appearance and treatment in the early period were significant predisposing factors for inappropriate choice of polypectomy.For histologically incompletely resected small RNETs,follow-up may be a safe and feasible alternative to rigorous salvage therapy. | Xiaoduan Zhuang Shaoheng Zhang Guiquan Chen Zongqi Luo Huiqin Hu Wenfeng Huang Yu Guo Yongwen Ouyang Liang Peng Qing Qing Huiting Chen Bingsheng Li Jie Chen Xinying Wang | 2023 | Gastroenterology Report2023，11，1： | 0 |
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