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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | The dielectrie properties of biological tissues:I Literature survey显示文摘 | GABRIEL C GABRIEL S CORTHOUT E | 1996 | Physics in Medicine and Biology1996，41，11： | 1 |
| 3 | Distribution of in situ forces in the anterior cruciate ligament in response to rotatory loads 显示文摘 | Gabriel M T Wong E K Woo S L Y | 2004 | Journal of Orthopaedics Research2004，22，1： | 1 |
| 4 | Synthesis and light gas separations in cross-linked Gemini room tempertature ionic liquid polymer membranes 显示文摘 | Bara J E Hatakeyama E S Gabriel C J | 2008 | J Membrane Science2008，316，12： | 1 |
| 5 | A functional cloning strategy, based on a binary PVX-expression vector, to isolate HR-inducing cDNAs of plant pathogens 显示文摘 | Takken F L W Luderer R Gabriels S H E J | 2000 | The Plant Journal2000，24，2： | 1 |
| 6 | Development of reduced kidney function in rheumatoid arthritis显示文摘 | Hickson L J Crowson C S Gabriel S E | 2014 | Am J Kidney Dis2014，63，2： | 1 |
| 7 | Dielectric parameters relevant to microwave dielectric heating显示文摘 | GABRIEL C GABRIEL S BRANT E H | 1998 | Chemical Society Review1998，27，： | 1 |
| 8 | Renal impairment and heart failure with preserved ejection fraction early post-myocardial infarction显示文摘AIM:To study if impaired renal function is associated with increased risk of peri-infarct heart failure (HF) in patients with preserved ejection fraction (EF).METHODS:Patients with occluded infarct-related arteries (IRAs) between 1 to 28 d after myocardial infarction (MI) were grouped into chronic kidney disease (CKD) stages based on estimated glomerular filtration rate (eGFR).Rates of early post-MI HF were compared among eGFR groups.Logistic regression was used to explore independent predictors of HF.RESULTS:Reduced eGFR was present in 71.1% of 2160 patients,with significant renal impairment (eGFR < 60 mL/min every 1.73 m2) in 14.8%.The prevalence of HF was higher with worsening renal function:15.5%,17.8% and 29.4% in patients with CKD stages 1,2 and 3 or 4,respectively (P < 0.0001),despite a small absolute difference in mean EF across eGFR groups:48.2 ± 10.0,47.9 ± 11.3 and 46.2 ± 12.1,respectively (P=0.02).The prevalence of HF was again higher with worsening renal function among patients with preserved EF:10.1%,13.6% and 23.6% (P < 0.0001),but this relationship was not significant among patients with depressed EF:27.1%,26.2% and 37.9% (P= 0.071).Moreover,eGFR was an independent correlate of HF in patients with preserved EF (P=0.003) but not in patients with depressed EF (P=0.181).CONCLUSION:A significant proportion of post-MI patients with occluded IRAs have impaired renal function.Impaired renal function was associated with an increased rate of early post-MI HF,the association being strongest in patients with preserved EF.These findings have implications for management of peri-infarct HF. | Vinod Jorapur Gervasio A Lamas Zygmunt P Sadowski Harmony R Reynolds Antonio C Carvalho Christopher E Buller James M Rankin Jean Renkin Philippe Gabriel Steg Harvey D White Carlos Vozzi Eduardo Balcells Michael Ragosta C Edwin Martin Vankeepuram S Srinivas William W Wharton III Staci Abramsky Ana C Mon Shari S Kronsberg Judith S Hochman | 2010 | World Journal of Cardiology2010，2，1： | 1 |
| 9 | IL-15 triggers an antiapoptotic pathway in human intraepithelial lymphocytes that is a potential new target in celiac disease-associated inflammation and lymphomagenesis显示文摘 | Malamut Georgia El Machhour Raja Montcuquet Nicolas Martin-Lannerée Séverine Dusanter-Fourt Isabelle Verkarre Virginie Mention Jean-Jacques Rahmi Gabriel Kiyono Hiroshi Butz Eric A Brousse Nicole Cellier Christophe Cerf-Bensussan Nadine Meres | 2010 | Journal of Clinical Investigation2010，，6： | 1 |
| 10 | Epidemiological studies in incidence,prevalence,mortality,and comorbidity of the rheumatic diseases显示文摘 | Gabriel S E Michaud K | 2009 | Arthritis Res Ther2009，11，3： | 1 |
| 11 | Explorato- ry ananlysis of seeding effects on rainfall: Illinois 1989 显示文摘 | Changnon S A Gabriel K R W estcott N E | 1995 | Appl Meteor1995，34，： | 1 |
| 12 | Electrophy siologic abnormalities of the hippocampus in the pilocarpine/cycloheximide model of chronic spontaneous seizures显示文摘 | Longo B M Sanabria E R Gabriel S | 2002 | J Epilepsia2002，43，5： | 1 |
| 13 | Die- lectric parameters relevant to microwave dielectric heating 显示文摘 | GABRIEL C GABRIEL S GRANT E H | 1998 | Chem Soc Rev1998，27，3： | 1 |
| 14 | Direct medical costs attributable to osteoporotic fractures显示文摘 | GABRIEL S E TOSTESON A N LEIBSON C L | 2002 | Osteoporos Int2002，13，4： | 1 |
| 15 | Distribution of in situ forces in the anterior cruciate ligament in response to rotatory loads 显示文摘 | Gabriel M Wong E Woo S L | 2004 | Orthopaedic Research2004，22，： | 1 |
| 16 | Assessing the total cost of management of a patient with deep vein thrombosis (DVT) in France and Italy显示文摘 | Levy E Gabriel S Dinet J | 2001 | Value Health2001，4，2： | 1 |
| 17 | The dielectric properties of biological tissues: Ⅰ Literature survey显示文摘 | GABRIEL C GABRIEL S CORTHOUT E | 1996 | Phys Med Biol1996，41，11： | 1 |
| 18 | Differentiation and selection ofhepatocyte precursors in suspension spheroid culture of transgenic murine embryonic stem cells显示文摘 | Gabriel E Schievenbusch S Kolossov E | 2012 | PLoS One2012，7，44： | 1 |
| 19 | Pulse wave velocity and vascular calcification at different stages of chronic kidney disease显示文摘 | Mohamed Temmar Sophie Liabeuf Cédric Renard Sébastien Czernichow Najeh El Esper Irina Shahapuni Claire Presne Raifah Makdassi Michel Andrejak Christophe Tribouilloy Pilar Galan Michel E Safar Gabriel Choukroun Ziad Massy | 2010 | Journal of Hypertension2010，，1： | 1 |
| 20 | Dielectric parameters relevant to microwave dielectric heating显示文摘 | Gabriel C Gabriel S Brant E H | 1998 | Chemical Society Review1998，27，： | 1 |
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