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| 1 | Hepatic resection beyond barcelona clinic liver cancer indication:When and how显示文摘Hepatocellular carcinoma(HCC)is the main common primary tumour of the liver and it is usually associated with cirrhosis.The barcelona clinic liver cancer(BCLC)classification has been approved as guidance for HCC treatment algorithms by the European Association for the Study of Liver and the American Association for the Study of Liver Disease.According to this algorithm,hepatic resection should be performed only in patients with small single tumours of 2-3 cm without signs of portal hypertension(PHT)or hyperbilirubinemia.BCLC classification has been criticised and many studies have shown that multiple tumors and large tumors,as wide as those with macrovascular infiltration and PHT,could benefit from liver resection.Consequently,treatment guidelines should be revised and patients with intermediate/advanced stage HCC,when technically resectable,should receive the opportunity to be treated with radical surgical treatment.Nevertheless,the surgical treatment of HCC on cirrhosis is complex:The goal to be oncologically radical has always to be balanced with the necessity to minimize organ damage.The aim of this review was to analyze when and how liver resection could be indicated beyond BCLC indication.In particular,the role of multidisciplinary approach to assure a proper indication,of the intraoperative ultrasound for intraoperative restaging and resection guidance and of laparoscopy to minimize surgical trauma have been enhanced. | Mattia Garancini Enrico Pinotti Stefano Nespoli Fabrizio Romano Luca Gianotti Vittorio Giardini | 2016 | World Journal of Hepatology2016，8，11： | 8 |
| 2 | Rethinking the Barcelona clinic liver cancer guidelines:Intermediate stage and Child-Pugh B patients are suitable for surgery?显示文摘According to Barcelona Clinic Liver Cancer recommendations,intermediate stage hepatocellular carcinomas(stage B)are excluded from liver resection and are referred to palliative treatment.Moreover,Child-Pugh B patients are not usually candidates for liver resection.However,many hepatobiliary centers in the world manage patients with intermediate stage hepatocellular carcinoma or Child-Pugh B cirrhosis with liver resection,maintaining that hepatic resection is not contraindicated in selected patients with non–early-stage hepatocellular carcinoma and without normal liver function.Several studies demonstrate that resection provides the best survival benefit for selected patients in very early/early and even in intermediate stages of Barcelona Clinic Liver Cancer classification,and this treatment gives good results in the setting of multinodular,large tumors in patients with portal hypertension and/or Child-Pugh B cirrhosis.In this review we explore this controversial topic,and we show through the literature analysis how liver resection may improve the short-and long-term survival rate of carefully selected Barcelona Clinic Liver Cancer B and Child-Pugh B hepatocellular carcinoma patients.However,other large clinical studies are needed to clarify which patients with intermediate stage hepatocellular carcinoma are most likely to benefit from liver resection. | Fabrizio Romano Marco Chiarelli Mattia Garancini Mauro Scotti Mauro Zago Gerardo Cioffi Matilde De Simone Ugo Cioffi | 2021 | World Journal of Gastroenterology2021，27，21： | 5 |
| 3 | Is there a role for treatment-oriented surgery in liver metastases from gastric cancer?显示文摘BACKGROUND Distant metastases are found in approximately 35%of patients with gastric cancer at their first clinical observation,and of these,4%-14%involves the liver.Unfortunately,only 0.4%-2.3%of patients with metastatic gastric cancer are eligible for radical surgery.Although surgical resection for gastric cancer metastases is still debated,there have been changes in recent years,although several clinical issues remain to be defined and that must be taken into account before surgery is proposed.AIM To analyze the clinicopathological factors related to primary gastric tumor and metastases that impact the survival of patients with liver metastatic gastric cancer.METHODS We performed a systematic review of the literature from 2000 to 2018 according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement.The study protocol was based on identifying studies with clearly defined purpose,eligibility criteria,methodological analysis,and patient outcome.RESULTS We selected 47 studies pertaining to the purpose of the review,which involved a total of 2304 patients.Median survival was 7-52.3 mo,median disease-free survival was 4.7-18 mo.The 1-,2-,3-,and 5-year overall survival(OS)was 33%-90.1%,10%-60%,6%-70.4%,and 0%-40.1%,respectively.Only five papers reported the 10-year OS,which was 5.5%–31.5%.The general recurrence rate was between 55.5%and 96%,and that for hepatic recurrence was between 15%and 94%.CONCLUSION Serous infiltration and lymph node involvement of the primary cancer indicate an unfavorable prognosis,while the presence of single metastasis or≤3 metastases associated with a size of<5 cm may be considered data that do not contraindicate liver resection. | Fabio Uggeri Lorenzo Ripamonti Enrico Pinotti Mauro Alessandro Scotti Simone Famularo Mattia Garancini Luca Gianotti Marco Braga Fabrizio Romano | 2020 | World Journal of Clinical Oncology2020，11，7： | 3 |
| 4 | Never stimalator and multiple injectios technique for upper and lower limb blockade:failure rate,patient acceptance and neurologic complications显示文摘 | Fanelli G Casati A Garancini P | 1999 | Anesth Anglg1999，88，4： | 1 |
| 5 | Clinical and epidemiological aspects of Alzheimer's disease with presenile onset:a case-control study显示文摘 | Ferini Strambi I Smirne S Garancini P | 1990 | Neuroepidemiology1990，36，1： | 1 |
| 6 | Therapeutic management of primary central nervous system lymphoma in immunocompetent patients: results of a critical review of the literature显示文摘 | Reui M Ferreri AJM Garancini MP | 1997 | Ann Oncol1997，8，3： | 1 |
| 7 | Nerve stimulator and multiple injection technique for upper and lower limb blockade: Failure rate, patient acceptance, and neurological complications 显示文摘 | Casati A Garancini P Torri G | 1999 | Anesth Analg1999，88，： | 1 |
| 8 | Laparoscopic versus open liver surgery: a single center analysis of post-operative in-hospital and post-discharge results显示文摘 | Abdallah Slim Mattia Garancini Stefano Sandro Iacopo Mangoni Andrea Lauterio Alessandro Giacomoni Luciano Carlis | 2012 | Langenbeck’s Archives of Surgery2012，，8： | 1 |
| 9 | Nerve stimulator and multiple injection technique for upperand lower limb blockade: failure rate, patient acceptance, and neurological complications 显示文摘 | Fanelli G Casati A Garancini P | 1999 | Anesth Analg1999，88，4： | 1 |
| 10 | Nerve stimulator and multiple injections technique for upper and lower limb blockade:failure rate,patient acceptance and neurologic complications显示文摘 | Fanelli G Casati A Garancini P | 1999 | Anesth Analg1999，88，： | 1 |
| 11 | Never stimalator and multiple injectios technique for upper and lower limb blockade: failure rate, patient acceptance and neurologic complications显示文摘 | Fanelli G Casati A Garancini P | 1999 | Anesth Anglg1999，88，4： | 1 |
| 12 | Clinical and epidemiological aspects of Alzherimer's disease with presenile onset:a case control study显示文摘 | Smirne S Garancini P | 1990 | Neuroepidemiology1990，9，： | 1 |
| 13 | Therapeutic management of primary central nervous system lymphoma in immunocompetent patients:results of a critical review of the literature显示文摘 | Reni M Ferreri AJM Garancini MP | 1997 | Ann Oncol1997，8，： | 1 |
| 14 | Therapeutic management of primary central nervous system lymphoma in immunocompetent patients: results of a critical review of the literature显示文摘 | RENI M FERRERI A J GARANCINI M P | 1997 | Ann Oncol1997，8，： | 1 |
| 15 | Lipoprotein(a),fibrinogen and vascular mortality in an elderly northern Italian population显示文摘 | D’Angelo A Ruotolo G Garancini P | 2006 | Haematologica2006，91，： | 1 |
| 16 | Nerve stimulator and multiple injection technique for upper and lower limb blockade:failure rate,patient acceptance and neurologic complication 显示文摘 | Fanelli G Gasati A Garancini P | 1999 | Anaesth Analg1999，88，： | 1 |
| 17 | Clinical and epide- miological aspects of Alzheimer's disease with presenile onset : a case control study 显示文摘 | Ferini-Strambi I Smirne S Garancini P | 1990 | Neuroepidemiology1990，9，1： | 1 |
| 18 | Nerve stimulator and multiple injection telnique for upper and lower limb blockade:failure rate、patient acceptance and neurologic complications显示文摘 | Fanelli G Casati A Garancini P et a1 | 1999 | Anesth Analg1999，88，4： | 1 |
| 19 | Nerve stimulator and multiple injections technique for upper and lower limb blockade: failure rate, patient acceptance and neurologic compli- cations显示文摘 | FANELLI G CASATI A GARANCINI P | 1999 | Anesth Analg1999，88，： | 1 |
| 20 | Nerve stimulator and multiple injection technique for upper and lower limb blockade: Failure rate, patient acceptance, and neurologic complications 显示文摘 | Fanelli G Casati A Garancini R | 1999 | Anesth Analg1999，88，4： | 1 |
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