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| 1 | Evaluation of anti-apoptotic activity of different dietary antioxidants in renal cell carcinoma against hydrogen peroxide显示文摘Objective:To evaluate the anti-apoptotic and radical scavenging activities of dietary phenolics, namely ascorbic acid,a-tocopherol acetate,citric acid,salicylic acid,and estimate H_2O_2induced apoptosis in renal cell carcinoma cells.Methods:The intracellular antioxidant potency of antioxidants was investigated.H_2O-2-induced apoptosis in RCC-26 was assayed with the following parameters:cell viability(%apoptosis),nucleosomal damage and DNA fragmentation, bcl-2 levels and flow cytometery analysis(ROS production evaluation).Results:Ine anticancer properties of antioxidants such as ascorbic acid,a- tocopherol acetate,citric acid,salicylic acid with perdurable responses were investigated.It was observed that these antioxidants had protective effect(anti-apoptotic activity) against hydrogen peroxide(H_2O_2) in renal cell carcinoma(RCC-26) cell line.Conclusions:This study reveals and proves the anticancer properties.However,in cancer cell lines anti-apoptotic activity can indirectly reflect the cancer promoter activity through radicals scavenging,and significantly protect nucleus and bcl-2. | Garg Neeraj K Mangal Sharad Sahu Tejram Mehta Abhinav Vyas Suresh P Tyagi Rajeev K | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，1： | 4 |
| 2 | Thermodynamic interdiffusion coefficient in binary systems with intermediate phases显示文摘 | Garg S P Kale G B Patil R V Kundu T | 1999 | Intermetallics1999，7，： | 2 |
| 3 | Combination immunotherapy with Survivin and luteinizing hormone-releasing hormone fusion protein in murine breast cancer model显示文摘AIM To investigate the therapeutic potential of two recombinant proteins, Survivin and luteinizing hormone-releasing hormone (LHRH) fusion protein [LHRH(6 leu)-LTB] for immunotherapy of breast cancer.METHODS Murine 4 T-1 breast cancer model was used to evaluate the efficacy of recombinant proteins in vivo. Twenty four Balb/c mice were divided into 4 groups of 6 mice each. Recombinant Survivin and LHRH fusion protein, alone or in combination, were administered along with immunomodulator Mycobacterium indicus pranii (MIP) in Balb/c mice. Unimmunized or control group mice were administered with phosphate buffer saline. Each group was then challenged with syngeneic 4 T-1 cells to induce the growth of breast tumor. Tumor growth was monitored to evaluate the efficacy of immune-response in preventing the growth of cancer cells.RESULTS Preventive immunization with 20 μg recombinant Survivin and MIP was effective in suppressing growth of 4 T-1 mouse model of breast cancer (P = 0.04) but 50 μg dose was ineffective in suppressing tumor growth. However, combination of Survivin and LHRH fusion protein was more effective in suppressing tumor growth (P = 0.02) as well as metastasis in vivo in comparison to LHRH fusion protein as vaccine antigen alone.CONCLUSION Recombinant Survivin and MIP suppress tumor growth significantly. Combining LHRH fusion protein with Survivin and MIP enhances tumor suppressive effects marginally which provides evidence for recombinant Survivin and LHRH fusion protein as candidates for translating the combination cancer immunotherapy approaches. | Himani Garg Rohit Singh Hada Jagdish C Gupta G P Talwar Shweta Dubey | 2018 | World Journal of Clinical Oncology2018，9，8： | 2 |
| 4 | Vesicular systems in ocular drug delivery: an overview 显示文摘 | KAUR I P GARG A SINGLA A K | 2004 | lnt J Pharm2004，269，1： | 1 |
| 5 | : The epidemiological features and laboratory resuhs of fungal keratitis: a 10-year re- view at a referral eye care center in South India 显示文摘 | Gopinathan U Garg P Fernandes M | 2002 | Cornea2002，21，： | 1 |
| 6 | A prospective randomized trial comparing two-stage versus single-stage management of patients with gallstone disease and common bile duet stones显示文摘 | Bansal VK Misra MC Garg P | 2010 | Surg En- dose2010，24，8： | 1 |
| 7 | Laparoscopic repair of perforatedpeptic ulcer with delayed presentation 显示文摘 | Vaidya B B Garg C P Shah J B | 2009 | 7 Laparoendosc AdvSurg Tech A2009，19，2： | 1 |
| 8 | A parameter opti- mization approach to controller partitioning for integrated flight/propulsion control application显示文摘 | Schmidt P H Garg S Holowecky B R | 1993 | IEEE Transac- tions on Control Systems Technology1993，1，1： | 1 |
| 9 | Intracellular mechanisms ofN-acyletha nolamine-mediated neuroprotection in a rat model ofstroke显示文摘 | Garg P Duncan RS Kaja S | 2010 | Neuroscience2010，166，1： | 1 |
| 10 | Vermicomposting of different types of waste using Eisenia foetida:A comparative study 显示文摘 | Garg P Gupta A Satya S | 2006 | Bioresour Technol2006，97，3： | 1 |
| 11 | An experimental study on the effect of ultrasonication on viscosity and heat transfer performance of multi-wall carbonnanotube-based aqueous nanofluids 显示文摘 | Garg P Alvarado J L Marsh C | 2009 | International Journal of Heat and Mass Transfer2009，52，21： | 1 |
| 12 | Dentification of candidate coding region single nucleotide polymorphisms in 165 human genes using assembled expressed sequence tags显示文摘 | Garg K Green P Nickerson D A | 1999 | Genome Res1999，9，： | 1 |
| 13 | Arsenic toxicity in crop plants:physiological effects and tolerance mechanisms显示文摘 | GARG N SINGLA P | 2011 | Environmental Chemistry Letters2011，9，3： | 1 |
| 14 | Performance analysis of a hybrid photovoltaic/thermal (PV/T) collector with integrated CPC troughs显示文摘 | Garg H P Adhikari R S | 1999 | International joumal of energy research1999，23，15： | 1 |
| 15 | Theoretical and experimental studies on collector/storage type solar water heater显示文摘 | H P Garg R Usha | 1982 | International Journal of Solar Energy1982，29，： | 1 |
| 16 | Modelling of Corex Process for Optimisation of OperatiOnal Parameters显示文摘 | Prachethan Kumar P Garg L M Gupta S S | 2006 | Ironmaking and Steelmaking2006，33，1： | 1 |
| 17 | Laparoscopic total extraperitoneal inguinal hernia repair with nonfixation of the mesh for 1 692 hernias显示文摘 | Garg P Rajagopal M Varghese V | 2009 | Surg Endosc2009，23，6： | 1 |
| 18 | Overuse of Acid Suppres-sion TheraPy in Hospitalized Patients显示文摘 | Gupta R Garg P Kottoor R | | 0，，03： | 1 |
| 19 | Vermicomposting of mixed solid tex- tile mill sluge and cow dung with the epigeic earthworm Eise- nia foetida显示文摘 | Kaushik P Garge V K | 2003 | Bioresource Technology2003，90，3： | 1 |
| 20 | Multiplicative watermarking of audio in Dlrr magnitude 显示文摘 | Singh J Garg P De A | 2014 | Multimedia Tools and Applications2014，71，3： | 1 |
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