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| 1 | Use of a disposable circumcision suture device versus conventional circumcision: a systematic review and meta-analysis显示文摘这系统的评论在冗余的包皮和 phimosis 的治疗估计了可处理的割礼缝术设备(DCSD ) 和常规割礼(CC ) 的安全和功效。二个独立评论家在中国和国外为冗余的包皮或 phimosis 的处理用 DCSD 和 CC 为使随机化的控制试用(RCT ) 进行了文学搜索。九 RCT (1898 个盒子) 被包括。与 CC 组相比, DCSD 组有一更短的起作用的时间(标准化吝啬的差别[SMD ]= 21.44;95% 信心间隔[95% CI ][25.08, 17.79 ] ;P < 0.00001 ) ,更短的创伤愈合时间(SMD = 3.66;95% CI [5.46, 1.85 ] ;P < 0.0001 ) ,更少的 intraoperative 血损失(SMD = 9.64;95% CI [11.37, 7.90 ] ;P < 0.00001 ) ,更好化妆的阴茎外观(机会比率[或]=8.77;95% CI [5.90, 13.02 ] ;P < 0.00001 ) ,更低的 intraoperative 疼痛分数,更低的 24-h 手术后的疼痛分数,感染的更低的发生,更少的切口浮肿,和更少不利事件。在裂开,或 hematoma 的发生的 CC 和 DCSD 组之间没有差别。这元分析的结果显示 DCSD 看起来比 CC 更安全、更有效。然而,有更大的学习人口的另外的高质量的 RCT 被需要。 | Zhong-Chao Huo Gang Liu Xiao-Yan Li Fei Liu Wen-Ju Fan Ru-Hua Guan Pei-Feng Li De-Yang Mo Yong-Zhi He | 2017 | Asian Journal of Andrology2017，19，3： | 19 |
| 2 | Staged carotid artery angioplasty and stenting for patients with high-grade carotid stenosis with high risk of developing hyperperfusion injury:a retrospective analysis of 44 cases显示文摘Background:Hyperperfusion syndrome(HPS)is a rare but potentially a life-threatening complication after carotid artery angioplasty and stenting(CAS).Staged CAS has been an alternative to prevent HPS.Materials and methods:44 of 908 patients with high-grade internal carotid artery stenosis or near occlusion were at risk of HPS because of poor collateral flow and impaired cerebral blood flow(CBF).They were treated with first(stage 1),followed by a full CAS(stage 2)1 month later.Their 30-day outcomes were tabulated and analysed.Results:During follow-up,1 of the 44(2.2%)patients developed HPS immediately,3(7%)had postprocedural HPS(ie,transcranial Doppler(TCD)>120%)without clinical symptoms and 3(7%)required stenting at stage 1 for carotid dissections.After stage 1,there were significant improvement between the preprocedural and postprocedural CBF(0.98±0.06 vs 0.85±0.05,p<0.05),mean transit time(MTT;1.05±0.05 vs 1.15±0.05,p<0.05),time to peak(TTP;1.04±0.06 vs 1.20±0.06,p<0.05)on CT perfusion(CTP),and CBF(66.41±7.41 vs 44.44±6.43,p<0.05)on TCD.After stage 2,improvement was seen in CBF(1.01±0.07 vs 0.98±0.06,p<0.05),MTT(1.01±0.05 vs 1.05±0.05,p<0.05),TTP(0.99±0.06 vs 1.04±0.06,p<0.05)on CTP and CBF(66.41±7.41 vs 93.78±18.81,p<0.05)on TCD.2 had postoperative increase of middle cerebral artery mean flow velocity of 120%after stage 2 without clinical symptoms.Conclusion:Staged carotid artery stenting probably decreased the chance of developing HPS in this group of selected patients.Although requiring a 2-step intervention,staged CAS may be a safe and effective alternative. | Dapeng Mo Gang Luo Bo Wang Ning Ma Feng Gao Xuan Sun Xiaotong Xu Zhongrong Miao | 2016 | Stroke & Vascular Neurology2016，1，4： | 14 |
| 3 | Roles of dietary supplementation with arginine or N-carbamylglutamate in modulating the inflammation, antioxidant property, and m RNA expression of antioxidant-relative signaling molecules in the spleen of rats under oxidative stress显示文摘This study evaluated the effects of arginine(Arg) or N-carbamylglutamate(NCG) on inflammation, antioxidant property, and antioxidant-related gene expression in rat spleen under oxidative stress. A total of 52 rats were randomly distributed into 4 treatment groups with 13 replicates per group. Rats were fed a basal diet(BD) or BD supplemented with Arg or NCG for 30 days. On day 28, half of the BD-fed rats were intraperitoneally injected with sterile saline(control group), and the other half with 12 mg/kg body weight of diquat(DT; DT group). The other 2 diet groups were intraperitoneally injected with 12 mg/kg body weight of DT with either Arg(1%)(DT t Arg) or NCG(0.1%)(DT t NCG). Rat spleen samples were collected for analysis at 48 h after DT injection. Results showed that DT damaged the antioxidant defense in rats compared with the control group(P < 0.05). Compared with the DT group, the DT t Arg and DT t NCG groups manifested improved anti-hydroxyl radical, catalase, and total superoxide dismutase(T-SOD) activities, increased glutathione content(P < 0.05), and decreased malondialdehyde content(P < 0.05).Moreover, compared with the DT group, the DT t Arg and DT t NCG groups enhanced mRNA expression of superoxide dismutase(SOD), glutathione peroxidase 1(GPx1), glutathione reductase(GR), nuclear factor erythroid 2-related factor 2(Nrf2), Kelch-like ECH-associated protein 1(Keap-1), and mammalian target of rapamycin(m TOR)(P < 0.05). Both NCG and Arg significantly increased anti-inflammatory cytokine mRNA level but suppressed the pro-inflammatory cytokine mRNA expression under oxidative stress(P < 0.05). In summary, NCG and Arg effectively alleviated oxidative stress, improved the antioxidant capacity and regulated the antioxidant-related signaling molecular expression in rat spleen. N-carbamylglutamate and Arg reduced the inflammation in the spleen by mediating the gene expression of anti-inflammatory and pro-inflammatory cytokines and transforming growth factor-β(TGF-β). | Weiwei Mo Xianjian Wu Gang Jia Hua Zhao Xiaoling Chen Jiayong Tang Caimei Wu Jingyi Cai Gang Tian Jing Wang Gangmang Liu | 2018 | Animal Nutrition2018，，3： | 9 |
| 4 | 禽腺病毒4型(FAdV-4)分离株对鸡的致病力及其基因组分析(英文)显示文摘目的:了解禽腺病毒4型(FAd V-4)分离株在口服、滴鼻点眼和肌注三种感染途径下对7~35日龄鸡的致病性,并分析该分离株与其他参考毒株在基因组水平上的差异。创新点:用原代鸡胚肾细胞(CEK)成功培养了FAd V-4分离株。发现除了常用的口服和肌注途径,FAd V-4也可通过滴鼻点眼接种途径感染7、21和35日龄鸡。肌注方法最为敏感,导致感染鸡100%死亡;35日龄鸡较7和21日龄鸡表现出更明显的临床症状和剖检病变。方法:通过口服、滴鼻点眼和肌注三种途径将FAd V-4分离株的CEK细胞培养物接种7~35日龄的无特定病原体(SPF)鸡。通过临床症状观察、排毒检测、病理解剖、免疫组化和组织中毒载量测定来判断分离株的致病性及病毒在组织脏器中的分布情况。通过病毒中和试验检测感染存活鸡的血清中和抗体。通过全基因组测序分析,比较FAd V-4分离株与国内外参考毒株的基因组序列差异。结论:本研究分离鉴定的FAd V-4分离株SD1511可以在CEK细胞上适应,并可以通过口服、滴鼻点眼和肌注三种感染途径引起7~35日龄的SPF鸡50%~100%的死亡,其中肌注最为敏感,死亡率达100%。感染鸡持续排毒至感染后的40天,产生具有明显中和作用的中和抗体。全基因组测序分析结果显示,SD1511基因组与最近国内分离的FAd V-4具有很高的同源性,但与国外的分离株有明显的差异。 | Kai-kun MO Chen-fei LYU Shang-shang CAO Xia LI Gang XING Yan YAN Xiao-juan ZHENG Min LIAO Ji-yong ZHOU | 2019 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2019，20，9： | 9 |
| 5 | The role of climate factors in geographic variation in body mass and wing length in a passerine bird显示文摘Background: Geographic variation in body size is assumed to reflect adaptation to local environmental conditions. Although Bergmann's rule is usually sufficient to explain such variation in homeotherms, some exceptions have been documented. The relationship between altitude, latitude and body size, has been well documented for some vertebrate taxa during the past decades. However, relatively little information is available on the effects of climate variables on body size in birds.Methods: We collected the data of 267 adult Eurasian Tree Sparrow(Passer montanus) specimens sampled at 48 localities in China's mainland, and further investigated the relationships between two response variables, body mass and wing length, as well as a suit of explanatory variables, i.e. altitude, latitude, mean annual temperature(MAT), annual precipitation(PRC), annual sunshine hours(SUN), average annual wind speed(WS), air pressure(AP) and relative humidity(RH).Results: Our study showed that(1) although the sexes did not differ significantly in body mass, males had longer wings than females;(2) body mass and wing length were positively correlated with altitude but not with latitude;(3) body mass and wing length were negatively correlated with AP and RH, but not significantly correlated with WS. Body mass was positively correlated with SUN and inversely correlated with MAT. Wing length was not correlated with MAT in either sex, but was positively correlated with SUN and negatively correlated with PRC in male sparrows;(4) variation in body mass could be best explained by AP and SUN, whereas variation in wing length could be explained by RH and AP in both sexes. In addition, variation in male sparrows can be explained by SUN, WS and PRC but not in females.Conclusions: Two different proxies of body size, body mass and wing length, correlated with same geographic factors and different climate factors. These differences may reflect selection for heat conservation in the case of body mass, and for efficient flight in the case of wing length. | Yanfeng Sun Mo Li Gang Song Fumin Lei Dongming Li Yuefeng Wu | 2017 | Chinese Birds2017，，1： | 7 |
| 6 | Appropriately adapted properties of hot-extruded Zn-0.5Cu-xFe alloys aimed for biodegradable guided bone regeneration membrane application显示文摘Appropriately adapted comprehensive mechanical properties,degradation behavior and biocompatibility are prerequisites for the application of Zn-based biodegradable implants.In this study,hot-extruded Zn-0.5Cu-xFe(x=0.1,0.2 and 0.4 wt%)alloys were fabricated as candidates for biodegradable materials for guided bone regeneration(GBR)membranes.The hot-extrusion process and Cu alloying were expected mostly to enhance the mechanical properties,and the Fe alloying was added mainly for regulating the degradation.The microstructure,mechanical properties and in vitro degradation behavior were systematically investigated.The ZnCuFe alloys were composed of a Zn matrix and FeZn13 phase.With increasing Fe content,a higher FeZn13 phase precipitation with larger particles was observed.Since elongation declined significantly until fracture with increasing Fe content up to 0.4 wt%,the ZnCuFe(0.2 wt%)alloy achieved a good balance between mechanical strength and ductility,with an ultimate tensile strength of 202.3 MPa and elongation at fracture of 41.2%.Moreover,the addition of Fe successfully accelerated the degradation of ZnCuFe alloys.The ZnCuFe(0.2 wt%)alloy showed relatively uniform corrosion in the long-term degradation test.Furthermore,extracts of the ZnCuFe(0.2 wt%)alloy showed no apparent cytotoxic effects against L929 fibroblasts,Saos-2 osteoblasts or TAg periosteal cells.The ZnCuFe(0.2 wt%)alloy exhibited the potential to inhibit bacterial adhesion of Streptococcus gordonii and mixed oral bacteria.Our study provides evidence that the ZnCuFe(0.2 wt%)alloy can represent a promising material for the application as a suitable GBR membrane. | Wentai Zhang Ping Li Gang Shen Xiaoshan Mo Chao Zhou Dorothea Alexander Frank Rupp Jürgen Geis-Gerstorfer Haijun Zhang Guojiang Wan | 2021 | Bioactive Materials2021，6，4： | 6 |
| 7 | 分期血管成形术治疗颈动脉重度狭窄伴高灌注风险患者的初步探索:44例患者回顾性研究显示文摘1背景
运用颈动脉支架置入术(carotid artery stenting,CAS)治疗颈动脉狭窄的患者日益普及,但该手术仍然有一定的并发症,特别是术后高灌注综合征。该并发症是CAS后最危险的并发症之一,据报道颈动脉狭窄CAS术后1.1%-6.8%的患者可发生脑组织高灌注损伤,产生半球脑肿胀或脑出血。有报道提示对于术前有高灌注风险颈动脉狭窄的患者行常规颈动脉支架术出现该并发症高达14.1%-56%。 | Dapeng Mo Gang Luo Bo Wang 莫大鹏 | 2017 | 中国卒中杂志2017，12，7： | 6 |
| 8 | Integrated genomic analysis identifies deregulated JAK/STAT-MYC-biosynthesis axis in aggressive NK-cell leukemia显示文摘好攻击的 NK 房间白血病(ANKL ) 是在从亚洲的人之中是更流行的 NK 房间瘤的一种稀罕形式并且中央并且南美洲。病人们通常在天以内死到月,甚至在收到迅速的治疗学的管理以后。这里,我们由集成整个染色体执行了 ANKL 的第一全面研究, transcriptome 并且定序指向,象功能的试金一样的 cytokine 数组。在 JAK-STAT 小径的变化在 48% 被识别(14/29 ) ANKL 病人,当细胞外的 STAT3 激发器 IL10 被 56 褶层的一般水准提高时(P < 0.0001 ) 在检查的所有病人的血浆。另外的经常变异的基因包括的 TP53 (34%) , TET2 (28%) , CREBBP (21%) 和 MLL2 (21%) 。耐心的 NK 白血病房间在多重新陈代谢的小径显示出 STAT3 phosphorylation, MYC 表示和 transcriptional 活动的突出的激活。机能上地, STAT3 激活和 MYC 表示为 ANKL 房间的增长和幸存是批评的。发信号的 STAT 调整了发信号的 MYC 抄写节目,和两 STAT, MYC 抄写被要求维持核苷酸合成和 glycolysis 的激活。一起, JAK-STAT 小径在 ANKL 为 genomic 改变和 IL10 刺激代表一个主要目标。这最新发现的 JAK/STAT-MYC-biosynthesis 轴可以在对待白血病的这种子类型为新奇治疗学的策略的发展提供机会。 | Liang Huang Dan Liu Na Wang Shaoping Ling Yuting Tang Jun Wu Lingtong Hao Hui Luo Xuelian Hu Lingshuang Sheng Lijun Zhu Di Wang Yi Luo Zhen Shang Min Xiao Xia Mao Kuangguo Zhou Lihua Cao Lili Dong Xinchang Zheng Pinpin Sui Jianlin He Shanlan Mo Jin Yan Qilin Ao Lugui Qiu Hongsheng Zhou Qifa Liu Hongyu Zhang Jianyong Li Jie Jin Li Fu Weili Zhao Jieping Chen Xin Du Guoliang Qing Hudan Liu Xin Liu Gang Huang Ding Ma Jianfeng Zhou Qian-fei Wang | 2018 | Cell Research2018，28，2： | 5 |
| 9 | Safety profile of two-dimensional Pd nanosheets for photothermal therapy and photoacoustic imaging显示文摘二维(2D ) nanosheets 在 biomedicines 的领域里与大潜力作为 nanomaterial 的一个重要的类出现了,特别地在癌症 theranostics。然而,由于综合的有效方法的缺乏有控制尺寸的一致 2D nanomaterials, 2D nanomaterials 的尺寸依赖者简历行为的系统的评估很少被报导。就我们的知识而言,我们是第一报导对他们的简历行为的 2D nanomaterials 的尺寸的影响的系统的评估。有从 5 ~ 80 nm 的直径的 2D Pd nanosheets 被综合并且在房间和动物模型测试了估计他们基因表示介绍的尺寸依赖者 bioapplication, biodistribution,消除,毒性,和 genomic。我们的结果证明尺寸显著地影响 Pd nanosheets 的生物行为,包括他们的 photothermal 和 photoacoustic 效果, pharmacokinetics,和毒性。比作大尺寸的 Pd nanosheets,更展出的小尺寸的 Pd nanosheets 在 ultralow 之上预付 photoacoustic 成像和 photothermal 效果激光照耀。而且,在 vivo,结果显示 5-nm Pd nanosheets 与更长的血半衰期逃离网状内皮组织的系统并且能被肾的排泄清除,当时有更大的尺寸的 Pd nanosheets 主要在肝和怒气积累。30-nm Pd nanosheets 展出了最高的肿瘤累积。尽管 Pd nanosheets 没在细胞的水平引起任何可估计的毒性,我们在怒气在肝和发炎观察了细微类脂化合物累积。Genomic 基因表达式分析证明 80-nm Pd nanosheets 与更细胞的部件交往了并且在肝影响了更生物的进程,作为与 5-nm Pd nanosheets 相比。我们相信这个工作将作为 nanomedicines 提供珍贵信息和卓见进 2D Pd nanosheets 的临床的申请。 | Mei Chen Shuzhen Chen Chengyong He Shiguang Mo Xiaoyong Wang Gang Liu Nanfeng Zheng | 2017 | Nano Research2017，10，4： | 5 |
| 10 | Cloning and Functional Analysis of the MADS-box CiMADS9 Gene from Carya illinoinensis显示文摘A MADS-box gene,CiMADS9,was cloned from the male flowers of Carya illinoinensis by rapid amplification of cDNA ends. The gene was 1 077 bp with a 768 bp open reading frame encoding 255 amino acids. Multiple sequence comparisons revealed that Ci MADS9 is a typical MIKC-type MADS-box gene with a MADS-box domain and a K semi-conserved region. Phylogenetic analysis indicated that CiMADS9 belongs to the AGL15 group of the MADS-box gene family. Quantitative reverse transcription polymerase chain reaction analysis indicated that the expression levels in reproductive organs(i.e.,flowers and young fruits) were considerably higher than in vegetative tissues(i.e.,leaves and branches). The highest expression levels were observed in male flowers. An overexpression vector for CiMADS9 was constructed and the gene was inserted into the Arabidopsis thaliana genome. CiMADS9 expression was confirmed in all transgenic lines. Compared with wild-type plants,transgenic A. thaliana plants overexpressing CiMADS9 exhibited delayed flowering and an increased number of leaves. | ZHANG Jiyu MO Zhenghai LI Yongrong WANG Gang XUAN Jiping JIA Xiaodong GUO Zhongren QIAN Meihua | 2015 | Horticultural Plant Journal2015，1，1： | 3 |
| 11 | Effects of Nitrogen Fertilizer Treatments on Caryopsis Filling and Respiratory Rate of Rice显示文摘An experiment was conducted to study the effects of nitrogen (N) rate and application time on grain filling and respiratory trait of caryopsis in two rice varieties, IR36 and Dali. The treatments were consisted of no N application topdressing at both tillering and booting stages (CK), 6 g/pot of N topdressing at the tillering stage and 2 g/pot of N topdressing at the booting stage, 2 g/pot of N topdressing at the tillering stage and 6 g/pot of N topdressing at the booting stage. The results showed that the proper utilization of N fertilizer can be helpful to maintain the higher water content, higher respiratory rate and higher dehydrogenase activity of rice caryopsis in late filling phase, and prolong the course for filling and maintaining higher respiratory rate and dehydrogenase activity of rice caryopsis. More N application at booting was more effective compared to more N application at tillering. | CHEN Juan WANG Zhong CHEN Gang Mo Yi-wei | 2006 | Rice science2006，13，3： | 3 |
| 12 | Rare earth elements and yttrium in ferromanganese deposits from the South China Sea:distribution,composition and resource considerations显示文摘Ferromanganese nodules and crusts contain relatively high concentration of rare earth elements(REE) and yttrium(REY),with a growing interest in exploitation as an alternative to land-based REY resources.On the basis of comprehensive geochemical approach,the abundance and distribution of REY in the ferromanganese nodules from the South China Sea are analyzed.The results indicate that the REY contents in ferromanganese deposits show a clear geographic regularity.Total REY contents range from 69.1×10^(–6) to 2 919.4×10^(–6),with an average value of 1 459.5×10^(–6).Especially,the enrichment rate of Ce content is high,accounting for almost 60% of the total REY.This REE enrichment is controlled mainly by the sorption of ferromanganese oxides and clay minerals in the nodules and crusts.Moreover,the total REY are higher in ferromanganese deposits of hydrogenous origin than of diagenetic origin.Finally,Light REE(LREE) and heavy REE(HREE) oxides of the ferromanganese deposits in the study area can be classified into four grades: non-enriched type,weakly enriched type,enriched type,and extremely enriched type.According to the classification criteria of rare earth resources,the Xisha and Zhongsha platform-central deep basin areas show a great potential for these rare earth metals. | ZHONG Yi CHEN Zhong GONZALEZ Francisco Javier ZHENG Xufeng LI Gang LUO Yun MO Aibin XU Antao WANG Shuhong | 2018 | Acta Oceanologica Sinica2018，37，7： | 3 |
| 13 | Simultaneous pancreas-kidney transplantation in a single center: 10-year retrospective analysis显示文摘背景同时的胰肾移植(SPKT ) 是为有先进长期的肾的失败的糖尿病的病人的最好的治疗选择。当前的学习试图分析我们回顾地分析了的 SPKT.Methods 的外科的指示,治疗和 SPKT 的 40 个盒子在我们的中心在1999年12月和2010年1月之间执行了的预后,包括幸存率,复杂并发症和所有 40 个 SPKT 盒子的 reoperation.Results 的原因,接受者,肾和胰的一个年幸存率移植接枝是97.6%,97.6%和92.7%97.6%,91.1%,92.7%在 3 年并且83.6%,78.0%,79.4%在 5 年, respe 手术率是25%,包括有血尿症的 2 个病人( 4 个手术),有腹的出血的 4 个病人,有腹的感染的 2 个病人( 3 个手术),有胰腺的静脉的血栓的 1 个病人,有 anastomotic 的 1 个病人漏,并且有 fistula.Conclusion 的 1 个病人尽管 SPKT 为糖尿病患者向成功、有效的治疗提供结束阶段肾的疾病,怎么减少这治疗的复杂并发症需要仍然推进努力。 | ZHENG Jian-ming SONG Wen-li TU Jin-peng FENG Gang MO Chun-bai SHEN Zhong-yang | 2011 | Chinese Medical Journal2011，，5： | 2 |
| 14 | Performance of wavecatcher intakes at angles of attack and sideslip显示文摘A wavecatcher type scramjet intake,that reduces the Mach number number from 4 to 1.552,is used as the basis for a study of flow starting/unstarting as affected by freestream angles of attack and sideslip.The intake design is based on a morphed streamtube consisting of two conical flow streamlines using streamline tracing and osculating axisymmetric design theory.Intake flow and performance is modeled using the numerical CFD code and the k-e turbulence model.The intake unstarts at a sideslip angle of 2,a positive angle of attack of 1.Both positive angle of attack and sideslip angle have an adverse effect on the startability of the MBus intake.At negative angles,the intake initially unstarts at5angle of attack,due to the thickened shear layer induced by the streamwise vortex.Then it re-starts at8angle of attack,mainly due to the expansion fan formed at the leading edge,causing the shock wave structures inside the intake to be reestablished. | Fengyuan ZUO Sannu MO LDER Gang CHEN | 2021 | Chinese Journal of Aeronautics2021，34，7： | 2 |
| 15 | Carbon Accumulation and Distribution in Ecosystems of Taiwania flousiana Plantation and Successive Rotation Plantation of Cunninghamia lanceolata显示文摘The 23-year-old T. flousiana plantation and successive rotation plantation of C. lanceolata at Shankou Forest Farm of Nandan County,Guangxi were tested by the method of plot investigation combining with biomass measurement. Carbon storage and spatial distribution of different components in the two forests were analyzed. The results indicated that carbon content in different organs of T. flousiana ranged from 426. 0 to503. 9 g/kg,and the order was bark > stem > root > branch > leaf. The carbon contents in shrub,herb and litter layers were 452. 9,408. 0 and 428. 9 g/kg,respectively. Carbon content in the soil( 0-80 cm) was 16. 59 g/kg. The carbon content in different organs of C. lanceolata ranged from464. 5 to 508. 9 g/kg,and the order was bark > stem > branch > root > leaf. The carbon contents in shrub,herb and litter layers were 456. 2,416. 3 and 468. 1 g/kg,respectively. Carbon content in the soil( 0-80 cm) was 15. 77 g/kg. Total carbon storage amounts of T. flousiana plantation and successive rotation plantation of C. lanceolata were 245. 83 and 213. 52 t/hm^2,respectively. The carbon storage order of different structure layers from T. flousiana plantation and successive rotation plantation of C. lanceolata was soil layer( 0-80 cm) > vegetation layer > litter layer. Annual net productivity in the arbor layers of T. flousiana plantation and successive rotation plantation of C. lanceolata plantations was 10. 75 and17. 13 t/( hm^2·a); annual net carbon fixation amounts were estimated as 5.05 and 3. 47 t/( hm^2·a); annual net absorption CO_2 amounts were18. 53 and 12. 73 t/( hm^2·a) respectively. | Zhou Gang He Bin Wei Jiaguo Liu Fansheng Mo Shaozhuang Yang Zhengwen | 2018 | Meteorological and Environmental Research2018，9，4： | 2 |
| 16 | Discovery of β-arrestin-biased β2-adrenoceptor agonists from 2-amino-2-phenylethanol derivatives显示文摘β-Arrestins are a small family of proteins important for signal transduction at G protein-coupled receptors (GPCRs).β-Arrestins are involved in the desensitization of GPCRs. Recently, biased ligands possessing different ef?cacies in activating the G protein- versus the β-arrestin-dependent signals downstream of a single GPCR have emerged, which can be used to selectively modulate GPCR signal transduction in such a way that desirable signals are enhanced to produce therapeutic effects while undesirable signals of the same GPCR are suppressed to avoid side effects. In the present study, we evaluated agonist bias for compounds developed along a drug discovery project of β2-adrenoceptor agonists. About 150 compounds, including derivatives of fenoterol, 2-amino-1-phenylethanol and 2-amino-2-phenylethanol, were obtained or synthesized, and initially screened for their β-adrenoceptor-mediated activities in the guinea pig tracheal smooth muscle relaxation assay or the cardiomyocyte contractility assay. Nineteen bioactive compounds were further assessed using both the HTRF cAMP assay and the PathHunter β-arrestin assay. Their concentration-response data in stimulating cAMP synthesis and β-arrestin recruitment were applied to the Black–Leff operational model for ligand bias quantitation. As a result, three compounds (L-2, L-4, and L-12) with the core structure of 5-(1-amino-2-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one were identi?ed as a new series of β-arrestin-biased β2-adrenoceptor agonists, whereas salmeterol was found to be Gs-biased. These findings would facilitate the development of novel drugs for the treatment of both heart failure and asthma. | Yiu-Ho Woo Xin-yue Ge Li Pan Gang Xing Yong-mei Mo Rui-juan Xing Xiao-ran Li Yu-yang Zhang Irving W. Wainer Mao-sheng Cheng Rui-ping Xiao | 2019 | Acta Pharmacologica Sinica2019，40，8： | 2 |
| 17 | Nutrient Accumulation and Distribution of Mature Pinus massoniana Plantation in Northwestern Guangxi显示文摘[Objectives]This study was conducted to reveal the characteristics of nutrient absorption and accumulation in Pinus massoniana plantations in Northwestern Guangxi.[Methods]Based on field investigation and indoor analysis,the contents,accumulation and annual net accumulation of five nutrient elements(N,P,K,Ca and Mg)in a mature P.massoniana plantation(26-year-old)in Nandan County,Guangxi Province were studied.[Results]The contents of nutrient elements in different organs of the mature P.massoniana plantation were the highest in the leaves,followed by the bark,branch and root,and the lowest in the stem.In general,among the contents of the five elements in different organs,N content was the highest,followed by K or Ca,and P and Mg were the lowest.The total accumulation of nutrient elements in the 26-year-old mature P.massoniana plantation in northwestern Guangxi was 1 384.05 kg/hm^2.Among the different structural levels of the stand,the tree layer had the highest accumulation of nutrient elements,which was 1 198.41 kg/hm^2,accounting for 86.59%of the total accumulation of nutrients in the plantation,and the accumulation of nutrients in other layers from the largest to the smallest was the litter layer(91.97 kg/hm^2),herb layer(49.86 kg/hm^2)and shrub layer(43.92 kg/hm^2),accounting for 3.17%,3.60%and 6.64%of the total nutrient accumulation of the plantation,respectively.The annual net accumulation of nutrient elements in the tree layer of the mature P.massoniana plantation was 46.09 kg/(hm^2·a),and the order of the annual net accumulation of different nutrient elements followed N>K>Ca>Mg>P;and the accumulation of 1 t of dry matter needed 6.37 kg of the five nutrients.[Conclusions]This study provides a scientific basis for the rational management of P.massoniana plantations,especially forest soil management. | Minyang XIE Zhenge HUANG Mingbao WEI Bin HE Shaozhuang MO Gang ZHOU JI LIANG | 2019 | Agricultural Biotechnology2019，8，4： | 2 |
| 18 | Inhibition of Hecl expression enhances the sensitivity of human ovarian cancer cells to paclitaxel显示文摘 | Qing-qing MO Ping-bo CHEN Xin JIN Qian CHEN Lan TANG Bei-bei WANG Ke-zhen LI Peng WU Yong FANG Shi-xuan WANG Jian-feng ZHOU Ding MA Gang CHEN | 2013 | Acta Pharmacologica Sinica2013，34，4： | 2 |
| 19 | MYC translocation partner gene determines survival of patients with large B-cell lymphoma with MYC- or double-hit MYC/BCL2 translocations 显示文摘 | Pedersen MO Gang AO Poulsen TS | 2014 | Eur J Haemato12014，92，1： | 1 |
| 20 | Effects of foliage clumping on the estimation of global terrestrial gross primary productivity显示文摘 | Chen Jing M. Mo Gang Pisek Jan Liu Jane Deng Feng Ishizawa Misa Chan Douglas | 2012 | EN2012，，1： | 1 |
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