|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Analysis of the clinical characteristics and neonatal outcomes of seven cases of pregnancy luteoma discovered incidentally at cesarean section显示文摘Objective:In this study,we summarize the clinical characteristics and neonatal outcomes of patients with pregnancy luteomas that were identified incidentally at cesarean section in our hospital.We also provide a review of the existing literature relating to this condition.Methods:A total of seven cases of pregnancy luteoma were enrolled from our hospital into this retrospective study between March 2013 and February 2018.We then evaluated the clinical characteristics and neonatal outcomes of these patients.Results:All seven patients with pregnancy luteomas found incidentally during Cesarean sections at term as a result of obstetric indications.These masses were unilateral and ranged from 2 to 10 cm in size.All patients underwent partial ovariectomies or oophorocystectomy due to presumptive benign ovarian tumors.Two patients had gestational diabetes and one patient had gestational hypertension.One patient developed hirsutism and a deepened voice.Of the seven newborns,three were girls and four were boys.Physical examinations of the newborns were normal and no virilization was detected among the infant girls.Conclusion:Pregnancy luteoma may be more common than expected.Better strategies are now needed to educate obstetricians about the clinical features of pregnancy luteoma so that they can avoid unnecessary surgery. | Junhua Shen Lanlan Tang Genping Huang Xiaoxia Bai Baohua Li Zhengping Wang | 2021 | Gynecology and Obstetrics Clinical Medicine2021，1，2： | 0 |
| 2 | Ni-catalyzed highly regio- and stereo-selective diborylative cyclization of 1,6-enynes with diboron reagent显示文摘The Ni-catalyzed highly selective diborylative cyclization of 1,6-enynes with diboron reagent has been developed. When pinB-Bdan was used, multiple types of boron-containing functional groups could be installed into organic molecule with great chemoselectivity and regioselectivity though this reaction. Meanwhile, if B_2pai_2 was employed, the asymmetric diborylative cyclization could be well induced by using strategy of dynamic kinetic resolution. Importantly, the above reactions could afford desired product with 100% atomic economy, and could be compatible with different series of substituents. The studies of further transformation well illustrated that different type products could serve diverse synthetic strategy. Notably, the reaction mechanism was intensively studied by density functional theory(DFT) calculations, which could reveal the mechanism of regio- and enantio-selective control. | Qitao Guan Zhen Shen Yiqiang Tian Genping Huang Chun Zhang | 2024 | Science China Chemistry2024，67，3： | 0 |
| 3 | Mechanism and selectivity of nickel-catalyzed[3+2]cycloaddition of cyclopropenones andα,β-unsaturated ketones:A computational study显示文摘Density functional theory calculations have been performed to investigate the nickel-catalyzed[3+2]cycloaddition of cyclopropenones andα,β-unsaturated ketones.The computations show that the overall catalytic cycle consists of four major steps,including:(1)C-C oxidative addition of the cyclopropenone to afford the four-membered nickelacycle,(2)isomerization,(3)migratory insertion via a 4,1-insertion fashion,and(4)C-C reductive elimination to deliver the[3+2]cycloaddition product.The enantioselectivity is mainly attributed to the p-p interaction between the diphenylcyclopropenone moiety and the phenyl substituent of the oxazoline ring of the ligand.The chemoselectivity of the C=O versus C=C insertion was rationalized in terms of the steric effect. | Lingling Liu Hongli Wu Genping Huang | 2021 | Chinese Chemical Letters2021，32，10： | 0 |
| 4 | Origins of catalyst-controlled enantiodivergent hydroamination of enones with pyridazinones:A computational study显示文摘Density functional theory calculations have been performed to investigate the dipeptide phosphinecatalyzed hydroamination of enones with pyridazinones.The computations reveal that a number of the N-H...O hydrogen-bonding interactions with the pyridazinone moiety and the C–H...O hydrogenbonding interactions with the enone moiety are present in the enantioselectivity-determining Michael addition transition states.The experimentally-observed catalyst-controlled enantiodivergence is mainly attributed to the significant impact of the substituent of the amide moiety of the dipeptide phosphine on the relative strength of the N-H...O hydrogen-bonding interactions,which was found to affect the Si face attack transition state,enabling the enantioselectivity switch upon change of chiral dipeptide phosphine catalyst. | Xiangwei Ren Hongli Wu Mei Zhang Wentao Zhao Genping Huang | 2021 | Chinese Chemical Letters2021，32，9： | 0 |
| 5 | Palladium-Catalyzed Intramolecular Dehydrogenative Arylboration of Alkenes显示文摘The palladium-catalyzed borylative cyclization via C—H activation has been developed.By this chemistry,the indole-fused dihydro-pyrrole motif,which is a kind of important unit in natural products and bio-active molecules,could be constructed and installed with a boric ester group.Furthermore,the utilities of products have been illustrated by the study of further transformations.Importantly,by using chiral ligand,the enantioselectivity of this borylative cyclization reaction could be controlled.Moreover,the borylative mechanism,which should proceed through a Pd(II)/Pd(IV)catalytic cycle,has been proposed based on the DFT calculations. | Chenchen Zou Hongli Wu Yuqi Ji Penglin Zhang Huanhuan Cui Genping Huang Chun Zhang | 2022 | Chinese Journal of Chemistry2022，40，20： | 0 |
| 6 | Mechanism of rhodium(Ⅲ)-catalyzed formal C(sp^3)-H activation/spiroannulation of a-arylidene pyrazolones with alkynes:A computational study显示文摘The rhodium-catalyzed formal C(sp^3)-H activation/spiroannulation of a-arylidene pyrazolones with alkynes was investigated by means of density functional theory calculations. The calculations indicate that the spiroannulation through the proposed C—C reductive elimination is kinetically unfeasible.Instead, the C—C coupling from the eight-membered rhodacycle was proposed to account for the experimental results. The overall catalytic cycle consists of six steps:(1) the keto-enol isomerization;(2)the O—H deprotonation,(3) the C(sp^2)—H bond cleavage;(4) the migratory insertion of alkyne into the Rh—C bond;(5) the C—C coupling and(6) the regeneration of the active catalyst. | Hongyan Zou Zhong-Liang Wang Yang Cao Genping Huang | 2018 | Chinese Chemical Letters2018，29，9： | 0 |
| 7 | Mechanism and selectivity of copper-catalyzed borocyanation of 1-aryl-1,3-butadienes:A computational study显示文摘Density functional theory calculations have been performed to investigate the copper-catalyzed borocyanation of 1-aryl-1,3-butadienes.The computations show that the regio-and enantioselectivity is determined by the borocupration step.The π-electron withdrawing aryl group at the C' atom makes the C4 atom more electrophilic than the other carbon atoms,which together with the steric repulsion around the forming C-B bond,re sults in the experimentally observed exclusive 4,3-regioselectivity.The origins of the enantioselectivity were attributed to the steric effect and π-π stacking interaction between the butadiene moiety and the ligand. | Xinzhi Li Xiangwei Ren Hongli Wu Wentao Zhao Xiangyang Tang Genping Huang | 2021 | Chinese Chemical Letters2021，32，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员