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| 1 | Effect of nutritional counselling on hepatic,muscle and adipose tissue fat content and distribution in non-alcoholic fatty liver disease显示文摘AIM: To assess the effectiveness of the current UK clinical practice in reducing hepatic fat (IHCL). METHODS: Whole body MRI and 1H MRS were obtained, before and after 6 mo nutritional counselling, from liver, soleus and tibialis muscles in 10 subjects with non-alcoholic fatty liver disease (NAFLD). RESULTS: A 500 Kcal-restricted diet resulted in an average weight loss of 4% (-3.4 kg,) accompanied by significant reductions in most adipose tissue (AT) depots, including subcutaneous (-9.9%), abdominal subcutaneous (-10.2%) and intra-abdominal-AT (-11.4%). Intramyocellular lipids (IMCL) were significantly reduced in the tibialis muscle (-28.2%). Decreases in both IHCL (-39.9%) and soleus IMCL (-12.2%) content were also observed, although these were not significant. Several individuals showed dramatic decreases in IHCL, while others paradoxically showed increases in IHCL content. Changes in body composition were accompanied by improvements in certain liver function tests: serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT). Significant correlations were found between decreases in IHCL and reductions in both intra-abdominal and abdominal subcutaneous AT. Improvements in liver function tests were associated with reductions in intra-abdominal AT, but not with changes in IHCL. CONCLUSION: This study shows that even a very modest reduction in body weight achieved through lifestyle modification can result in changes in body fat depots and improvements in LFTs. | E Louise Thomas Audrey E Brynes Gavin Hamilton Nayna Patel Adam Spong Robert D Goldin Gary Frost Jimmy D Bell Simon D Taylor-Robinson | 2006 | World Journal of Gastroenterology2006，12，36： | 13 |
| 2 | Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development 显示文摘 | Gavin MA Torgerson TR Houston E | 2006 | Proe Natl Aead Sci USA2006，103，17： | 1 |
| 3 | Spatial statistical methods in environmental epidemiology:a critique显示文摘 | Paul E Marco M Gavin S | 1995 | Statistical Methods in Medical Research1995，4，： | 1 |
| 4 | An antigen produced by splicing of noncontiguous peptides in the reverse order 显示文摘 | Warren E H Vigneron N J Gavin M A | 2006 | Science2006，313，5792： | 1 |
| 5 | Upregulation of TET1 and down- regulation of APOBEC3A and APOBEC3C in the parietal cortex of psychotic patients 显示文摘 | Dong E Gavin DP Chen Y | 2012 | Transl Psychiatry2012，2，： | 1 |
| 6 | Toll-like receptor 4 is involved in the mechanism of early alcohol-induced liver injury in mice显示文摘 | Takehiko U Matthias F Gavin E A | 2001 | Hepatology2001，34，： | 1 |
| 7 | Activation of group Ⅱ metabotropic glutamate receptors promotes DNA demethylation inthe mouse brain 显示文摘 | Matrisciano F Dong E Gavin DP | 2011 | Mol Pharmaeol2011，80，： | 1 |
| 8 | Manganese and calcium transport in mitochondria: implications for manganese toxicity 显示文摘 | GAVIN C E GUNTER K K GUNTER T E | 1999 | Neurotoxicology1999，20，23： | 1 |
| 9 | High power,low frequency uhrasound:meniscal tissue interaction and ablation characteristics 显示文摘 | Morris E Gavin GP O' Keane C | 2011 | Ultrasound Med Biol2011，37，4： | 1 |
| 10 | Hepatotoxicity in an African antiretroviral therapy cohort: the effect of tuberculosis and hepatitis B显示文摘 | Christopher J Hoffmann Salome Charalambous Chloe L Thio Desmond J Martin Lindiwe Pemba Katherine L Fielding Gavin J Churchyard Richard E Chaisson Alison D Grant | 2007 | AIDS2007，，10： | 1 |
| 11 | Information asymmetry and information sharing 显示文摘 | GAVIN C TROND E J ARCHER L B | 2007 | Government Information Quarter- ly2007，，24： | 1 |
| 12 | Blood Pressure,C- Reactive Protein, and Risk of Future Cardiovascular Events显示文摘 | Blake Gavin J Rifai Nader Buring Julie E | 2003 | Circulation2003，108，24： | 1 |
| 13 | Electro-rheological damper I : analysis and design 显示文摘 | Gavin H P Hanson R I) Filisko F E | 1996 | Transactions of the ASME Journal Applied Mechanic1996，63，： | 1 |
| 14 | Programs to strengthen parent-adolescent communication about reproductive health:A systematic review显示文摘 | Gavin L E Williams J R Rivera M I | 2015 | Am J Prev Med2015，49，21： | 1 |
| 15 | Characterization of genes encoding translation initiation factor elF-2gamma in mouse and human:sex chromosome localiza-tion,escape from X-inactivation and evolution显示文摘 | Ellis P S Mazeyrat S Duthie S Brockdorff N Mattei M-G Gavin M A Affara N A Brown G M Simpson E Mitchell M J Scott D M | 1998 | Hum Mol Genet1998，7，： | 1 |
| 16 | B lymphocyte stimulator (BLyS) isoforms in systemic lupus erythematosus: disease activity correlates better with blood leukocyte BLyS mRNA levels than with plasma BLyS protein levels显示文摘 | Christopher E Collins Amanda L Gavin Thi-Sau Migone | 2006 | Arthritis Res Ther2006，8，1： | 1 |
| 17 | The role of ion mobility spectrometry-mass spectrometry in the analysis of protein reference standards显示文摘 | Caroline P Gavin O Alison E A | 2013 | Analytical Chemistry2013，85，15： | 1 |
| 18 | Systematic analysis of microRNA expression of RNA extracted from fresh frozen and formalin-fixed paraffin-embedded samples显示文摘 | Xi Y Nakajima G Gavin E | 2007 | RNA2007，13，10： | 1 |
| 19 | Single-cell analysis of normal and FOXP3-mutant human T cells:FOXP3 expression without regulatory T cell development显示文摘 | Gavin M A Torgerson T R Houston E | 2006 | Proc Natl Acad Sci U S A2006，103，17： | 1 |
| 20 | Systemic arterial expression of matrixmetalloproteinases 2 and 9 in acute Kawasaki disease显示文摘 | Gavin P J Crawford S E Shulman S T | 2003 | Vasc Biol2003，23，4： | 1 |
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