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| 1 | Sialic acid-engineered mesoporous polydopamine nanoparticles loaded with SPIO and Fe3+as a novel theranostic agent for T1/T2 dual-mode MRI-guided combined chemo-photothermal treatment of hepatic cancer显示文摘diagnostic and therapeutic capability are highly needed for the treatment of hepatic cancer.Herein,we aimed to develop a novel mesoporous polydopamine(MPDA)-based theranostic agent for T1/T2 dual magnetic resonance imaging(MRI)-guided cancer chemo-photothermal therapy.Superparamagnetic iron oxide(SPIO)-loaded MPDA NPs(MPDA@SPIO)was firstly prepared,followed by modifying with a targeted molecule of sialic acid(SA)and chelating with Fe^(3+)(SA-MPDA@SPIO/Fe^(3+) NPs).After that,doxorubicin(DOX)-loaded SA-MPDA@SPIO/Fe^(3+) NPs(SA-MPDA@SPIO/DOX/Fe^(3+))was prepared for tumor theranostics.The prepared SAPEG-MPDA@SPIO/Fe^(3+) NPs were water-dispersible and biocompatible as evidenced by MTT assay.In vitro photothermal and relaxivity property suggested that the novel theranostic agent possessed excellent photothermal conversion capability and photostability,with relaxivity of being r1=4.29 mM��1s��1 and r2=105.53 mM��1s��1,respectively.SAPEG-MPDA@SPIO/Fe^(3+) NPs could effectively encapsulate the DOX,showing dual pH-and thermal-triggered drug release behavior.In vitro and in vivo studies revealed that SA-MPDA@SPIO/DOX/Fe^(3+) NPs could effectively target to the hepatic tumor tissue,which was possibly due to the specific interaction between SA and the overexpressed E-selectin.This behavior also endowed SA-MPDA@SPIO/DOX/Fe^(3+)NPs with a more precise T1-T2 dual mode contrast imaging effect than the one without SA modification.In addition,SAPEG-MPDA@SPIO/DOX/Fe^(3+) NPs displayed a superior therapeutic effect,which was due to its active targeting ability and combined effects of chemotherapy and photothermal therapy.These results demonstrated that SAPEG-MPDA@SPIO/DOX/Fe^(3+) NPs is an effective targeted nanoplatform for tumor theranostics,having potential value in the effective treatment of hepatic cancer. | Gaofeng Shu Minjiang Chen Jingjing Song Xiaoling Xu Chenying Lu Yuyin Du Min Xu Zhongwei Zhao Minxia Zhu Kai Fan Xiaoxi Fan Shiji Fang Bufu Tang Yiyang Dai Yongzhong Du Jiansong Ji | 2021 | Bioactive Materials2021，6，5： | 4 |
| 2 | Comprehensive test stand for high-intensity cyclotron development显示文摘A comprehensive test stand for high-intensity cyclotron development,a 10 MeV 430 μA cyclotron,has been successfully constructed at China Institute of Atomic Energy (CIAE) for the experimental verification of the viability of a 100 MeV high-intensity cyclotron (CYCIAE-100) being constructed at CIAE.The verification includes the overall design technology,detail design and engineering technology for the crucial parts of the machine,e.g.main magnet and beam diagnostics.It will also pave the way for future enhancement of the beam intensity.The test stand consists of a H-ion source,axial injection system,central region,main magnet and coil,RF resonator,stripping extraction,and auxiliary systems,which include the RF power amplifier,high voltage and DC power supplies,electric apparatus,beam diagnostics,control,vacuum,water cooling,pneumatic system,and safety interlock.This paper presents the work regarding the design and sub-system development of the test sand,and the results of the beam commissioning of the machine. | ZHANG TianJue LI ZhenGuo CHU ChengJie XING JianSheng GUAN FengPing ZHONG JunQing JI Bin GE Tao YIN ZhiGuo HOU ShiGang PAN GaoFeng YAO HongJuan LU YinLong WANG ZhenHui WU LongCheng LIN Jun JIA XianLu WEI SuMin WEN LiPeng WANG Feng XIA Le CAI HongRu XIE HuaiDong CHEN RongFan ZHANG Yan ZHANG SuPing LIU GengShou ZOU Jian AN ShiZhong YANG JianJun BI YuanJie YANG Fang | 2011 | Chinese Science Bulletin2011，56，3： | 3 |
| 3 | EAT-NAS: elastic architecture transfer for accelerating large-scale neural architecture search显示文摘Neural architecture search(NAS) methods have been proposed to relieve human experts from tedious architecture engineering. However, most current methods are constrained in small-scale search owing to the issue of huge computational resource consumption. Meanwhile, the direct application of architectures searched on small datasets to large datasets often bears no performance guarantee due to the discrepancy between different datasets. This limitation impedes the wide use of NAS on large-scale tasks. To overcome this obstacle, we propose an elastic architecture transfer mechanism for accelerating large-scale NAS(EATNAS).In our implementations, the architectures are first searched on a small dataset, e.g., CIFAR-10. The best one is chosen as the basic architecture. The search process on a large dataset, e.g., ImageNet, is initialized with the basic architecture as the seed. The large-scale search process is accelerated with the help of the basic architecture. We propose not only a NAS method but also a mechanism for architecture-level transfer learning. In our experiments, we obtain two final models EATNet-A and EATNet-B, which achieve competitive accuracies of 75.5% and 75.6%, respectively, on ImageNet. Both the models also surpass the models searched from scratch on ImageNet under the same settings. For the computational cost, EAT-NAS takes only fewer than 5 days using 8 TITAN X GPUs, which is significantly less than the computational consumption of the state-of-the-art large-scale NAS methods. | Jiemin FANG Yukang CHEN Xinbang ZHANG Qian ZHANG Chang HUANG Gaofeng MENG Wenyu LIU Xinggang WANG | 2021 | Science China(Information Sciences)2021，64，9： | 1 |
| 4 | Deep space multi-file delivery protocol based on LT codes显示文摘A deep space multi-file delivery protocol(DSMDP) based on LT codes is proposed to reduce the influence of long delay and a high bit error rate(BER) in deep space communication. The protocol increases sending redundancy by LT codes to improve the success rate of file delivery, and adopts different protective strategies for different situations of packet loss. At the same time, the multi-file united delivery strategy is adopted to make full use of the retransmission time to reduce the end-toend transmission delay. Furthermore, the protocol determines the quantity of encoded packets according to the feedback for controlling redundancy. The simulation results show that the proposed protocol can significantly reduce the transmission delay of files, which would be effectively suitable for deep space communication environment of high BER and long delay. | Ruyan Wang Hua Liang Hui Zhao Gaofeng Fang | 2016 | Journal of Systems Engineering and Electronics2016，27，3： | 0 |
| 5 | High-resolution sea surface wind speeds of Super Typhoon Lekima (2019) retrieved by Gaofen-3 SAR显示文摘Gaofen-3(GF-3)is the first Chinese spaceborne multi-polarization synthetic aperture radar(SAR)instrument at C-band(5.43 GHz).In this paper,we use data collected from GF-3 to observe Super Typhoon Lekima(2019)in the East China Sea.Using a VH-polarized wide ScanSAR(WSC)image,ocean surface wind speeds at 100m horizontal resolution are obtained at 21:56:59 UTC on 8 August 2019,with the maximum wind speed,38.9 m·s^(-1).Validating the SAR-retrieved winds with buoymeasured wind speeds,we find that the root mean square error(RMSE)is 1.86 m·s^(-1),and correlation coefficient,0.92.This suggests that wind speeds retrieved from GF-3 SAR are reliable.Both the European Centre for MediumRange Weather Forecasts(ECMWF)fine grid operational forecast products with spatial resolution,and China Global/Regional Assimilation and Prediction Enhance System(GRAPES)have good performances on surface wind prediction under weak wind speed condition(<24 m·s^(-1)),but underestimate the maximum wind speed when the storm is intensified as a severe tropical storm(>24m·s^(-1)).With respect to SAR-retrieved wind speeds,the RMSEs are 5.24 m·s^(–1) for ECMWF and 5.17 m·s^(–1) for GRAPES,with biases of 4.16 m·s^(–1) for ECMWF and 3.84 m·s^(-1)for GRAPES during Super Typhoon Lekima(2019). | He FANG William PERRIE Gaofeng FAN Zhengquan LI Juzhen CAI Yue HE Jingsong YANG Tao XIE Xuesong ZHU | 2022 | Frontiers of Earth Science2022，16，1： | 0 |
| 6 | Automatic Extraction of the Sparse Prior Correspondences for Non-Rigid Point Cloud Registration显示文摘Non-rigid registration of point clouds is still far from stable,especially for the largely deformed one.Sparse initial correspondences are often adopted to facilitate the process.However,there are few studies on how to build them automatically.Therefore,in this paper,we propose a robust method to compute such priors automatically,where a global and local combined strategy is adopted.These priors in different degrees of deformation are obtained by the locally geometrical-consistent point matches from the globally structural-consistent region correspondences.To further utilize the matches,this paper also proposes a novel registration method based on the Coherent Point Drift framework.This method takes both the spatial proximity and local structural consistency of the priors as supervision of the registration process and thus obtains a robust alignment for clouds with significantly different deformations.Qualitative and quantitative experiments demonstrate the advantages of the proposed method. | Yan Zhu Lili Tian Fan Ye Gaofeng Sun Xianyong Fang | 2023 | Computer Modeling in Engineering & Sciences2023，，8： | 0 |
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