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| 1 | Modeling study of regional severe hazes over mid-eastern China in January 2013 and its implications on pollution prevention and control显示文摘The Nested Air Quality Prediction Model System(NAQPMS)was used to investigate the temporal and spatial variations of PM2.5over tropospheric central eastern China in January 2013.The impact of regional transport and its implications on pollution prevention and control were also examined.Comparison between simulated and observed PM2.5showed NAQPMS was able to reproduce the evolution of PM2.5during heavy haze episodes.The results indicated that regional transport of PM2.5played an important role in regional haze episodes in the city cluster including Hebei,Beijing and Tianjin(HBT).The cross-city clusters transport outside HBT and transport among cities inside HBT contributed 20%–35%and 26%–35%of PM2.5as compared with local emission,in HBT respectively.To meet the Air Quality Standards for Grade II,90%,90%and65%of emissions would have to be cut down in Hebei,Tianjin and Beijing,if non-control strategy was taken in the surrounding city clusters of HBT.This implicated that control of emissions in one city cluster is not sufficient to reduce regional haze events,and joint efforts among city clusters are essential.Besides regional transports,two-way feedback between boundary-layer evolution and PM2.5also significantly contributed to the formation of heavy hazes,which contributed 30%of monthly average PM2.5concentration in HBT. | WANG ZiFa LI Jie WANG Zhe YANG WenYi TANG Xiao GE BaoZhu YAN PinZhong ZHU LiLi CHEN XueShun CHEN HuanSheng WAND Wei LI JianJun LIU Bing WANG XiaoYan WAND Wei ZHAO YiLin LU Ning SU DeBin | 2014 | Science China Earth Sciences2014，57，1： | 106 |
| 2 | FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis显示文摘 | Xu Zhao Ying Yang Bao-Fa Sun Yue Shi Xin Yang Wen Xiao Ya-Juan Hao Xiao-Li Ping Yu-Sheng Chen Wen-Jia Wang Kang-Xuan Jin Xing Wang Chun-Min Huang Yu Fu Xiao-Meng Ge Shu-Hui Song Hyun Seok Jeong Hiroyuki Yanagisawa Yamei Niu Gui-Fang Jia Wei Wu Wei-Min Tong Akimitsu Okamoto Chuan He Jannie M Rendtlew Danielsen Xiu-Jie Wang Yun-Gui Yang | 2014 | Cell Research2014，24，12： | 109 |
| 3 | Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer's disease progression显示文摘Recently,increasing evidence has suggested the association between gut dysbiosis and Alzheimer's disease(AD)progression,yet the role of gut microbiota in AD pathogenesis remains obscure.Herein,we provide a potential mechanistic link between gut microbiota dysbiosis and neuroinflammation in AD progression.Using AD mouse models,we discovered that,during AD progression,the alteration of gut microbiota composition leads to the peripheral accumulation of phenylalanine and isoleucine,which stimulates the differentiation and proliferation of pro-inflammatory T helper 1(Thl)cells.The brain-infiltrated peripheral Th1 immune cells are associated with the Ml microglia aaivation,contributing to AD-associated neuroinflammation.Importantly,the elevation of phenylalanine and isoleucine concentrations and the increase of Th1 cell frequency in the blood were also observed in two small independent cohorts of patients with mild cognitive impairment(MCI)due to AD.Furthermore,GV-971,a sodium oligomannate that has demonstrated solid and consistent cognition improvement in a phase 3 clinical trial in China,suppresses gut dysbiosis and the associated phenylalanine/isoleucine accumulation,harnesses neuroinflammation and reverses the cognition impairment.Together,our findings highlight the role of gut dysbiosis-promoted neuroinflammation in AD progression and suggest a novel strategy for AD therapy by remodelling the gut microbiota. | Xinyi Wang Guangqiang Sun Teng Feng Jing Zhang Xun Huang Tao Wang Zuoquan Xie Xingkun Chu Jun Yang Huan Wang Shuaishuai Chang Yanxue Gong Lingfei Ruan Guanqun Zhang Siyuan Yan Wen Lian Chen Du Dabing Yang Qingli Zhang Feifei Lin Jia Liu Haiyan Zhang Changrong Ge Shifu Xiao Jian Ding Meiyu Geng | 2019 | Cell Research2019，29，10： | 192 |
| 4 | Prevalence of Autism Spectrum Disorder in China:A Nationwide Multi-center Population-based Study Among Children Aged 6 to 12 Years显示文摘This study aimed to obtain the first national estimate of the prevalence of autism spectrum disorder(ASD) in Chinese children.We targeted the population of 6 to 12-year-old children for this prevalence study by multistage convenient cluster sampling.The Modified Chinese Autism Spectrum Rating Scale was used for the screening process.Of the target population of 142,086 children,88.5%(n=125,806) participated in the study.A total of 363 children were confirmed as having ASD.The observed ASD prevalence rate was 0.29%(95% CI:0.26%-0.32%) for the overall population.After adjustment for response rates,the estimated number of ASD cases was867 in the target population sample,thereby achieving an estimated prevalence of 0.70%(95% CI:0.64%-0.74%).The prevalence was significantly higher in boys than in girls(0.95%;95% CI:0.87%-1.02% versus 0.30%;95%CI:0.26%-0.34%;P <0.001).Of the 363 confirmed ASD cases,43.3% were newly diagnosed,and most of those(90.4%) were attending regular schools,and 68.8% of the children with ASD had at least one neuropsychiatric comorbidity.Our findings provide reliable data on the estimated ASD prevalence and comorbidities in Chinese children. | Hao Zhou Xiu Xu Weili Yan Xiaobing Zou Lijie Wu Xuerong Luo Tingyu Li Yi Huang Hongyan Guan Xiang Chen Meng Mao Kun Xia Lan Zhang Erzhen Li Xiaoling Ge Lili Zhang Chunpei Li Xudong Zhang Yuanfeng Zhou Ding Ding Andy Shih Eric Fombonne Yi Zheng Jisheng Han Zhongsheng Sun Yong-hui Jiang Yi Wang LATENT-NHC Study Team | 2020 | Neuroscience Bulletin2020，36，9： | 158 |
| 5 | Human colorectal cancer-specific CCAT1-L IncRNA regulates long-range chromatin interactions at the MYC locus显示文摘人的 8q24 基因沙漠包含多重 enhancers 形式织物特定的远程的染色质与 MYC oncogene 循环,但是染色质在 MYC 地点循环怎么被调整,仍然保持糟糕理解。这里,我们表明那长 noncoding RNA (lncRNA ) , CCAT1-L,从一个地点在人的 colorectal 癌症明确地被抄录 MYC 在上游的 515 kb。这 lncRNA 在 MYC transcriptional 规定起一个作用并且支持远程的染色质循环。重要地, CCAT1-L 地点位于强壮的超级提高以内并且离 MYC 空间地靠近。CCAT1-L 击倒在 MYC 倡导者和它的 enhancers 之间的减少的远程的相互作用。另外, CCAT1-L 与 CTCF 交往并且在这些环区域调制染色质符合构造。这些结果揭示一个重要角色一以前在在 MYC 地点的基因规定的 unannotated lncRNA。 | Jian-Feng Xiang Qing-Fei Yin Tian Chen Yang Zhang Xiao-Ou Zhang Zheng Wu Shaofeng Zhang Hai-Bin Wang Junhui Ge Xutiua Lu Li Yang Ling-Ling Chen | 2014 | Cell Research2014，24，5： | 67 |
| 6 | Research advances in the Mesozoic tectonic regimes during the formation of Jiaodong ore cluster area显示文摘在诺思中国的东方区域在中生代时代在 Jiaodong 矿石簇区域和相关构造政体转变把构造政体的进展基于研究,在这篇论文,我们首先总结要求后面被学习的一些关键问题。然后,我们建议一条途径到处理这些问题。在 Jiaodong 矿石的金存款聚类区域,这被知道,它具有不同矿化作用式样,空间 istributions 和地质的背景,可能作为从在中生代的至少一个地质的事件的结果。到现在为止,特别在上述事件的 geodynamic 机制上,关于时间的进化和空间迁居顺序的这种研究是远非足够的。而且,描述行动模式和构造动态政体的时间空间的框架并且提出每构造动态政体的相对贡献因为 metallogensis 是静止的质问到地质学家在 Jiaodong 的形成上学习的份量上矿石簇区域。根据地区性的构造分析,结构的动力学,观察和矿化作用网络的探索的解释,我们建议有一些的一个 geological-physical-chemical 模型抑制从全面分析发源。我们然后使用这个模型模仿结构的变丑,热运输,液体流动和化学反应的联合过程。获得的结果显示模型在进一步在 Jiaodong 矿石簇区域并且在进一步理解集体 metallogensis 的性质分析构造政体的时间空间的进化小道是有效的。 | DENG Jun YANG Liqiang GE Liangsheng WANG Qingfei ZHANG Jing GAO Bangfei ZHOU Yinghua JIANG Shaoqing | 2006 | Progress in Natural Science:Materials International2006，16，8： | 51 |
| 7 | The Sunway TaihuLight supercomputer: system and applications显示文摘The Sunway Taihu Light supercomputer is the world's first system with a peak performance greater than 100 PFlops. In this paper, we provide a detailed introduction to the Taihu Light system. In contrast with other existing heterogeneous supercomputers, which include both CPU processors and PCIe-connected many-core accelerators(NVIDIA GPU or Intel Xeon Phi), the computing power of Taihu Light is provided by a homegrown many-core SW26010 CPU that includes both the management processing elements(MPEs)and computing processing elements(CPEs) in one chip. With 260 processing elements in one CPU, a single SW26010 provides a peak performance of over three TFlops. To alleviate the memory bandwidth bottleneck in most applications, each CPE comes with a scratch pad memory, which serves as a user-controlled cache. To support the parallelization of programs on the new many-core architecture, in addition to the basic C/C++and Fortran compilers, the system provides a customized Sunway Open ACC tool that supports the Open ACC2.0 syntax. This paper also reports our preliminary efforts on developing and optimizing applications on the Taihu Light system, focusing on key application domains, such as earth system modeling, ocean surface wave modeling, atomistic simulation, and phase-field simulation. | Haohuan FU Junfeng LIAO Jinzhe YANG Lanning WANG Zhenya SONG Xiaomeng HUANG Chao YANG Wei XUE Fangfang LIU Fangli QIAO Wei ZHAO Xunqiang YIN Chaofeng HOU Chenglong ZHANG Wei GE Jian ZHANG Yangang WANG Chunbo ZHOU Guangwen YANG | 2016 | Science China(Information Sciences)2016，59，7： | 45 |
| 8 | Subduction history of the Paleo-Pacific slab beneath Eurasian continent: Mesozoic-Paleogene magmatic records in Northeast Asia显示文摘This paper presents a review on the rock associations, geochemistry, and spatial distribution of Mesozoic-Paleogene igneous rocks in Northeast Asia. The record of magmatism is used to evaluate the spatial-temporal extent and influence of multiple tectonic regimes during the Mesozoic, as well as the onset and history of Paleo-Pacific slab subduction beneath Eurasian continent. Mesozoic-Paleogene magmatism at the continental margin of Northeast Asia can be subdivided into nine stages that took place in the Early-Middle Triassic, Late Triassic, Early Jurassic, Middle Jurassic, Late Jurassic, early Early Cretaceous, late Early Cretaceous, Late Cretaceous, and Paleogene, respectively. The Triassic magmatism is mainly composed of adakitic rocks,bimodal rocks, alkaline igneous rocks, and A-type granites and rhyolites that formed in syn-collisional to post-collisional extensional settings related to the final closure of the Paleo-Asian Ocean. However, Triassic calc-alkaline igneous rocks in the Erguna-Xing'an massifs were associated with the southward subduction of the Mongol-Okhotsk oceanic slab. A passive continental margin setting existed in Northeast Asia during the Triassic. Early Jurassic calc-alkaline igneous rocks have a geochemical affinity to arc-like magmatism, whereas coeval intracontinental magmatism is composed of bimodal igneous rocks and A-type granites. Spatial variations in the potassium contents of Early Jurassic igneous rocks from the continental margin to intracontinental region, together with the presence of an Early Jurassic accretionary complex, reveal that the onset of the PaleoPacific slab subduction beneath Eurasian continent occurred in the Early Jurassic. Middle Jurassic to early Early Cretaceous magmatism did not take place at the continental margin of Northeast Asia. This observation, combined with the occurrence of low-altitude biological assemblages and the age population of detrital zircons in an Early Cretaceous accretionary complex,indicates that a strike-slip tectonic regime existed between the continental margin and Paleo-Pacific slab during the Middle Jurassic to early Early Cretaceous. The widespread occurrence of late Early Cretaceous calc-alkaline igneous rocks, I-type granites, and adakitic rocks suggests low-angle subduction of the Paleo-Pacific slab beneath Eurasian continent at this time. The eastward narrowing of the distribution of igneous rocks from the Late Cretaceous to Paleogene, and the change from an intracontinental to continental margin setting, suggest the eastward movement of Eurasian continent and rollback of the PaleoPacific slab at this time. | Jie TANG Wenliang XU Feng WANG Wenchun GE | 2018 | Science China Earth Sciences2018，61，5： | 48 |
| 9 | Plant DNA barcoding in China显示文摘Identification is the keystone of biology (Bell, 1986).However, to biologists and students of biology, the total numbers of species that must be identified far outnumber the names commonly used in English, Chinese, or other living languages.In addition, the identification cues vary greatly between different taxonomical groups.Even for the taxonomists with long training and experience, it is difficult to remember all specific terms for a given group, e.g., Orchidaceae or Poaceae, without help of floristic books or monographs.It takes much time and effort to train a taxonomist, at a time when fewer and fewer young students are interested in this 'classical' and 'out-of-style', but extremely important, discipline.Many students elect to learn the more 'advanced'' and 'modem' biological disciples like molecular biology and biochemistry.Thus, in China and therest of the world, taxonomists are themselves becoming 'endangered'.The rise of the DNA barcoding is expected to mitigate, at least in part, this dilemma. | De-Zhu LI jian-Quan LIU Zhi-Duan CHEN Hong WANG Xue-Jun GE Shi-Liang ZHOU Lian-Ming GAO Cheng-Xin FU Shi-Lin CHEN | 2011 | Journal of Systematics and Evolution2011，49，3： | 37 |
| 10 | Behavioral responses for evaluating the attractiveness of specific tea shoot volatiles to the tea green leafhopper, Empoaca vitis显示文摘 | Dan Mu Lin Cui Jian Ge Meng-Xin Wang Li-Fang Liu Xiao-Ping Yu Qing-He Zhang Bao-Yu Han | 2012 | Insect Science2012，19，2： | 35 |
| 11 | Extract of Naotaifang, a compound Chinese herbal medicine, protects neuron ferroptosis induced by acute cerebral ischemia in rats显示文摘Objective:Our previous research showed that Naotaifang(a compound traditional Chinese herbal medicine)extract(NTE)has clinically beneficial effects on neurological improvement of patients with acute cerebral ischemia.In this study,we investigated whether NTE protected acute brain injury in rats and whether its effects on ferroptosis could be linked to the dysfunction of glutathione peroxidase 4(GPX4)and iron metabolism.Methods:We established an acute brain injury model of middle cerebral artery occlusion(MCAO)in rats,in which we could observe the accumulation of iron in neurons,as detected by Perl’s staining.Using assay kits,we measured expression levels of ferroptosis biomarkers,such as iron,glutathione(GSH),reactive oxygen species(ROS)and malonaldehyde(MDA);further the expression levels of transferrin receptor1(TFR1),divalent metal transporter 1(DMT1),solute carrier family 7 member 11(SLC7 A11)and GPX4 were determined using immunohistochemical analysis,real-time quantitative polymerase chain reaction and Western blot assays.Results:We found that treatment with NTE reduced the expression levels of TFR1 and DMT1,reduced ROS,MDA and iron accumulation and reduced neurobehavioral scores,relative to untreated MCAO rats.Treatment with NTE increased the expression levels of SLC7 A11,GPX4 and GSH,and the number of Nissl bodies in the MCAO rats.Conclusion:Taken together,our data suggest that acute cerebral ischemia induces neuronal ferroptosis and the effects of treating MCAO rats with NTE involved inhibition of ferroptosis through the TFR1/DMT1 and SCL7 A11/GPX4 pathways. | Bin Lan Jin-wen Ge Shao-wu Cheng Xi-long Zheng Jun Liao Chao He Zheng-qing Rao Guo-zuo Wang | 2020 | Journal of Integrative Medicine2020，18，4： | 37 |
| 12 | Incidence and mortality of thyroid cancer in China, 2008-2012显示文摘Objective: To analyze the incidence and mortality rates of thyroid cancer(TC) in China from 2008 to 2012.Methods: Incident and death cases of TC were retrieved from the National Central Cancer Registry(NCCR)database collecting from 135 cancer registries in China during 2008-2012. The crude incidence and mortality rates of TC were calculated by area(urban/rural), region(eastern, middle, western), gender and age group(0, 1-4, 5-9,…, 85+). China census in 2000 and world Segi's population were applied for age-standardized rates. Joinpoint(Version 4.6.0.0) model was used for time-trend analysis.Results: The crude incidence rate of TC was 7.56/100,000 which ranked the seventh in overall cancers. The agestandardized incidence rates by China population(ASIRC) and by World population(ASIRW) were 6.25/100,000 and 5.52/100,000, respectively. The crude mortality of TC in China was 0.52/100,000. The age-standardized mortality rates by Chinese standard population(ASMRC) and by world standard population(ASMRW) were0.34/100,000 and 0.32/100,000, respectively. Incidence and mortality rates of TC were higher in females than in males and higher in urban areas than in rural areas. Eastern areas had the highest incidence followed by middle and western areas. TC incidence increased dramatically after age of 15 years, then peaked at 14.08/100,000 in the group of 50-54 years and finally decreased sharply after 55 years old. TC mortality increased with age in population,reaching the peak of 5.09/100,000 in sub-population aged 85 years or older. TC incidence increased by 4.73 times from 2.40/100,000 in 2003 to 13.75/100,000 in 2012 with an average annual increase of 20%, while TC mortality only increased slightly around 0.32/100,000 from 0.26/100,000 to 0.36/100,000.Conclusions: Appropriate targeted prevention, early detection and treatment programs can be carried out to curb the rapid growth trend of TC and control the disease burden. | Lingbin Du Runhua Li Minghua Ge Youqing Wang Huizhang Li Wanqing Chen Jie He | 2019 | Chinese Journal of Cancer Research2019，31，1： | 31 |
| 13 | Metallogenic epoch and genesis of the gold deposits in Jiaodong Peninsula, Eastern China: a regional review显示文摘金存款被多来源,重迭,大规模和时间空间的集中在 Jiaodong 半岛描绘,东方中国。在这篇论文,我们在 metallogenic 年表和金存款的开始上考察历史和学习的发展,总结附加 metallogenesis 的主要特征,提供中生代复杂 metallogenic 系统的证据,并且从一个地区性的看法为 Jiaodong 金存款簇的进一步的研究指出一些问题。尽管金存款在基因类型,形成矿石的材料和地质的背景是不同的,我们的研究显示形成矿石的材料的累积和炮兵阵地 temporally 空间地被专注于大规模,和 Jiaodong 金存款的主要 metallogenic 时代在中生代被集中。Metallogenic 年表和 geological-geochemical 数据显示有金矿化作用的二个时期在 Jiaodong 分别地发生在 130-110 妈和 90-80 妈矿石簇。从 polygenetic 矿化作用的重迭的金存款簇结果,和进一步的学习被需要调查中生代复杂 metallogenic 系统的形成和进化。 | YANG Liqiang DENG Jun GE Liangsheng WANG Oingfei ZHANG Jing GAO Bangfei J IANGShaoqing XU Hao | 2007 | Progress in Natural Science:Materials International2007，17，2： | 30 |
| 14 | Neuroprotective effects of salvianolic acid B against oxygen-glucose deprivation/reperfusion damage in primary rat cortical neurons显示文摘背景服的 ischemia-reperfusion 损害是为在 ischemic 的神经原的损失的主要原因脑血管的疾病。因此,深深地理解它的致病并且发现一个新目标是要解决的关键问题。这研究试图调查对氧葡萄糖 deprivation/reperfusion (OGD/RP ) 的 salvianolic 酸 B (SalB ) 的效果在主要老鼠损坏的 neuroprotective 外皮的 neurons.Methods 新生的威斯特老鼠的主要文化随机被划分成控制组, OGD/RP 组和 SalB 处理组(10 mg/L ) 。房间模型被分别地剥夺氧和葡萄糖 3 个小时和灌注 3 个小时和 24 个小时建立。神经原生存能力被 MTT 试金决定。细胞的反应的氧种类(ROS ) 的水平被荧光灯的标记检测方法和纺纱套住技术分别地。neuronal Mn-superoxide dismutase (Mn 草皮) 的活动,过氧化氢酶(猫) 和谷胱甘肽 peroxidase (GSH-PX ) 是由 chromatometry 的 assayed。线粒体膜潜力(m) 是流动 cytometry 分析的份量上。细胞色素 c 的版本率被西方的弄污检测。neuronal 超微结构被传播电子显微镜学观察。统计意义被 Student-Newman-Keuls test.Results OGD/RP 跟随的变化(ANOVA ) 的分析评估增加了细胞的 ROS 的水平,但是减少房间生存能力和 Mn 草皮,猫和 GSH-PX 的活动;SalB 处理显著地减少了 ROS (P 0.05 ) 的水平;并且提高了房间生存能力(P 0.05 ) 和这些 antioxidases (P 0.05 ) 的活动。另外, OGD/RP 导致了 m 的荧光价值减少并且到上升的细胞色素 c 的版本率尤其是;SalB 显著地提高了 m (P 0.01 ) 的水平并且压抑细胞色素 c (P 0.05 ) 的版本率;它也改善了 neuronal 词法 injury.Conclusion SalB 的 neuroprotection 可以被归因于 ROS 的消除和 apoptosis 的抑制。 | WANG Yun JIANG Yu-feng HUANG Qi-fu GE Gui-ling CUI Wei | 2010 | Chinese Medical Journal2010，，24： | 30 |
| 15 | Land use changes and their relations with carbon cycles over the past 300 a in China显示文摘Land use and land cover in China have changed greatly during the past 300 a, indicated by the rapid abrupt decrease of forest land area and the rapid increase of cropland area, which can affect terrestrial carbon cycle greatly. The first-hand materials are used to analyze main characteristics for land use and land cover changes in China during the study period. The following conclusions can be drawn from this study. The cropland area in China kept increasing from 60.78×106 hm2 in 1661 to 96.09×106 hm2 in 1998. Correspondingly, the forest land area decreased from 248.13×106 hm2 in 1700 to 109.01×106 hm2 in 1949. Affected by such changes, the terrestrial ecosystem carbon storage decreased in the mean time. Car-bon lost from land use and land cover changes mainly consist of the loss from vegetation biomass and soil. In the past 300 a, about 3.70 PgC was lost from vegetation biomass, and emissions from soil ranged from 0.80 to 5.84 PgC. The moderate evaluation of soil losses was 2.48 PgC. The total loss from vegetation and soil was between 4.50 and 9.54 PgC. The moderate and optimum evaluation was 6.18 PgC. Such carbon losses distribution varied spatially from region to region. Carbon lost more significantly in Northeast China and Southwest China than in other regions, because losses of forest land in these two regions were far greater than in the other regions during the past 300 a. And losses of carbon in the other regions were also definite, such as Inner Mongolia, the western part of South China, the Xinjiang Uygur Autonomous Region, and the Qinghai-Tibet Plateau. But the carbon lost very little from the traditional agricultural regions in China, such as North China and East China. Studies on the relationship between land use and land cover change and carbon cycle in China show that the land use activities, especially those related to agriculture and forest management, began to affect terrestrial carbon storage positively in recent years. | GE QuanSheng DAI JunHu HE FanNeng PAN Yuan WANG MengMai | 2008 | Science China Earth Sciences2008，51，6： | 30 |
| 16 | The Association of Maternal Body Composition and Dietary Intake with the Risk of Gestational Diabetes Mellitus during the Second Trimester in a Cohort of Chinese Pregnant Women显示文摘Objective To investigate the association of maternal body composition and dietary intake with the risk of gestational diabetes mellitus(GDM). Methods A total 154 GDM subjects and 981 controls were enrolled in a prospective cohort study in 11 hospitals from May 20, 2012 to December 31, 2013. Bioelectrical impedance analysis and dietary surveys were used to determine body composition and to evaluate the intake of nutrients in subjects at 21-24 weeks' gestation(WG). Logistic regression analysis was applied to explore the relationships of maternal body composition and dietary intake with the risk of GDM morbidity. Results Age, pre-pregnant body weight(BW), and body mass index(BMI) were associated with increased risk of GDM. Fat mass(FM), fat mass percentage(FMP), extracellular water(ECW), BMI, BW, energy, protein, fat, and carbohydrates at 21-24 WG were associated with an increased risk of GDM. In contrast, fat free mass(FFM), muscular mass(MM), and intracellular water(ICW) were associated with a decreased risk of GDM. Conclusion Maternal body composition and dietary intake during the second trimester of pregnancy were associated with the risk of GDM morbidity. | Xu Qing Gao Zhi Ying Li Li Ming Wang Lu Zhang Qian Teng Yue Zhao Xia Ge Sheng Jing Hong Jiang Yang Yong Tao Liu Xiao Jun Lyu Chun Jian Mao Lun Yu Xiao Ming Liu Ying Hua Kong Ai Jing Yang Xue Yan Liu Zhao Zhang Yong Wang Jin Zhang Xin Sheng Xue Chang Yong Lu Yan Ping | 2016 | Biomedical and Environmental Sciences2016，29，1： | 29 |
| 17 | 5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers显示文摘象 5-methylcytosine (5mC ) 和 5-hydroxymethylcytosine (5hmC ) 那样的 DNA 修正是知道在哺乳动物影响全球基因表示的 epigenetic 标记。在人的染色体,与基因表示的靠近的关联和高化学的稳定性给他们的流行,这些 DNA epigenetic 标记能为癌症用作理想的 biomarkers 诊断。利用一种高度敏感、选择的化学标记技术,我们这里报导在传播没有房间的 DNA ( cfDNA )并且在从最近与 colorectal 诊断的 260 个病人的一个队收集的配对的肿瘤和邻近的纸巾的 genomic DNA ( gDNA )的 5hmC 的染色体宽的介绍,胃,胰腺,从 90 个健康个人的肝或甲状腺癌症和正常纸巾。5hmC 主要在与开的染色质和容许的 histone 修正重合的 transcriptionally 活跃的区域被散布。柔韧的联系癌症的 5hmC 签名在 cfDNA 被识别为特定的癌症类型是特征的。传播 cfDNA 的 5hmC 底 biomarkers colorectal 和胃的癌症是高度预兆的并且比常规 biomarkers 优异并且比得上从织物活体检视的 5hmC biomarkers。因此,这新策略能从血样品的分析为癌症的诊断和预后导致有效、最低限度地侵略的方法的发展。 | Wenshuai Li Xu Zhang Xingyu Lu Lei You Yanqun Song Zhongguang Luo Jun Zhang Ji Nie Wanwei Zheng Diannan Xu Yaping Wang Yuanqiang Dong Shulin Yu Jun Hong Jianping Shi Hankun Hao Fen Luo Luchun Hua Peng Wang Xiaoping Qian Fang Yuan Lianhuan Wei Ming Cui Taiping Zhang Quan Liao Menghua Dai Ziwen Liu Ge Chen Katherine Meckel Sarbani Adhikari Guifang Jia Marc B Bissonnette Xinxiang Zhang Yupei Zhao Wei Zhang Chuan He Jie Liu | 2017 | Cell Research2017，27，10： | 30 |
| 18 | Chinese Multidisciplinary Expert Consensus on the Diagnosis and Treatment of Hyperuricemia and Related Diseases显示文摘 | Zou, He-Jian Wu, Hu-Sheng Zhou, Jing-Guo Zeng, Xue-Jun Dai, Lie Wu, Hua-Xiang Zhu, Xiao-Xia Mei, Chang-Lin Hao, Chuan-Ming Chen, Nan Liu, Bi-Cheng Chen, Jiang-Hua Yang, Li Nie, Jing Yu, Chen Peng, Ai Yu, Sheng-Qiang Li, Lin Ge, Jun-Bo Huo, Yong Zhang, Shu-Yang Chen, Yun-Dai Dong, Yu-Gang Liang, Chun Dai, Yu-Xiang Gao, Xin Li, Chang-Gui Zhao, Jia-Jun Chen, Hai-Bing Cheng, Zhi-Feng Lin, Huan-Dong Guan, Yang-Tai Wang, Kai Luo, Ben-Yan Dai, Ruo-Lian Jiang, Quan Xue, Luan Liang, Chao-Chao Chen, Ming Fan, Song | 2017 | Chinese Medical Journal2017，，20： | 30 |
| 19 | Genetic diversity and construction of core collection in Chinese wheat genetic resources显示文摘Genetic diversity among 5029 accessions representing a proposed Chinese wheat core collection was analyzed using 78 pairs of fluorescent microsatellite (SSR) primers mapped to 21 chromosomes. A stepwise hierarchical sampling strategy with priority based on 4×105 SSR data-points was used to construct a core collection from the 23090 initial collections. The core collection consisted of 1160 accessions, including 762 landraces, 348 modern varieties and 50 introduced varieties. The core ac-counts for 23.1% of the 5029 candidate core accessions and 5% of the 23090 initial collections, but retains 94.9% of alleles from the candidate collections and captures 91.5% of the genetic variation in the initial collections. These data indicate that it is possible to maintain genetic diversity in a core collection while retaining fewer accessions than the accepted standard, i.e., 10% of the initial collections captured more than 70% of their genetic diversity. Estimated genetic representation of the core con-structed by preferred sampling (91.5%) is much higher than that by random sampling (79.8%). Both mean genetic richness and genetic diversity indices of the landraces were higher than those of the modern varieties in the core. Structure and principal coordinate analysis revealed that the landraces and the modern varieties were two relatively independent subpopulations. Strong genetic differentiation associated with ecological environments has occurred in the landraces, but was relatively weak in the modern cultivars. In addition, a mini-core collection was constructed, which consisted of 231 accessions with an estimated 70% representation of the genetic variation from the initial collections. The mini-core has been distributed to various research and breeding institutes for detailed phenotyping and breeding of genetic introgression lines. | HAO ChenYang DONG YuChen WANG LanFen YOU GuangXia ZHANG HongNa GE HongMei JIA JiZeng ZHANG XueYong | 2008 | Chinese Science Bulletin2008，53，10： | 27 |
| 20 | Mechanisms of hepatocellular carcinoma and challenges and opportunities for molecular targeted therapy显示文摘The incidence and mortality of hepatocellular carcinoma(HCC) have fallen dramatically in China and elsewhere over the past several decades. Nonetheless, HCC remains a major public health issue as one of the most common malignant tumors worldwide and one of the leading causes of death caused by cancer in China. Hepatocarcinogenesis is a very complex biological process associated with many environmental risk factors and factors in heredity, including abnormal activation of cellular and molecular signaling pathways such as Wnt/β-catenin, hedgehog, MAPK, AKT, and ERK signaling pathways, and the balance between the activation and inactivation of the proto-oncogenes and anti-oncogenes, and the differentiation of liver cancer stem cells. Molecule-targeted therapy, a new approach for the treatment of liver cancer, blocks the growth of cancer cells by interfering with the molecules required for carcinogenesis and tumor growth, making it both specific and selective. However, there is no one drug completely designed for liver cancer, and further development in the research of liver cancer targeted drugs is now almost stagnant. The purpose of this review is to discuss recent advances in our understanding of the molecular mechanisms underlying the development of HCC and in the development of novel strategies for cancer therapeutics. | Chuan Chen Ge Wang | 2015 | World Journal of Hepatology2015，7，15： | 28 |
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