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| 1 | Clinical analysis and follow-up study of chronic active Epstein-Barr virus infection in 53 pediatric cases显示文摘背景长期的活跃 Epstein-Barr 病毒感染(CAEBV ) 以前被报导了有时与一堂好攻击的临床的功课被联系。在大陆中国小儿科的病人的 CAEBV 的特征大部分是 unreported。这调查的主要目的是在孩子认出 CAEBV 的临床的特征并且探索它的诊断标准和风险 factors.Methods A 回顾的学习与 CAEBV 在 53 个小儿科的病人(36 个男孩和 17 个女孩) 上被执行进入北京孩子在 2003 和 2007 之间的医院。所有他们的医药记录被考察并且分析。为每个病人,人口统计,临床,实验室数据和结果被收集。独立样品的 t 测试被用于在 CAEBV 的发作的年龄从 2 个月到 14.6 年的统计 analysis.Results (平均数(5. | LU Gen XIE Zheng-de ZHAO Shun-ying YE Ling-jun WU Run-hui LIU Chun-yan YANG Shuang JIN Ying-kang SHEN Kun-ling | 2009 | Chinese Medical Journal2009，，3： | 36 |
| 2 | Mutations in the perforin gene in children with hemophagocytic lymphohistiocytosis显示文摘 | LU Gen XIE Zheng-de SHEN Kun-ling YE Ling-jun WU Run-hui LIU Chun-yan JIN Ying-kang YANG Shuang | 2009 | Chinese Medical Journal2009，，23： | 16 |
| 3 | Parkinson’s disease in China:a forty-year growing track of bedside work显示文摘The number and health burden of Parkinson’s disease increase rapidly in China.It is estimated that China will have nearly half of the Parkinson’s disease population in the world in 2030.In this review,we present an overview of epidemiology and health economics status of Parkinson’s disease across China and discuss the risk factors of Parkinson’s disease and related complications.From the view of clinical research,we also discuss the current status of clinical trials,diagnostic biomarkers,treatment of Parkinson’s disease,tertiary network and post-occupation education in Chinese Parkinson’s disease clinics. | Gen Li Jianfang Ma Shishuang Cui Yixi He Qin Xiao Jun Liu Shengdi Chen | 2019 | Translational Neurodegeneration2019，8，1： | 16 |
| 4 | Generalized Empirical Likelihood Inference in Semiparametric Regression Model for Longitudinal Data显示文摘在这篇论文,我们为纵的数据认为半是参量的回归模型。由于在组以内的关联,为在模型的未知参数的一个概括实验木头可能性比率统计数值被介绍工作协变性矩阵建议。建议统计数值是 asymptotically 标准的,这被证明在一些合适的条件下面摆平 chi,并且因此,构造参数的信心区域能被用来。模拟研究被进行以范围精确性和信心间隔的平均长度把建议方法与概括最少的广场方法作比较。 | Gao Rong LI Ping TIAN Liu Gen XUE | 2008 | Acta Mathematica Sinica,English Series2008，24，12： | 12 |
| 5 | How Work Organization Affects the Prevalence of WMSDs: A Case-control Study显示文摘Objective In this study, we aimed at exploring the association between work-related musculoskeletal disorders(WMSDs) and work organization based on a case-control study. Methods A total of 1938 workers who claimed to suffer from WMSDs were selected from Beijing, Henan, Hubei, and the Guangdong province. The control group consisted of 2009 workers employed in similar industries without severe disease or musculoskeletal discomforts. We used a modified version of the questionnaire developed by the NMQ and the DMQ to investigate individual and work-related factors. Results A total of 13 variables(P<0.1) were selected by the chi-square test and finally, 7 variables entered into the equation, with 6 variables reaching statistical significance(P<0.05). The odds ratios(OR) of ‘work changing with season' and ‘sufficient rest time' did not reach 1(0.749 and 0.441, respectively). In addition, ‘sufficient rest time' seemed to be the stronger protective factor according to its higher standardized coefficient. And ‘repetitive work every minute', ‘constantly repetitive work'(every day), ‘shortage of site personnel', and ‘often switching shifts with others' seemed to be the risk factors. Conclusion Work organization may have comprehensive effects on the occurrence of WMSDs. This pattern of associations suggests that further investigation into the mechanism of how work organization affects the prevalence of WMSDs is required. | LIU Lu CHEN Song Gen TANG Shi Chuan WANG Sheng HE Li Hua GUO Ze Hua LI Jing Yun YU Shan Fa WANG Zhong Xu | 2015 | Biomedical and Environmental Sciences2015，28，9： | 11 |
| 6 | Seasonal and diurnal variations of atmospheric peroxyacetyl nitrate, peroxypropionyl nitrate, and carbon tetrachloride in Beijing显示文摘Atmospheric peroxyacetyl nitrate(PAN), peroxypropionyl nitrate(PPN), and carbon tetrachloride(CCl4) were measured from September 2010 to August 2011 in Beijing. PAN exhibited low values from mid-autumn to early spring(October to March) with monthly average concentrations ranging from 0.28 to 0.73 ppbV, and increased from early spring to summer(March to August), ranging from 1.37–3.79 ppbV. The monthly variation of PPN was similar to PAN, with low values(below detection limit to 0.18 ppbV) from mid-autumn to early spring, and a monthly maximum in September(1.14 ppbV). The monthly variation of CCl4was tightly related to the variation of temperature, exhibiting a minimum in winter(69.3 pptV) and a maximum of 180.6 pptV in summer. Due to weak solar intensity and short duration, PAN and O3showed no distinct diurnal patterns from morning to night during winter, whereas for other seasons, they both exhibited maximal values in the late afternoon(ca. 15:00 to 16:00 local time) and minimal values during early morning and midnight. Good linear correlations between PAN and PPN were found in autumn(R = 0.91), spring(R = 0.94), and summer(R = 0.81), with slopes of 0.130, 0.222, and 0.133, respectively, suggesting that anthropogenic hydrocarbons dominated the photochemical formation of PANs in Beijing. Positive correlation between PAN and O3 in summer with the low slopes( O3 / PAN) ranging from 9.92 to 18.0 indicated serious air pollution in Beijing, and strong negative correlation in winter reflected strong O3consumption by NO titration and less thermal decompositin of PAN. | Gen Zhang Yujing Mu Junfeng Liu Chenglong Zhang Yuanyuan Zhang Yujie Zhang Hongxing Zhang | 2014 | Journal of Environmental Sciences2014，26，1： | 11 |
| 7 | Updated diagnosis, treatment and prevention of COVID-19 in children: experts' consensus statement (condensed version of the second edition)显示文摘In the early February,2020,we called up an experts' committee with more than 30 Chinese experts from 11 national medical academic organizations to formulate the first edition of consensus statement on diagnosis,treatment and prevention of coronavirus disease 2019 (COVID-19) in children,which has been published in this journal.With accumulated experiences in the diagnosis and treatment of COVID-19 in children,we have updated the consensus statement and released the second edition recently.The current version in English is a condensed version of the second edition of consensus statement on diagnosis,treatment and prevention of COVID-19 in children.In the current version,diagnosis and treatement criteria have been optimized,and early identification of severe and critical cases is highlighted.The early warning indicators for severe pediatric cases have been summarized which is utmost important for clinical practice.This version of experts consensus will be valuable for better prevention,diagnosis and treatment of COVID-19 in children worldwide. | Kun-Ling Shen Yong-Hong Yang Rong-Meng Jiang Tian-You Wang Dong-Chi Zhao Yi Jiang Xiao-Xia Lu Run-Ming Jin Yue-Jie Zheng Bao-Ping Xu Zheng-De Xie Zhi-sheng Liu Xing-wang Li Li-Kai Lin Yun-Xiao Shang Sai-Nan Shu Yan Bai Min Lu Gen Lu Ji-Kui Deng Wan-Jun Luo Li-Juan Xiong Miao Liu Yu-Xia Cui Le-Ping Ye Jia-Fu Li Jian-Bo Shao Li-Wei Gao Yong-Yan Wang Xue-Feng Wang | 2020 | World Journal of Pediatrics2020，16，3： | 9 |
| 8 | Variable Selection for Semiparametric Varying-Coefficient Partially Linear Models with Missing Response at Random显示文摘在这份报纸,我们在场由把基础功能近似与为 semiparametric 变化系数估计方程惩罚相结合的一个可变选择过程有失踪的反应在的部分线性的模型随机。建议过程同时在参量的部件和 nonparametric 部件选择重要变量。与调节参数的适当选择,我们建立可变选择过程的一致性和调整评估者的集中率。模拟研究被承担估计建议可变选择过程的有限样品表演。 | Pei Xin ZHAO Liu Gen XUE | 2011 | Acta Mathematica Sinica,English Series2011，27，11： | 9 |
| 9 | Onset of Coronary Heart Disease is Associated with HCMV Infection and Increased CD14^+CD16^+Monocytes in a Population of Weifang,China显示文摘Objective To investigate the relationship between human cytomegalovirus(HCMV)infection and peripheral blood CD14+CD16+monocytes in the pathogenesis of coronary heart disease(CHD),and to elucidate the mechanism of pathogenesis in CHD by analyzing the correlation between infection,inflammation,and CHD,to provide a basis for the prevention,evaluation,and treatment of the disease.Methods In total,192 patients with CHD were divided into three groups:latent CHD,angina pectoris,and myocardial infarction.HCMV-IgM and-IgG antibodies were assessed using ELISA;CD14+CD16+monocytes were counted using a five-type automated hematology analyzer;mononuclear cells were assessed using fluorescence-activated cell sorting;and an automatic biochemical analyzer was used to measure the levels of triglyceride,cholesterol,high-and low-density lipoprotein cholesterols,lipoprotein,hs-CRp and Hcy.Results The positive rates of HCMV-IgM and-IgG were significantly higher in the CHD groups than in the control group.HCMV infection affects lipid metabolism to promote immune and inflammatory responses.Conclusion HCMV infection has a specific correlation with the occurrence and development of CHD.The expression of CD14+CD16+mononuclear cells in the CHD group was increased accordingly and correlated with acute HCMV infection.Thus,HCMV antibody as well as peripheral blood CD14+CD16+mononuclear cells can be used to monitor the occurrence and development of CHD. | LI Hong Zheng WANG Qin ZHANG Yi Yuan WANG Jin Dong WU Hong Juan ZHANG Mo Gen LI Ji Chen LIU Zhi Jun | 2020 | Biomedical and Environmental Sciences2020，33，8： | 8 |
| 10 | Effects of different factors during the de-silication of diaspore by direct flotation显示文摘Most of the bauxite resources in China are kaolinite-diaspore bauxite of middle to low grade, with a fine dissemination, and are difficultly separated. Direct flotation de-silication has been shown to be an effective method for de-silication of diaspore. In this study the effect of different factors, including pulp temperature, density, pH value, depressant, and collector dosage, on direct flotation of diaspore were investigated by laboratory experiments. The optimum conditions were identified and the flotation performance was improved. The results show that under optimum conditions (a pulp temperature around 40 °C, a pulp density from 30% to 33%, a pH value from 9.0 to 10.0, an air flow rate of 0.5 m3/(m2 min), a dispersant level from 35 to 70 g/t, and a collector level around 1000 g/t) an Al/Si ratio of 6.97 is obtained starting from an initial Al/Si ratio of about 4.71. The recovery of Al2O3 under these conditions was 86.94%. | Huang Gen Zhou Changchun Liu Jiongtian | 2012 | International Journal of Mining Science and Technology2012，22，3： | 7 |
| 11 | The Tashisayi nephrite deposit from South Altyn Tagh, Xinjiang,northwest China显示文摘The Tashisayi nephrite deposit is located in South Altyn Tagh.in Qiemo County,Xinjiang Province,northwest China.It is a recent discovery in the vast,well-known Kunlun-Altyn nephrite belt distributed along the south of the Tarim Basin,producing more than half of the nephrite from the whole belt in 2017.Field investigations revealed that it is a dolomitic marble-related(D-type)nephrite deposit,but little is known about its age of formation and relationships between the granites and marble.Here we report field investigations,petrography of the neph rite,as well as petrography,geochemistry,geochronology of the zoisite-quartz altered intrusive rock and adjacent granites.An A-type granite is identified with a SHRIMP U-Pb zircon age of 926±7 Ma,suggesting it was emplaced in an extensional tectonic environment at that time.The altered intrusive rock has a cluster of U-Pb zircon age of 433±10 Ma.with similar trace element features to the A-type granite,suggesting it was formed in an extensional regime at this later time.Nephrite formed because of the metasomatism of dolomite marble by hydrothermal fluids.It is inferred that Ca^2+was released from the dolomitic marble by metasomatism forming Ca-rich fluids,which caused alteration of both the intrusive rocks(6.00-8.22 wt.%CaO)and granite(1.76-3.68 wt.%CaO)near the nephrite ore bodies.It is also inferred that Fe^2+from the granite migrated towards the dolomite marble.The fluids gave rise to the formation of Ca-minerals.such as zoisite,in the nephrite and altered intrusive rock,and epidote in the granite.Based on the contact relationships.similarity in hydrothermal processes,and consumption of Ca^2+,the Tashisayi nephrite is considered to have formed at the same time as the alteration of the intrusive rocks,i.e.~433 Ma.The geochronological similarity(~926 Ma.433 Ma)of South Altyn and North Qaidam may suggest that tectonically they belong to one single complex in the past,which was offset by the Altyn Tagh fault(ATF).The similar formation ages of the nephrites from Altyn Tagh(433 Ma)and the previously studied areas of West Kunlun(378-441 Ma)and East Kunlun(416 Ma)indicate that these nephrites formed during the closure of Proto-Tethys and in the accompanving post-collisional.extensional environment. | Kong Gao Guanghai Shi Meili Wang Gen Xie Jian Wang Xiaochong Zhang Ting Fang Weiyan Lei Yan Liu | 2019 | Geoscience Frontiers2019，10，4： | 6 |
| 12 | Hollow spherical rare-earth-doped yttrium oxysulfate: A novel structure for upconversion显示文摘锻烧跟随的一条灵巧的 帮助biomolecule 的热水的线路为空范围与另外的稀土元素的离子做了的单斜晶的钇 oxysulfate 的准备被采用了( Yb <啜class=“ a-plus-plus ”>3+和 Eu <啜class=“ a-plus-plus ”>3+或嗯<啜class=“ a-plus-plus ”>3+)。空范围的形成可以包含 Ostwald 成熟。产生混合材料被用于 upconversion 应用。主人水晶结构允许容易没有显著地改变主人格子,二个不同稀土元素的金属离子共同做。光性质被稀土元素的金属离子由于精力转移和水晶的对称回答的掺杂物的比率和集中影响。光中心的类型和样品的 crystallinity 也被显示在同样准备的产品的光性质上有重要影响。 | Gen Chen Fashen Chen Xiaohe Liu Wei Ma Hongmei Luo Junhui Li Renzhi Ma Guanzhou Qiu | 2014 | Nano Research2014，7，8： | 6 |
| 13 | A New Alkaloid from Patrinia scabra显示文摘A new alkaloid has been isolated from the root of Patrinia scabra. Its structure was elucidated as 2-acetamido-3-phenyl propyl 2-benzamido-3-phenyl propionate by extensive spectr- oscopic analysis. | Zheng Bing GU*, Gen Jin YANG, Wen Yong LIU, Ting Zhao LI, Yan QIU, Wei Dong ZHANG College of Pharmacy, Second Military Medical University, Shanghai 200433 | 2002 | Chinese Chemical Letters2002，13，10： | 5 |
| 14 | Unsteady bio-fluid dynamics in flying and swimming显示文摘Flying and swimming in nature present sophisticated and exciting ventures in biomimetics, which seeks sustainable solutions and solves practical problems by emulating nature's time-tested patterns, functions, and strategies. Bio-fluids in insect and bird flight, as well as in fish swimming are highly dynamic and unsteady; however, they have been studied mostly with a focus on the phenomena associated with a body or wings moving in a steady flow. Characterized by unsteady wing flapping and body undulation, fluid-structure interactions, flexible wings and bodies, turbulent environments, and complex maneuver, bio-fluid dynamics normally have challenges associated with low Reynolds number regime and high unsteadiness in modeling and analysis of flow physics. In this article, we review and highlight recent advances in unsteady bio-fluid dynamics in terms of leading-edge vortices, passive mechanisms in flexible wings and hinges, flapping flight in unsteady environments, and micro-structured aerodynamics in flapping flight, as well as undulatory swimming, flapping-fin hydrodynamics, body–fin interac-tion, C-start and maneuvering, swimming in turbulence,collective swimming, and micro-structured hydrodynamics in swimming. We further give a perspective outlook on future challenges and tasks of several key issues of the field. | Hao Liu Dmitry Kolomenskiy Toshiyuki Nakata Gen Li | 2017 | Acta Mechanica Sinica2017，33，4： | 5 |
| 15 | MAP4K4 induces early blood-brain barrier damage in a murine subarachnoid hemorrhage model显示文摘Sterile-20-like mitogen-activated protein kinase kinase kinase kinase 4(MAP4 K4)is expressed in endothelial cells and activates inflammatory vascular damage.Endothelial cells are important components of the blood-brain barrier.To investigate whether MAP4 K4 plays a role in the pathophysiology of subarachnoid hemorrhage,we evaluated the time-course expression of MAP4 K4 after subarachnoid hemorrhage.A subarachnoid hemorrhage model was established using the intravascular perforation method.The model mice were assigned to four groups:MAP4 K4 recombinant protein,scramble small interfering RNA,and MAP4 K4 small interfering RNA were delivered by intracerebroventricular injection,while PF-06260933,a small-molecule inhibitor of MAP4 K4,was administrated orally.Neurological score assessments,brain water assessments,Evans blue extravasation,immunofluorescence,western blot assay,and gelatin zymography were performed to analyze neurological outcomes and mechanisms of vascular damage.MAP4 K4 expression was elevated in the cortex at 24 hours after subarachnoid hemorrhage,and colocalized with endothelial markers.MAP4 K4 recombinant protein aggravated neurological impairment,brain edema,and blood-brain barrier damage;upregulated the expression of phosphorylated nuclear factor kappa B(p-p65)and matrix metalloproteinase 9(MMP9);and degraded tight junction proteins(ZO-1 and claudin 5).Injection with MAP4 K4 small interfering RNA reversed these effects.Furthermore,administration of the MAP4 K4 inhibitor PF-06260933 reduced blood-brain barrier damage in mice,promoted the recovery of neurological function,and reduced p-p65 and MMP9 protein expression.Taken together,the results further illustrate that MAP4 K4 causes early blood-brain barrier damage after subarachnoid hemorrhage.The mechanism can be confirmed by inhibiting the MAP4 K4/NF-κB/MMP9 pathway.All experimental procedures and protocols were approved by the Experimental Animal Ethics Committee of General Hospital of Northern Theater Command(No.2018002)on January 15,2018. | Zheng Zou Yu-Shu Dong Dong-Dong Liu Gen Li Guang-Zhi Hao Xu Gao Peng-Yu Pan Guo-Biao Liang | 2021 | Neural Regeneration Research2021，16，2： | 5 |
| 16 | Microstructural evolution in Al–Zn–Mg–Cu–Sc–Zr alloys during short-time homogenization显示文摘Microstructural evolution in a new kind of aluminum(Al) alloy with the chemical composition of Al–8.82Zn–2.08Mg– 0.80Cu–0.31Sc–0.3Zr was investigated. It is found that the secondary phase Mg Zn2 is completely dissolved into the matrix during a short homogenization treatment(470°C, 1 h), while the primary phase Al3(Sc,Zr) remains stable. This is due to Sc and Zr additions into the Al alloy, high Zn/Mg mass ratio, and low Cu content. The experimental findings fit well with the results calculated by the homogenization diffusion kinetics equation. The alloy shows an excellent mechanical performance after the short homogenization process followed by hot-extrusion and T6 treatment. Consequently, a good combination of low energy consumption and favorable mechanical properties is obtained. | Tao Liu Chun-nian He Gen Li Xin Meng Chun-sheng Shi Nai-qin Zhao | 2015 | International Journal of Minerals,Metallurgy and Materials2015，22，5： | 5 |
| 17 | Negishi Coupling for Highly Selective Syntheses of Allenes via Ligand Effect and Mechanistic Study via SAESI-MS/MS显示文摘β-H elimination is an intrinsic problem in transition metal-catalyzed reactions.We describe herein an interesting ligand effect for Et2Zn acting as either ethyl provider or H provider,respectively:by applying SPhos or Gorlos-Phos as the ligand,β-H elimination has been successfully controlled in the corresponding Negishi coupling reaction affording different poly-substituted allenes in good yields and excellent selectivities.SAESI-MS (Solvent Assisted Electrospray Ionization Mass Spectrometry) has been applied to successfully capture the highly reactive organometallic intermediates,which show the different coordination behaviors of Pd with SPhos or Gorlos-Phos as the ligand in the catalytic cycle.In addition,the different reactivities of Int 1 and Int 2 towards the formation of the final allene products have been demonstrated via SAESI-MS/MS experiments.These MS studies visualized the whole catalytic cycle for the Negishi coupling reaction while nicely explain the observed reactivity and selectivity. | Yangguangyan Zheng Bukeyan Miao Anni Qin Junzhe Xiao Qi Liu Gen Li Li Zhang Fang Zhang Yinlong Guo Shengming Ma | 2019 | Chinese Journal of Chemistry2019，37，10： | 5 |
| 18 | A New Method for Blood NT-proBNP Determination Based on a Near-infrared Point of Care Testing Device with High Sensitivity and Wide Scope显示文摘Objective To develop a rapid, highly sensitive, and quantitative method for the detection of NT-proBNP levels based on a near-infrared point-of-care diagnostic(POCT) device with wide scope. Methods The lateral flow assay(LFA) strip of NT-proBNP was first prepared to achieve rapid detection. Then, the antibody pairs for NT-proBNP were screened and labeled with the near-infrared fluorescent dye Dylight-800. The capture antibody was fixed on a nitrocellulose membrane by a scribing device. Serial dilutions of serum samples were prepared using NT-proBNP-free serum series. The prepared test strips, combined with a near-infrared POCT device, were validated by known concentrations of clinical samples. The POCT device gave the output of the ratio of the intensity of the fluorescence signal of the detection line to that of the quality control line. The relationship between the ratio value and the concentration of the specimen was plotted as a work curve. The results of 62 clinical specimens obtained from our method were compared in parallel with those obtained from the Roche E411 kit. Results Based on the log-log plot, the new method demonstrated that there was a good linear relationship between the ratio value and NT-proBNP concentrations ranging from 20 pg/mL to 10 ng/mL. The results of the 62 clinical specimens measured by our method showed a good linear correlation with those measured by the Roche E411 kit. Conclusion The new LFA detection method of NT-proBNP levels based on the near-infrared POCT device was rapid and highly sensitive with wide scope and was thus suitable for rapid and early clinical diagnosis of cardiac impairment. | ZHANG Xiao Guang SHU Yao Gen GAO Ju WANG Xuan LIU Li Peng WANG Meng CAO Yu Xi ZENG Yi | 2017 | Biomedical and Environmental Sciences2017，30，6： | 4 |
| 19 | Involvement of cAMP/cAMP-dependent protein kinase signaling pathway in regulation of Na^+, K^+-ATPase upon activation of opioid receptors by morphine显示文摘 | Liu Jing- Gen Wu Zhao-Qiu | 2006 | 中国药理通讯2006，23，4： | 4 |
| 20 | Bootstrap Approximation of Wavelet Estimates in a Semiparametric Regression Model显示文摘为在一个 semiparametric 回归模型的参数的推理被使用小浪和 bootstrap 方法学习。bootstrap 统计被使用 Efron 鈥檚 采样技术构造,并且 bootstrap 近似的强壮的一致集中被证明。我们的结果能被用来为兴趣的参数构造大样品信心间隔。模拟研究被进行评估 bootstrap 方法的有限样品的表演并且把它与正常基于近似的方法作比较。关键词自举近似-信心间隔- semiparametric 回归模型-强壮的一致集中-小浪估计先生( 2000 )题目分类 62F12 - 62F40 由中国的国家自然科学基础支持了(资助 Nos. 10571008 , 10871013 ),北京自然科学基础(资助号码 1072004 )和中国(资助号码 20070005003 ) | Liu Gen XUE Qiang LIU | 2010 | Acta Mathematica Sinica,English Series2010，26，4： | 4 |
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