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| 1 | DZNep inhibits the proliferation of colon cancer HCT116 cells by inducing senescence and apoptosis显示文摘EZH2 is over-expressed in human colon cancer and is closely associated with tumor proliferation,metastasis and poor prognosis.Targeting and inhibiting EZH2 may be an effective therapeutic strategy for colon cancer.3-Deazaneplanocin A(DZNep),as an EZH2 inhibitor,can suppress cancer cell growth.However,the anti-cancer role of DZNep in colon cancer cells has been rarely studied.In this study,we demonstrate that DZNep can inhibit the growth and survival of colon cancer HCT116 cells by inducing cellular senescence and apoptosis.The study provides a novel view of anti-cancer mechanisms of DZNep in human colon cancer cells. | Mingquan Sha Genxiang Mao Guofu Wang Yufeng Chen Xiaojian Wu Zhen Wang | 2015 | Acta Pharmaceutica Sinica B2015，5，3： | 10 |
| 2 | A complementarity for extended Langmuir method显示文摘 | Qingdao Wang Genxiang Luo Haoping Wang Chuangye Hou Jun Jin | 2006 | Journal of Colloid and Interface Science2006，，297： | 1 |
| 3 | Strong interaction of colloidal particles:an extension of Langmuir's method显示文摘 | Luo Genxiang Wang Haoping J in Jun | 2001 | Langmuir2001，17，7： | 1 |
| 4 | BSA stabilized photothermal-fenton reactor with cisplatin for chemo/chemodynamic cascade oncotherapy显示文摘Cisplatin(CDDP)-based chemotherapy is substantially limited in the clinic due to its high postoperative recurrence rate.Synergy therapy has been proven as a potent approach to minimize recurrence and achieve enhanced treatment effects.Herein,chemotherapy drug CDDP is assembled with the photothermal-Fenton agent of bovine serum albumin(BSA)stabilized gallic acid-functionalized iron nanoparticles(GA-Fe NPs)to achieve chemo/chemodynamic synergistic cascade oncotherapy.The Pt-GA-Fe NPs can be utilized to generate H_(2)O_(2) via the activation of nicotinamide adenine dinucleotide phosphate(NADPH)oxidases(NOXs)in the tumor microenvironment(TME),which would then greatly boost H2O2-depending chemodynamic therapy(CDT).The generated cytotoxic reactive oxygen species(hydroxyl radicals,·OH)and the depletion of glutathione(GSH)would further promote CDDP-induced DNA damage.Moreover,benefiting from the absorption in the near-infrared(NIR)region,Pt-GA-Fe NPs exhibit excellent photothermal conversion efficiency(η=45.5%)and allow photoacoustic imaging(PAI)guided photothermal therapy(PTT).In vitro and in vivo experiments show that synergy therapy can effectively kill cancer cells and successfully cure cancer without systemic toxicity.The work highlights a new type of therapeutic agent based on CDDP with the ability of H_(2)O_(2) self-generation,thermal responsiveness,and enhanced CDT effects for applications in cancer therapy. | Nan Yang Tian Zhang Changyu Cao Genxiang Mao Jinjun Shao Xuejiao Song Wenjun Wang Xiaozhou Mou Xiaochen Dong | 2022 | Nano Research2022，15，3： | 0 |
| 5 | The resonance scattering of underwater elastic cylinders显示文摘If the frequency of the incident sound wave coincides with oneof the eigenfrequencies of the underwater elastic cylinder,the corre-sponding eigenvibration will be excited by incident sound wave andstrongly reradiate sound wave towards surronding water.It has been re-vealed by previous investigations that the amplitude of backscatteringsound appears to be minimum at the eigenfrequencies of the underwatermetallic cylinders because of the destructive interference between reradiatedwave of the eigenvibration and the geometrical reflected wave from surfaceof the cylinders.In this paper,a new phenomenon has been revealed.The amplitude of backscattering sound appears to be maximum at theeigenfrequencies of a cylinder made from nonmetallic material in which thevelocity of elastic transverse wave is less than the sound velocity in water. | JING Tinghua, WANG Runtian, ZHOU Genxiang WU Zhihao, XU Zhe and FENG Shaosong(institude of Acoustics, Academia sinica) | 1990 | Chinese Journal of Acoustics1990，9，3： | 0 |
| 6 | Fucoidan sulfate from Sargassum fusiforme regulates the SARS-CoV-2 receptor AXL expression in human embryonic lung diploid fibroblast cells显示文摘Coronavirus disease 2019(COVID-19)is a global infectious disease that seriously endangers human life and health and affects normal social activities.Since the pandemic outbreak from December 2019 to February 2023,the total number of confirmed cases has exceeded 753 million,and the deaths caused by COVID-19 have reached 6.6 million(http://gffzze7c39cdc9e894ca6sxnn6p6qx99c66wxu.ffgz.tsg.suse.edu.cn;accessed on Feb.16,2023). | Xuqiang ZHOU Weihua JIN Di JIANG Yipeng XU Sanying WANG Xinna WU Yunchuang CHANG Huili SU Tianjun ZHU Xiaogang XU Genxiang MAO | 2023 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2023，24，11： | 0 |
| 7 | Pyropia haitanensis polysaccharide extends lifespan by inhibiting protein aggregation in Caenorhabditis elegans显示文摘Pyropia haitanensis polysaccharide(LP)have been found for having many excellent functions such as anti-aging.Using Caenorhabditis elegans models,we evaluated the anti-aging activity of LP by observing the lifespan,reproduction,pharyngeal pumping,stress response,quantitative fluorescence of polyglutamic acid,and nuclear localization of DAF-16 of worms.The results reveal that LP could extend the adult lifespan of wild-type and polyQ nematodes,indicating a connection of its anti-aging benefit with the toxicity-suppressing effect.The number of polyglutamic acid aggregates in high concentration groups decreased by 24.39%(P<0.05)to the control.The high-dose group strongly induced DAF-16 nuclear translocation over intermediate and cytosolic localizations compared with the control(P<0.001).Therefore,we believe that LP could extend the lifespan and reduce the protein aggregation in C.elegans through nuclear DAF-16∷GFP expression. | Zhongshan ZHANG Xiaomei WANG Yongliang PAN Zhanqi WANG Zhengshun WEN Feng LIU Genxiang MAO | 2021 | Journal of Oceanology and Limnology2021，39，2： | 0 |
| 8 | Bifunctional Mn-doped CoSe_(2) nanonetworks electrode for hybrid alkali/acid electrolytic H_(2) generation and glycerol upgrading显示文摘Electrolytic water splitting,as a promising route to hydrogen(H_(2))production,is still confronted with the sluggish anodic oxygen evolution reaction(OER)and its less value-added O2 production.Herein,we report a bifunctional electrode fabricated by in situ growth of Mn-doped CoSe_(2)nanonetworks on carbon fiber cloth(Mn-CoSe_(2)/CFC),which shows attractive electrocatalytic properties toward glycerol oxidation reaction(GOR)in alkali and hydrogen evolution reaction(HER)in acid.A flow alkali/acid hybrid electrolytic cell(fA/A-hEC)was then developed by coupling anodic GOR with cathodic HER with the Mn-CoSe_(2)/CFC bifunctional electrode.Such fA/A-hEC enables a rather low voltage of 0.54 V to achieve 10 mA cm^(-2),and maintain long-term electrolysis stability over 300-h operation at 100 mA cm^(-2)with Faraday efficiencies of over 99%for H_(2)and 90%for formate production.The designed bifunctional electrode in such innovative fA/A-hEC device provides insightful guidance for coupling energy-efficient hydrogen production with biomass upgradation. | Linfeng Fan Yaxin Ji Genxiang Wang Zhifang Zhang Luocai Yi Kai Chen Xi Liu Zhenhai Wen | 2022 | Journal of Energy Chemistry2022，31，9： | 0 |
| 9 | An interfacial engineering strategy of electrocatalyst boosts ammonia electrosynthesis显示文摘Ammonia (NH3) is not only an essential chemical feedstock for the manufacture of nitrogen-rich fertilizers but also a promising carbofree energy carrier for storing H2 due to its high content of hydrogen (17.6% by mass). At present, industrial NH3 is still dominantly produced by the traditional Haber-Bosch process, which reduces nitrogen (N2) to NH3 (N2+3H2←→2NH 3) at high temperatures (350-550 °C) and high pressures (150-350 atm)[1]. Such a process not only requires the raw materials of high-purity streams of nitrogen and hydrogen but also consumes tremendous energy;noting that the consumed hydrogen occupied approximately 50% of its global production that produced exclusively from transformations of fossil resources with the emission of greenhouse gas [1]. | Yichun Ding Genxiang Wang Zhenhai Wen | 2019 | Science China Chemistry2019，62，8： | 0 |
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