|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Irritable bowel syndrome: A concise review of current treatment concepts显示文摘Irritable bowel syndrome(IBS) is one of the most common gastrointestinal disorders causing patients to seek medical treatment. It is relatively resource intensive and the source of significant morbidity. Recent insights into the pathophysiology and treatment of IBS has given clinicians more options than ever to contend with this disorder. The purpose of our paper is to review older, 'classic' treatments for IBS as well as newer agents and 'alternative' therapies. We discuss the evidence base of these drugs and provide context to help develop appropriate treatment plans for IBS patients. | Geoffrey C Wall Ginelle A Bryant Michelle M Bottenberg Erik D Maki rew R Miesner | 2014 | World Journal of Gastroenterology2014，20，27： | 5 |
| 2 | Testing for HCV Infection: An Update of Guidance for Clinicians and Laboratorians显示文摘 | Getchell Jane P Wroblewski Kelly E DeMaria Alfred Bean Christine L Parker Monica M Pandori Mark Dufour D Robert Busch Michael P Brecher Mark E Meyer William A Pesano Rick L Teo Chong-Gee Beckett Geoffrey A Araujo Aufra C Branson Bernard M D | 2013 | MMWR. Morbidity and Mortality Weekly Report2013，，18： | 3 |
| 3 | 对应用选择性环氧酶2抑制剂或传统非甾体类抗炎药物老年患者上消化道出血的观察研究显示文摘目的 对应用选择性环氧酶2(COX 2)抑制剂和非选择性的非甾体类抗炎药(NSAIDs)的老年患者上消化道出血的比率进行比较。 设计 观察性队列研究。 设置 利用来自加拿大安大略2000年4月17日~2001年3月31日的官方数据,以确认基于人群的、初次使用NSAID的队列患者。 对象 年龄≥66岁,开始服用非选择性NSAIDs(n=5391)、双氯芬酸(diclofenac)加米索前列醇(misoprostol)(n=5087)、罗非昔布(rofecoxib)(n=14 583)或塞来昔布(celecoxib)(n=18 908),以及随机选择的没有服用NSAIDs的对照组(n=100 000)。 衡量结局的主要指标 每个药物组因上消化道出血入院的比值比(经过调整潜在的混杂因子)。 结果 与对照组相比,多变量模型表明,在服用非选择性NSAIDs(调整比值比为4.0,95%,可信区间为2.3~6.9,)、双氯芬酸加米索前列醇(3.0,1.7~5.6)以及罗非昔布(1.9,1.3~2.8)时,上消化道出血的短期危险性是增加的,而塞来昔布并没有增加(1.0,0.7~1.6)。与塞来昔布相比,非选择性的NSAIDs(4.4,2.3~8.5)、双氯芬酸加 米索前列醇(3.2,1.6—6.5)以及罗非昔布(1.9,1.2~2.8)的上消化道出血危险性显著增加。与罗非昔布相比,非选择性NSAIDs的上消化道出血危险性显著增加(1.9,1.0~3.5)。 结论 选择性COX | Muhammad Mamdani Paula A Rochon David N Juurlink Alex Kopp Geoffrey M Anderson Gary Naglie Peter C Austin Andreas Laupacis 邓瑞雪 | 2003 | 英国医学杂志中文版2003，6，3： | 2 |
| 4 | An interna for the determination of puri fled microcystin-LR and microcystins in cyanobacterial field material显示文摘 | JUTTA F GEOFFREY A C tional intercomparison exercise JAMES S | 2002 | Anal Bioanal Chem2002，374，： | 1 |
| 5 | Fatigue performance of concrete beams strengthened with CFRP plates 显示文摘 | Richard A B Geoffrey C M | 1999 | Journal of Composites for Construction1999，3，2： | 1 |
| 6 | Flavonol tetraglycosides and other constituents from leaves of Styphnolobiumjaponicum (Leguminosae) and related taxa显示文摘 | Geoffrey C Kite Charlotte A Sroneham Nigel C Veitch | 2007 | Phytochemistry2007，68，10： | 1 |
| 7 | Oxidation of^6-to^5 by peroxomonosulfate in strong and weak acid solutions,an example of zero-order kinetics显示文摘 | Annette L N Robert C B Geoffrey A L | 1998 | J Chem Soc Dalton Trans1998，，5： | 1 |
| 8 | Nomenclature of natural orifice translumenal endoscopic surgery ( NOTESTM ) and Laparoendoscopic single-site surgery (LESS) produres in urology 显示文摘 | Geoffrey B Timothy A Jeffrey C | 2008 | J Endourol2008，22，11： | 1 |
| 9 | Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans显示文摘 | Rhee Eugene P Cheng Susan Larson Martin G Walford Geoffrey A Lewis Gregory D McCabe Elizabeth Yang Elaine Farrell Laurie Fox Caroline S O’Donnell Christopher J Carr Steven A Vasan Ramachandran S Florez Jose C Clish Clary B Wang Thomas J Ger | 2011 | Journal of Clinical Investigation2011，，4： | 1 |
| 10 | Effect of crizotinib on overall survival in patients with advanced non-small-cell lung cancer harbouring ALK gene rearrangement: a retrospective analysis显示文摘 | Alice T Shaw Beow Y Yeap Benjamin J Solomon Gregory J Riely Justin Gainor Jeffrey A Engelman Geoffrey I Shapiro Daniel B Costa Sai-Hong I Ou Mohit Butaney Ravi Salgia Robert G Maki Marileila Varella-Garcia Robert C Doebele Yung-Jue Bang Kimary Kulig Pauli | 2011 | Lancet Oncology2011，，11： | 1 |
| 11 | Tranexamic acid for intracerebral haemorrhage within 2 hours of onset: protocol of a phase Ⅱ randomised placebo-controlled double-blind multicentre trial显示文摘Rationale Haematoma growth is common early after intracerebral haemorrhage(ICH),and is a key determinant of outcome.Tranexamic acid,a widely available antifibrinolytic agent with an excellent safety profile,may reduce haematoma growth.Methods and design Stopping intracerebral haemorrhage with tranexamic acid for hyperacute onset presentation including mobile stroke units(STOP-MSU)is a phase Ⅱ double-blind,randomised,placebo-controlled,multicentre,international investigator-led clinical trial,conducted within the estimand statistical framework.Hypothesis In patients with spontaneous ICH,treatment with tranexamic acid within 2 hours of onset will reduce haematoma expansion compared with placebo.Sample size estimates A sample size of 180 patients(90 in each arm)would be required to detect an absolute difference in the primary outcome of 20%(placebo 39%vs treatment 19%)under a two-tailed significance level of 0.05.An adaptive sample size re-estimation based on the outcomes of 144 patients will allow a possible increase to a prespecified maximum of 326 patients.Intervention Participants will receive 1 g intravenous tranexamic acid over 10 min,followed by 1 g intravenous tranexamic acid over 8 hours;or matching placebo.Primary efficacy measure The primary efficacy measure is the proportion of patients with haematoma growth by 24±6 hours,defined as either≥33%relative increase or≥6 mL absolute increase in haematoma volume between baseline and follow-up CT scan.Discussion We describe the rationale and protocol of STOP-MSU,a phase Ⅱ trial of tranexamic acid in patients with ICH within 2 hours from onset,based in participating mobile stroke units and emergency departments. | Nawaf Yassi Henry Zhao Leonid Churilov Bruce C V Campbell Teddy Wu Henry Ma Andrew Cheung Timothy Kleinig Helen Brown Philip Choi Jiann-Shing Jeng Annemarei Ranta Hao-Kuang Wang Geoffrey C Cloud Rohan Grimley Darshan Shah Neil Spratt Der-Yang Cho Karim Mahawish Lauren Sanders John Worthington Ben Clissold Atte Meretoja Vignan Yogendrakumar Mai Duy Ton Duc Phuc Dang Nguyen Thai My Phuong Huy-Thang Nguyen Chung Y Hsu Gagan Sharma Peter J Mitchell Bernard Yan Mark W Parsons Christopher Levi Geoffrey A Donnan Stephen M Davis | 2022 | Stroke & Vascular Neurology2022，7，2： | 1 |
| 12 | Effect of crizotinib on overall survival in patients with advanced non-small-cell lung cancer harbouring ALK gene rearrangement: a retrospective analysis显示文摘 | Alice T Shaw Beow Y Yeap Benjamin J Solomon Gregory J Riely Justin Gainor Jeffrey A Engelman Geoffrey I Shapiro Daniel B Costa Sai-Hong I Ou Mohit Butaney Ravi Salgia Robert G Maki Marileila Varella-Garcia Robert C Doebele Yung-Jue Bang Kimary Kulig Pauli | 2011 | Lancet Oncology2011，，11： | 1 |
| 13 | Prevalence of and Risk Factors for Hepatic Steatosis and Nonalcoholic Fatty Liver Disease in People With Type 2 Diabetes: the Edinburgh Type 2 Diabetes Study显示文摘 | Williamson Rachel M Price Jackie F Glancy Stephen Perry Elisa Nee Lisa D Hayes Peter C Frier Brian M Van Look Liesbeth A F Johnston Geoffrey I Reynolds Rebecca M Strachan Mark W J | 2011 | Diabetes Care2011，，5： | 1 |
| 14 | Cyanobacterial toxins:Risk management for health protection显示文摘 | GEOFFREY A C LOUISE F M JAMES S M | 2005 | Toxicology and Applied Pharmacology2005，203，3： | 1 |
| 15 | Air transportation demand forecasts in emerging market economies显示文摘 | Richard C Cline Terry A Ruhl Geoffrey D Gosling David W Gillen | 1998 | Journal of Air Transport Management1998，4，： | 1 |
| 16 | Peltogynoids and homoisoflavonoids from Caesalpiniapulcherrima显示文摘 | David D M Geoffrey A C Djaja D S | 1983 | Phytochemistry1983，22，： | 1 |
| 17 | Production of viable homozygous, doubled haploid channel catfish (Ictalurus punctatus) 显示文摘 | Geoffrey C W Brian G B Sylvie M A Q | 2009 | Marine Biotechnology2009，12，： | 1 |
| 18 | Models, Strategies,And Tools显示文摘 | Sales A Smith J Geoffrey C | 2006 | Journal of General Internal Medicine2006，21，2： | 1 |
| 19 | Fatigue performance of concrete beams strengthened with CFRP plates 显示文摘 | Richard A B Geoffrey C M | 1999 | Journal of Composites for Construction1999，3，2： | 1 |
| 20 | Visualization in 3-D seismic interpretation显示文摘 | Geoffrey A D Mary J C Kenneth M T | 1995 | The Leading Edge1995，14，10： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员