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| 1 | EGFR and HER2 expression in advanced biliary tract cancer显示文摘AIM:To analyze the pathogenetic role and potential clinical usefulness of the epidermal growth factor receptor(EGFR)and the human epidermal growth factor receptor 2(HER2)in patients with advanced biliary tract cancer(BTC). METHODS:EGFR and HER2 expression was studied in biopsy samples from 124 patients(51%women; median age 64.8 years),with advanced BTC diagnosed between 1997 and 2004.Five micrometers sections of paraffin embedded tissue were examined by standard, FDA approved immunohistochemistry.Tumors with scores of 2+or 3+for HER2 expression on immunochemistry were additionally tested for HER2 gene amplification by fluorescence in situ hybridisation(FISH).RESULTS:34/124 patients(27.4%)had gallbladder cancer,47(37.9%)had intrahepatic BTC and 43(34.7%)had extrahepatic or perihilar BTC.EGFR expression was examined in a subset of 56 samples. EGFR expression was absent in 22/56 tumors(39.3%). Of the remaining samples expression was scored as 1+in 12(21.5%),2+in 13(23.2%)and 3+in 9(16%), respectively.HER2 expression was as follows:score 0 73/124(58.8%),score 1+27/124(21.8%),score 2+ 21/124(17%)and score 3+4/124(3.2%).HER2 gene amplification was present in 6/124,resulting in an overall amplification rate of 5%. CONCLUSION:Our data suggest that routine testing and therapeutic targeting of HER2 does not seem to be useful in patients with BTC,while targeting EGFR may be promising. | Jan Harder Oliver Waiz Florian Otto Michael Geissler Manfred Olschewski Brigitte Weinhold Hubert E Blum Annette Schmitt-Graeff Oliver G Opitz | 2009 | World Journal of Gastroenterology2009，15，36： | 18 |
| 2 | Chemical oxygen demand reduction in coffee wastewater through chemical flocculation and advanced oxidation processes显示文摘在通过化学凝结絮凝和先进氧化过程( AOP )的咖啡 processingwastewater 在场的自然有机物的移动用商业凝聚剂 andUV/H2O2 , UV/O3 和 UV/H2O2/O3 有自然有机物的移动的 beenstudied.The 有效性过程在 theseprocesses 的酸的 conditions.For 各个下面被决定,不同运作的条件被探索优化 thecoffee wastewater.Coffee 废水的处理效率是 | ZAYAS Pérez Teresa GEISSLER Gunther HERNANDEZ Fernando | 2007 | Journal of Environmental Sciences2007，19，3： | 6 |
| 3 | Anemia and long-term outcome in adjuvant and neoadjuvant radiochemotherapy of stage Ⅱ and Ⅲ rectal adenocarcinoma:The Freiburg experience(1989-2002)显示文摘AIM:To evaluate the long-term outcome of standard5-FU based adjuvant or neoadjuvant radiochemotherapyand to identify the predictive factors,especially anemiabefore and after radiotherapy as well as hemoglobinincrease or decrease during radiotherapy.METHODS:Two hundred and eighty-six patientswith Union International Contre Cancer(UICC)stageⅡ and Ⅲ rectal adenocarcinomas,who underwentresection by conventional surgical techniques(lowanterior or abdominoperineal resection),receivedeither postoperative(n=233)or preoperative(n=53)radiochemotherapy from January 1989 until July 2002.Overall survival(OAS),cancer-specific survival(CSS),disease-free survival(DFS),local-relapse-free(LRS)and distant-relapse-free survival(DRS)were evaluatedusing Kaplan-Meier,Log-rank test and Cox's proportionalhazards as statistical methods.Multivariate analysis wasused to identify prognostic factors.Median follow-uptime was 8 years.RESULTS:Anemia before radiochemotherapy was anindependent prognostic factor for improved DFS(riskratio 0.76,P=0.04)as well as stage,grading,R status(free radial margins),type of surgery,carcinoembryonicantigen(CEA)levels,and gender.The univariate analysisrevealed that anemia was associated with impaired LRS (better local control)but with improved DFS.In contrast,hemoglobin decrease during radiotherapy was anindependent risk factor for DFS(risk ratio 1.97,P=0.04).During radiotherapy,only 30.8% of RO-resected patientssuffered from hemoglobin decrease compared to 55.6%if R1/2 resection was performed(P=0.04).The 5-yearOAS,CSS,DFS,LRS and DRS were 47.0%,60.0%,41.4%,67.2%,and 84.3%,respectively.Significantdifferences between preoperative and postoperativeradiochemotherapy were not found.CONCLUSION:Anemia before radiochemotherapyand hemoglobin decrease during radiotherapy have nopredictive value for the outcome of rectal cancer.Stage,grading,R status(free radial margins),type of surgery,CEA levels,and gender have predictive value for theoutcome of rectal cancer. | Christian Weissenberger Geissler Michael Otto Florian Barke Annette Henne Karl von Plehn Georg Rein Alex Müller Christine Bartelt Susanne Henke Michael | 2006 | World Journal of Gastroenterology2006，12，12： | 4 |
| 4 | PRO- AND ANTI-CANCER EFFECTS OF IMMUNOSUPPRESSIVE AGENTS USED IN ORGAN TRANSPLANTATION显示文摘 | Markus Guba Christian Graeb Karl-Walter Jauch Edward K. Geissler | 2004 | Transplantation2004，，12： | 2 |
| 5 | Intralcarpal softtissue lessions associated with an intra-articular fratures of the distal end of the radius显示文摘 | Geissler WB Freeland AE Savoie FH | 1996 | J Bone Joint Surg Am1996，78，： | 1 |
| 6 | Mapping neutralizing and non neutralizing epitopes in the capsid protein if feline calicivirus显示文摘 | Geissler K Schneider K Truyen U | 2002 | Vet Med B Infect Dis Vet Public Health2002，49，1： | 1 |
| 7 | Habitability of Europa's crust:The role of tidal-tectonic processes显示文摘 | Greenberg R Geissler P Tufts B R | 2000 | Journal of Geophysics Research2000，105，17： | 1 |
| 8 | Treatment of complex intra-articular distal radius fractures显示文摘 | Leibovic SJ Geissler WB | 1994 | Orthop Clin North Am1994，25，4： | 1 |
| 9 | Liver transplantation for hepatic and neurological Wilsons disease显示文摘 | Geissler I Heinemann K Rohm S | 2003 | Transplant Proc2003，35，4： | 1 |
| 10 | Pathways involved in Drosophila and human canc- er development : the Notch, Hedgehog, Wingless, Runt, and Trithorax pathway 显示文摘 | Geissler K Zach O | 2012 | Ann Hematol2012，91，5： | 1 |
| 11 | Unique brown star shape on dermatoscopy of generalized Dowling-Degos disease显示文摘 | Geissler S Dyall-Smith D Coras B | 2011 | Australas J Dermatol2011，52，2： | 1 |
| 12 | Prospective evaluation of circulating hepatocytes by alpha-fetoprotein messenger RNA in patients with hepatocellular carcinoma显示文摘 | Witzigmann H Geissler F Benedix F | 2002 | Surgery2002，131，1： | 1 |
| 13 | The potential benefits of rapamycin on renal function,tolerance,fibrosis,and malignancy following transplantation显示文摘 | Geissler E K Schlitt H J | 2010 | Kidney Int2010，78，11： | 1 |
| 14 | Olfactory train- ing for patients with olfactory loss after upper respiratory tract infections 显示文摘 | Geissler K Reimann H Gudziol H | 2014 | Eur Arch Otorhinolaryngol2014，271，6： | 1 |
| 15 | Dose dependent reduction of erythroid progenitor cells and inappropriate erythropoitein response in exposure to lead:new aspects of anaemia induced by lead显示文摘 | Osterode W Barnas U Geissler K | 1999 | Occup Environ Med1999，56，2： | 1 |
| 16 | 显示文摘 | Geissler M Wands G Gesien A | 1997 | Lab Lnvest1997，76，6： | 1 |
| 17 | Prospective evalu ation of circulating hepatocytes by alpha-fetoprotein messen ger RNA in patients with hepatocellular carcinoma 显示文摘 | Witzigmann H Geissler F Benedix F et ai | 2002 | surgery2002，131，1： | 1 |
| 18 | Chemical force titration of plasma polymer - modified PDMS substrates by using plasma polymer- modified AFM tips显示文摘 | Geissler A Vallat M F Vidal L | 2008 | Langmuir2008，24，： | 1 |
| 19 | Arthroscopic suture fixation of displaced tibial eminence fractures显示文摘 | Matthews DE Geissler WB | 1994 | Arthroscopy1994，10，4： | 1 |
| 20 | Genetic and antigenic heterogeneity among feline calicivirus isolates from distinct disease manifestations显示文摘 | Geissler K Schneider K Platzer G | 1997 | 48:193-2061997，48，： | 1 |
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