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| 1 | A bi-directional gap model for simulating the directional thermal radiance of row crops显示文摘Row crops are a kind of typical vegetation canopy between discrete canopy and continuous canopy. Kimes et al. studied the directional thermal radiation of row crops using the geometrical optical model, which simplified row structure as 'box' and neglected the gap among foliage and did not consider the emissivity effects. In this work we take account of the gaps along illumination and viewing directions and propose a bi-direction gap model on the basis of the idea of gap probability of discrete vegetation canopy introduced by 'Li-Strahler' and inter-correlation of continuous vegetation developed by Kuusk. It can be used to explain 'hot spot' effects in thermal infrared region. The gap model has been validated by field experiment on winter wheat planted in shape of rows and results show that the gap model is better than Kimes' model in describing the directionality of thermal infrared emission for row crops. | CHEN Liangfu (陈良富) LIU Qinhuo (柳钦火) FAN Wenjie (范闻捷) LI Xiaowen (李小文) XIAO Qing (肖青) YAN Guangjian (闫广建) TIAN Guoliang (田国良) | 2002 | Science China Earth Sciences2002，45，12： | 12 |
| 2 | Hsp90 inhibition results in autophagy-mediated proteasome-independent degradation of IκB kinase(IKK)显示文摘Autophagic and proteasomal proteolysis are two major pathways for degradation of cellular constituents.Currentmodels suggest that autophagy is responsible for the nonselective bulk degradation of long-lived proteins and organelleswhile the proteasome specifically degrades short-lived proteins including misfolded proteins caused by the absence ofHsp90 function.Here,we show that the IκB kinase(IKK),an essential activator of NF-κB,is selectively degraded byautophagy when Hsp90 is inhibited by geldanamycin(GA),a specific Hsp90 inhibitor showing highly effective anti-tumoractivity.We find that in this case inactivation of ubiquitination or proteasome fails to block IKK degradation.However,inhibition of autophagy by an autophagy inhibitor or knockout of Atg5,a key component of the autophagy pathway,significantly rescues IKK from GA-induced degradation.These findings provide the first evidence that an Hsp90 clientmay be degraded by a mechanism different from the proteasome pathway and establish a molecular link among Hsp90,NF-κB and | Guoliang Qing Pengrong Yan Gutian Xiao | 2006 | Cell Research2006，16，11： | 7 |
| 3 | Integrated genomic analysis identifies deregulated JAK/STAT-MYC-biosynthesis axis in aggressive NK-cell leukemia显示文摘好攻击的 NK 房间白血病(ANKL ) 是在从亚洲的人之中是更流行的 NK 房间瘤的一种稀罕形式并且中央并且南美洲。病人们通常在天以内死到月,甚至在收到迅速的治疗学的管理以后。这里,我们由集成整个染色体执行了 ANKL 的第一全面研究, transcriptome 并且定序指向,象功能的试金一样的 cytokine 数组。在 JAK-STAT 小径的变化在 48% 被识别(14/29 ) ANKL 病人,当细胞外的 STAT3 激发器 IL10 被 56 褶层的一般水准提高时(P < 0.0001 ) 在检查的所有病人的血浆。另外的经常变异的基因包括的 TP53 (34%) , TET2 (28%) , CREBBP (21%) 和 MLL2 (21%) 。耐心的 NK 白血病房间在多重新陈代谢的小径显示出 STAT3 phosphorylation, MYC 表示和 transcriptional 活动的突出的激活。机能上地, STAT3 激活和 MYC 表示为 ANKL 房间的增长和幸存是批评的。发信号的 STAT 调整了发信号的 MYC 抄写节目,和两 STAT, MYC 抄写被要求维持核苷酸合成和 glycolysis 的激活。一起, JAK-STAT 小径在 ANKL 为 genomic 改变和 IL10 刺激代表一个主要目标。这最新发现的 JAK/STAT-MYC-biosynthesis 轴可以在对待白血病的这种子类型为新奇治疗学的策略的发展提供机会。 | Liang Huang Dan Liu Na Wang Shaoping Ling Yuting Tang Jun Wu Lingtong Hao Hui Luo Xuelian Hu Lingshuang Sheng Lijun Zhu Di Wang Yi Luo Zhen Shang Min Xiao Xia Mao Kuangguo Zhou Lihua Cao Lili Dong Xinchang Zheng Pinpin Sui Jianlin He Shanlan Mo Jin Yan Qilin Ao Lugui Qiu Hongsheng Zhou Qifa Liu Hongyu Zhang Jianyong Li Jie Jin Li Fu Weili Zhao Jieping Chen Xin Du Guoliang Qing Hudan Liu Xin Liu Gang Huang Ding Ma Jianfeng Zhou Qian-fei Wang | 2018 | Cell Research2018，28，2： | 5 |
| 4 | CRISPR-Cas9-mediated genome editing in one blastomere of two-cell embryos reveals a novel Tet3 function in regulating neocortical development显示文摘学习必要基因的早功能是在发展生物学的一个重要、挑战性的问题。这里,我们为很快在二房间的阶段胚胎的一个分裂球导致 CRISPR-Cas9-mediated 变化建立了一个方法,称为的 2 房间 embryo-CRISPR-Cas9 注射(2CC ) ,学习在里面必需品的 vivo 功能(或未知) 在创始人的基因妄想的鼠标。由注射指向兴趣的基因进的 Cre mRNA 和 CRISPR-Cas9 荧光灯记者老鼠, 2CC 方法能在不同发展阶段跟踪野类型、变异的房间,为变异的房间的 phenotypic 分析的出现内部控制。用这个方法,我们在在发展中的鼠标调整有刺激性、禁止的 synaptic 传播识别了必要基因 Tet3 的新奇函数服的外皮。由产生妄想的变异的老鼠, 2CC 方法允许在多重纸巾和房间的基因功能的快速的屏蔽录入妄想的老鼠创始人,显著地扩展基因工具的当前的一套设备。 | Wang, Lingbo Li, Min-Yin Qu, Chao Miao, Wan-Ying Yin, Qi Liao, Jiaoyang Cao, Hua-Teng Huang, Min Wang, Kai Zuo, Erwei Peng, Guangdun Zhang, Shu-Xin Chen, Guodong Li, Qing Tang, Ke Yu, Qian Li, Zhoujie Wong, Catherine C. L. Xu, Guoliang Jing, Naihe Yu, Xiang Li, Jinsong | 2017 | Cell Research2017，27，6： | 5 |
| 5 | Targeting oncogenic Myc as a strategy for cancer treatment显示文摘The MYC family oncogene is deregulated in>50%of human cancers,and this deregulation is frequently associated with poor prognosis and unfavorable patient survival.Myc has a central role in almost every aspect of the oncogenic process,orchestrating proliferation,apoptosis,differentiation,and metabolism.Although Myc inhibition would be a powerful approach for the treatment of many types of cancers,direct targeting of Myc has been a challenge for decades owing to its“undruggable”protein structure.Hence,alternatives to Myc blockade have been widely explored to achieve desirable anti-tumor effects,including Myc/Max complex disruption,MYC transcription and/or translation inhibition,and Myc destabilization as well as the synthetic lethality associated with Myc overexpression.In this review,we summarize the latest advances in targeting oncogenic Myc,particularly for cancer therapeutic purposes. | Hui Chen Hudan Liu Guoliang Qing | 2018 | Signal Transduction and Targeted Therapy2018，3，1： | 5 |
| 6 | Chinese expert consensus on conversion therapy for hepatocellular carcinoma(2021 edition)显示文摘Recent advances in systemic and locoregional treatments for patients with unresectable or advanced hepatocellular carcinoma(HCC)have resulted in improved response rates.This has provided an opportunity for selected patients with initially unresectable HCC to achieve adequate tumor downstaging to undergo surgical resection,a‘conversion therapy’strategy.However,conversion therapy is a new approach to the treatment of HCC and its practice and treatment protocols are still being developed.Review the evidence for conversion therapy in HCC and develop consensus statements to guide clinical practice.Evidence review:Many research centers in China have accumulated significant experience implementing HCC conversion therapy.Preliminary findings and data have shown that conversion therapy represents an important strategy to maximize the survival of selected patients with intermediate stage to advanced HCC;however,there are still many urgent clinical and scientific challenges for this therapeutic strategy and its related fields.In order to summarize and learn from past experience and review current challenges,the Chinese Expert Consensus on Conversion Therapy for Hepatocellular Carcinoma(2021 Edition)was developed based on a review of preliminary experience and clinical data from Chinese and non-Chinese studies in this field and combined with recommendations for clinical practice.Sixteen consensus statements on the implementation of conversion therapy for HCC were developed.The statements generated in this review are based on a review of clinical evidence and real clinical experience and will help guide future progress in conversion therapy for patients with HCC. | Hui-Chuan Sun Jian Zhou Zheng Wang Xiufeng Liu Qing Xie Weidong Jia Ming Zhao Xinyu Bi Gong Li Xueli Bai Yuan Ji Li Xu Xiao-Dong Zhu Dousheng Bai Yajin Chen Yongjun Chen Chaoliu Dai Rongping Guo Wenzhi Guo Chunyi Hao Tao Huang Zhiyong Huang Deyu Li Gang Li Tao Li Xiangcheng Li Guangming Li Xiao Liang Jingfeng Liu Fubao Liu Shichun Lu Zheng Lu Weifu Lv Yilei Mao Guoliang Shao Yinghong Shi Tianqiang Song Guang Tan Yunqiang Tang Kaishan Tao Chidan Wan Guangyi Wang Lu Wang Shunxiang Wang Tianfu Wen Baocai Xing Bangde Xiang Sheng Yan Dinghua Yang Guowen Yin Tao Yin Zhenyu Yin Zhengping Yu Bixiang Zhang Jialin Zhang Shuijun Zhang Ti Zhang Yamin Zhang Yubao Zhang Aibin Zhang Haitao Zhao Ledu Zhou Wu Zhang Zhenyu Zhu Shukui Qin Feng Shen Xiujun Cai Gaojun Teng Jianqiang Cai Minshan Chen Qiang Li Lianxin Liu Weilin Wang Tingbo Liang Jiahong Dong Xiaoping Chen Xuehao Wang Shusen Zheng Jia Fan 无 | 2022 | Hepatobiliary Surgery and Nutrition2022，11，2： | 4 |
| 7 | Electrochemical Lithium Storage Performance of Molten Salt Derived V_(2)SnC MAX Phase显示文摘MAX phases are gaining attention as precursors of two-dimensional MXenes that are intensively pursued in applications for electrochemical energy storage.Here,we report the preparation of V_(2)SnC MAX phase by the molten salt method.V_(2)SnC is investigated as a lithium storage anode,showing a high gravimetric capacity of 490 mAh g−1 and volumetric capacity of 570 mAh cm^(−3) as well as superior rate performance of 95 mAh g^(−1)(110 mAh cm^(−3))at 50 C,surpassing the ever-reported performance of MAX phase anodes.Sup-ported by operando X-ray diffraction and density functional theory,a charge storage mechanism with dual redox reaction is proposed with a Sn-Li(de)alloying reaction that occurs at the edge sites of V_(2)SnC particles where Sn atoms are exposed to the electrolyte followed by a redox reaction that occurs at V_(2)C layers with Li.This study offers promise of using MAX phases with M-site and A-site elements that are redox active as high-rate lithium storage materials. | Youbing Li Guoliang Ma Hui Shao Peng Xiao Jun Lu Jin Xu Jinrong Hou Ke Chen Xiao Zhang Mian Li Per OÅPersson Lars Hultman Per Eklund Shiyu Du Zhifang Chai Zhengren Huang Na Jin Jiwei Ma Ying Liu Zifeng Lin Qing Huang | 2021 | Nano-Micro Letters2021，13，10： | 2 |
| 8 | Regulation of cancer cell metabolism:oncogenic MYC in the driver’s seat显示文摘Cancer cells must rewire cellular metabolism to satisfy the demands of unbridled growth and proliferation.As such,most human cancers differ from normal counterpart tissues by a plethora of energetic and metabolic reprogramming.Transcription factors of the MYC family are deregulated in up to 70%of all human cancers through a variety of mechanisms.Oncogenic levels of MYC regulates almost every aspect of cellular metabolism,a recently revisited hallmark of cancer development.Meanwhile,unrestrained growth in response to oncogenic MYC expression creates dependency on MYC-driven metabolic pathways,which in principle provides novel targets for development of effective cancer therapeutics.In the current review,we summarize the significant progress made toward understanding how MYC deregulation fuels metabolic rewiring in malignant transformation. | Yang Dong Rongfu Tu Hudan Liu Guoliang Qing | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 2 |
| 9 | Hypoxia inducible factor-2α: a critical mediator of aggressive tumor phenotypes显示文摘 | Guoliang Qing M Celeste Simon | 2008 | Current Opinion in Genetics & Development2008，，1： | 1 |
| 10 | Asymmetric epigenome maps of subgenomes reveal imbalanced transcription and distinct evolutionary trends in Brassica napus显示文摘The complexity of the epigenome landscape and transcriptional regulation is significantly increased during plant polyploidization,which drives genome evolution and contributes to the increased adaptability to diverse environments.However,a comprehensive epigenome map of Brassica napus is still unavailable.In this study,we performed integrative analysis of five histone modifications,RNA polymerase Ⅱ CCU-pancy,DNA methylation,and transcriptomes in two B.napus lines(2063A and B409),and established global maps of regulatory elements,chromatin states,and their dynamics for the whole genome(including the An and Cn subgenomes)in four tissue types(young leaf,flower bud,silique,and root)of these two lines.Approximately 65.8% of the genome was annotated with different epigenomic signals.Compared with the Cn subgenome,the An subgenome possesses a higher level of active epigenetic marks and lower level of repressive epigenetic marks.Genes from subgenome-unique regions contribute to the major differences between the An and Cn subgenomes.Asymmetric histone modifications between homeologous gene pairs reflect their biased expression patterns.We identified a novel bivalent chromatin state(with H3K4me1 and H3K27me3)in B.napus that is associated with tissue-specific gene expression.Furthermore,we observed that different types of duplicated genes have discrepant patterns of histone modification and DNA methylation levels.Collectively,our findings provide a valuable epigenetic resource for allopolyploid plants. | Qing Zhang Pengpeng Guan Lun Zhao Meng Ma Liang Xie Yue Li Ruiqin Zheng Weizhi Ouyang Shunyao Wang Hongmeijuan Li Ying Zhang Yong Peng Zhilin Cao Wei Zhang Qin Xiao Yuanling Xiao Tingdong Fu Guoliang Li Xingwang Li Jinxiong Shen | 2021 | Molecular Plant2021，14，4： | 1 |
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