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| 1 | Single-cell RNA-seq reveals the diversity of trophoblast subtypes and patterns of differentiation in the human placenta显示文摘胎盘为成功的怀孕和胎儿和怀孕女人的健康是关键的。然而,人的 trophoblast 系怎么被调整,包括胎盘的房间的分类,子类型糟糕被理解。这里,我们在排序的胎盘的房间上执行了定序的单个房间的 RNA (RNA-seq ) 从第一三个月并且秒三个月人胎盘。已知的 cytotrophoblast 房间(CTB ) 的房间的新子类型, extravillous trophoblast 房间(EVT ) , Hofbauer 房间,和间充质的 stromal 房间被识别, cell-type-specific 基因签名被定义。机能上地,这研究揭示了人的胎盘的许多以前未知的功能。尤其是, 102 多肽荷尔蒙基因被发现被胎盘的房间的各种各样的子类型表示,它在调整母亲的生理学的胎儿的生长和改编到怀孕建议建筑群和这些荷尔蒙的重要角色。这些结果在单个房间的分辨率记录人的胎盘的 trophoblast 区别并且因此在怀孕的早阶段期间推进我们人的胎座式的理解。 | Yawei Liu Xiaoying Fan Rui Wang Xiaoyin Lu Yan-Li Dang Huiying Wang Hai-Yan Lin Cheng Zhu Hao Ge James C. Cross Hongmei Wang | 2018 | Cell Research2018，28，8： | 15 |
| 2 | Distribution of tetraether lipids in surface sediments of the northern South China Sea:Implications for TEX_(86) proxies显示文摘Archaea 有能习惯于的类脂化合物开发的唯一的甘油 dialkyl 甘油 tetraether (GDGT ) paleotemperature 代理象 TEX86 那样。这研究是在华南海(SCS ) 为 paleotemperature 决心验证建议 GDGT 代理。样品在北 SCS 从核心顶沉积(05 厘米) 被收集。全部的类脂化合物被提取获得核心 GDGT,它被识别并且确定了使用液体层析团 spectrometry (最小公倍数) 。许多 isoprenoidal GDGT (iGDGTs ) 从 271.5 ng/g 干燥沉积到 1266.3 ng/g,弄干沉积分叉的 GDGT (bGDGTs ) ,据说源于陆上的来源,从 22.2 ng/g 干燥沉积到 56.7 ng/g 干燥沉积。导出 TEX86 的海表面温度从 20.9 牡敧挠湯瑳畲瑣潩獮椠 ? 散瑮慲? 湡 ? 潳瑵敨湲匠湩楡沈 ? 沈吗?? | Huangmin Ge Chuanlun L.Zhang Hongyue Dang Chun Zhu Guodong Jia | 2013 | Geoscience Frontiers2013，4，2： | 10 |
| 3 | Sorption of tylosin and sulfamethazine on solid humic acid显示文摘Tylosin(TYL) and sulfamethazine(SMT) are ionizable and polar antimicrobial compounds,which have seeped into the environment in substantial amounts via fertilizing land with manure or sewage. Sorption of TYL and SMT onto humic acid(HA) may affect their environmental fate. In this study, the sorption of TYL and SMT on HA at different conditions(pH, ionic strength) was investigated. All sorption isotherms fitted well to the Henry and Freundlich models and they were highly nonlinear with values of n between 0.5 and 0.8, which suggested that the HA had high heterogeneity. The sorption of TYL and SMT on HA decreased with increasing p H(2.0–7.5), implying that the primary sorption mechanism could be due to cation exchange interactions between TYL^+/SMT^+ species and the functional groups of HA.Increasing ionic strength resulted in a considerable reduction in the K_d values of TYL and SMT,hinting that interactions between H bonds and π–π EDA might be an important factor in the sorption of TYL and SMT on HA. Results of Fourier transform infrared(FT-IR) and ~13C-nuclear magnetic resonance(NMR) analysis further demonstrated that carboxyl groups and O-alkyl structures in the HA could interact with TYL and SMT via ionic interactions and H bonds,respectively. Overall, this work gives new insights into the mechanisms of sorption of TYL and SMT on HA and hence aids us in assessing the environmental risk of TYL and SMT under diverse conditions. | Xuetao Guo Bei Tu Jianhua Ge Chen Yang Xiaomei Song Zhi Dang | 2016 | Journal of Environmental Sciences2016，28，5： | 9 |
| 4 | Hydrothermal synthesis of peony-like CuO micro/nanostructures for high-performance lithium-ion battery anodes显示文摘The peony-like CuO micro/nanostructures were fabricated by a facile hydrothermal approach. The peonylike CuO micro/nanostructures about 3-5 μm in diameter were assembled by CuO nanoplates. These CuO nanoplates, as the building block, were self-assembled into multilayer structures under the action of ethidene diamine, and then grew into uniform peony-like CuO architecture. The novel peony-like CuO micro/nanostructures exhibit a high cycling stability and improved rate capability. The peony-like CuO micro/nanostructures electrodes show a high reversible capacity of 456 mAh/g after 200 cycles, much higher than that of the commercial CuO nanocrystals at a current 0.1 C. The excellent electrochemical performance of peony-like CuO micro/nanostructures might be ascribed to the unique assembly structure, which not only provide large electrode/electrolyte contact area to accelerate the lithiation reaction, but also the interval between the multilayer structures of CuO nanoplates electrode could provide enough interior space to accommodate the volume change during Li^+ insertion and de-insertion process. | Rui Dang Xilai Jia Peng Wang Xiaowei Zhang Danni Wang Ge Wang | 2017 | Chinese Chemical Letters2017，28，12： | 4 |
| 5 | Morphology of polar ionospheric O^+ ion upflow: FAST observations during quiet time显示文摘With energetic ion measurements on FAST satellite, the morphologic features of quiet-time ionospheric O+ ion upflowing at altitudes of 2000 to 4000 km are drawn out for the first time. The pre-noon cusp/cleft is the predominant region of upflowing occurrence for O+ with lower energy. Meanwhile the pre-dawn sector near the equatorward edge of the plasma convection dominates the occurrence for the higher energy O+ ions. No matter whether the energy is lower or higher, the upflows occur often over a wide MLT range of lower latitudes outside the auroral oval. The upflowing within the pre-midnight (21:00― 22:00 MLT) auroral oval carrys larger energy fluxes, with extremely large fluxes for higher energy O+ appearing near the polar cap boundary. For altitudes of 2000―4200 km under observation, the ion conics occur much more frequently than ion beams. Ion beams are rarely found below 3000 km, while the conics occur uniformly over the observed altitudes. | DANG Ge MA ShuYing ZHOU YunLiang | 2007 | Chinese Science Bulletin2007，52，24： | 3 |
| 6 | Thaumarchaeotal Signature Gene Distrilmtlon in Sediments of the Northern South China Sea: an Indicator of the Metabolic Intersection of the Marine Carbon, Nitrogen, and Phosphorus Cycles?显示文摘 | DANG H ZHOU H YANG J GE H JIAO N LUAN X KLOTZ M G | 2013 | Applied and Enviromnental Microbiology2013，79，： | 1 |
| 7 | Field-aligned current distribution and response to interplanetary conditions during a superstorm——CHAMP observation显示文摘With geomagnetic measurements on board of CHAMP satellite, the characteristics of global large-scale field-aligned currents (FACs) in the topside ionosphere are investigated along with their responses to interplanetary conditions for the superstorm of November, 2003. It is found that (1) The storm-time FAC densities enhanced greatly in comparison with quiet period and the enhancements show hemispheric asymmetry of both summer-winter and sunlit-dark. (2) For the first time, it is revealed that the lati-tude-integrated FAC density is controlled mainly by solar wind dynamic pressure rather than IMF. (3) FACs expanded equatorward dramatically, with the lowest latitude being 45° MLat or more; on the day-side this expansion was controlled directly by IMF Bz, showing an interaction time scale of about 25 min in the solar wind-magnetosphere-ionosphere coupling system, and a nonlinear saturation of the equatorward expansion when IMF Bz < -30 nT; while on the nightside, the expansion and recovery lagged about 3 h behind the IMF changes but nearly in phase with changes of SYM-H index. (4) During the storm main phase, the nightside FAC latitude coverage extended to 25° or wider, appearing multi-sheet current structure with more than 10 sheets. | WANG Hui MA ShuYing Hermann LUEHR ZHOU YunLiang DANG Ge | 2007 | Chinese Science Bulletin2007，52，2： | 1 |
| 8 | In search of rat stem Leydig cells: identification, isolation, and lineage-specific development 显示文摘 | Ge RS Dang Q Sottas CM | 2006 | Proc Natl Acad Sci USA2006，103，8： | 1 |
| 9 | Application of TRMM/PR data for numerical simulation with mesose, ale model MMS显示文摘 | XU Z F GE W Z DANG R Q | 2003 | Adv Atmos Sci2003，20，： | 1 |
| 10 | Targeted inhibition of osteoclastogenesis reveals the pathogenesis and therapeutics of bone loss under sympathetic neurostress显示文摘Sympathetic cues via the adrenergic signaling critically regulate bone homeostasis and contribute to neurostress-induced bone loss,but the mechanisms and therapeutics remain incompletely elucidated.Here,we reveal an osteoclastogenesis-centered functionally important osteopenic pathogenesis under sympatho-adrenergic activation with characterized micro RNA response and efficient therapeutics.We discovered that osteoclastic mi R-21 was tightly regulated by sympatho-adrenergic cues downstream theβ2-adrenergic receptor(β2AR)signaling,critically modulated osteoclastogenesis in vivo by inhibiting programmed cell death 4(Pdcd4),and mediated detrimental effects of both isoproterenol(ISO)and chronic variable stress(CVS)on bone.Intriguingly,without affecting osteoblastic bone formation,bone protection against ISO and CVS was sufficiently achieved by a(D-Asp8)-lipid nanoparticle-mediated targeted inhibition of osteoclastic mi R-21 or by clinically relevant drugs to suppress osteoclastogenesis.Collectively,these results unravel a previously underdetermined molecular and functional paradigm that osteoclastogenesis crucially contributes to sympatho-adrenergic regulation of bone and establish multiple targeted therapeutic strategies to counteract osteopenias under stresses. | Bingdong Sui Jin Liu Chenxi Zheng Lei Dang Ji Chen Yuan Cao Kaichao Zhang Lu Liu Minyan Dang Liqiang Zhang Nan Chen Tao He Kun Xuan Fang Jin Ge Zhang Yan Jin Chenghu Hu | 2022 | International Journal of Oral Science2022，14，4： | 1 |
| 11 | Three- dimensional imaging via wideband MIMO radar system 显示文摘 | Qing Ge Dang Dan Wang Wei | 2010 | IEEE Geoseiences and Remote Sensing Letters2010，7，3： | 1 |
| 12 | A novel mutation of p.F32I in GJA8 in human dominant congenital cataracts显示文摘· AIM: To identify a causative mutation in a three-generation family with autosomal dominant congenital total cataract and dissect the molecular consequence of the identified mutation.·METHODS: Clinical and ophthalmological examinations were performed on the affected and unaffected family members. Mutation were screened in recruited family members by polymerase chain reaction(PCR) of the two reported genes(CRYAA and GJA8) which were linked to human total cataracts and direct sequencing of the PCR product. The molecular consequences of the identified mutation was dissected. The plasmids carrying wild-type and mutant mouse ORF of Gja8, coding for connexin 50(Cx50), were generated and ectopic expressed in 293 cells. Recombinant protein expression and cellular localization of recombinated Cx50 were assessed by confocal microscopy.·RESULTS: Clinical and ophthalmological examinations were performed on the affected and unaffected family members. Mutation were screened in recruited family members by PCR of the two reported genes(CRYAA and GJA8) which were linked to human total cataractsand direct sequencing of the PCR product. The molecular consequences of the identified mutation was dissected.The plasmids carrying wild-type and mutant mouse ORF of Gja8, coding for Cx50, were generated and ectopic expressed in 293 cells. Recombinant protein expression and cellular localization of recombinated Cx50 were assessed by confocal microscopy.· CONCLUSION: This study has identified a novel cataract mutation in GJA8, which adds a novel mutation to the existing spectrum of Cx50 mutations with cataract.The molecular consequences of p.F32 I mutation in GJA8 exclude instability and the mislocalization of mutant Cx50 protein. | Feng-Tao Dang Fa-Yu Yang Ye-Qin Yang Xiang-Lian Ge Ding Chen Liu Zhang Xin-Ping Yu Feng Gu Yi-Hua Zhu | 2016 | International Journal of Ophthalmology(English edition)2016，9，11： | 1 |
| 13 | Practical synthesis of an orally active renin inhibitor aliskiren显示文摘 | Hua Dang Zhi-Liu Zhang Jia-Hui Huang Rujian Ma Shu-Hui Chen and Ge Li | 2005 | Tetrahedron Letters2005，46，： | 1 |
| 14 | An effective global learning framework for hyperspectral image classification based on encoder-decoder architecture显示文摘Most deep learning methods in hyperspectral image(HSI)classification use local learning methods,where overlapping areas between pixels can lead to spatial redundancy and higher computational cost.This paper proposes an efficient global learning(EGL)framework for HSI classification.The EGL framework was composed of universal global random stratification(UGSS)sampling strategy and a classification model BrsNet.The UGSS sampling strategy was used to solve the problem of insufficient gradient variance resulted from limited training samples.To fully extract and explore the most distinguishing feature representation,we used the modified linear bottleneck structure with spectral attention as a part of the BrsNet network to extract spectral spatial information.As a type of spectral attention,the shuffle spectral attention module screened important spectral features from the rich spectral information of HSI to improve the classification accuracy of the model.Meanwhile,we also designed a double branch structure in BrsNet that extracted more abundant spatial information from local and global perspectives to increase the performance of our classification framework.Experiments were conducted on three famous datasets,IP,PU,and SA.Compared with other classification methods,our proposed method produced competitive results in training time,while having a greater advantage in test time. | Lanxue Dang Chongyang Liu Weichuan Dong Yane Hou Qiang Ge Yang Liu | 2022 | International Journal of Digital Earth2022，15，1： | 0 |
| 15 | The multifaceted functions of cGAS显示文摘Pattern recognition receptors arecritical forthe sensing of pathogen-associated molecular patterns or danger-associated molecular patterns and subsequent mounting of innate immunityandshaping ofadaptive immunity.The identification of 2'3'-cyclic guanosine monophosphate-adenosine monophosphate(cGAMP)synthase(cGAS)as a major cytosolic DNA receptor is a milestone in the field of DNA sensing.The engagement of cGAS by double-stranded DNA from different origins,including invading pathogens,damaged mitochondria,ruptured micronuclei,and genomic DNA results in the generation of cGAMP and activation of stimulator of interferon genes,which thereby activates innate immunity mainly characterized by the activation of type I interferon response.In recent years,great progress has been made in understanding the subcellular localization and novel functions of cGAS.In this review,we particularlyfocus on summarizingthe multifaceted roles ofcGAS in regulating senescence,autophagy,cell stemness,apoptosis,angiogenesis,cell proliferation,antitumor effect,DNA replication,DNA damage repair,micronucleophagy,as well as cell metabolism. | Haipeng Liu Fei Wang Yajuan Cao Yifang Dang Baoxue Ge | 2022 | Journal of Molecular Cell Biology2022，14，5： | 0 |
| 16 | CB1 agonism prolongs time window for estrogen replacement therapy显示文摘OBJECTIVE To detect the underlying mechanism of time window for estrogen(E2)replacement treating cognitive decline.METHODS E2 begun 1 week after the ovariectomy(OVXST)or 3 months after the ovariectomy(OVXLT).Learning and memory ability were examined by trace fear memory test and inhibitory avoidance test.LTP and LTD were detected by MED64.High throughput gene expression sequencing and microRNA(miR NA) sequencing were used to detecte the differently expressed genes between OVXSTand OVXLTafter estrogen treatment.RESULTS Subcutaneous injection of E2 improved fear memory formation in both 1 week after ovariectomy(OVXST) mice or 3 months after ovariectomy(OVXLT) mice.However,for fear memory extinction,facilitated by E2 in OVXSTmice,but impaired by E2 in OVXLTmice.Further researches showed in medial prefrontal cortex(mPFC),estrogen facilitates LTD in OVXSTmice but impairs LTD in OVXLTmice.Results of highthroughput sequencings of mR NA and miRNA in mPFC from sham,OVXSTmice,E2 treated OVXST mice,OVXLTmice,and E2 treated OVXLTmice indicated decreased miR-221-5 p expression in OVXLTmice compared with OVXSTmice.In OVXLT mice,miR-221-5 p could be further reduced by E2 treatment.Additionally,miR-221-5 p targeted neuralized E3 ubiquitin protein ligase 1 a/b(Neurl1 a/b) m RNA.Decreased miR-221-5 p will promotes cannabinoid receptor 1(CB1) ubiquitination through up-regulating Neurl1 a/b protein levels in E2 treated OVXLTmice,which disrupted the retrograde endocanabinoids system.Replenishing miR-221-5 p or treating with CB1 agonist rescued the fear extinction impairment in E2 treated OVXLTmice.CONCLUSION These results uncovered a epigenetic change after long term E2 responsible for failure of E2 improving cognitive performance in OVXLTmice,moreover miR-221-5 p and CB1 agonist as potential targets for prolonging the time window for E2 replacement therapy. | ZHANG Kun LI Yan-jiao YANG Qi LI Yu-jiao YANG Le WANG Xin-shang DANG Rui-li GUAN Shao-yu GUO Yan-yan GE Xiang-wei SUN Ting WU Yu-mei LIU Shui-bing ZHAO Ming-gao | 2018 | 中国药理学与毒理学杂志2018，32，9： | 0 |
| 17 | Probability Loop Closure Detection with Fisher Kernel Framework for Visual SLAM显示文摘A typical approach to describe an image in loop closure detection for visual SLAM is to extract a set of local patch descriptors and encode them into a co-occurrence vector.The most common patch encoding strategy is known as bag-of-visual-words(BoVW)representation,which consists of clustering the local descriptors into visual vocabulary.The distinctiveness of images is difficult to represent since most of them contain similar texture information,which may lead to false positive results.In this paper,the vocabulary is used as a whole by adopting the Fisher kernel(FK)framework.The new representation describes the image as the gradient vector of the likelihood function.The efficiently computed vectors can be compressed with a minimal loss of accuracy using product quantization and perform well in the task of loop closure detection.The proposed method achieves a higher recall rate with 100%precision in loop closure detection compared with state-of-the-art methods,and the detection on bidirectional loops is also enhanced.vSLAM systems may perceive the environment more efficiently by constructing a globally consistent map with the proposed loop closure detection method,which is potentially valuable for applications such as autonomous driving. | Ge Zhang Qian Zuo Hao Dang | 2022 | 国际计算机前沿大会会议论文集2022，，1： | 0 |
| 18 | Neuro-11:a new questionnaire for the assessment of somatic symptom disorder in general hospitals显示文摘Background Somatic symptom disorder(SSD)commonly presents in general hospital settings,posing challenges for healthcare professionals lacking specialised psychiatric training.The Neuro-11 Neurosis Scale(Neuro-11)offers promise in screening and evaluating psychosomatic symptoms,comprising 11 concise items across three dimensions:somatic symptoms,negative emotions and adverse events.Prior research has validated the scale’s reliability,validity and theoretical framework in somatoform disorders,indicating its potential as a valuable tool for SSD screening in general hospitals.Aims This study aimed to establish the reliability,validity and threshold of the Neuro-11 by comparing it with standard questionnaires commonly used in general hospitals for assessing SSD.Through this comparative analysis,we aimed to validate the effectiveness and precision of the Neuro-11,enhancing its utility in clinical settings.Methods Between November 2020 and December 2021,data were collected from 731 patients receiving outpatient and inpatient care at Shenzhen People’s Hospital in China for various physical discomforts.The patients completed multiple questionnaires,including the Neuro-11,Short Form 36 Health Survey,Patient Health Questionnaire 15 items,Hamilton Anxiety Scale and Hamilton Depression Scale.Psychiatry-trained clinicians conducted structured interviews and clinical examinations to establish a gold standard diagnosis of SSD.Results The Neuro-11 demonstrated strong content reliability and structural consistency,correlating significantly with internationally recognised and widely used questionnaires.Despite its brevity,the Neuro-11 exhibited significant correlations with other questionnaires.A test-retest analysis yielded a correlation coefficient of 1.00,Spearman-Brown coefficient of 0.64 and Cronbach’sαcoefficient of 0.72,indicating robust content reliability and internal consistency.Confirmatory factor analysis confirmed the validity of the three-dimensional structure(p<0.001,comparative fit index=0.94,Tucker-Lewis index=0.92,root mean square error of approximation=0.06,standardised root mean square residual=0.04).The threshold of the Neuro-11 is set at 10 points based on the maximum Youden’s index from the receiver operating characteristic curve analysis.In terms of diagnostic efficacy,the Neuro-11 has an area under the curve of 0.67. | Silin Zeng Yian Yu Shan Lu Sirui Zhang Xiaolin Su Ge Dang Ying Liu Zhili Cai Siyan Chen Yitao He Xin Jiang Chanjuan Chen Lei Yuan Peng Xie Jianqing Shi Qingshan Geng Rafael H Llinas Yi Guo | 2023 | General Psychiatry2023，36，4： | 0 |
| 19 | En quête de neutralité carbone:La Chine s'efforce d'atteindre ses objectifs en matiere de carbone显示文摘 | GE LIJUN DANG XIAOFEI | 2022 | 中国与非洲(法文版)2022，14，4： | 0 |
| 20 | Spin-down and emission variations for PSR J0742-2822显示文摘PSR J0742-2822 is known for its quasi-periodic changes in the observed pulse profile and spindown rate.In this paper,we analyzed 13 years of timing data obtained with the Nanshan 25-m radio telescope and the Parkes 64-m radio telescope.We found that the average values of the spin-down rate((v))of this pulsar changed in four different states.We investigated the correlation between v and W50,and ascertained that the correlation changed in different states.Moreover,not all the changes in states and correlation can be associated with glitch activities.We examined the long term evolution ofγ-ray flux(0.1-300 GeV)and the pulse profiles corresponding to the four different states using Fermi-LAT Pass8(P8 R3)data from 2008 August 5 to 2019 October 1.We did not detect a significant change inγ-ray flux or the pulse profile.Our results suggest that the connection between pulsar rotation and emission is more complex than previously reported for this pulsar. | Shi-Jun Dang Na Wang Hui-Hui Wang Jian-Ping Yuan Lun-Hua Shang Rai Yuen Ming-Yu Ge Xia Zhou Shuang-Qiang Wang Fei-Fei Kou Wen-Ming Yan Jing-Bo Wang Zhi-Gang Wen Jun-Tao Bai Zhi-Yong Liu Zu-Rong Zhou | 2021 | Research in Astronomy and Astrophysics2021，21，2： | 0 |
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