|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Magnetostratigraphy of a Loess-Paleosol Sequence from Higher Terrace of the Daduhe River in the Eastern Margin of the Tibetan Plateau and Its Geological Significance显示文摘The eolian deposits distributed in the river valleys in the eastern margin of the Tibetan Plateau(TP)are very useful in neotectonic and paleoclimatic studies.Firstly,the climate in the eastern margin of the TP is mainly controlled by the Indian summer monsoon,and detailed studies on the loess-paleosol sequences in this region can provide valuable terrestrial evidence of past changes in the Indian summer monsoon.Secondly,the river terraces in the eastern margin of the TP are considered to be a sensitive recorder of neotectonism to reflect the timing and amplitude of the TP uplift.The formation ages of | QIAO Yansong WANG Yan YAO Haitao QI Lin HE Ze Xin CHENG Yu PENG Shasha GE Junyi | 2015 | Acta Geologica Sinica(English Edition)2015，89，1： | 5 |
| 2 | Intracellular effects of prodrug-like wortmannin probes显示文摘Wortmannin, a known inhibitor of phosphoinositide 3-kinases(PI3 Ks), their low selectivity and high toxicity is still problematic and less is known about their effects on PI3 Ks in cellular systems. Hence, we have synthesized a series of multifunctional wortmannin probes with the ability to self-activate, by installing a clickable handle at C11 site, and secondary amine and cancer-targeting moiety at C20 site respectively. MTT assay first confirmed that self-activating probes have better inhibition potency and biotin enhanced their cancer cell uptake. Further experiments showed most of probes can target PI3 K/Akt/mTOR pathway with prolonged turn-over time. Protein profiling and pull-down results were observed that the derivatives not only labelled four PI3 Ks with selectivity, but also engaged in covalent interactions with numerous cellular proteins which could be the major reason of their high toxicity. | Shasha Ying Shubo Du Jia Dong Bi Xuan Ng Chengwu Zhang Lin Li Jingyan Ge Qing Zhua | 2019 | Chinese Chemical Letters2019，30，1： | 1 |
| 3 | Short and simple peptide-based pH-sensitive hydrogel for antitumor drug delivery显示文摘Since self-assembled peptide hydrogels can solve the problems such as low solubility, poor selectivity and serious adverse effects of traditional chemotherapy drugs, they have been widely used as carrier materials for drug delivery. In this study, we developed a novel and injectable drug delivery platform for the antitumor drug doxorubicin(DOX) using a p H-responsive ionic-complementary octapeptide FOE.This octapeptide could self-assemble into stable hydrogel under neutral conditions, while disassemble under the tumor microenvironment. Especially, at p H 5.8, its micromorphology displayed a transition from nanofibers to nanospheres with the change of secondary structure, which enhanced cellular uptake of DOX. In addition, FOE hydrogel serves as a smart drug reservoir by localized injection to achieve sustained drug release and improve antitumor efficacy. This octapeptide opens up new avenues for promoting the clinical translation of anticancer drugs on account of excellent injectable properties and economic benefits of simple and short sequence. | Jie Li Zhongshi Wang Han Han Zhonghua Xu Shasha Li Ying Zhu Yuejian Chen Liang Ge Yuan Zhang | 2022 | Chinese Chemical Letters2022，33，4： | 1 |
| 4 | A pharmacokinet- ic/pharmaeodynamic analysis of a standard voriconazole regi- men in different CYP2C19 genotypes by Monte Carlo simula- tion显示文摘 | Liao Shasha Ge Tingyue Zhu Liqin | 2015 | Die Pharmazie2015，70，5： | 1 |
| 5 | A model for anticancer surveillance was pharmacologically developed to evaluate vitality principle in breast cancer rats显示文摘OBJECTIVE: To evaluate vitality principle in breast cancer rats by pharmacologically developing a model for anticancer surveillance.METHODS: The breast cancer in rats was replicated with 7,12-Dimethylbenz[a]anthracene(DMBA, i.g.,100 mg/kg) at d_(001). The anticancer surveillance was defined as the intervals between the primary sensitization and the first challenge stirred with complete Freund's adjuvant(CFA), the various intervals(k = 0.80) were dominated from d_(025)(600.00 h) to d_(095)(2288.82 h). The optimal surveillant status was confirmed with the median effective interval(EI_(50))from tumor volume regressive curve, for developing the pharmacodynamic model. The tumor and tumor infiltrating lymphocyte histopathology was used to confirm the immune surveillance being affected with CFA in breast cancer tumorigenesis.The availability of this model was confirmed with Shugan Liangxue prescription(SLP), from the vitality principle, and assured further from interleukin-12 levels.RESULTS: The regressive curve was set up between the intervals and tumor volumes, the EI_(50) in SLP-treated rats(1475.00 h, Y_(SLP)= 0.1026 +0.8780/[1 + 10^(27.1425-8.565x)]) was postponed, which was 1.87 multiple of the EI_(50) in CFA rats(791.40 h, y =-0.0525 + 0.9452/[1 + 10^(30.4870-10.52x)], so did prepone the curve between the intervals and the immunological biomarker, serum interleukin-12 levels, the EI_(50) in SLP-treated rats(744.90 h, Y_(SLP)=-0.0145 + 0.7455/[1 + 10^(52.09636-18.13x)]) be 0.78 multiple of the EI_(50) in CFA rats(960.10 h, Y_(CFA)= 0.2460 + 0.7270/[1 + 10^(-67.1546 +22.52x)]), this immunological action being mediated the anticancer prognosis. Tumor histology was confirmed the more tumor infiltrating lymphocytes activated in SLP rats with CFA stirred immunity than rats only received CFA.CONCLUSION: The model for anticancer surveillance was pharmacologically established as the optimal interval(791.40 h) between the primary sensitization and the first challenge stirred with complete Freund's adjuvant. This available model was confirmed with SLP, from the vitality principle, for evaluating immunological effects against breast cancer. | Liu Jinyu Zhang Mengyang Zhao Xin Ge Shasha Li Shuang Peng Lin Mu Yuxue Chen Chen Li Xiaoya Zhang Rui Feng Xuanye Deng Bo Jia Liqun Lin Yulin Wang Yueqi Cheng Zhiqiang TaeHoo Yi Cai Dayong | 2018 | Journal of Traditional Chinese Medicine2018，38，6： | 0 |
| 6 | Research on the Seismic Wave Characteristics of Low Frequency Signals before the Alxa Left Banner MS5.8 Earthquake in Inner Mongolia,China显示文摘In order to search for the seismic wave characteristics of low frequency signals in the Alxa Left Banner region,Inner Mongolia,the low frequency signals of seismic wave data are extracted from the earthquakes of MS5. 8 in 2015 and MS5. 0 in 2016 in this area. The results show that:① Before the MS5. 8 earthquake,the seismic stations located near the epicenter in Wuhai,Dongshengmiao,and Shizuishan recorded seismic waves that showed the phenomenon of spectrum shift from high to low frequency.② The low frequency signals recorded by different stations have obvious difference.③ According to the data recorded by the station closest to the epicenter,low-frequency signals were recorded about120 hours before the earthquake and had obvious anomalies. This may reflect slow slip before the earthquake. | Liang Shasha Gao Lixin Dai Yong Ge Gen Wang Lei | 2018 | Earthquake Research in China2018，32，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员