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| 1 | Sialic acid-engineered mesoporous polydopamine nanoparticles loaded with SPIO and Fe3+as a novel theranostic agent for T1/T2 dual-mode MRI-guided combined chemo-photothermal treatment of hepatic cancer显示文摘diagnostic and therapeutic capability are highly needed for the treatment of hepatic cancer.Herein,we aimed to develop a novel mesoporous polydopamine(MPDA)-based theranostic agent for T1/T2 dual magnetic resonance imaging(MRI)-guided cancer chemo-photothermal therapy.Superparamagnetic iron oxide(SPIO)-loaded MPDA NPs(MPDA@SPIO)was firstly prepared,followed by modifying with a targeted molecule of sialic acid(SA)and chelating with Fe^(3+)(SA-MPDA@SPIO/Fe^(3+) NPs).After that,doxorubicin(DOX)-loaded SA-MPDA@SPIO/Fe^(3+) NPs(SA-MPDA@SPIO/DOX/Fe^(3+))was prepared for tumor theranostics.The prepared SAPEG-MPDA@SPIO/Fe^(3+) NPs were water-dispersible and biocompatible as evidenced by MTT assay.In vitro photothermal and relaxivity property suggested that the novel theranostic agent possessed excellent photothermal conversion capability and photostability,with relaxivity of being r1=4.29 mM��1s��1 and r2=105.53 mM��1s��1,respectively.SAPEG-MPDA@SPIO/Fe^(3+) NPs could effectively encapsulate the DOX,showing dual pH-and thermal-triggered drug release behavior.In vitro and in vivo studies revealed that SA-MPDA@SPIO/DOX/Fe^(3+) NPs could effectively target to the hepatic tumor tissue,which was possibly due to the specific interaction between SA and the overexpressed E-selectin.This behavior also endowed SA-MPDA@SPIO/DOX/Fe^(3+)NPs with a more precise T1-T2 dual mode contrast imaging effect than the one without SA modification.In addition,SAPEG-MPDA@SPIO/DOX/Fe^(3+) NPs displayed a superior therapeutic effect,which was due to its active targeting ability and combined effects of chemotherapy and photothermal therapy.These results demonstrated that SAPEG-MPDA@SPIO/DOX/Fe^(3+) NPs is an effective targeted nanoplatform for tumor theranostics,having potential value in the effective treatment of hepatic cancer. | Gaofeng Shu Minjiang Chen Jingjing Song Xiaoling Xu Chenying Lu Yuyin Du Min Xu Zhongwei Zhao Minxia Zhu Kai Fan Xiaoxi Fan Shiji Fang Bufu Tang Yiyang Dai Yongzhong Du Jiansong Ji | 2021 | Bioactive Materials2021，6，5： | 4 |
| 2 | Recent progresses on the new condensed forms of single-walled carbon nanotubes and energy-harvesting devices显示文摘We demonstrate an effective method to prepare a new condensed form of single-walled carbon nanotubes(crystal of SWNTs) using a series of diamond wire drawing dies.X-ray diffraction indicates that the SWNTs form a two-dimensional triangular lattice with a lattice constant of 19.62 ?.An intertube spacing of 3.39 ? of between adjacent SWNTs results in a sharp(002) reflection in the X-ray diffraction pattern.Meanwhile,we developed an approach based on the Coulomb explosion to separate SWNTs from their bundle.The separated SWNTs have a typical length of several microns and form a nanotree at one end of the original bundle.The separation is convenient and involves no surfactant.In studying devices comprising SWNTs,we find that a four-probe technique can be employed to study the filling of and flow within the inner channel of an individual SWNT.Current/voltage can drive water molecules to have directional flow along an SWNT,and the flowing of water inside an SWNT can induce a voltage gradient force(an induced electromotive force) along the SWNT.This energy conversion is realized by the mutual coupling of water dipoles and charge carriers present in SWNTs.The results suggest that SWNTs can be exploited as molecular channels for water and may find potential application in nanoscale energy conversion.Moreover,a surface-energy generator comprising SWNTs was demonstrated to harvest the surface energy of ethanol.The performance(the induction rate for Voc,the value of Voc and the output power) can be significantly enhanced by the Marangoni effect. | CHEN MinJiang YU Fang HU LiJun SUN LianFeng | 2012 | Chinese Science Bulletin2012，57，2： | 3 |
| 3 | Prediction of major adverse cardiac events is the first critical task in the management of immune checkpoint inhibitor-associated myocarditis显示文摘Dear Editor,The application of immune checkpoint inhibitors(ICIs),anti-tumor immunotherapy unleashing the host immune system to eradicate tumor cells,has revolutionized the treatment of various advanced cancers and showed remarkable anti-tumor effects[1].However,emphasis must be placed on fatal immune-related adverse events(irAEs),especially some fulminant irAEs like ICI-related cardiovascular AEs[2,3].However,due to the low rate of cardiovascular AEs,little is known about the effective methods for evaluating the risk of catastrophic cardiac events in ICI-associated myocarditis and its management[4,5]. | Yan Xu Yanjun Song Xiaoyan Liu Yuequan Shi Yingxian Liu Hao Qian Xiaoxing Gao Minjiang Chen Ruili Pan Jing Zhao Wei Zhong Wei Wu Mengzhao Wang | 2022 | Cancer Communications2022，42，9： | 3 |
| 4 | Studies on the properties of surface and edges of N-layer graphenes显示文摘Graphene, a new two-dimensional carbon material, is a rising star of physics, chemistry and materials science. In this work, we report the recent experimental researches on the Raman spectra and the temperature-dependent features of graphenes and car- bon nanoscrolls, which are evolved from graphene and have an open tubular structure. The layer-dependent Raman enhancing characteristics of n-layer graphenes for crystal violet, and the thickness-dependent morphologies of gold on n-layer graphenes are also systematically investigated. Meanwhile, the aggregations of ferromagnetic and paramagnetic atoms at edges of gra- phenes and graphite are observed and the mechanisms are discussed. | CHEN MinJiang ZHOU HaiQing QIU CaiYu YANG HuaiChao YU Fang SUN LianFeng | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，10： | 2 |
| 5 | New mixed equilibrium problems and iterative algorithms for fixed point problems in Banach spaces显示文摘 | Chen Minjiang Song Jianmin Wang Shenghua | 2014 | J Appl Math2014，，： | 1 |
| 6 | Cerebrospinal Fluid Concentrations of Gefitinib in Patients With Lung Adenocarcinoma显示文摘 | Jing Zhao Minjiang Chen Wei Zhong Li Zhang Longyun Li Yi Xiao Ligong Nie Pei Hu Mengzhao Wang | 2012 | Clinical Lung Cancer2012，，： | 1 |
| 7 | Thickness-dependent morphologies of Ag on n-layer MoS2 and its surface-enhanced Raman scattering显示文摘n 层瞬间 2 上的 Ag nanoparticles 的尺寸和密度展出 thicknessdependent 行为。分别地,这些粒子的尺寸和密度与增加 n 层瞬间 2 的层数字(n) 增加了并且减少。而且,这底层上的 Ag 的散布的提高表面的拉曼(重量的单位) 被观察。这散布的改进因素与瞬间 2 的厚度变化了。管理上述的厚度依赖的机制被建议并且讨论。 | Ya Deng Minjiang Chen Jian Zhang Zihao Wang Wenbin Huang Yun Zhao Jean PierreNshimiyimana Xiao Hu Xiannian Chi Gu Hou ,Xueyao Zhang Yanjun Guo Lianfeng Sun | 2016 | Nano Research2016，9，6： | 1 |
| 8 | Case report of neurofibromatosis type 1 combined with primary ciliary dyskinesia显示文摘Neurofibromatosis(NF)is a genetic disease in which the lungs are rarely involved.However,in NF cases with lung involvement,chest computed tomography may show bilateral basal reticulations,apical bullae,and cysts without bronchiectasis.Herein,we report a patient diagnosed with NF on the basis of the results of genetic testing who presented with early-onset wet cough and bronchiectasis.Considering the differential diagnosis of bronchiectasis combined with his early-onset wet cough,sinusitis,and sperm quality decline,we considered the possibility of primary ciliary dyskinesia(PCD).Further electron microscopy analysis of cilia and identification of homozygous mutations in the RSPH4A gene confirmed the diagnosis of PCD.Therefore,for patients with NF,when an image change exists in the lungs that does not correspond to NF,the possibility of other diagnoses,including PCD,must be considered. | Chun Bian Xinyue Zhao Yaping Liu Minjiang Chen Shuying Zheng Xinlun Tian Kai-Feng Xu | 2021 | Frontiers of Medicine2021，15，6： | 1 |
| 9 | Precision interventional radiology显示文摘The recent interest in precision medicine among interventionists has led to the establishment of the concept of precision interventional radiology(PIR).This concept focuses not only on the accuracy of interventional operations using traditional image-guided techniques,but also on the comprehensive evaluation of diseases.The invisible features extracted from CT,MRI,or US improve the accuracy and specificity of diagnosis.The integration of multi-omics and molecule imaging provides more information for interventional operations.The development and application of drugs,embolic materials,and devices broaden the concept of PIR.Integrating medicine and engineering brings new image-guided techniques that increase the efficacy of interventional operations while reducing the complications of interventional treatment.In all,PIR,an important part of precision medicine,emphasizing the whole disease management process,including precision diagnosis,comprehensive evaluation,and interventional therapy,maximizes the benefits of patients with limited damage. | Jiansong Ji Shiji Fang Minjiang chen Liyun zheng Weiqian Chen Zhongwei Zhao Yongde Cheng | 2021 | Journal of Interventional Medicine2021，4，4： | 0 |
| 10 | Fucoidan-based dual-targeting mesoporous polydopamine for enhanced MRI-guided chemo-photothermal therapy of HCC via P-selectin-mediated drug delivery显示文摘The development of novel theranostic agents with outstanding diagnostic and therapeutic performances is still strongly desired in the treatment of hepatocellular carcinoma(HCC).Here,a fucoidan-modified mesoporous polydopamine nanoparticle dual-loaded with gadolinium iron and doxorubicin(FMPDA/Gd^(3+)/DOX)was prepared as an effective theranostic agent for magnetic resonance imaging(MRI)-guided chemo-photothermal therapy of HCC.It was found that FMPDA/Gd^(3+)/DOX had a high photothermal conversion efficiency of 33.4%and excellent T1-MRI performance with a longitudinal relaxivity(r1)value of 14.966 m M^(-1)·s^(-1).Moreover,the results suggested that FMPDA/Gd^(3+)/DOX could effectively accumulate into the tumor foci by dual-targeting the tumor-infiltrated platelets and HCC cells,which resulted from the specific interaction between fucoidan and overexpressed p-selectin receptors.The excellent tumor-homing ability and MRI-guided chemo-photothermal therapy therefore endowed FMPDA/Gd^(3+)/DOX with a strongest ability to inhibit tumor growth than the respective single treatment modality.Overall,our study demonstrated that FMPDA/Gd^(3+)/DOX could be applied as a potential nanoplatform for safe and effective cancer theranostics. | Gaofeng Shu Lin Shen Jiayi Ding Junchao Yu Xiaoxiao Chen Xiaoju Guo Enqi Qiao Yaning Chen Chenying Lu Zhongwei Zhao Yongzhong Du Minjiang Chen Jiansong Ji | 2022 | Asian Journal of Pharmaceutical Sciences2022，17，6： | 0 |
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