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| 1 | Ultrafine Grained HSLA Steels for Cold Forming显示文摘The industrial level production of ultrafine grained(or ultrafine ferrite)ferrous alloys was investigated through three examples of steels that complied with the EN 10149-2 Euronorm and were produced by advanced controlled hot rolling techniques.The steel samples were tension tested and chemically analyzed,and the microstructure was evaluated through quantitative metallographic techniques to determine parameters such as yield stress,amount of microalloying elements,strain hardening coefficient,grain size,and grain size distribution.These steels were microalloyed with Ti,Nb,and Mn with ASTM grain sizes of approximately 13-15.The careful control of chemical composition and deformation during production,giving a specific attention to the deformation sequences,austenite non-recrystallization temperatures and allotropic transformations during cooling,are indispensable to obtain steels with an adequate strain hardening coefficient that allows cold working operations such as bending,stretching or drawing. | R González J O García M A Barbés M J Quintana L F Verdeja J I Verdeja | 2010 | Journal of Iron and Steel Research(International)2010，17，10： | 7 |
| 2 | Prevalence of metabolic syndrome, obesity and diabetes type 2 in cryptogenic cirrhosis显示文摘AIM: To evaluate the prevalence of metabolic syndrome (MS), obesity and type 2 diabetes mellitus (T2DM) in a group of Mexican Mestizo patients with cryptogenic cirrhosis (CC) and to compare this group with patients with cirrhosis secondary to other causes (disease controls). METHODS: Patients with CC, diagnosed between January, 1990 and April, 2005, were included in a retrospective study. Patients with cirrhosis caused by chronic hepatitis C, alcohol abuse or autoimmune hepatitis (AIH) served as disease controls. RESULTS: A total of 134 patients with CC were analyzed. Disease controls consisted of 81 patients with chronic hepatitis C, 33 with alcohol abuse and 20 with AIH. The median age of patients with CC was 57 years (range, 16-87); 83 (61.9%) patients were female; 53 (39.6%) were Child A, 65 (48.5%) Child B, and 16 (11.9%) were Child C cirrhosis. The prevalence of MS (29.1% vs 6%; P < 0.001), obesity (16.4% vs 8.2%; P = 0.04) and T2DM (40% vs 22.4%; P = 0.013) was higher in CC patients than in disease controls. There were no differences in sex, age or liver function tests between the two groups. CONCLUSION: The prevalence of MS, obesityand T2DM were higher in patients with CC than in patients with cirrhosis secondary to others causes. Our findings support the hypothesis that non-alcoholic steatohepatitis (NASH) plays an under-recognized role in CC. | Felix I Tellez-Avila Francisco Sanchez-Avila Mauricio García-Saenz-de-Sicilia Norberto C Chavez-Tapia Ada M Franco-Guzman Gustavo Lopez-Arce Eduardo Cerda-Contreras Misael Uribe | 2008 | World Journal of Gastroenterology2008，14，30： | 6 |
| 3 | The magnetic response of graphene split-ring metamaterials显示文摘Graphene has emerged as a promising platform for THz plasmonics,allowing high confinement,long lifetimes and fast electrical tunability.Here,we predict a strong magnetic dipole response by graphene split nanorings at THz frequencies,allowing the attainment of metamaterials with a high degree of field confinement(approximately one hundredth of the excitation wavelength)that is not reachable with conventional noble metals.The magnetic response of highly doped graphene split-rings in the far-infrared is much stronger than that displayed by gold structures of similar thicknesses.We further explored stacked graphene layers as a practical way of producing high-frequency magnetism in thin,electrically tunable metamaterials.Our results support the great potential of using graphene to achieve electrically tunable magnetic metamaterials. | Nikitas Papasimakis Sukosin Thongrattanasiri Nikolay I Zheludev FJ Garcıa de Abajo | 2013 | Light(Science & Applications)2013，2，1： | 5 |
| 4 | Timing, method and discontinuation of hydrocortisone administration for septic shock patients显示文摘AIM To characterize the prescribing patterns for hydrocortisone for patients with septic shock and perform an exploratory analysis in order to identify the variables associated with better outcomes.METHODS This prospective cohort study included 59 patients with septic shock who received stress-dose hydrocortisone.It was performed at 2 critical care units in academic hospitals from June 1st, 2015, to July 31 st, 2016. Demographic data, comorbidities, medical management details, adverse effects related to corticosteroids, and outcomes were collected after the critical care physician indicated initiation of hydrocortisone. Univariate comparison between continuous and bolus administration of hydrocortisone was performed, including multivariate analysis, as well as Kaplan-Meier analysis to compare the proportion of shock reversal at 7 d after presentation. Receiver operating characteristic(ROC) curves determined the best cut-off criteria for initiation of hydrocortisone associated with the highest probability of shock reversal. We addressed the effects of the taper strategy for discontinuation of hydrocortisone, noting risk of shock relapse and adverse effects.RESULTS All-cause 30-d mortality was 42%. Hydrocortisone was administered as a continuous infusion in 54.2% of patients; time to reversal of shock was 49 h longer in patients who were given a bolus administration [59 h(range, 47.5-90.5) vs 108 h(range, 63.2-189); P = 0.001]. The maximal dose of norepinephrine after initiation of hydrocortisone was lower in patients on continuous infusion [0.19 μg/kg per minute(range, 0.11-0.28 μg)] compared with patients who were given bolus [0.34 μg/kg per minute(range, 0.16-0.49); P = 0.004]. Kaplan-Meier analysis revealed a higher proportion of shock reversal at 7 d in patients with continuous infusion compared to those given bolus(83% vs 63%; P = 0.004). There was a good correlation between time to initiation of hydrocortisone and time to reversal of shock(r = 0.80; P < 0.0001); ROC curve analysis revealed that the best criteria for prediction of shock reversal was a time to initiation of hydrocortisone of ≤ 13 h after administration of norepinephrine, with an area under the curve of 0.81(P < 0.001). The maximal dose of norepinephrine at initiation of hydrocortisone with the highest association with shock reversal was ≤ 0.28 μg/kg per minute, with an area under the curve of 0.75(P = 0.0002). On a logistic regression model, hydrocortisone taper was not associated with a lower risk of shock relapse(RR = 1.29; P = 0.17) but was related to a higher probability of hyperglycemia [odds ratio(OR), 5.3; P = 0.04] and hypokalemia(OR = 10.6; P = 0.01). CONCLUSION Continuous infusion of hydrocortisone could hasten the resolution of septic shock compared to bolus administration. Earlier initiation corresponds with a higher probability of shock reversal. Tapering strategy is unnecessary. | Miguel A Ibarra-Estrada Quetzalcóatl Chávez-Pe?a Claudia I Reynoso-Estrella Jorge Rios-Zerme?o Pável E Aguilera-González Miguel A García-Soto Guadalupe Aguirre-Avalos | 2017 | World Journal of Critical Care Medicine2017，6，1： | 4 |
| 5 | Model for end-stage liver disease-Na score or Maddrey discrimination function index, which score is best?显示文摘AIM: To compare the ability of model for end-stage liver disease(MELD)-Na and Maddrey discrimination function index(DFI) to predict mortality at 30 and 90 d in patients with alcoholic hepatitis(AH).METHODS: We prospectively assessed 52 patients with AH. Demographic, clinical and laboratory parameters were obtained. MELD-Na and Maddrey DFI were calculated on admission. Short-term mortality was assessed at 30 and 90 d. Receiver operating characteristic curve analysis was performed. RESULTS: Thirty-day and 90-d mortality was 44% and 58%, respectively. In the univariate analysis, sodium levels was associated with mortality at 30 and 90 d(P = 0.001 and P = 0.03). Child stage, encephalopathy, ascites, or types of treatment were not associated with mortality. MELD-Na was the only predictive factor for mortality at 90 d. For 30-d mortality area under the curve(AUC) was 0.763(95%CI: 0.63-0.89) for Maddrey DFI and 0.784 for MELD-Na(95%CI: 0.65-0.91, P = 0.82). For 90-d mortality AUC was 0.685(95%CI: 0.54-0.83) for Maddrey DFI and 0.8710 for MELD-Na(95%CI: 0.76-0.97, P = 0.041). CONCLUSION: AH is associated with high shortterm mortality. Our results show that MELD-Na is a more valuable model than DFI to predict short-term mortality. | Mercedes Amieva-Balmori Scherezada María Isabel Mejia-Loza Roberto Ramos-González Felipe Zamarripa-Dorsey Eli García-Ruiz Nuria Pérez y López Eumir I Juárez-Valdés Adriana López-Luria José María Remes-Troche | 2015 | World Journal of Hepatology2015，7，17： | 2 |
| 6 | Discrimination between active and inactive neurocysticercosis by metacestode excretory/secretory antigens of Taenia solium in an enzymelinked immunosorbent assay 显示文摘 | Molinari J L Garc i a-Mendoza E de la Garza Y | 2002 | Am J Trop Med Hyg2002，66，6： | 1 |
| 7 | Leukocyte attraction through the CCR5 receptor controls progress from insulitis to diabetes in non-obese diabetic mice显示文摘 | Carvalho-Pinto C García M I Gómez L | 2004 | Eur J Immunol2004，34，2： | 1 |
| 8 | Changes in VEGF ex- pression and DNA synthesis in hepatocytes from hepatecto- mized and tumour-bearing mice 显示文摘 | Garc I a M N Andrini L B Inda A M et aI | 2010 | Cell Biol Int2010，34，3： | 1 |
| 9 | Muta- tion of the PIK3CA gene in anaplastic thyroid cancer显示文摘 | Garc I a-Rost 6 n G Costa AM Pereira-Castro I | 2005 | Can- eer Res2005，65，10： | 1 |
| 10 | Elevated oxida- tive stress in the brain of senescence - accelerated mice at 5 months of age 显示文摘 | Alvarez - Garc ia O Vega - Naredo I Sierra V | 2006 | Biogemntology2006，7，1： | 1 |
| 11 | Inflammation, complement, ischemia and amoebic survival in acute experimental amoebic liver abscesses in hamsters显示文摘 | A Olivos-Garc??a M Nequiz-Avenda?o E Tello R.D Mart??nez A González-Canto R López-Vancell M.C Garc??a de León I Montfort R Pérez-Tamayo | 2004 | Experimental and Molecular Pathology2004，，1： | 1 |
| 12 | Applications for bronchial blockers in thoracic surgery显示文摘 | GARC(I)A-GUASCH R CAMPOS J H GRANELL M | | 0，，09： | 1 |
| 13 | Trial of complete weaning from immunosuppression for liver transplant recipients: Factors predictive of tolerance显示文摘 | Rocío García Garza Pablo Sarobe Juana Merino Juan J. Lasarte Delia D’Avola Virginia Belsue José A. Delgado Leyre Silva Mercedes I?arrairaegui Bruno Sangro Jesus J. Sola Fernando Pardo Jorge Quiroga J. Ignacio Herrero | 2013 | Liver Transpl2013，，9： | 1 |
| 14 | Control of Cel Migration and Inflammatory Mediators Production by CORM-2 in Osteoarthritic Synoviocytes显示文摘 | García-Arnandis I Guil én MI Gomar F | | 0，，09： | 1 |
| 15 | A comparative study of sensor array and GC-MS:application to Madrid wines characterization显示文摘 | Santos JP Arroyo T Aleixandre M Lozano J Sayago I García M Femández MJ Arésa L Gutiérrez J Cabellos JM Gil M Horrillo MC | | 0，，02： | 1 |
| 16 | Cellular automata models for the simulation of real-world urban processes:A review and analysis显示文摘 | SANTI GARCA A M MIRANDA D | 2010 | Landscape and Urban Planning2010，3，96： | 1 |
| 17 | Improving artificial neural network with a pruning methodology and genetic algorithms for their application in microbial growth prediction in foods显示文摘 | García-Gimeno R M Hervás-Mátinez C De Siloniz I | 2002 | International Journal of Food Microbiology2002，72，： | 1 |
| 18 | A numerical model for the flooding and drying of irregular domains 显示文摘 | BRUFAU P V A ZQUEZ-CEND O N M E GARC I A-NAVARRO P | 2002 | International Journal for Numerical Methods in Fluids2002，39，3： | 1 |
| 19 | Comparing methods for predicting the sintering of biomass ash in combustion显示文摘 | LLORENTE F M J GARC(I)A C J E | | 0，，14： | 1 |
| 20 | Aero- bic exercise reduces oxidative stress and improves vascular changes of small mesenteric and coronary arteries in hypertension显示文摘 | ROQUE F R BRIONES A M GARC I A-REDONDO A B | 2013 | British jour- nal of pharmacology2013，168，3： | 1 |
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