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| 1 | Fecal microbiota transplantation as novel therapy in gastroenterology:A systematic review显示文摘AIM:To study the clinical efficacy and safety of Fecal microbiota transplantation(FMT).We systematically reviewed FMT used as clinical therapy.METHODS:We searched MEDLINE,EMBASE,the Cochrane Library and Conference proceedings from inception to July,2013.Treatment effect of FMT was calculated as the percentage of patients who achieved clinical improvement per patient category,on an intention-to-treat basis.RESULTS:We included 45 studies;34 on Clostridium difficile-infection(CDI),7 on inflammatory bowel disease,1 on metabolic syndrome,1 on constipation,1 on pouchitis and 1 on irritable bowel syndrome(IBS).In CDI 90% resolution of diarrhea in 33 case series(n = 867) was reported,and 94% resolution of diarrhea after repeated FMT in a randomized controlled trial(RCT)(n = 16).In ulcerative colitis(UC) remission rates of 0% to 68% were found(n = 106).In Crohn's disease(CD)(n = 6),no benefit was observed.In IBS,70% improvement of symptoms was found(n = 13).100% Reversal of symptoms was observed in constipation(n = 3).In pouchitis,none of the patients(n = 8) achieved remission.One RCT showed significant improvement of insulin sensitivity in metabolic syndrome(n = 10).Serious adverse events were rare.CONCLUSION:FMT is highly effective in CDI,and holds promise in UC.As for CD,chronic constipation,pouchitis and IBS data are too limited to draw conclusions.FMT increases insulin sensitivity in metabolic syndrome. | Noortje G Rossen John K Mac Donald Elisabeth M de Vries Geert R D'Haens Willem M de Vos Erwin G Zoetendal Cyriel Y Ponsioen | 2015 | World Journal of Gastroenterology2015，21，17： | 41 |
| 2 | FOLFIRINOX and translational studies: Towards personalized therapy in pancreatic cancer显示文摘Pancreatic cancer is an extremely aggressive disease; although progress has been made in the last few years, the prognosis of these patients remains dismal. FOLFIRINOX is now considered a standard treatment in first-line setting, since it demonstrated an improved overall and progression-free survival vs gemcitabine alone. However, the enthusiasm over the benefit of this three-drug regimen is tempered by the associated increased toxicity profile, and many efforts have been made to improve the feasibility of this schedule. After a more recent phase Ⅲ trial showing an improved outcome over gemcitabine, the combination of gemcitabine/nab-paclitaxel emerged as another standard first-line treatment. However, this treatment is also associated with more side effects. In addition, despite initial promising data on the predictive role of SPARClevels, recent studies showed that these levels are not associated with nab-paclitaxel efficacy. The choice to use this treatment over FOLFIRINOX is therefore a topic of debate, also because no validated biomarkers to guide FOLFIRINOX treatment are available. In the era of actionable mutations and target agents it would be desirable to identify molecular factors or biomarkers to predict response to therapy in order to maximize the efficacy of treatment and avoid useless toxic effects for non-responding patients. However, until today the milestone of treatment for pancreatic cancer remains chemotherapy combinations, without predictive or monitoring tools existing to optimize therapy. This review analyzes the state-of-the-art treatments, promises and limitations of targeted therapies, ongoing trials and future perspectives, including potential role of microR NAs as predictive biomarkers. | Chiara Caparello Laura L Meijer Ingrid Garajova Alfredo Falcone Tessa Y Le Large Niccola Funel Geert Kazemier Godefridus J Peters Enrico Vasile Elisa Giovannetti | 2016 | World Journal of Gastroenterology2016，22，31： | 4 |
| 3 | The paradox of the unfolded protein response in cancer显示文摘 | VANDEWYNCKEL Y P LAUKENS D GEERTS A | 2013 | Anticancer Res2013，33，11： | 1 |
| 4 | Lacto- ferrin is a lipid A-binding protein 显示文摘 | APPELMELK B J AN Y Q GEERTS M | 1994 | Infect Immun1994，62，6： | 1 |
| 5 | Rapid charge transport along self-assembling graphitic nanowires显示文摘 | van de Craats A M Warman J M Müllen K Geerts Y Brand J D | | 0，，01： | 1 |
| 6 | Classification of epileptic seizures, a comparison of two systems 显示文摘 | Parra J Augustijn PB Geerts Y | 2001 | Epilepsia2001，42，4： | 1 |
| 7 | Challenging protein purification from anammox bacteria 显示文摘 | Cirpus I E Y Geerts W Hermans J H M | 2006 | International Journal of Biological Macromolecules2006，39，13： | 1 |
| 8 | A high performance muhibit delta-sigma CMOS ADC显示文摘 | GEERTS Y STEYAERT M S J SANSEN W | 2000 | IEEE J Sol Sta Circ2000，35，12： | 1 |
| 9 | Ovine surfrantprotein cDNAs: use in studies on fetal lung growth and maturation after prolonged hypoxemia显示文摘 | GEERT A BRAEMS LIJUAN Y | 2000 | Am J Physiol Lung Cell Mol Physiol2000，278，4： | 1 |
| 10 | A High-performance Multi-bit △∑ CMOS ADC 显示文摘 | Geerts Y Steyaert M S J Sansen W | 2000 | IEEE Journal of Solid-State Circuits (S0018-9200)2000，35，12： | 1 |
| 11 | Lactoferrin is a lipid A-binding protein显示文摘 | Appelmelk B J An Y Q Geerts M | 1994 | Infect Immun1994，62，： | 1 |
| 12 | Challenging protein purification from anammox bacteria显示文摘 | Cirpus I E Y Geerts W Hermans J H M | | 0，，1： | 1 |
| 13 | 查看详情显示文摘 | Savage R C Mativetsky J M Orgiu E Palma M Gbabode G Geerts Y H Samori P | | 0，，： | 1 |
| 14 | A high-performance muhibit Σ-Δ CMOS ADC 显示文摘 | GEERTS Y | 2000 | IEEE Journal Solid-State Circuits2000，35，12： | 1 |
| 15 | Classification of epileptic seizures : a comparison of two systems 显示文摘 | Parra J Augustijn PB Geerts Y | 2001 | Epilepsia2001，42，4： | 1 |
| 16 | A high-performance multibit △-∑ CMOS ADC显示文摘 | Geerts Y Steyaert M S J Sansen W | 2000 | IEEE J Solid-State Circuit2000，35，12： | 1 |
| 17 | Discotic liquid crystals: A new generation of organic semioonduetors 显示文摘 | Sergeyev S Pisula W Geerts Y H | 2007 | Chemcial Society Review2007，36，12： | 1 |
| 18 | A high - performance multibit ∑Δ CMOS ADC显示文摘 | Geerts Y Steyaert M S J Sansen W | 2000 | IEEE Journal of Solid - state Circuits2000，，35： | 1 |
| 19 | A high-performance multibit ∑△ CMOS ADC 显示文摘 | GEERTS Y STEYAERT M S J SANSEN W | 2000 | IEEE J Sol Sta Circ2000，35，12： | 1 |
| 20 | Estimating the evaporative cooling bias of an airborne reverse flow thermometer显示文摘 | Wang Y G Geerts B | 2009 | Journal of Atmospheric and Oceanic Technology2009，26，： | 1 |
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