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| 1 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 2 | Bilateral pleural effusion as an initial manifestation of multiple myeloma : A case report and literature review 显示文摘 | Jiang AG Yang YT Gao XY | 2015 | Exp Ther Med2015，9，3： | 1 |
| 3 | New records of submarine hydrothermal activity in middle part of the Okinawa Trough显示文摘THE hydrothermal activity area investigated is located at the middle of the trough (126°50′—127°30′E; 27°20′—27°50′N). Some surface sediment samples and core samples were collected, with other samples from non-hydrothermal activity area (128°20′—129°10′E; 30°30′—31°40′N) in the north of the trough for comparison. Analyses for elements and | Zhao, YY Zhai, SK Li, RZ Li, FY Gao, AG He, LJ Wang, ZG Zhu, XQ | 1997 | Chinese Science Bulletin1997，42，7： | 1 |
| 4 | Deletion-targeted multiplex PCR (DTM-PCR) for identification of Beijing/W genotypes of Mycobacterium tuberculosis显示文摘 | Chen J Tsolaki AG Shen X Jiang X Mei J Gao Q | 2007 | Tuberculosis (Edinb)2007，87，5： | 1 |
| 5 | De-letion-targeted multiplex PCR (DTM-PCR) for identifica- tion of Beijing/W genotypes of Mycobacterium tuberculosis 显示文摘 | Chen J Tsolaki AG Shen X Jiang X Mei J Gao Q | 2007 | Tuberculosis (Edinb)2007，87，5： | 1 |
| 6 | Waveshrink within firm shrinkage显示文摘 | GAO FlY | 1997 | Statistica Sincia1997，7，4： | 1 |
| 7 | Development of radioligands with optimized imaging properties for quantification of nicotinic acetylcholine receptors by positron emission tomography显示文摘 | Horti AG Gao Y Kuwabara H | | 0，，： | 1 |
| 8 | 显示文摘 | MaeDiarmid AG Jones Jr WE Norris ID Gao J Johnson Jr AT Pinto NJ | 2001 | Synth Met2001，117，： | 1 |
| 9 | Effect of Nd on microstrueture and wear resistance of hypereutectic AI-20 % Si alloy显示文摘 | Shi W X Gao B Tu G F et ag | 2010 | Journal of Alloys and Compounds2010，508，2： | 1 |
| 10 | Wave shrinks with firm shrinkage 显示文摘 | BRUCE AG GAO HY | 1995 | StatisticsInca1995，7，4： | 1 |
| 11 | Radiologic - pathologic correlation epidermoid tumor of the cerebellopontine angle 显示文摘 | Gao PY Osborn AG Smirniotopoulos JG | 1992 | AJNR1992，13，5： | 1 |
| 12 | A tri- phenylamine - grafted imidazo phenan- throline ruthenium(Ⅱ) complex : acid - base and photo- electric propemes 显示文摘 | Fan SH Zhang AG Ju CC Gao LH Wang KZ | 2010 | Inorg Chem2010，49，： | 1 |
| 13 | The thrombospondin receptor integrin-a ssociated protein (CD 47) functionally couples to heterotrimeric显示文摘 | Gao AG Dimitry J | 1999 | G J Biol Chem1999，274，： | 1 |
| 14 | Deletiontargeted multiplex PCR (DTM-PCR) for identification of Beijing/W genotypes of Mycobacterium tuberculosis 显示文摘 | Chen J Tsolaki AG Shen X Jiang X Mei J Gao Q | 2007 | Tuberculosis2007，87，5： | 1 |
| 15 | Waveshrink with firm shrinkage显示文摘 | BRUCE AG GAO HY | 1997 | Statistica Sinica1997，7，4： | 1 |
| 16 | Diagnosis and management of a patient with primary pulmonary diffuse large B-cell lymphoma: a case report and review of the literature显示文摘 | Jiang AG Gao XY Lu HY | 2014 | Exp Ther Med2014，8，3： | 1 |
| 17 | Predicting penetrometer resistance from the compression characteristic of soil显示文摘 | Gao W Ren T Bengough AG | 2012 | Soil Sci Soc Am J2012，76，34： | 1 |
| 18 | Single cell analysis of PKC activation during proliferation and apoptosis induced by laser irradiation显示文摘 | X Gao T Chen D Xing et ag | 2006 | J Cell Physiol2006，206，2： | 1 |
| 19 | Stability of high-energy pho sphates in right ventricle: myocardial energetics during right coronary hypotension显示文摘 | Mallet Z Gao AG | 1996 | Am J Physiol1996，271，40： | 1 |
| 20 | Fungal pathogen protection in potato by expression of a plant defensin peptide 显示文摘 | Gao AG Hakimi SM Mittanck CA | 2000 | Nature Bioteehnology2000，18，12： | 1 |
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