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| 1 | TP53-induced glycolysis and apoptosis regulator alleviates hypoxia/ischemia-induced microglial pyroptosis and ischemic brain damage显示文摘Our previous studies have demonstrated that TP53-induced glycolysis and apoptosis regulator(TIGAR)can protect neurons after cerebral ischemia/reperfusion.However,the role of TIGAR in neonatal hypoxic-ischemic brain damage(HIBD)remains unknown.In the present study,7-day-old Sprague-Dawley rat models of HIBD were established by permanent occlusion of the left common carotid artery followed by 2-hour hypoxia.At 6 days before induction of HIBD,a lentiviral vector containing short hairpin RNA of either TIGAR or gasdermin D(LV-sh_TIGAR or LV-sh_GSDMD)was injected into the left lateral ventricle and striatum.Highly aggressively proliferating immortalized(HAPI)microglial cell models of in vitro HIBD were established by 2-hour oxygen/glucose deprivation followed by 24-hour reoxygenation.Three days before in vitro HIBD induction,HAPI microglial cells were transfected with LV-sh_TIGAR or LV-sh_GSDMD.Our results showed that TIGAR expression was increased in the neonatal rat cortex after HIBD and in HAPI microglial cells after oxygen/glucose deprivation/reoxygenation.Lentivirusmediated TIGAR knockdown in rats markedly worsened pyroptosis and brain damage after hypoxia/ischemia in vivo and in vitro.Application of exogenous nicotinamide adenine dinucleotide phosphate(NADPH)increased the NADPH level and the glutathione/oxidized glutathione ratio and decreased reactive oxygen species levels in HAPI microglial cells after oxygen/glucose deprivation/reoxygenation.Additionally,exogenous NADPH blocked the effects of TIGAR knockdown in neonatal HIBD in vivo and in vitro.These findings show that TIGAR can inhibit microglial pyroptosis and play a protective role in neonatal HIBD.The study was approved by the Animal Ethics Committee of Soochow University of China(approval No.2017LW003)in 2017. | Lan-Lan Tan Xiao-Lu Jiang Li-Xiao Xu Gen Li Chen-Xi Feng Xin Ding Bin Sun Zheng-Hong Qin Zu-Bin Zhang Xing Feng Mei Li | 2021 | Neural Regeneration Research2021，16，6： | 9 |
| 2 | Optimization of equimolar reverse constant-temperature mass-diffusion process for minimum entransy dissipation显示文摘The mass entransy describes the mass-diffusion ability of the solution system, and the mass-diffusion process with the finite concentration difference always leads to the mass-entransy dissipation. This paper studies the equimolar reverse constant-temperature mass-diffusion process with Fick's law( g∝Δ(c)). The optimal concentration paths for the MED(Minimum Entransy Dissipation) are derived and compared with those for the MEG(Minimum Entropy Generation) and CCR(Constant Concentration Ratio) operations. It is indicated that the strategy of the MED is equivalent to that of the CCD(Constant Concentration Difference) of the same component; whether the MED or the MEG is selected as the optimization objective, the strategy of the CCD is much better than that of the CCR. | XIA Shao Jun CHEN Lin Gen SUN Feng Rui | 2016 | Science China(Technological Sciences)2016，59，12： | 7 |
| 3 | Selective conversion of syngas to propane over ZnCrO_x-SSZ-39 OX-ZEO catalysts显示文摘Oxide-Zeolite(OX-ZEO) bifunctional catalyst design concept has been exemplified in several processes to direct conversion syngas to value-added chemicals and fuels such as mixed light olefins, ethylene, aromatics and gasoline.Herein we demonstrate that the product can be steered toward liquefied petroleum gas(LPG) with a selectivity up to 89% in hydrocarbons especially propane selectivity reaching 80% at CO conversion of 63% using ZnCrOx-H-SSZ-39 catalyst.Interestingly, the quantity of the acid sites of SSZ-39 does not influence obviously the hydrocarbon distribution but the strength is crucial for selective formation of propane.This finding provides an alternative route of LPG synthesis from a variety of carbon resources via syngas. | Gen Li Feng Jiao Dengyun Miao Yong Wang Xiulian Pan Toshiyuki Yokoi Xiangju Meng Feng-Shou Xiao Andrei-Nicolae Parvulescu Ulrich Müller Xinhe Bao | 2019 | Journal of Energy Chemistry2019，28，9： | 6 |
| 4 | On Signed Edge Total Domination Numbers of Graphs显示文摘Let G = (V,E) be a graph.A function f : E → {-1,1} is said to be a signed edge total dominating function (SETDF) of G if e ∈N(e) f(e ) ≥ 1 holds for every edge e ∈ E(G).The signed edge total domination number γ st (G) of G is defined as γ st (G) = min{ e∈E(G) f(e)|f is an SETDF of G}.In this paper we obtain some new lower bounds of γ st (G). | Jin Feng ZHAO Bao Gen XU | 2011 | Journal of Mathematical Research and Exposition2011，31，2： | 6 |
| 5 | ABSTRACTS OF CHINESE MEDICAL LITERATURE显示文摘 | Lu Gen, Feng Jiemei,Huang Jian, et al. Guangzhou Institute of Tuberculosis, Guangzhou 510180. Chin J Tuberculosis & Respirat Dis 1995 | 1995 | Chinese Medical Journal1995，，6： | 5 |
| 6 | Thermal performance analysis of non-uniform height rectangular fin based on constructal theory and entransy theory显示文摘A model of non-uniform height rectangular fin, in which the variation of base's thickness and width are taken into account, is established in this paper. The dimensionless maximum thermal resistance(DMTR) and the dimensionless equivalent thermal resistance(DETR) defined based on the entransy dissipation rate(EDR) are taken as performance evaluation indexes. According to constructal theory, the variations of the two indexes with the geometric parameters of the fin are analyzed by using a finite-volume computational fluid dynamics code, the effects of the fin-material fraction on the two indexes are analyzed. It is found that the two indexes decrease monotonically as the ratio between the front height and the back height of the fin increases subjected to the non-uniform height rectangular fin. When the model is reduced to the uniform height fin, the two indexes increase first and then decrease with increase in the ratio between the height of the fin and the fin space. The fin-material fraction has no effect on the change rule of the two indexes with the ratio between the height of the fin and the fin space. The sensitivity of the DETR to the geometric parameters of the fin is higher than that of the DMTR to the geometric parameters. The results obtained herein can provide some theoretical support for the thermal design of rectangular fins. | YANG Ai Bo CHEN Lin Gen XIE Zhi Hui FENG Hui Jun SUN Feng Rui | 2016 | Science China(Technological Sciences)2016，59，12： | 4 |
| 7 | Effect of Different Bacterial-Feeding Nematode Species on Soil Bacterial Numbers,Activity,and Community Composition显示文摘The effects of bacterial-feeding nematodes on bacterial number,activity,and community composition were studied through a microcosm experiment using sterilized soil inoculated with soil bacteria(soil suspension)and with bacteria and three species of bacterial-feeding nematodes(Cephalobus persegnis,Protorhabditis filiformis,and Caenorhabditis elegans).Catalyzed reporter deposition-fluorescence in situ hybridization,CO_2 evolution,and denaturing gradient gel electrophoresis(DGGE)of PCR.amplified 16S rRNA gene fragments were used to investigate bacterial numbers,activity,and community composition,respectively.Our results showed that bacterial numbers and activity significantly increased in the presence of bacterial-feeding nematodes,which indicated that bacterial-feeding nematodes had a significant positive effect on soil bacteria.The different nematode species had different effects on bacterial numbers and activity.C.persegnis and P.filiformis,isolated from native soil,increased the bacterial number and activity more than C.elegans.The DGGE analysis results showed that dominant bacterial species significantly differed among the treatments,which suggested that bacterial-feeding nematode species modified the bacterial community composition in soil.Further gene sequence analysis results showed that the dominant bacterial species in this study were gram-negative bacteria.Given the completely same conditions except nematode species,the varied selective feeding behavior of different nematode species was the most likely reason for the altered bacterial community composition.Overall,the alteration of bacterial numbers,activity and community composition resulting from the bacterial-feeding nematodes may ultimately affect soil ecological functioning and processes. | XIAO Hai-Feng LI Gen LI Da-Ming HU Feng LI Hui-Xin | 2014 | Pedosphere2014，24，1： | 4 |
| 8 | Coastal environment of the past millennium recorded by a coastal dune in Fujian,China显示文摘Coastal dune is a common aeolian geomorphology in a sandy coast,which records the evolution process of the aeolian landscape system and reflects the complex interaction among land surface,atmosphere and ocean.Coast is a sensitive area to global climate change.Restricted by chronology,most previous researches in China focused only on the cause of formation of coastal dunes.In recent years,the development of optically stimulated luminescence (OSL) dating provides a good method and acts as a carrier for coastal dunes to paleoclimate and paleoenvironmental studies.In this study,we selected an aeolian dune at the Anshan archaeological site,Fujian,China as the research object based on field observations.For determining their sedimentary stages and the primary influencing factors,we used the OSL dating method to construct a chronological framework for the aeolian dune.In addition,the sizes of grains were analyzed for identifying factors influencing the winter monsoon during the Medieval Warm Period (MWP) and the Little Ice Age (LIA) in this area.The results showed that the deposition of the aeolian dune was closely related to variations in the winter monsoon intensity.The changes of the winter monsoon were similar to the tendency of the East Asian winter monsoon,although there were several sub-fluctuations.From an overall perspective,the winter monsoon was strengthened during the MWP (1050–1300) .The results of a power spectrum analysis showed that the intensity of the East Asian winter monsoon is correlated with sunspot activity. | JIN Jianhui LI Zhizhong JIANG Feng deng tao HU Fan'gen LING Zhiyong | 2016 | Journal of Arid Land2016，8，5： | 3 |
| 9 | A new triterpenoid saponin from Clematis ganpiniana显示文摘A new triterpenoid saponin,named clematiganoside A(1),was isolated from the whole plant of Clematis ganpiniana.Its structure was elucidated on the basis of 1D,2D NMR,TOF-MS and ESI-MS techniques,and physicochemical properties. | Feng Sun Qing He Pei Gen Xiao Yi Yu Cheng | 2007 | Chinese Chemical Letters2007，18，9： | 3 |
| 10 | Effects of the momentum dependence of nuclear symmetry potential on pion observables in Sn+Sn collisions at 270 MeV/nucleon显示文摘Within a transport model,we investigated the effects of the momentum dependence of the nuclear symmetry potential on the pion observables in central Sn+Sn collisions at 270 MeV/nucleon.To this end,the quantity U^(∞)_(sym)(ρ_(0))(i.e.,the value of the nuclear symmetry potential at the saturation densityρ_(0) and infinitely large nucleon momentum)was used to characterize the momentum dependence of the nuclear symmetry potential.With a certain L(i.e.,the slope of the nuclear symmetry energy at(ρ_(0))),the characteristic parameter U^(∞)_(sym)(ρ_(0))of the symmetry potential significantly affects the production of−and+and their pion ratios.Moreover,by comparing the charged pion yields,pion ratios,and spectral pion ratios of the theoretical simulations for the reactions ^(108) Sn+^(112) Sn and ^(132)Sn+^(124)Sn with the corresponding data in the SRIT experiments,we found that our results favor a constraint on U^(∞)_(sym)(ρ_(0))(i.e.,−160_(−9)^(+18) MeV),and L is also suggested within a range of 62.7 MeV | Gao‑Feng Wei Xin Huang Qi‑Jun Zhi Ai‑Jun Dong Chang‑Gen Peng Zheng‑Wen Long | 2022 | Nuclear Science and Techniques2022，33，12： | 3 |
| 11 | Experimental research on the residual stress of polycrystalline diamond compacts for oil drilling显示文摘Practical experiences gained in the past several years show that the thermal residual stress(TRS) is a main cause leading polycrystalline diamond compacts(PDC) to premature failure.It is the very important to measure the TRS accurately for optimizing the interface and improving the service performance of PDC.In this paper,the TRS in 1913 flat-interface PDC was measured using improved stress-release method(ISRM). The TRS on the surface of polycrystalline diamond(PCD) table was obtained,which can be used to calculate the radial thermal residual stress(RTRS) at the interface of PCD table via a refutation process.The obtained results show that there are compressive residual stress at the PCD table interface and in the most region of PCD table surface.The exception occurs near the outer diameter of the PCD table,where the PDC begins to bend and put the PCD table surface into a tension state,an undesirable state for a brittle material.The ISRM has covered the shortage existing in traditional stress-release method,in which only finite points on the surface of PCD table can be tested for one specimen and one time.Simple as the experimental procedures are,the test results are also very accurate and reliable.This method provides the theoretical and experimental basis for testing TRS of PDC accurately. | Xu Gen~1 Xu Guoping~2 Chen Feng~3 Ma Chunde~3 (1.School of Resources and Safety Engineering,Central South University,Changsha 410083,China) (2.King-ray New Materials Science & Technology Co,Ltd,Changsha 410012,China) (3.Testing Center,Central South University,Changsha 410083,China) | 2008 | 金刚石与磨料磨具工程2008，28，S1： | 3 |
| 12 | Enhanced radioimmunotherapeutic efficacy of a monoclonal antibody cocktail against SMMC-7721 human hepatocellular carcinoma显示文摘The improved tumoricidal effect of the radioatibody mixture ('cocktail') has been reported recently for the treatment of colon tumor. In the present study, we demonstrated the enhanced radioimmunotherapeutic efficacy of a monoclonal atibody (MAb) cocktail against human hepatocellular carcinoma. Therapeutic efficacy was determined by measuring the change in tumor size over a period, determining the percentage of growth inhibition of each treatment at various times after radioantibody therapy. boioimmunotherapy of SMMC-7721 human hepatoma xenografts in athymic nude mice with combination of 131I labeled Hepama-1 and 131Llabeled 9403 mouse MAbs was more effective than using either Hepeam-1 or 9403 Mab alone The MAb cocktail could target a greater number of hepstoma cells and increase the magnitude of hepatoma cen uptde of radioamibodies. The in vjtro results explain the enhanced effect of the MAb cocktail in in vjvo model system. | SONG YI QIANG GEN FENG WANG XIN LAN DAI HONG XIE(Shanghai Institute of Cell Biology, Chinese Academy of Sciences, Shanghai 200031, China) | 1998 | Cell Research1998，8，3： | 2 |
| 13 | Bernstein n-Widths for Classes of Convolution Functions with Kernels Satisfying Certain Oscillation Properties显示文摘在这篇论文,我们考虑 2 π-periodic 卷绕旋转功能的一些班,并且用有某些摆动性质的核,它作为特殊大小写包括古典 Sobolev 班。在的帮助下非线性的不可分的方程光谱,我们决定班的伯恩斯坦 n 宽度的准确价值,在空间 L p 为 1 <
p <
∞
。 | Guo FENG Gen Sun FANG | 2009 | Acta Mathematica Sinica,English Series2009，25，3： | 2 |
| 14 | Inferring the invasion mechanisms of the red swamp crayfish in China using mitochondrial DNA sequences显示文摘The red swamp crayfish,Procambarus clarkii,is a native species in north-eastern Mexico and south-central USA.P.clarkii was introduced to China in 1929 and has been used as an aquaculture species in China since 1983.It currently exists in most of the provinces of China,but threatens local fish,crustaceans,aquatic plants and local freshwater ecosystems.We examined the genetic variation in partial mitochondrial ND2 gene of 831 individuals collected from 25 P.clarkii populations in 13 provinces of China to infer the expansion pathways and mechanisms.Six haplotypes were detected.All six haplotypes appeared in four populations in Nanjing and a population located near Nanjing whereas only 1–5 of the six haplotypes were present in other populations.These data suggest that the populations in Nanjing are probably the source of all other populations in China.There were no significant relationships between geographic distances and genetic distances in 25 populations,whereas significant relationship was found in four populations in Qinhuai River covering 50 km in Nanjing.These data suggest that the expansion mainly be human-mediated in large scale,and active disposal or non-anthropogenic passive dispersal might have played an important role in expansion at a smaller scale.In some places far away from Nanjing,several haplotypes existed,suggested multiple introduction events may have happened.Although aquaculture of this species could bring huge economic benefit,its potential to negatively affect native biota and entire ecosystems should not be ignored. | Gen Hua Yue Jian-Bin Feng Jun Hong Xia Su Yin Cao Chun Ming Wang | 2021 | Aquaculture and Fisheries2021，6，1： | 2 |
| 15 | The interferon-stimulated exosomal hACE2 potently inhibits SARS-CoV-2 replication through competitively blocking the virus entry显示文摘Since the outbreak of coronavirus disease 2019(COVID-19),it has become a global pandemic.The spike(S)protein of etiologic severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)specifically recognizes human angiotensin-converting enzyme 2(hACE2)as its receptor,which is recently identified as an interferon(IFN)-stimulated gene.Here,we find that hACE2 exists on the surface of exosomes released by different cell types,and the expression of exosomal hACE2 is increased by IFNα/β treatment.In particular,exosomal hACE2 can specifically block the cell entry of SARS-CoV-2,subsequently inhibit the replication of SARS-CoV-2 in vitro and ex vivo.Our findings have indicated that IFN is able to upregulate a viral receptor on the exosomes which competitively block the virus entry,exhibiting a potential antiviral strategy. | Junsong Zhang Feng Huang Baijin Xia Yaochang Yuan Fei Yu Guanwen Wang Qianyu Chen Qian Wang Yuzhuang Li Rong Li Zheng Song Ting Pan Jingliang Chen Gen Lu Hui Zhang | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 2 |
| 16 | Genetic diversity and population structure of the invasive alien red swamp crayfish显示文摘 | Gen Hua Yue Jiale Li Zhiyi Bai Chun Ming Wang Felicia Feng | 2010 | Biological Invasions2010，，8： | 1 |
| 17 | Effect of biochar amendment on maize yield and greenhouse gas e- missions from a soil organic Carbon poor calcareous loamy soil from Central China Plain 显示文摘 | ZHANG A - feng LIU Yu - ming PAN Gen - xing | 2012 | Plant and Soil2012，351，12： | 1 |
| 18 | Magnetic noise in MgO-based magnetic tunnel junction rings 显示文摘 | Feng J F Diao Z Feng Gen | 2010 | Appl Phys Lett2010，96，05： | 1 |
| 19 | Mercuryemission to atmosphere from primary Zn production in China 显示文摘 | LI Guang -hui FENG Xin -bin LI Zhong -gen | 2010 | Science of the Total Environment2010，408，： | 1 |
| 20 | Application of Fiber Bragg Grating Sensor on Measurement of Texsile steel strand显示文摘 | LIU tie gen JIANG jun feng LIN xin | 2005 | Jour- nal of Optoelectronies Laser2005，16，10： | 1 |
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