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| 1 | Parameters affecting the growth and hydrogen production of the green alga Chlamydomonas reinhardtil显示文摘 | Bojan T Fessehaye W Z Geoffrey C M | 2011 | Intemafional Journal of Hydrogen Energy2011，36，13： | 1 |
| 2 | Obesity and diabetes accelerate hepatocarcinogenesis via hepatocyte proliferation independent of NF-κB or Akt/mTORC1显示文摘Background:There are strong links between obesity,diabetes and hepatocellular carcinoma(HCC),but molecular mechanisms remain unclear.Aim:We tested the proposed involvement of NF-κB,IL-6/STAT3 and Akt/mTORC1 before onset(at 3 months)and at onset(6 months)of accelerated hepatocarcinogenesis in DEN-injected obese and diabetic foz/foz compared to lean wildtype(Wt)mice,and also studied the hepatocyte proliferative response to DNA damage between the obese and lean lines.Methods:Male foz/foz and Wt littermates fed normal chow were DEN-injected(10mg/kg i.p.)at age 12-15 days.To test the effect of mTOR inhibitor on growth of dysplastic hepatocytes,a separate cohort of DEN-injected foz/foz mice was administered rapamycin(4 mg/kg body weight/day).Results:foz/foz mice developed obesity,hyperinsulinemia,diabetes,adipokine dysregulation and fatty liver,without increased serum or liver TNF-αor serum IL-6.All DEN-injected foz/foz mice developed HCC by 6 mths vs.0/10 lean Wt.At 3 mths,there were more dysplastic hepatocytes in DEN-injected foz/foz than Wt,with increased liver injury(serum ALT),hepatocyte apoptosis(M30-positive cells)and proliferation(cyclin D1,cyclin E,PCNA),but neither NF-κB nor STAT3 activation.foz/foz livers exhibited upregulation of DNA damage sensors ATM and ATR,with inadequate cell cycle checkpoint controls(CHK1,CHK2,p53,p21).Akt and mTORC1 were highly activated in livers from foz/foz vs.Wt mice.Despite such activation,rapamycin failed to reduce growth of dysplastic hepatocytes.Conclusions:Accelerated DEN-induced HCC in obese/diabetic mice is linked to enhanced growth of dysplastic hepatocytes that cannot be attributed to NF-κB or IL-6/STAT3 activation,nor to sustained mTORC1 activation.The critical mechanism for obesity-enhanced hepatocarcinogenesis lies in the disconnection between hepatocellular injury with DNA damage,and an unrestrained proliferative response.Relevance for patients:This study supports the epidemiological data linking obesity,diabetes and fatty liver disease with increased risk for developing HCC.The findings also suggest that mTORC1 inhibition may not be beneficial in the prevention of obesity-related hepatocarcinogenesis. | Evi Arfianti Claire Z Larter Seungsoo Lee Vanessa Barn Geoffrey Haigh Matthew M.Yeh George NIoannou Narci C.Teoh Geoffrey C.Farrell | 2016 | Journal of Clinical & Translational Research2016，2，1： | 1 |
| 3 | Benefiting from network position:firmcapabilities,structural holes,and performance显示文摘 | Akbar Z Geoffrey G Bell | 2005 | Strategic Management Journal2005，26，9： | 1 |
| 4 | Benefitting from network position: firm capabilities,structural holes,and performance显示文摘 | AKBAR Z GEOFFREY G B | 2005 | Strategic Management Journal2005，26，： | 1 |
| 5 | Analysis of early hepatic stage schistosomula gene expression by subtractive expressed sequence tags library 显示文摘 | Wang X Z Geoffrey N Gobert | 2009 | Molecular and Biochemical Parasitology2009，166，： | 1 |
| 6 | Nonalcoholic fatty liver disease:from steatosis to cirrhosis显示文摘 | Farrell Geoffrey C Larter Claire Z | 2006 | Hepatology2006，43，21： | 1 |
| 7 | Acute passive stretch- ing alters the meehianieal properities of human plantar flexors and the optimal angle for maximal voluntary contraction 显示文摘 | Weir DE Tingley J Geoffrey Z Elder GCB | 2005 | Eur J Appl Physiol2005，93，： | 1 |
| 8 | Effect of organic-matter type and thermal maturity on methane adsorption in shale-gas systems 显示文摘 | TONGWEI Z GEOFFREY S E STEPHEN C R | 2012 | Organic Geochemistry2012，，： | 1 |
| 9 | Circular permutation and receptor insertion within green fluorescent proteins 显示文摘 | Geoffrey S B David A Z Roger Y | 1999 | Proc Natl Acad Sci USA1999，96，11： | 1 |
| 10 | Low - usage codons in Escherichi- a coli,yeast,fruit,fly and primates显示文摘 | Zhang S P Geoffrey Z Emanuel G | 1991 | Gene1991，105，： | 1 |
| 11 | Low usage codons in Escherichia coil,yeast,fruit fly and primates显示文摘 | Shiping Zh Geoffrey Z Ernanuel G | 1991 | Gene1991，105，： | 1 |
| 12 | Sofosbuvir and ribavirin in HCV genotypes 2 and 3 显示文摘 | Stefan Z Geoffrey MD Riina S | 2014 | N Engl J Med2014，370，21： | 1 |
| 13 | Treatment outcomes of advanced esophageal cancer patients and polymorphisms of nucleotide and base excision repair pathway genes显示文摘 | Geoffrey L Ariela LM Wei Z | 2006 | Proc Amer Assoc Cancer Res2006，47，1： | 1 |
| 14 | Nonalcoholic fatty liver disease:from steatosis to cirrhosis显示文摘 | Geoffrey F Larter Claire Z | 2006 | Hepatology2006，43，2： | 1 |
| 15 | Low usage codon in Escherichia coli,yeast,fruit fly and primates显示文摘 | Zhang S Geoffrey Z Emanel G | 1991 | Gene1991，105，： | 1 |
| 16 | Videoendoscopic distortion correction and its application to virtual guidance of endoscopy显示文摘 | JAMES P H CHAO Z GEOFFREY M | 2001 | IEEE Trans on Medical Imaging2001，20，7： | 1 |
| 17 | 19-(R)-and 19-(S)- hydroxydihydrokoumine from Gelsemium elegans 显示文摘 | Lin L Z Geoffrey A C Ni C Z | 1990 | Phyto- chemistry1990，29，3： | 1 |
| 18 | Gelsamydine, an indole alkaloid from Gelsemium elegans with two monoterpene unites 显示文摘 | Lin L Z Geoffrey A C | 1989 | J Org Chem1989，54，： | 1 |
| 19 | New humantenine-type al- kaloids from Gelsemium elegans 显示文摘 | Lin L Z Geoffrey A C Ni C Z | 1989 | J Nat Prod1989，52，3： | 1 |
| 20 | Gelsemamide and 11 -me- thoxygelsemamide, two novel secoindole alkaloids from Gelsemium elegans 显示文摘 | Lin L Z Geoffrey A C Ni C Z | 1989 | Tetrahedron Lett1989，30，10： | 1 |
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